I am interested in understanding the mechanisms of right ventricular adaptation and failure in pulmonary hypertension, particularly the role of inflammation and inflammatory cell types as well as biologic sex and sex hormones on right ventricular function.
Publications
Gu S, Goel K, Forbes LM, Kheyfets VO, Yu YA, Tuder RM, Stenmark KR. Tensions in Taxonomies: Current Understanding and Future Directions in the Pathobiologic Basis and Treatment of Group 1 and Group 3 Pulmonary Hypertension. Compr Physiol. 2023 Jan 30;13(1):4295-4319. PubMed PMID: 36715285
Bousseau S, Sobrano Fais R, Gu S, Frump A, Lahm T. Pathophysiology and new advances in pulmonary hypertension. BMJ Med. 2023;2(1):e000137. PubMed PMID: 37051026
Gu S, Goel K, Forbes LM, Kheyfets VO, Yu YA, Tuder RM, Stenmark KR. Tensions in Taxonomies: Current Understanding and Future Directions in the Pathobiologic Basis and Treatment of Group 1 and Group 3 Pulmonary Hypertension. Compr Physiol. 2023 Jan 30;13(1):4295-4319. PubMed PMID: 36715285
Bousseau S, Sobrano Fais R, Gu S, Frump A, Lahm T. Pathophysiology and new advances in pulmonary hypertension. BMJ Med. 2023;2(1):e000137. PubMed PMID: 37051026
Gu S, Mickael C, Kumar R, Lee MH, Sanders L, Kassa B, Harral J, Williams J, Hansen KC, Stenmark KR, Tuder RM, Graham BB. The role of macrophages in right ventricular remodeling in experimental pulmonary hypertension. Pulm Circ. 2022 Jul;12(3):e12105. PubMed PMID: 35874852
Campbell NV, Mickael C, Kumar S, Zhang H, Campbell IL, Gillen AE, Trentin CO, Diener K, Gao B, Kheyfets VO, Gu S, Kumar R, Phang T, Brown RD, Graham BB, Stenmark KR. Single-cell RNA sequencing and binary hierarchical clustering define lung interstitial macrophage heterogeneity in response to hypoxia. Am J Physiol Lung Cell Mol Physiol. 2022 Jul 1;323(1):L58-L68. PubMed PMID: 35608266
Kassa B, Kumar R, Mickael C, Sanders L, Vohwinkel C, Lee MH, Gu S, Poth JM, Stenmark KR, Zhao YY, Tuder RM, Graham BB. Endothelial cell PHD2-HIF1a-PFKFB3 contributes to right ventricle vascular adaptation in pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2021 Oct 1;321(4):L675-L685. PubMed PMID: 34346780
Forbes LM, Gu S, Badesch DB. Surrogate Markers for Pulmonary Hypertension May Inform Prognosis in Lung Cancer. Am J Respir Crit Care Med. 2021 May 15;203(10):1220-1221. PubMed PMID: 33789070
Mickael C, Lee MH, Gu S, Graham BB. Comparing pulmonary hypertension severity between rat strains suggests right ventricle NK cells are protective. Cardiovasc Res. 2019 Mar 15;115(4):699-700. PubMed PMID: 30517607
Gu S, Kumar R, Lee MH, Mickael C, Graham BB. Common genetic variants in pulmonary arterial hypertension. Lancet Respir Med. 2019 Mar;7(3):190-191. PubMed PMID: 30527955
Mickael C, Kumar R, Hernandez-Saavedra D, Kassa B, Sanders L, Koyanagi D, Gu S, Lee MH, Tuder RM, Graham BB. IL-6Ra in Smooth Muscle Cells Protects against Schistosoma- and Hypoxia-induced Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2019 Jul;61(1):123-126. PubMed PMID: 31259624
Ahmad N, Ahuja SD, Akkerman OW, Alffenaar JC, Anderson LF, Baghaei P, Bang D, Barry PM, Bastos ML, Behera D, Benedetti A, Bisson GP, Boeree MJ, Bonnet M, Brode SK, Brust JCM, Cai Y, Caumes E, Cegielski JP, Centis R, Chan PC, Chan ED, Chang KC, Charles M, Cirule A, Dalcolmo MP, D'Ambrosio L, de Vries G, Dheda K, Esmail A, Flood J, Fox GJ, Fréchet-Jachym M, Fregona G, Gayoso R, Gegia M, Gler MT, Gu S, Guglielmetti L, Holtz TH, Hughes J, Isaakidis P, Jarlsberg L, Kempker RR, Keshavjee S, Khan FA, Kipiani M, Koenig SP, Koh WJ, Kritski A, Kuksa L, Kvasnovsky CL, Kwak N, Lan Z, Lange C, Laniado-Laborín R, Lee M, Leimane V, Leung CC, Leung EC, Li PZ, Lowenthal P, Maciel EL, Marks SM, Mase S, Mbuagbaw L, Migliori GB, Milanov V, Miller AC, Mitnick CD, Modongo C, Mohr E, Monedero I, Nahid P, Ndjeka N, O'Donnell MR, Padayatchi N, Palmero D, Pape JW, Podewils LJ, Reynolds I, Riekstina V, Robert J, Rodriguez M, Seaworth B, Seung KJ, Schnippel K, Shim TS, Singla R, Smith SE, Sotgiu G, Sukhbaatar G, Tabarsi P, Tiberi S, Trajman A, Trieu L, Udwadia ZF, van der Werf TS, Veziris N, Viiklepp P, Vilbrun SC, Walsh K, Westenhouse J, Yew WW, Yim JJ, Zetola NM, Zignol M, Menzies D. Treatment correlates of successful outcomes in pulmonary multidrug-resistant tuberculosis: an individual patient data meta-analysis. Lancet. 2018 Sep 8;392(10150):821-834. PubMed PMID: 30215381
Mohan S, Gu S, Parikh A, Radhakrishnan J. Prevalence of hyponatremia and association with mortality: results from NHANES. Am J Med. 2013 Dec;126(12):1127-37.e1. PubMed PMID: 24262726
Lungs and Breathing - Chronic Thromboembolic Pulmonary Hypertension (CTEPH)
Lungs and Breathing - Lung Disease
Lungs and Breathing - Pulmonary Embolism
Lungs and Breathing - Pulmonary Hypertension
Lungs and Breathing - Pulmonary Disorders
Care Philosophy
I strive to provide the best care for my patients. I believe in treating the person as a whole, taking every aspect of a patient’s body and health into consideration during diagnosis and treatment.
General Information
Medical Schools:
MD, Columbia University College of Physicians and Surgeons
(2013)
Graduate Schools:
MSPH, Charite - Universitatsmedizin Berlin
(2009)
Undergraduate Schools:
BA, Yale University (CT)
(2008)
Internships:
University of Colorado
(2014)
Residency Programs:
University of Colorado, Internal Medicine (2016)
Fellowships:
University of Colorado, Pulmonary Disease and Critical Care Medicine
(2020)