Our main goal is to identify potential new therapeutic agents for the treatment of heart failure.
Publications
A {beta}1-adrenergic receptor, CaM Kinase II dependent pathway mediates cardiac myocyte fetal gene induction. Am J Physiol Heart Circ Physiol.
Gene expression and heart failure. 24-27 July 2005, 2nd Annual Symposium of the American Heart Association Council on Basic Cardiovascular Sciences. Expert Rev Cardiovasc Ther. 3(6):983-4.
Beta1-adrenergic stimulation results in ERK1/2 activation that is prohypertrophic and dependent on CaMKII and Calcineurin. Second Annual Symposium of the American Heart Association Council on Basic Cardiovascular Sciences.
TRPC channels and beta1-adrenergic-mediated activation of the fetal gene program. Second Annual Symposium of the American Heart Association Council on Basic Cardiovascular Sciences.
(2005) Beta1-adrenergic stimulation results in ERK1/2 activation that is prohypertrophic and dependent on CaMKII and Calcineurin. 9th Annual Scientific Meeting – Heart Failure Society of America.
Sucharov, C.C., Langer S., Bristow M.R. and Leinwand L.A. Shuttling of HDAC5 in H9C2 cells regulates YY1 function through CaMKIV/PKD and PP2A. 2006. Am J Physiol Cell Physiol. 291(5):C1029-37.
Sucharov, C.C. Beta-adrenergic pathways in human heart failure. 2007. Expert Rev Cardiovasc Ther. 2007 Jan;5(1):119-24.
Taylor, M.R.G.; Slavov, D.; Ku, L.; Di Lenarda. A.; Sinagra, G.; Carniel, E.; Haubold, K.; Boucek, M.; Ferguson, D.; Graw, S.; Zhu, X.; Cavanaugh, J.; Sucharov, C.C.; Long, C.S.; Lavori, P.; Mestroni, L.; and the Familial Cardiomyopathy Registry and the BEST DNA Bank. Prevalence of desmin mutations in dilated cardiomyopathy. 2007. Circulation.
Gene expression changes in beta-adrenegic treated human trabeculae presented at the 3rd Annual Symposium of the American Heart Association Council on Basic Cardiovascular Sciences.
Sucharov, C.C., Dockstader, K., McKinsey, T. 2008 YY1 prevents against pathologic cardiac hypertrophy by interacting with HDAC5. Mol Biol Cell. 19(10):4141-53.
Sucharov, C.C., Bristow, M.R., Port, D. 2008 Regulation of miRNA Expression in the Failing Human Heart: Functional Correlates. J Mol Cell Cardiol. 45(2): p. 185-92.
Cresci, S., Jones, P.G., Sucharov, C.C., Marsh. S., Lanfear, D.E., Garsa, A., Courtois, M., Weinheimer, C.J., Wu, J., Province, M.A., Kelly, D., McLeod, H.L., Spertus, J.A. 2008 Interaction Between PPARA Genotype and b-Blocker Treatment Influences Clinical Outcomes Following Acute Coronary Syndromes. Pharmacogenomics. 9(10):1403-17.
Sihag S, Cresci S, Li AY, Sucharov CC, Lehman JJ. 2009 PGC-1alpha and ERRalpha target gene downregulation is a signature of the failing human heart. J Mol Cell Cardiol. 46(2):201-12.
Sucharov, C.C., Port, J.D. 2010 Role of microRNAs in cardiovascular disease: therapeutical challenges and potentials. J Cardiovasc Pharmacol. 2010 56(5):444-53.
Stauffer BL, Sobus R, Sucharov, CC. Sex differences in cardiomyocyte Connexin 43 expression. Journal of Cardiovascular Pharmacology, 2011, in press.
Sucharov CC, Dockstader K, Nunley K, McKinsey TA, Bristow MR. 2011. ?-adrenergic receptor stimulation and activation of PKA protect against ??-adrenergic mediated phosphorylation of PKD and HDAC5. Journal of Cardiac Failure, in press.
Sucharov CC*, Dockstader K, Nunley K, McKinsey TA, Bristow MR. 2011. b-adrenergic receptor stimulation and activation of PKA protect against a1-adrenergic mediated phosphorylation of PKD and HDAC5. Journal of Cardiac Failure, 17(7):592-600. PMC21703532
Stauffer BL, Sobus R, Sucharov, CC. Sex differences in cardiomyocyte Connexin 43 expression. Journal of Cardiovascular Pharmacology, 58(1):32-39. PMC21753256.
2. Port J.D., Walker L.A., Polk J., Nunley K., Buttrick P.M., Sucharov C.C.* 2011. Temporal Expression of miRNAs and mRNAs in a Mouse Model of Myocardial Infarction. Physiol Genomics, 43(19): 1087-95. PMC21771878.
3. Dockstader K., Nunley K., Karimpour-Fard A., Medway A., Nelson, P., Port J.D., Liggett S.B., Bristow M.R., Sucharov C.C.* 2011. Temporal Analysis of mRNA and miRNA Expression in Transgenic Mice Over Expressing Arg- and Gly389 Polymorphic Variants of the ß1-Adrenergic Receptor. Physiol Genomics, 43(23):1294-306. PMC21954455
Miyamoto S.D., Stauffer B.L., Nakano S., Sobus R., Nunley K., Nelson P., Sucharov C.C.* Beta-Adrenergic Adaptation in Pediatric Idiopathic DCM. European Heart Journal. In press. PMC22843448
Stauffer BL, Russell G, Nunley K, Miyamoto SD, Sucharov CC*. miRNA expression in the pediatric failing human heart. Journal of Molecular and Cellular Cardiology. 2012:In Press.
Wang D, Zhang H, Li M, Frid MG, Flockton AR, McKeon BA, Yeager ME, Fini MA, Morrell NW, Pullamsetti SS, Velegala S, Seeger W, McKinsey TA, Sucharov CC, Stenmark KR. MicroRNA-124 controls the proliferative, migratory, and inflammatory phenotype of pulmonary vascular fibroblasts. Circ Res. 2014 Jan 3;114(1):67-78. PubMed PMID: 24122720
Sucharov CC, Hijmans JG, Sobus RD, Melhado WF, Miyamoto SD, Stauffer BL. ß-Adrenergic receptor antagonism in mice: a model for pediatric heart disease. J Appl Physiol (1985). 2013 Oct 1;115(7):979-87. PubMed PMID: 23887897
Stauffer BL, Russell G, Nunley K, Miyamoto SD, Sucharov CC. miRNA expression in pediatric failing human heart. J Mol Cell Cardiol. 2013 Apr;57:43-6. PubMed PMID: 23333438
Gene Expression and beta-adrenergic Signaling are Altered in Hypoplastic Left Heart Syndrome.
Journal of Heart and Lung Transplantation
Medina E, Sucharov CC, Nelson P, Miyamoto SD, Stauffer BL. Molecular Changes in Children with Heart Failure Undergoing Left Ventricular Assist Device Therapy. J Pediatr. 2016 Nov 29. [Epub ahead of print] PubMed PMID: 27908653
Woulfe KC, Siomos AK, Nguyen H, SooHoo M, Galambo C, Stauffer BL, Sucharov C, Miyamoto S. Fibrosis and Fibrotic Gene Expression in Pediatric and Adult Patients With Idiopathic Dilated Cardiomyopathy. J Card Fail. 2016 Nov 24. [Epub ahead of print] PubMed PMID: 27890770
Nakano SJ, Sucharov J, van Dusen R, Cecil M, Nunley K, Wickers S, Karimpur-Fard A, Stauffer BL, Miyamoto SD, Sucharov CC. Cardiac Adenylyl Cyclase and Phosphodiesterase Expression Profiles Vary by Age, Disease, and Chronic Phosphodiesterase Inhibitor Treatment. J Card Fail. 2017 Jan;23(1):72-80. PubMed PMID: 27427220
Stratton MS, Lin CY, Anand P, Tatman PD, Ferguson BS, Wickers ST, Ambardekar AV, Sucharov CC, Bradner JE, Haldar SM, McKinsey TA. Signal-Dependent Recruitment of BRD4 to Cardiomyocyte Super-Enhancers Is Suppressed by a MicroRNA. Cell Rep. 2016 Aug 2;16(5):1366-78. PubMed PMID: 27425608
Nakano SJ, Nelson P, Sucharov CC, Miyamoto SD. Myocardial Response to Milrinone in Single Right Ventricle Heart Disease. J Pediatr. 2016 Jul;174:199-203.e5. PubMed PMID: 27181939
Woulfe KC, Sucharov CC. Midkine's Role in Cardiac Pathology. J Cardiovasc Dev Dis. 2017 Sep;4(3). PubMed PMID: 28920060
Kheyfets VO, Sucharov CC, Truong U, Dunning J, Hunter K, Ivy D, Miyamoto S, Shandas R. Circulating miRNAs in Pediatric Pulmonary Hypertension Show Promise as Biomarkers of Vascular Function. Oxid Med Cell Longev. 2017;2017:4957147. PubMed PMID: 28819545
Tatman PD, Woulfe KC, Karimpour-Fard A, Jeffrey DA, Jaggers J, Cleveland JC, Nunley K, Taylor MR, Miyamoto SD, Stauffer BL, Sucharov CC. Pediatric dilated cardiomyopathy hearts display a unique gene expression profile. JCI Insight. 2017 Jul 20;2(14). [Epub ahead of print] PubMed PMID: 28724804
Patil MA, Upadhyay AK, Hernandez-Lagunas L, Good R, Carpenter TC, Sucharov CC, Nozik-Grayck E, Kompella UB. Targeted delivery of YSA-functionalized and non-functionalized polymeric nanoparticles to injured pulmonary vasculature. Artif Cells Nanomed Biotechnol. 2018 Nov 19;:1-8. [Epub ahead of print] PubMed PMID: 30450979
Jiang X, Sucharov J, Stauffer BL, Miyamoto SD, Sucharov CC. Exosomes from pediatric dilated cardiomyopathy patients modulate a pathological response in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2017 Apr 1;312(4):H818-H826. PubMed PMID: 28130338
Garcia AM, Nakano SJ, Karimpour-Fard A, Nunley K, Blain-Nelson P, Stafford NM, Stauffer BL, Sucharov CC, Miyamoto SD. Phosphodiesterase-5 Is Elevated in Failing Single Ventricle Myocardium and Affects Cardiomyocyte Remodeling In Vitro. Circ Heart Fail. 2018 Sep;11(9):e004571. PubMed PMID: 30354365
Jeffrey DA, Sucharov CC. CELF1 regulates gap junction integrity contributing to dilated cardiomyopathy. Noncoding RNA Investig. 2018 Mar;2. PubMed PMID: 30198017
Coverstone ED, Bach RG, Chen L, Bierut LJ, Li AY, Lenzini PA, O'Neill HC, Spertus JA, Sucharov CC, Stitzel JA, Schilling JD, Cresci S. A novel genetic marker of decreased inflammation and improved survival after acute myocardial infarction. Basic Res Cardiol. 2018 Aug 10;113(5):38. PubMed PMID: 30097758
Medina E, Sucharov CC, Nelson P, Miyamoto SD, Stauffer BL. Molecular Changes in Children with Heart Failure Undergoing Left Ventricular Assist Device Therapy. J Pediatr. 2017 Mar;182:184-189.e1. PubMed PMID: 27908653
Woulfe KC, Siomos AK, Nguyen H, SooHoo M, Galambos C, Stauffer BL, Sucharov C, Miyamoto S. Fibrosis and Fibrotic Gene Expression in Pediatric and Adult Patients With Idiopathic Dilated Cardiomyopathy. J Card Fail. 2017 Apr;23(4):314-324. PubMed PMID: 27890770
Woulfe KC, Wilson CE, Nau S, Chau S, Phillips EK, Zang S, Tompkins C, Sucharov CC, Miyamoto SD, Stauffer BL. Acute isoproterenol leads to age-dependent arrhythmogenesis in guinea pigs. Am J Physiol Heart Circ Physiol. 2018 Oct 1;315(4):H1051-H1062. PubMed PMID: 30028197
Good RJ, Hernandez-Lagunas L, Allawzi A, Maltzahn JK, Vohwinkel CU, Upadhyay AK, Kompella UB, Birukov KG, Carpenter TC, Sucharov CC, Nozik-Grayck E. MicroRNA dysregulation in lung injury: the role of the miR-26a/EphA2 axis in regulation of endothelial permeability. Am J Physiol Lung Cell Mol Physiol. 2018 Oct 1;315(4):L584-L594. PubMed PMID: 30024304
Garcia AM, Allawzi A, Tatman P, Hernandez-Lagunas L, Swain K, Mouradian G, Bowler R, Karimpour-Fard A, Sucharov CC, Nozik-Grayck E. R213G polymorphism in SOD3 protects against bleomycin-induced inflammation and attenuates induction of proinflammatory pathways. Physiol Genomics. 2018 Sep 1;50(9):807-816. PubMed PMID: 30004839
Toni LS, Garcia AM, Jeffrey DA, Jiang X, Stauffer BL, Miyamoto SD, Sucharov CC. Optimization of phenol-chloroform RNA extraction. MethodsX. 2018;5:599-608. PubMed PMID: 29984193
Mariner PD, Korst A, Karimpour-Fard A, Stauffer BL, Miyamoto SD, Sucharov CC. Improved Detection of Circulating miRNAs in Serum and Plasma Following Rapid Heat/Freeze Cycling. Microrna. 2018;7(2):138-147. PubMed PMID: 29658445
Nakano SJ, Sucharov J, van Dusen R, Cecil M, Nunley K, Wickers S, Karimpur-Fard A, Stauffer BL, Miyamoto SD, Sucharov CC. Cardiac Adenylyl Cyclase and Phosphodiesterase Expression Profiles Vary by Age, Disease, and Chronic Phosphodiesterase Inhibitor Treatment. J Card Fail. 2017 Jan;23(1):72-80. PubMed PMID: 27427220
Sucharov CC. Paracrine Factors in Uremic Cardiomyopathy. JACC Basic Transl Sci. 2020 Feb;5(2):167-168. PubMed PMID: 32142069
Garcia AM, McPhaul JC, Sparagna GC, Jeffrey DA, Jonscher RL, Patel S, Sucharov CC, Stauffer BL, Miyamoto SD, Chatfield KC. Alteration of Cardiolipin Biosynthesis and Remodeling in Single Right Ventricle Congenital Heart Disease. Am J Physiol Heart Circ Physiol. 2020 Feb 14. [Epub ahead of print] PubMed PMID: 32056460
Nakano SJ, Walker JS, Walker LA, Li X, Du Y, Miyamoto SD, Sucharov CC, Garcia AM, Mitchell MB, Ambardekar AV, Stauffer BL. Increased myocyte calcium sensitivity in end-stage pediatric dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 2019 Dec 1;317(6):H1221-H1230. PubMed PMID: 31625780
Allawzi A, McDermott I, Delaney C, Nguyen K, Banimostafa L, Trumpie A, Hernandez-Lagunas L, Riemondy K, Gillen A, Hesselberth J, El Kasmi K, Sucharov CC, Janssen WJ, Stenmark K, Bowler R, Nozik-Grayck E. Redistribution of EC-SOD resolves bleomycin-induced inflammation via increased apoptosis of recruited alveolar macrophages. FASEB J. 2019 Dec;33(12):13465-13475. PubMed PMID: 31560857
Aguado BA, Schuetze KB, Grim JC, Walker CJ, Cox AC, Ceccato TL, Tan AC, Sucharov CC, Leinwand LA, Taylor MRG, McKinsey TA, Anseth KS. Transcatheter aortic valve replacements alter circulating serum factors to mediate myofibroblast deactivation. Sci Transl Med. 2019 Sep 11;11(509). PubMed PMID: 31511425
Chatfield KC, Sparagna GC, Chau S, Phillips EK, Ambardekar AV, Aftab M, Mitchell MB, Sucharov CC, Miyamoto SD, Stauffer BL. Elamipretide Improves Mitochondrial Function in the Failing Human Heart. JACC Basic Transl Sci. 2019 Apr;4(2):147-157. PubMed PMID: 31061916
Sucharov CC, Nakano SJ, Slavov D, Schwisow JA, Rodriguez E, Nunley K, Medway A, Stafford N, Nelson P, McKinsey TA, Movsesian M, Minobe W, Carroll IA, Taylor MRG, Bristow MR. A PDE3A Promoter Polymorphism Regulates cAMP-Induced Transcriptional Activity in Failing Human Myocardium. J Am Coll Cardiol. 2019 Mar 19;73(10):1173-1184. PubMed PMID: 30871701
Gist KM, Korst A, Nakano SJ, Stauffer BL, Karimpour-Fard A, Zhou W, Campbell K, Wempe MF, Sucharov CC, Miyamoto SD. Circulating cyclic adenosine monophosphate concentrations in milrinone treated paediatric patients after congenital heart surgery. Cardiol Young. 2021 Sep;31(9):1393-1400. PubMed PMID: 33533327
Hailu FT, Karimpour-Fard A, Toni LS, Bristow MR, Miyamoto SD, Stauffer BL, Sucharov CC. Integrated analysis of miRNA-mRNA interaction in pediatric dilated cardiomyopathy. Pediatr Res. 2021 May 19. [Epub ahead of print] PubMed PMID: 34012027
Woulfe KC, Jeffrey DA, Pires Da Silva J, Wilson CE, Mahaffey JH, Lau E, Slavov D, Hailu F, Karimpour-Fard A, Dockstader K, Bristow MR, Stauffer BL, Miyamoto SD, Sucharov CC. Serum response factor deletion 5 regulates phospholamban phosphorylation and calcium uptake. J Mol Cell Cardiol. 2021 Oct;159:28-37. PubMed PMID: 34139234
Schuchardt EL, Miyamoto SD, Crombleholme T, Karimpour-Fard A, Korst A, Neltner B, Howley LW, Cuneo B, Sucharov CC. Amniotic Fluid microRNA in Severe Twin-Twin Transfusion Syndrome Cardiomyopathy-Identification of Differences and Predicting Demise. J Cardiovasc Dev Dis. 2022 Jan 23;9(2). PubMed PMID: 35200691
Willner EC, Galan HL, Cuneo BF, Hoffman HA, Neltner B, Schuchardt EL, Karimpour-Fard A, Miyamoto SD, Sucharov CC. Amniotic fluid microRNA profiles in twin-twin transfusion syndrome with and without severe recipient cardiomyopathy. Am J Obstet Gynecol. 2021 Oct;225(4):439.e1-439.e10. PubMed PMID: 34153234
Hailu FT, Karimpour-Fard A, Toni LS, Bristow MR, Miyamoto SD, Stauffer BL, Sucharov CC. Integrated analysis of miRNA-mRNA interaction in pediatric dilated cardiomyopathy. Pediatr Res. 2022 Jul;92(1):98-108. PubMed PMID: 34012027
Ohlstrom DJ, Sul C, Vohwinkel CU, Hernandez-Lagunas L, Karimpour-Fard A, Mourani PM, Carpenter TC, Nozik ES, Sucharov CC. Plasma microRNA and metabolic changes associated with pediatric acute respiratory distress syndrome: a prospective cohort study. Sci Rep. 2022 Aug 26;12(1):14560. PubMed PMID: 36028738
Jeffrey DA, Pires Da Silva J, Garcia AM, Jiang X, Karimpour-Fard A, Toni LS, Lanzicher T, Peña B, Miyano CA, Nunley K, Korst A, Sbaizero O, Taylor MR, Miyamoto SD, Stauffer BL, Sucharov CC. Serum circulating proteins from pediatric patients with dilated cardiomyopathy cause pathologic remodeling and cardiomyocyte stiffness. JCI Insight. 2021 Oct 8;6(19). PubMed PMID: 34383712
Hailu FT, Karimpour-Fard A, Neltner B, Stauffer BL, Lipshultz S, Miyamoto SD, Sucharov CC. Circulating and Cardiac Tissue miRNAs in Children with Dilated Cardiomyopathy. J Cardiovasc Dev Dis. 2023 Sep 11;10(9). PubMed PMID: 37754820
Tatman PD, Kao DP, Chatfield KC, Carroll IA, Wagner JA, Jonas ER, Sucharov CC, Port JD, Lowes BD, Minobe WA, Huebler SP, Karimpour-Fard A, Rodriguez EM, Liggett SB, Bristow MR. An extensive ß1-adrenergic receptor gene signaling network regulates molecular remodeling in dilated cardiomyopathies. JCI Insight. 2023 Aug 22;8(16). PubMed PMID: 37606047
Nyarko OO, Sucharov CC. The secretome as a biomarker and functional agent in heart failure. J Cardiovasc Aging. 2023 Jul;3(3). PubMed PMID: 37484982
Nyarko OO, Sucharov CC. Big tau aggregation and the broken heart. Eur Heart J. 2023 May 1;44(17):1571-1573. PubMed PMID: 37122095
Garcia AM, Toni LS, Miyano CA, Sparagna GC, Jonscher R, Phillips EK, Karimpour-Fard A, Chapman HL, Baybayon-Grandgeorge AN, Pietra AE, Selner E, Chatfield KC, Stauffer BL, Sucharov CC, Miyamoto SD. Cardiac Transcriptome Remodeling and Impaired Bioenergetics in Single-Ventricle Congenital Heart Disease. JACC Basic Transl Sci. 2023 Mar;8(3):258-279. PubMed PMID: 37034285
Sucharov CC, Neltner B, Pietra AE, Karimpour-Fard A, Patel J, Ho CY, Miyamoto SD. Circulating MicroRNAs Identify Early Phenotypic Changes in Sarcomeric Hypertrophic Cardiomyopathy. Circ Heart Fail. 2023 Jun;16(6):e010291. PubMed PMID: 36880380