Kika Sucharov, PhD

Research Interests

Publications

• A {beta}1-adrenergic receptor, CaM Kinase II dependent pathway mediates cardiac myocyte fetal gene induction. Am J Physiol Heart Circ Physiol.
• Gene expression and heart failure. 24-27 July 2005, 2nd Annual Symposium of the American Heart Association Council on Basic Cardiovascular Sciences. Expert Rev Cardiovasc Ther. 3(6):983-4.
• Beta1-adrenergic stimulation results in ERK1/2 activation that is prohypertrophic and dependent on CaMKII and Calcineurin. Second Annual Symposium of the American Heart Association Council on Basic Cardiovascular Sciences.
• TRPC channels and beta1-adrenergic-mediated activation of the fetal gene program. Second Annual Symposium of the American Heart Association Council on Basic Cardiovascular Sciences.
• (2005) Beta1-adrenergic stimulation results in ERK1/2 activation that is prohypertrophic and dependent on CaMKII and Calcineurin. 9th Annual Scientific Meeting – Heart Failure Society of America.
• Sucharov, C.C., Langer S., Bristow M.R. and Leinwand L.A. Shuttling of HDAC5 in H9C2 cells regulates YY1 function through CaMKIV/PKD and PP2A. 2006. Am J Physiol Cell Physiol. 291(5):C1029-37.
• Sucharov, C.C. Beta-adrenergic pathways in human heart failure. 2007. Expert Rev Cardiovasc Ther. 2007 Jan;5(1):119-24.
• Taylor, M.R.G.; Slavov, D.; Ku, L.; Di Lenarda. A.; Sinagra, G.; Carniel, E.; Haubold, K.; Boucek, M.; Ferguson, D.; Graw, S.; Zhu, X.; Cavanaugh, J.; Sucharov, C.C.; Long, C.S.; Lavori, P.; Mestroni, L.; and the Familial Cardiomyopathy Registry and the BEST DNA Bank. Prevalence of desmin mutations in dilated cardiomyopathy. 2007. Circulation.
• Gene expression changes in beta-adrenegic treated human trabeculae presented at the 3rd Annual Symposium of the American Heart Association Council on Basic Cardiovascular Sciences.
• http://www.ncbi.nlm.nih.gov/pubmed/17187463?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
• http://www.ncbi.nlm.nih.gov/pubmed/17325244?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
• http://www.ingentaconnect.com/search/article?author=sucharov&year_from=2003&year_to=2008&database=1&pageSize=20&index=1
• Sucharov, C.C., Dockstader, K., McKinsey, T. 2008 YY1 prevents against pathologic cardiac hypertrophy by interacting with HDAC5. Mol Biol Cell. 19(10):4141-53.
• Sucharov, C.C., Bristow, M.R., Port, D. 2008 Regulation of miRNA Expression in the Failing Human Heart: Functional Correlates. J Mol Cell Cardiol. 45(2): p. 185-92.
• Cresci, S., Jones, P.G., Sucharov, C.C., Marsh. S., Lanfear, D.E., Garsa, A., Courtois, M., Weinheimer, C.J., Wu, J., Province, M.A., Kelly, D., McLeod, H.L., Spertus, J.A. 2008 Interaction Between PPARA Genotype and b-Blocker Treatment Influences Clinical Outcomes Following Acute Coronary Syndromes. Pharmacogenomics. 9(10):1403-17.
• Sihag S, Cresci S, Li AY, Sucharov CC, Lehman JJ. 2009 PGC-1alpha and ERRalpha target gene downregulation is a signature of the failing human heart. J Mol Cell Cardiol. 46(2):201-12.
• Sucharov, C.C., Port, J.D. 2010 Role of microRNAs in cardiovascular disease: therapeutical challenges and potentials. J Cardiovasc Pharmacol. 2010 56(5):444-53.
• Stauffer BL, Sobus R, Sucharov, CC. Sex differences in cardiomyocyte Connexin 43 expression. Journal of Cardiovascular Pharmacology, 2011, in press.
• Sucharov CC, Dockstader K, Nunley K, McKinsey TA, Bristow MR. 2011. ?-adrenergic receptor stimulation and activation of PKA protect against ??-adrenergic mediated phosphorylation of PKD and HDAC5. Journal of Cardiac Failure, in press.
• Sucharov CC*, Dockstader K, Nunley K, McKinsey TA, Bristow MR. 2011. b-adrenergic receptor stimulation and activation of PKA protect against a1-adrenergic mediated phosphorylation of PKD and HDAC5. Journal of Cardiac Failure, 17(7):592-600. PMC21703532
• Stauffer BL, Sobus R, Sucharov, CC. Sex differences in cardiomyocyte Connexin 43 expression. Journal of Cardiovascular Pharmacology, 58(1):32-39. PMC21753256.
• 2. Port J.D., Walker L.A., Polk J., Nunley K., Buttrick P.M., Sucharov C.C.* 2011. Temporal Expression of miRNAs and mRNAs in a Mouse Model of Myocardial Infarction. Physiol Genomics, 43(19): 1087-95. PMC21771878.
• 3. Dockstader K., Nunley K., Karimpour-Fard A., Medway A., Nelson, P., Port J.D., Liggett S.B., Bristow M.R., Sucharov C.C.* 2011. Temporal Analysis of mRNA and miRNA Expression in Transgenic Mice Over Expressing Arg- and Gly389 Polymorphic Variants of the ß1-Adrenergic Receptor. Physiol Genomics, 43(23):1294-306. PMC21954455
• Miyamoto S.D., Stauffer B.L., Nakano S., Sobus R., Nunley K., Nelson P., Sucharov C.C.* Beta-Adrenergic Adaptation in Pediatric Idiopathic DCM. European Heart Journal. In press. PMC22843448
• Stauffer BL, Russell G, Nunley K, Miyamoto SD, Sucharov CC*. miRNA expression in the pediatric failing human heart. Journal of Molecular and Cellular Cardiology. 2012:In Press.
• Wang D, Zhang H, Li M, Frid MG, Flockton AR, McKeon BA, Yeager ME, Fini MA, Morrell NW, Pullamsetti SS, Velegala S, Seeger W, McKinsey TA, Sucharov CC, Stenmark KR. MicroRNA-124 controls the proliferative, migratory, and inflammatory phenotype of pulmonary vascular fibroblasts. Circ Res. 2014 Jan 3;114(1):67-78. PubMed PMID: 24122720
• Sucharov CC, Hijmans JG, Sobus RD, Melhado WF, Miyamoto SD, Stauffer BL. ß-Adrenergic receptor antagonism in mice: a model for pediatric heart disease. J Appl Physiol (1985). 2013 Oct 1;115(7):979-87. PubMed PMID: 23887897
• Stauffer BL, Russell G, Nunley K, Miyamoto SD, Sucharov CC. miRNA expression in pediatric failing human heart. J Mol Cell Cardiol. 2013 Apr;57:43-6. PubMed PMID: 23333438
• Gene Expression and beta-adrenergic Signaling are Altered in Hypoplastic Left Heart Syndrome. Journal of Heart and Lung Transplantation
• Medina E, Sucharov CC, Nelson P, Miyamoto SD, Stauffer BL. Molecular Changes in Children with Heart Failure Undergoing Left Ventricular Assist Device Therapy. J Pediatr. 2016 Nov 29. [Epub ahead of print] PubMed PMID: 27908653
• Woulfe KC, Siomos AK, Nguyen H, SooHoo M, Galambo C, Stauffer BL, Sucharov C, Miyamoto S. Fibrosis and Fibrotic Gene Expression in Pediatric and Adult Patients With Idiopathic Dilated Cardiomyopathy. J Card Fail. 2016 Nov 24. [Epub ahead of print] PubMed PMID: 27890770
• Nakano SJ, Sucharov J, van Dusen R, Cecil M, Nunley K, Wickers S, Karimpur-Fard A, Stauffer BL, Miyamoto SD, Sucharov CC. Cardiac Adenylyl Cyclase and Phosphodiesterase Expression Profiles Vary by Age, Disease, and Chronic Phosphodiesterase Inhibitor Treatment. J Card Fail. 2017 Jan;23(1):72-80. PubMed PMID: 27427220
• Stratton MS, Lin CY, Anand P, Tatman PD, Ferguson BS, Wickers ST, Ambardekar AV, Sucharov CC, Bradner JE, Haldar SM, McKinsey TA. Signal-Dependent Recruitment of BRD4 to Cardiomyocyte Super-Enhancers Is Suppressed by a MicroRNA. Cell Rep. 2016 Aug 2;16(5):1366-78. PubMed PMID: 27425608
• Nakano SJ, Nelson P, Sucharov CC, Miyamoto SD. Myocardial Response to Milrinone in Single Right Ventricle Heart Disease. J Pediatr. 2016 Jul;174:199-203.e5. PubMed PMID: 27181939
• Nakano SJ, Siomos AK, Garcia AM, Nguyen H, SooHoo M, Galambos C, Nunley K, Stauffer BL, Sucharov CC, Miyamoto SD. Fibrosis-Related Gene Expression in Single Ventricle Heart Disease. J Pediatr. 2017 Dec;191:82-90.e2. PubMed PMID: 29050751
• Woulfe KC, Sucharov CC. Midkine's Role in Cardiac Pathology. J Cardiovasc Dev Dis. 2017 Sep;4(3). PubMed PMID: 28920060
• Kheyfets VO, Sucharov CC, Truong U, Dunning J, Hunter K, Ivy D, Miyamoto S, Shandas R. Circulating miRNAs in Pediatric Pulmonary Hypertension Show Promise as Biomarkers of Vascular Function. Oxid Med Cell Longev. 2017;2017:4957147. PubMed PMID: 28819545
• Tatman PD, Woulfe KC, Karimpour-Fard A, Jeffrey DA, Jaggers J, Cleveland JC, Nunley K, Taylor MR, Miyamoto SD, Stauffer BL, Sucharov CC. Pediatric dilated cardiomyopathy hearts display a unique gene expression profile. JCI Insight. 2017 Jul 20;2(14). [Epub ahead of print] PubMed PMID: 28724804
• Jiang X, Sucharov J, Stauffer BL, Miyamoto SD, Sucharov CC. Exosomes from pediatric dilated cardiomyopathy patients modulate a pathological response in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2017 Apr 1;312(4):H818-H826. PubMed PMID: 28130338
• Medina E, Sucharov CC, Nelson P, Miyamoto SD, Stauffer BL. Molecular Changes in Children with Heart Failure Undergoing Left Ventricular Assist Device Therapy. J Pediatr. 2017 Mar;182:184-189.e1. PubMed PMID: 27908653
• Woulfe KC, Siomos AK, Nguyen H, SooHoo M, Galambos C, Stauffer BL, Sucharov C, Miyamoto S. Fibrosis and Fibrotic Gene Expression in Pediatric and Adult Patients With Idiopathic Dilated Cardiomyopathy. J Card Fail. 2017 Apr;23(4):314-324. PubMed PMID: 27890770
• Nakano SJ, Sucharov J, van Dusen R, Cecil M, Nunley K, Wickers S, Karimpur-Fard A, Stauffer BL, Miyamoto SD, Sucharov CC. Cardiac Adenylyl Cyclase and Phosphodiesterase Expression Profiles Vary by Age, Disease, and Chronic Phosphodiesterase Inhibitor Treatment. J Card Fail. 2017 Jan;23(1):72-80. PubMed PMID: 27427220
• Patil MA, Upadhyay AK, Hernandez-Lagunas L, Good R, Carpenter TC, Sucharov CC, Nozik-Grayck E, Kompella UB. Targeted delivery of YSA-functionalized and non-functionalized polymeric nanoparticles to injured pulmonary vasculature. Artif Cells Nanomed Biotechnol. 2018 Nov 19;:1-8. [Epub ahead of print] PubMed PMID: 30450979
• Garcia AM, Nakano SJ, Karimpour-Fard A, Nunley K, Blain-Nelson P, Stafford NM, Stauffer BL, Sucharov CC, Miyamoto SD. Phosphodiesterase-5 Is Elevated in Failing Single Ventricle Myocardium and Affects Cardiomyocyte Remodeling In Vitro. Circ Heart Fail. 2018 Sep;11(9):e004571. PubMed PMID: 30354365
• Jeffrey DA, Sucharov CC. CELF1 regulates gap junction integrity contributing to dilated cardiomyopathy. Noncoding RNA Investig. 2018 Mar;2. PubMed PMID: 30198017
• Coverstone ED, Bach RG, Chen L, Bierut LJ, Li AY, Lenzini PA, O'Neill HC, Spertus JA, Sucharov CC, Stitzel JA, Schilling JD, Cresci S. A novel genetic marker of decreased inflammation and improved survival after acute myocardial infarction. Basic Res Cardiol. 2018 Aug 10;113(5):38. PubMed PMID: 30097758
• Woulfe KC, Wilson CE, Nau S, Chau S, Phillips EK, Zang S, Tompkins C, Sucharov CC, Miyamoto SD, Stauffer BL. Acute isoproterenol leads to age-dependent arrhythmogenesis in guinea pigs. Am J Physiol Heart Circ Physiol. 2018 Oct 1;315(4):H1051-H1062. PubMed PMID: 30028197
• Good RJ, Hernandez-Lagunas L, Allawzi A, Maltzahn JK, Vohwinkel CU, Upadhyay AK, Kompella UB, Birukov KG, Carpenter TC, Sucharov CC, Nozik-Grayck E. MicroRNA dysregulation in lung injury: the role of the miR-26a/EphA2 axis in regulation of endothelial permeability. Am J Physiol Lung Cell Mol Physiol. 2018 Oct 1;315(4):L584-L594. PubMed PMID: 30024304
• Garcia AM, Allawzi A, Tatman P, Hernandez-Lagunas L, Swain K, Mouradian G, Bowler R, Karimpour-Fard A, Sucharov CC, Nozik-Grayck E. R213G polymorphism in SOD3 protects against bleomycin-induced inflammation and attenuates induction of proinflammatory pathways. Physiol Genomics. 2018 Sep 1;50(9):807-816. PubMed PMID: 30004839
• Toni LS, Garcia AM, Jeffrey DA, Jiang X, Stauffer BL, Miyamoto SD, Sucharov CC. Optimization of phenol-chloroform RNA extraction. MethodsX. 2018;5:599-608. PubMed PMID: 29984193
• Miyamoto SD, Sucharov CC, Woulfe KC. Differential Response to Heart Failure Medications in Children. Prog Pediatr Cardiol. 2018 Jun;49:27-30. PubMed PMID: 29962825
• Mariner PD, Korst A, Karimpour-Fard A, Stauffer BL, Miyamoto SD, Sucharov CC. Improved Detection of Circulating miRNAs in Serum and Plasma Following Rapid Heat/Freeze Cycling. Microrna. 2018;7(2):138-147. PubMed PMID: 29658445
• Sucharov CC. Paracrine Factors in Uremic Cardiomyopathy. JACC Basic Transl Sci. 2020 Feb;5(2):167-168. PubMed PMID: 32142069
• Garcia AM, McPhaul JC, Sparagna GC, Jeffrey DA, Jonscher RL, Patel S, Sucharov CC, Stauffer BL, Miyamoto SD, Chatfield KC. Alteration of Cardiolipin Biosynthesis and Remodeling in Single Right Ventricle Congenital Heart Disease. Am J Physiol Heart Circ Physiol. 2020 Feb 14. [Epub ahead of print] PubMed PMID: 32056460
• Nakano SJ, Walker JS, Walker LA, Li X, Du Y, Miyamoto SD, Sucharov CC, Garcia AM, Mitchell MB, Ambardekar AV, Stauffer BL. Increased myocyte calcium sensitivity in end-stage pediatric dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 2019 Dec 1;317(6):H1221-H1230. PubMed PMID: 31625780
• Allawzi A, McDermott I, Delaney C, Nguyen K, Banimostafa L, Trumpie A, Hernandez-Lagunas L, Riemondy K, Gillen A, Hesselberth J, El Kasmi K, Sucharov CC, Janssen WJ, Stenmark K, Bowler R, Nozik-Grayck E. Redistribution of EC-SOD resolves bleomycin-induced inflammation via increased apoptosis of recruited alveolar macrophages. FASEB J. 2019 Dec;33(12):13465-13475. PubMed PMID: 31560857
• Aguado BA, Schuetze KB, Grim JC, Walker CJ, Cox AC, Ceccato TL, Tan AC, Sucharov CC, Leinwand LA, Taylor MRG, McKinsey TA, Anseth KS. Transcatheter aortic valve replacements alter circulating serum factors to mediate myofibroblast deactivation. Sci Transl Med. 2019 Sep 11;11(509). PubMed PMID: 31511425
• Chatfield KC, Sparagna GC, Chau S, Phillips EK, Ambardekar AV, Aftab M, Mitchell MB, Sucharov CC, Miyamoto SD, Stauffer BL. Elamipretide Improves Mitochondrial Function in the Failing Human Heart. JACC Basic Transl Sci. 2019 Apr;4(2):147-157. PubMed PMID: 31061916
• Sucharov CC, Nakano SJ, Slavov D, Schwisow JA, Rodriguez E, Nunley K, Medway A, Stafford N, Nelson P, McKinsey TA, Movsesian M, Minobe W, Carroll IA, Taylor MRG, Bristow MR. A PDE3A Promoter Polymorphism Regulates cAMP-Induced Transcriptional Activity in Failing Human Myocardium. J Am Coll Cardiol. 2019 Mar 19;73(10):1173-1184. PubMed PMID: 30871701
• Gist KM, Korst A, Nakano SJ, Stauffer BL, Karimpour-Fard A, Zhou W, Campbell K, Wempe MF, Sucharov CC, Miyamoto SD. Circulating cyclic adenosine monophosphate concentrations in milrinone treated paediatric patients after congenital heart surgery. Cardiol Young. 2021 Sep;31(9):1393-1400. PubMed PMID: 33533327
• Hailu FT, Karimpour-Fard A, Toni LS, Bristow MR, Miyamoto SD, Stauffer BL, Sucharov CC. Integrated analysis of miRNA-mRNA interaction in pediatric dilated cardiomyopathy. Pediatr Res. 2021 May 19. [Epub ahead of print] PubMed PMID: 34012027
• Woulfe KC, Jeffrey DA, Pires Da Silva J, Wilson CE, Mahaffey JH, Lau E, Slavov D, Hailu F, Karimpour-Fard A, Dockstader K, Bristow MR, Stauffer BL, Miyamoto SD, Sucharov CC. Serum response factor deletion 5 regulates phospholamban phosphorylation and calcium uptake. J Mol Cell Cardiol. 2021 Oct;159:28-37. PubMed PMID: 34139234
• Willner EC, Galan HL, Cuneo BF, Hoffman HA, Neltner B, Schuchardt EL, Karimpour-Fard A, Miyamoto SD, Sucharov CC. Amniotic fluid microRNA profiles in twin-twin transfusion syndrome with and without severe recipient cardiomyopathy. Am J Obstet Gynecol. 2021 Oct;225(4):439.e1-439.e10. PubMed PMID: 34153234
• Jeffrey DA, Pires Da Silva J, Garcia AM, Jiang X, Karimpour-Fard A, Toni LS, Lanzicher T, Peña B, Miyano CA, Nunley K, Korst A, Sbaizero O, Taylor MR, Miyamoto SD, Stauffer BL, Sucharov CC. Serum circulating proteins from pediatric patients with dilated cardiomyopathy cause pathologic remodeling and cardiomyocyte stiffness. JCI Insight. 2021 Oct 8;6(19). PubMed PMID: 34383712
• Schuchardt EL, Miyamoto SD, Crombleholme T, Karimpour-Fard A, Korst A, Neltner B, Howley LW, Cuneo B, Sucharov CC. Amniotic Fluid microRNA in Severe Twin-Twin Transfusion Syndrome Cardiomyopathy-Identification of Differences and Predicting Demise. J Cardiovasc Dev Dis. 2022 Jan 23;9(2). PubMed PMID: 35200691
• Hailu FT, Karimpour-Fard A, Toni LS, Bristow MR, Miyamoto SD, Stauffer BL, Sucharov CC. Integrated analysis of miRNA-mRNA interaction in pediatric dilated cardiomyopathy. Pediatr Res. 2022 Jul;92(1):98-108. PubMed PMID: 34012027
• Ohlstrom DJ, Sul C, Vohwinkel CU, Hernandez-Lagunas L, Karimpour-Fard A, Mourani PM, Carpenter TC, Nozik ES, Sucharov CC. Plasma microRNA and metabolic changes associated with pediatric acute respiratory distress syndrome: a prospective cohort study. Sci Rep. 2022 Aug 26;12(1):14560. PubMed PMID: 36028738
• Hailu FT, Karimpour-Fard A, Neltner B, Stauffer BL, Lipshultz S, Miyamoto SD, Sucharov CC. Circulating and Cardiac Tissue miRNAs in Children with Dilated Cardiomyopathy. J Cardiovasc Dev Dis. 2023 Sep 11;10(9). PubMed PMID: 37754820
• Tatman PD, Kao DP, Chatfield KC, Carroll IA, Wagner JA, Jonas ER, Sucharov CC, Port JD, Lowes BD, Minobe WA, Huebler SP, Karimpour-Fard A, Rodriguez EM, Liggett SB, Bristow MR. An extensive ß1-adrenergic receptor gene signaling network regulates molecular remodeling in dilated cardiomyopathies. JCI Insight. 2023 Aug 22;8(16). PubMed PMID: 37606047
• Nyarko OO, Sucharov CC. The secretome as a biomarker and functional agent in heart failure. J Cardiovasc Aging. 2023 Jul;3(3). PubMed PMID: 37484982
• Nyarko OO, Sucharov CC. Big tau aggregation and the broken heart. Eur Heart J. 2023 May 1;44(17):1571-1573. PubMed PMID: 37122095
• Garcia AM, Toni LS, Miyano CA, Sparagna GC, Jonscher R, Phillips EK, Karimpour-Fard A, Chapman HL, Baybayon-Grandgeorge AN, Pietra AE, Selner E, Chatfield KC, Stauffer BL, Sucharov CC, Miyamoto SD. Cardiac Transcriptome Remodeling and Impaired Bioenergetics in Single-Ventricle Congenital Heart Disease. JACC Basic Transl Sci. 2023 Mar;8(3):258-279. PubMed PMID: 37034285
• Sucharov CC, Neltner B, Pietra AE, Karimpour-Fard A, Patel J, Ho CY, Miyamoto SD. Circulating MicroRNAs Identify Early Phenotypic Changes in Sarcomeric Hypertrophic Cardiomyopathy. Circ Heart Fail. 2023 Jun;16(6):e010291. PubMed PMID: 36880380

Practice Locations

• University of Colorado Hospital