Michele Yang, MD

Professional Titles

• Associate Professor

Publications

• Hsu SC, Sears RL, Lemos RR, Quintáns B, Huang A, Spiteri E, Nevarez L, Mamah C, Zatz M, Pierce KD, Fullerton JM, Adair JC, Berner JE, Bower M, Brodaty H, Carmona O, Dobricic V, Fogel BL, García-Estevez D, Goldman J, Goudreau JL, Hopfer S, Jankovic M, Jaumà S, Jen JC, Kirdlarp S, Klepper J, Kostic V, Lang AE, Linglart A, Maisenbacher MK, Manyam BV, Mazzoni P, Miedzybrodzka Z, Mitarnun W, Mitchell PB, Mueller J, Novakovic I, Paucar M, Paulson H, Simpson SA, Svenningsson P, Tuite P, Vitek J, Wetchaphanphesat S, Williams C, Yang M, Schofield PR, de Oliveira JR, Sobrido MJ, Geschwind DH, Coppola G. Mutations in SLC20A2 are a major cause of familial idiopathic basal ganglia calcification. Neurogenetics 2013
• Kaufmann P, McDermott MP, Darras BT, Finkel RS, Sproule DM, Kang PB, Oskoui M, Constantinescu A, Gooch CL, Foley AR, Yang ML, Tawil R, Chung WK, Martens WB, Montes J, Battista V, O'Hagen J, Dunaway S, Flickinger J, Quigley J, Riley S, Glanzman AM, Benton M, Ryan PA, Punyanitya M, Montgomery MJ, Marra J, Koo B, De Vivo DC; Muscle Study Group (MSG); Pediatric Neuromuscular Clinical Research Network for Spinal Muscular Atrophy (PNCR). Prospective cohort study of spinal muscualr atrophy types 2 and 3. Neurology 2012; 79:1889-1897.
• Wright MA, Yang ML, Parsons JA, Westfall JM, Yee AS. Consider musclar disease in children with elevated transaminase. J Am Board Fam Med 2012;25:536-540.
• West NA, Yang ML, Weitzenkamp DA, Andrews J, Meaney FJ, Oleszek J, Miller LA, Matthews D, DiGuiseppi C. Patterns of growth in ambulatory males with Duchenne muscular dystrophy. J Pediatr. 2013 Dec;163(6):1759-1763.e1. PubMed PMID: 24103921
• Kang PB, Gooch CL, McDermott MP, Darras BT, Finkel RS, Yang ML, Sproule DM, Chung WK, Kaufmann P, De Vivo DC, Muscle Study Group (MSG), Pediatric Neuromuscular Clinical Research Network for Spinal Muscular Atrophy (PNCR). The motor neuron response to SMN1 deficiency in spinal muscular atrophy. Muscle Nerve. 2013 Jul 24. [Epub ahead of print] PubMed PMID: 23893312
• Barber BJ, Andrews JG, Lu Z, West NA, Meaney FJ, Price ET, Gray A, Sheehan DW, Pandya S, Yang M, Cunniff C. Oral corticosteroids and onset of cardiomyopathy in Duchenne muscular dystrophy. J Pediatr. 2013 Oct;163(4):1080-4.e1. PubMed PMID: 23866715
• Yang ML, Shin J, Kearns CA, Langworthy MM, Snell H, Walker MB, Appel B. CNS Myelination Requires Cytoplasmic Dynein Function. Dev Dyn. 2014 Dec 8. [Epub ahead of print] PubMed PMID: 25488883
• Finkel RS, McDermott MP, Kaufmann P, Darras BT, Chung WK, Sproule DM, Kang PB, Foley AR, Yang ML, Martens WB, Oskoui M, Glanzman AM, Flickinger J, Montes J, Dunaway S, O'Hagen J, Quigley J, Riley S, Benton M, Ryan PA, Montgomery M, Marra J, Gooch C, De Vivo DC. Observational study of spinal muscular atrophy type I and implications for clinical trials. Neurology. 2014 Aug 26;83(9):810-7. PubMed PMID: 25080519
• Kang PB, Gooch CL, McDermott MP, Darras BT, Finkel RS, Yang ML, Sproule DM, Chung WK, Kaufmann P, De Vivo DC, Muscle Study Group and the Pediatric Neuromuscular Clinical Research Network for Spinal Muscular Atrophy. Reply: To PMID 23893312. Muscle Nerve. 2014 Sep;50(3):458-9. PubMed PMID: 24935909
• Kang PB, Gooch CL, McDermott MP, Darras BT, Finkel RS, Yang ML, Sproule DM, Chung WK, Kaufmann P, de Vivo DC, Muscle Study Group and the Pediatric Neuromuscular Clinical Research Network for Spinal Muscular Atrophy. The motor neuron response to SMN1 deficiency in spinal muscular atrophy. Muscle Nerve. 2014 May;49(5):636-44. PubMed PMID: 23893312
• Zhu Y, Romitti PA, Caspers Conway KM, Kim S, Zhang Y, Yang M, Mathews KD, the MD STARnet. Genitourinary health in a population-based cohort of males with Duchenne and Becker muscular dystrophies. Muscle Nerve. 2014 Oct 9. [Epub ahead of print] PubMed PMID: 25297835
• Moss M, Yang M, Macht M, Sottile P, Gray L, McNulty M, Quan D. Screening for critical illness polyneuromyopathy with single nerve conduction studies. Intensive Care Med. 2014 May;40(5):683-90. PubMed PMID: 24623137
• Zukosky K, Meilleur K, Traynor BJ, Dastgir J, Medne L, Devoto M, Collins J, Rooney J, Zou Y, Yang ML, Gibbs JR, Meier M, Stetefeld J, Finkel RS, Schessl J, Elman L, Felice K, Ferguson TA, Ceyhan-Birsoy O, Beggs AH, Tennekoon G, Johnson JO, Bönnemann CG. Association of a Novel ACTA1 Mutation With a Dominant Progressive Scapuloperoneal Myopathy in an Extended Family. JAMA Neurol. 2015 Jun;72(6):689-98. PubMed PMID: 25938801
• Donkervoort S, Papadaki M, de Winter JM, Neu MB, Kirschner J, Bolduc V, Yang ML, Gibbons MA, Hu Y, Dastgir J, Leach ME, Rutkowski A, Foley AR, Krüger M, Wartchow EP, McNamara E, Ong R, Nowak KJ, Laing NG, Clarke NF, Ottenheijm CA, Marston SB, Bönnemann CG. TPM3 deletions cause a hypercontractile congenital muscle stiffness phenotype. Ann Neurol. 2015 Sep 29. [Epub ahead of print] PubMed PMID: 26418456
• Yang ML, Shin J, Kearns CA, Langworthy MM, Snell H, Walker MB, Appel B. CNS myelination requires cytoplasmic dynein function. Dev Dyn. 2015 Feb;244(2):134-45. PubMed PMID: 25488883
• Zhu Y, Romitti PA, Caspers Conway KM, Kim S, Zhang Y, Yang M, Mathews KD. Genitourinary health in a population-based cohort of males with Duchenne and Becker Muscular dystrophies. Muscle Nerve. 2015 Jul;52(1):22-7. PubMed PMID: 25297835
• Scoto M, Rossor AM, Harms MB, Cirak S, Calissano M, Robb S, Manzur AY, Martínez Arroyo A, Rodriguez Sanz A, Mansour S, Fallon P, Hadjikoumi I, Klein A, Yang M, De Visser M, Overweg-Plandsoen WC, Baas F, Taylor JP, Benatar M, Connolly AM, Al-Lozi MT, Nixon J, de Goede CG, Foley AR, Mcwilliam C, Pitt M, Sewry C, Phadke R, Hafezparast M, Chong WK, Mercuri E, Baloh RH, Reilly MM, Muntoni F. Novel mutations expand the clinical spectrum of DYNC1H1-associated spinal muscular atrophy. Neurology. 2015 Feb 17;84(7):668-79. PubMed PMID: 25609763
• Messacar K, Schreiner TL, Van Haren K, Yang M, Glaser CA, Tyler KL, Dominguez SR. Acute flaccid myelitis: A clinical review of US cases 2012-2015. Ann Neurol. 2016 Sep;80(3):326-38. PubMed PMID: 27422805
• Lamb MM, West NA, Ouyang L, Yang M, Weitzenkamp D, James K, Ciafaloni E, Pandya S, DiGuiseppi C. Corticosteroid Treatment and Growth Patterns in Ambulatory Males with Duchenne Muscular Dystrophy. J Pediatr. 2016 Jun;173:207-213.e3. PubMed PMID: 27039228
• Watne L, Yang ML. Clinical course of growth in patients with congenital neuromuscular disease in a single multidisciplinary neuromuscular clinic. J Pediatr Rehabil Med. 2016;9(1):13-21. PubMed PMID: 26966796
• Martin JA, Messacar K, Yang ML, Maloney JA, Lindwall J, Carry T, Kenyon P, Sillau SH, Oleszek J, Tyler KL, Dominguez SR, Schreiner TL. Outcomes of Colorado children with acute flaccid myelitis at 1 year. Neurology. 2017 Jul 11;89(2):129-137. PubMed PMID: 28615421
• Becker AB, Qian J, Gelman BB, Yang M, Bauer P, Koeppen AH. Heart and Nervous System Pathology in Compound Heterozygous Friedreich Ataxia. J Neuropathol Exp Neurol. 2017 Aug 1;76(8):665-675. PubMed PMID: 28789479
• Paramsothy P PhD, MPH, Herron AR PhD, MA, Lamb MM PhD, Kinnett K MSN, APRN, Wolff J PhD, Yang ML MD, Oleszek J MD, Pandya S DPT, Kennedy A BS, Cooney D MS, Fox D MPH, Sheehan D PhD, MD. Health Care Transition Experiences of Males with Childhood-onset Duchenne and Becker Muscular Dystrophy: Findings from the Muscular Dystrophy Surveillance Tracking and Research Network (MD STARnet) Health Care Transitions and Other Life Experiences Survey. PLoS Curr. 2018 Aug 21;10. PubMed PMID: 30210936
• Beggs AH, Byrne BJ, De Chastonay S, Haselkorn T, Hughes I, James ES, Kuntz NL, Simon J, Swanson LC, Yang ML, Yu ZF, Yum SW, Prasad S. A multicenter, retrospective medical record review of X-linked myotubular myopathy: The recensus study. Muscle Nerve. 2018 Apr;57(4):550-560. PubMed PMID: 29149770
• Beck DB, Subramanian T, Vijayalingam S, Ezekiel UR, Donkervoort S, Yang ML, Dubbs HA, Ortiz-Gonzalez XR, Lakhani S, Segal D, Au M, Graham JM Jr, Verma S, Waggoner D, Shinawi M, Bönnemann CG, Chung WK, Chinnadurai G. A pathogenic CtBP1 missense mutation causes altered cofactor binding and transcriptional activity. Neurogenetics. 2019 Aug;20(3):129-143. PubMed PMID: 31041561
• Vision DMD: A Phase IIb Randomized, Double-blind, Parallel Group, Placebo- and Active-controlled Study to Assess the Efficacy and Safety of Vamorolone in Boys with Duchenne Muscular Dystrophy
• Graham RJ, Muntoni F, Hughes I, Yum SW, Kuntz NL, Yang ML, Byrne BJ, Prasad S, Alvarez R, Genetti CA, Haselkorn T, James ES, LaRusso LB, Noursalehi M, Rico S, Beggs AH. Mortality and respiratory support in X-linked myotubular myopathy: a RECENSUS retrospective analysis. Arch Dis Child. 2019 Sep 4. [Epub ahead of print] PubMed PMID: 31484632
• James KA, Gralla J, Ridall LA, Do TN, Czaja AS, Mourani PM, Ciafaloni E, Cunniff C, Donnelly J, Oleszek J, Pandya S, Price E, Yang ML, Auerbach SR. Left ventricular dysfunction in Duchenne muscular dystrophy. Cardiology Young (in press).
• Sensitive Assessment of Duchenne Muscular Dystrophy Progression with a Dedicated Electrical Impedance Myography Device, AAN 2019
• Leitner ML, Kapur K, Darras BT, Yang, M, Wong B, Dalle Pazze L, Florence J, Buck M, Freedman L, Bohorquez J, Rutkove S, Zaidman C. Electrical impedance myography for reducing sample size in Duchenne muscular dystrophy trials. Ann Clin Trans Neurol (in press)
• Leitner ML, Kapur K, Darras BT, Yang M, Wong B, Pazze LD, Florence J, Buck M, freedman L, Bohorquez J, Rutkove S, Zaidman C. Electrical impedance myography for reducing sampe size in Duchenne muscular dystrophy trials. Annal of Clinical and Translational Neurology 2020; 7(10)-4-14.
• Kour S, Rajan DS, Fortuna TR, Anderson EN, Ward C, Lee Y, Lee S, Shin YB, Chair JH, Choi M, Siquier L, Cantagrel V, Amiel J, Stolerman ES, Barnett SS, Cousin MA, Castro D, McDonald K, Kirmse B, Nemeth AH, Rajasundaram D, Innes M, Lynch D, Frosk P, COllins A, Gibbons M, Yang M, Desguerre I, Boddaert N, Gitiaux C, Rydning SL, Selmer KK, Urreizti R, Garcia-Oguiza A, Osorio AN, Adriescu EC, Moody SB, Phornphutkul C, Guillen Sacoto MJ, Begtrup A, Houlden H, Kirschner J, Schilling D, Rudnik-Schoneborn S, Strom TM, Lenz S, Juliette K, Richardson R, Platzer K, Donkervoort S, Bonnemann CG, Wagner M, Issa MY, Elbendary HM, Stanley V, Maroofian R, Gleeson JG, Zaki MS, Senderek J, Pandey UB. Mutations in GEMIN5 cause a novel cerebellar ataxia syndrome by disrupting the dynamics of GEMIN5 expression, interaction, and assembly. Nature communications (in press).
• Joshi C, Yang M, Eschbach K, Tong S, Jacobson M, Stillman C, Kropp A, Shea S, Frunzi G, Thomas F, and Olson C. Quality and safety analysis of 2999 telemedicine encounters during the COVID-19 pandemic. Neurology in Clinical Practice (in press).
• Joshi CN, Yang ML, Eschbach K, Tong S, Jacobson MP, Stillman C, Kropp AE, Shea SA, Frunzi GM, Thomas JF, Olson CA. Quality and Safety Analysis of 2,999 Telemedicine Encounters During the COVID-19 Pandemic. Neurol Clin Pract. 2021 Apr;11(2):e73-e82. PubMed PMID: 33842074
• Joshi C, Jacobson M, Silveira L, Shea S, Yang M, Eschbach K. Risk of Admission to the Emergency Room/Inpatient Service After a Neurology Telemedicine Visit During COVID-19 Pandemic. Pediatr Neurol. 2021 Sep;122:15-19. PubMed PMID: 34243046
• Kour S, Rajan DS, Fortuna TR, Anderson EN, Ward C, Lee Y, Lee S, Shin YB, Chae JH, Choi M, Siquier K, Cantagrel V, Amiel J, Stolerman ES, Barnett SS, Cousin MA, Castro D, McDonald K, Kirmse B, Nemeth AH, Rajasundaram D, Innes AM, Lynch D, Frosk P, Collins A, Gibbons M, Yang M, Desguerre I, Boddaert N, Gitiaux C, Rydning SL, Selmer KK, Urreizti R, Garcia-Oguiza A, Osorio AN, Verdura E, Pujol A, McCurry HR, Landers JE, Agnihotri S, Andriescu EC, Moody SB, Phornphutkul C, Sacoto MJG, Begtrup A, Houlden H, Kirschner J, Schorling D, Rudnik-Schöneborn S, Strom TM, Leiz S, Juliette K, Richardson R, Yang Y, Zhang Y, Wang M, Wang J, Wang X, Platzer K, Donkervoort S, Bönnemann CG, Wagner M, Issa MY, Elbendary HM, Stanley V, Maroofian R, Gleeson JG, Zaki MS, Senderek J, Pandey UB. Loss of function mutations in GEMIN5 cause a neurodevelopmental disorder. Nat Commun. 2021 May 7;12(1):2558. PubMed PMID: 33963192
• Guglieri M, Clemens PR, Perlman SJ, Smith EC, Horrocks I, Finkel RS, Mah JK, Deconinck N, Goemans N, Haberlova J, Straub V, Mengle-Gaw LJ, Schwartz BD, Harper AD, Shieh PB, De Waele L, Castro D, Yang ML, Ryan MM, McDonald CM, Tulinius M, Webster R, McMillan HJ, Kuntz NL, Rao VK, Baranello G, Spinty S, Childs AM, Sbrocchi AM, Selby KA, Monduy M, Nevo Y, Vilchez-Padilla JJ, Nascimento-Osorio A, Niks EH, de Groot IJM, Katsalouli M, James MK, van den Anker J, Damsker JM, Ahmet A, Ward LM, Jaros M, Shale P, Dang UJ, Hoffman EP. Efficacy and Safety of Vamorolone vs Placebo and Prednisone Among Boys With Duchenne Muscular Dystrophy: A Randomized Clinical Trial. JAMA Neurol. 2022 Oct 1;79(10):1005-1014. PubMed PMID: 36036925
• Gorokhova S, Schessl J, Zou Y, Yang ML, Heydemann PT, Sufit RL, Meilleur K, Donkervoort S, Medne L, Finkel RS, Bönnemann CG. Unusually severe muscular dystrophy upon in-frame deletion of the dystrophin rod domain and lack of compensation by membrane-localized utrophin. Med. 2023 Apr 14;4(4):245-251.e3. PubMed PMID: 36905929
• https://podcasts.apple.com/us/podcast/american-association-of-neuromuscular/id383185385?i=1000630709058
• Dang UJ, Damsker JM, Guglieri M, Clemens PR, Perlman SJ, Smith EC, Horrocks I, Finkel RS, Mah JK, Deconinck N, Goemans NM, Haberlová J, Straub V, Mengle-Gaw L, Schwartz BD, Harper A, Shieh PB, De Waele L, Castro D, Yang ML, Ryan MM, McDonald CM, Tulinius M, Webster RI, Mcmillan HJ, Kuntz N, Rao VK, Baranello G, Spinty S, Childs AM, Sbrocchi AM, Selby KA, Monduy M, Nevo Y, Vilchez JJ, Nascimento-Osorio A, Niks EH, De Groot IJM, Katsalouli M, Van Den Anker JN, Ward LM, Leinonen M, D'Alessandro AL, Hoffman EP. Efficacy and Safety of Vamorolone Over 48 Weeks in Boys With Duchenne Muscular Dystrophy: A Randomized Controlled Trial. Neurology. 2024 Mar 12;102(5):e208112. PubMed PMID: 38335499

Practice Locations

• Children's Hospital Colorado

Specialty Information

• Child Neurology, Board Certification (2006)
• Neuromuscular Medicine, Board Certification (2011)
• ABEM Electrodiagnostic Medicine, Board Certification (2009)

• Brain and Nervous System