Professor
(2020)
School of Medicine,
Radiology
My Research focus is on vascular biology related to dialysis access failure & the molecular mechanisms of tumor development & immunotherapy
Publications
Burgio MD, Tselikas L, McLennan G, Deschamps F, Karuppasamy K, Levitin A, Rebet A, Coeuret S, Jugnon V, de Baere T, Gill A. Semi-Automatic Cone-Beam Computed Tomography Virtual Hepatic Volumetry for Intraarterial Therapies. J Vasc Interv Radiol. 2022 Dec 20. [Epub ahead of print] PubMed PMID: 36563933
Juan MCY, Patel P, Zerona N, Christie A, Fendrikova Mahlay N, McLennan G, Tefera L. Increased incidence of venous thromboembolism associated with inferior vena cava filter placement in patients diagnosed with isolated calf deep vein thrombosis after intracranial hemorrhage or intracranial operation. J Thromb Thrombolysis. 2022 Dec 16. [Epub ahead of print] PubMed PMID: 36525155
Koirala N, Joshi J, Duffy SF, McLennan G. Percutaneous-Reinforced Osteoplasty: A Review of Emerging Treatment Strategies for Bone Interventions. J Clin Med. 2022 Sep 22;11(19). PubMed PMID: 36233434
Chapiro J, Allen B, Abajian A, Wood B, Kothary N, Daye D, Bai H, Sedrakyan A, Diamond M, Simonyan V, McLennan G, Abi-Jaoudeh N, Pua B. Proceedings from the Society of Interventional Radiology Foundation Research Consensus Panel on Artificial Intelligence in Interventional Radiology: From Code to Bedside. J Vasc Interv Radiol. 2022 Sep;33(9):1113-1120. PubMed PMID: 35871021
McLennan G. Role of stenting for maintenance of the extremity fistula/graft overview. CARDIOVASCULAR DIAGNOSIS AND THERAPY. 2022 Apr 1.
Mobley D, Kalloo SD, Baskin KM, Koh E, McLennan G, Narayan R, Towbin R, White S, Weintraub JL. Research Priorities for Percutaneous Arteriovenous Fistula Creation in Patients with End-Stage Renal Disease: Proceedings and Recommendations from a Multidisciplinary Research Consensus Panel. J Vasc Interv Radiol. 2021 Aug;32(8):1240.e1-1240.e8. PubMed PMID: 34332723
Koirala N, McLennan G. Mathematical Models for Blood Flow Quantification in Dialysis Access Using Angiography: A Comparative Study. Diagnostics (Basel). 2021 Sep 26;11(10). PubMed PMID: 34679469
Mobley D, Kalloo SD, Baskin KM, Koh E, McLennan G, Narayan R, Towbin R, White S, Weintraub JL. Research Priorities for Percutaneous Arteriovenous Fistula Creation in Patients with End-Stage Renal Disease: Proceedings and Recommendations from a Multidisciplinary Research Consensus Panel. J Vasc Interv Radiol. 2021 Aug;32(8):1240.e1-1240.e8. PubMed PMID: 34332723
Sin D, McLennan G, Rengier F, Haddadin I, Heresi GA, Bartholomew JR, Fink MA, Thompson D, Partovi S. Acute pulmonary embolism multimodality imaging prior to endovascular therapy. Int J Cardiovasc Imaging. 2021 Jan;37(1):343-358. PubMed PMID: 32862293
Das D, Koirala N, Li X, Khan N, Dong F, Zhang W, Mulay P, Shrikhande G, Puskas J, Drazba J, McLennan G. Screening of Polymer-Based Drug Delivery Vehicles Targeting Folate Receptors in Triple-Negative Breast Cancer. J Vasc Interv Radiol. 2020 Nov;31(11):1866-1873.e2. PubMed PMID: 33129432
Young JL, McLennan G. Thoracic Central Vein Occlusion in the Dialysis Patient: An Interventional Perspective. Adv Chronic Kidney Dis. 2020 May;27(3):236-242. PubMed PMID: 32891308
Sin D, McLennan G, Rengier F, Haddadin I, Heresi GA, Bartholomew JR, Fink MA, Thompson D, Partovi S. Acute pulmonary embolism multimodality imaging prior to endovascular therapy. Int J Cardiovasc Imaging. 2020 Aug 30. [Epub ahead of print] PubMed PMID: 32862293
Li X, Haddadin I, McLennan G, Farivar B, Staub D, Beck A, Thompson D, Partovi S. Inferior vena cava filter - comprehensive overview of current indications, techniques, complications and retrieval rates. Vasa. 2020 Oct;49(6):449-462. PubMed PMID: 32660360
Mahameed M, Boukeileh S, Obiedat A, Darawshi O, Dipta P, Rimon A, McLennan G, Fassler R, Reichmann D, Karni R, Preisinger C, Wilhelm T, Huber M, Tirosh B. Pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapy. Nat Commun. 2020 Mar 11;11(1):1304. PubMed PMID: 32161259
Koirala N, McLennan G. Blood flow quantification in dialysis access using digital subtraction angiography: A retrospective study. Comput Methods Programs Biomed. 2020 Jul;190:105379. PubMed PMID: 32050137
Vachharajani TJ, Kirksey L, McLennan G. Endovascular Bypass for Thoracic Vein Occlusion: An Innovative Technique for Hemodialysis Vascular Access. Am J Kidney Dis. 2020 Apr;75(4):468-470. PubMed PMID: 32046863
Das D, Fayazzadeh E, Li X, Koirala N, Wadera A, Lang M, Zernic M, Panick C, Nesbitt P, McLennan G. Quiescent hepatic stellate cells induce toxicity and sensitivity to doxorubicin in cancer cells through a caspase-independent cell death pathway: Central role of apoptosis-inducing factor. J Cell Physiol. 2020 Sep;235(9):6167-6182. PubMed PMID: 31975386
Koirala N, McLennan G. Percutaneous reinforced osteoplasty for long bone metastases: a feasibility study. Skeletal Radiol. 2020 Mar;49(3):375-382. PubMed PMID: 31377837
Koirala N, Das D, Fayazzadeh E, Sen S, McClain A, Puskas JE, Drazba JA, McLennan G. Folic acid conjugated polymeric drug delivery vehicle for targeted cancer detection in hepatocellular carcinoma. J Biomed Mater Res A. 2019 Nov;107(11):2522-2535. PubMed PMID: 31334591
Koirala N, Chauhan N, Thompson D, Karimloo Z, Wunderle K, McLennan G. Quantification of Blood Flow in Dialysis Access Using Custom-Acquisition Protocol and Imaging Methods: A Clinical Validation Study. J Vasc Interv Radiol. 2019 Jul;30(7):1062-1068.e2. PubMed PMID: 30928484
Partovi S, Reiber JHC, McLennan G. Topical issue: advanced imaging and endovascular treatment in pulmonary artery diseases. Int J Cardiovasc Imaging. 2019 Aug;35(8):1405-1406. PubMed PMID: 31292780
Chen JX, Montgomery J, McLennan G, Stavropoulos SW. Endobronchial Forceps-Assisted and Excimer Laser-Assisted Inferior Vena Cava Filter Removal: The Data, Where We Are, and How It Is Done. Tech Vasc Interv Radiol. 2018 Jun;21(2):85-91. PubMed PMID: 29784126
Baskin KM, Durack JC, Abu-Elmagd K, Doellman D, Drews BB, Journeycake JM, Kocoshis SA, McLennan G, Rupp SM, Towbin RB, Wasse H, Mermel LA, Toomay SM, Camillus JC, Ahrar K, White SB. Chronic Central Venous Access: From Research Consensus Panel to National Multistakeholder Initiative. J Vasc Interv Radiol. 2018 Apr;29(4):461-469. PubMed PMID: 29456059
McDevitt JL, Alian A, Kapoor B, Bennett S, Gill A, Levitin A, Sands M, Narayanan Menon KV, Aucejo FN, Estfan B, Pillai AK, Kalva SP, McLennan G. Single-Center Comparison of Overall Survival and Toxicities in Patients with Infiltrative Hepatocellular Carcinoma Treated with Yttrium-90 Radioembolization or Drug-Eluting Embolic Transarterial Chemoembolization. J Vasc Interv Radiol. 2017 Oct;28(10):1371-1377. PubMed PMID: 28689934
Klungboonkrong V, Das D, McLennan G. Molecular Mechanisms and Targets of Therapy for Hepatocellular Carcinoma. J Vasc Interv Radiol. 2017 Jul;28(7):949-955. PubMed PMID: 28416267
Boules M, Haskins IN, Farias-Kovac M, Guerron AD, Schechtman D, Samotowka M, O'Rourke CP, McLennan G, Walsh RM, Morris-Stiff G. What is the fate of the cholecystostomy tube following percutaneous cholecystostomy?. Surg Endosc. 2017 Apr;31(4):1707-1712. PubMed PMID: 27519595
Murali AR, Romero-Marrero C, Miller C, Aucejo F, Levitin A, Gill A, McLennan G, Karuppasamy K, Zein NN, Lopez R, Menon KV. Predictors of Successful Downstaging of Hepatocellular Carcinoma Outside Milan Criteria. Transplantation. 2016 Nov;100(11):2391-2397. PubMed PMID: 27780187
Koirala N, Anvari E, McLennan G. Monitoring and Surveillance of Hemodialysis Access. Semin Intervent Radiol. 2016 Mar;33(1):25-30. PubMed PMID: 27013773
McLennan G. Stent and Stent-Graft Use in Arteriovenous Dialysis Access. Semin Intervent Radiol. 2016 Mar;33(1):10-4. PubMed PMID: 27011422
Liu F, Bennett S, Arrigain S, Schold J, Heyka R, McLennan G, Navaneethan SD. Patency and Complications of Translumbar Dialysis Catheters. Semin Dial. 2015 Jul-Aug;28(4):E41-7. PubMed PMID: 25800550
Ouzaid I, Autorino R, Fatica R, Herts BR, McLennan G, Remer EM, Haber GP. Active surveillance for renal angiomyolipoma: outcomes and factors predictive of delayed intervention. BJU Int. 2014 Sep;114(3):412-7. PubMed PMID: 24325283
Srinivas SM, Natarajan N, Kuroiwa J, Gallagher S, Nasr E, Shah SN, DiFilippo FP, Obuchowski N, Bazerbashi B, Yu N, McLennan G. Determination of Radiation Absorbed Dose to Primary Liver Tumors and Normal Liver Tissue Using Post-Radioembolization (90)Y PET. Front Oncol. 2014;4:255. PubMed PMID: 25353006
Kapoor BS, Esparaz A, Levitin A, McLennan G, Moon E, Sands M. Nonvascular and portal vein applications of cone-beam computed tomography: current status. Tech Vasc Interv Radiol. 2013 Sep;16(3):150-60. PubMed PMID: 23993077
Yu N, Srinivas SM, Difilippo FP, Shrikanthan S, Levitin A, McLennan G, Spain J, Xia P, Wilkinson A. Lung dose calculation with SPECT/CT for ?°Yittrium radioembolization of liver cancer. Int J Radiat Oncol Biol Phys. 2013 Mar 1;85(3):834-9. PubMed PMID: 22871239
Faramarzalian A, McLennan G, Bennett SL, Babsky A, Bansal N, Lieber M, Bonnac L, Pankiewicz K, Jayaram HN. Variability of apoptosis and response in N1-S1 rodent hepatomas to benzamide riboside and correlation to early changes in water apparent diffusion coefficient and sodium MR imaging. J Vasc Interv Radiol. 2013 Jun;24(6):894-900. PubMed PMID: 23566523
McLennan G, Bennett SL, Ju S, Babsky A, Bansal N, Shorten ML, Levitin S, Bonnac L, Panciewicz KW, Jayaram HN. Tumor response and apoptosis of N1-S1 rodent hepatomas in response to intra-arterial and intravenous benzamide riboside. Cardiovasc Intervent Radiol. 2012 Jun;35(3):645-52. PubMed PMID: 21431971
Babsky AM, Ju S, Bennett S, George B, McLennan G, Bansal N. Effect of implantation site and growth of hepatocellular carcinoma on apparent diffusion coefficient of water and sodium MRI. NMR Biomed. 2012 Feb;25(2):312-21. PubMed PMID: 21823182
Zhou D, Spain J, Moon E, Mclennan G, Sands MJ, Wang W. Retrospective review of 120 celect inferior vena cava filter retrievals: experience at a single institution. J Vasc Interv Radiol. 2012 Dec;23(12):1557-63. PubMed PMID: 23177101
Seth R, Manz RM, Dahan IJ, Nuara MJ, Meltzer NE, McLennan G, Alam DS. Comprehensive analysis of the anterolateral thigh flap vascular anatomy. Arch Facial Plast Surg. 2011 Sep-Oct;13(5):347-54. PubMed PMID: 21502468
Siskin GP, Haskal ZJ, McLennan G, Dake MD, Haacke EM, McDonald S, Royal W 3rd, Vedantham S, Hubbard D, Sclafani SJ, Andrews RT, Sauder H. Development of a research agenda for evaluation of interventional therapies for chronic cerebrospinal venous insufficiency: proceedings from a multidisciplinary research consensus panel. J Vasc Interv Radiol. 2011 May;22(5):587-93. PubMed PMID: 21514515
Babsky AM, Ju S, George B, Bennett S, Huang M, Jayaram HN, McLennan G, Bansal N. Predicting response to benzamide riboside chemotherapy in hepatocellular carcinoma using apparent diffusion coefficient of water. Anticancer Res. 2011 Jun;31(6):2045-51. PubMed PMID: 21737621
Zhu X, Tam MD, Pierce G, McLennan G, Sands MJ, Lieber MS, Wang W. Utility of the Amplatzer Vascular Plug in splenic artery embolization: a comparison study with conventional coil technique. Cardiovasc Intervent Radiol. 2011 Jun;34(3):522-31. PubMed PMID: 20700592
Lance C, McLennan G, Obuchowski N, Cheah G, Levitin A, Sands M, Spain J, Srinivas S, Shrikanthan S, Aucejo FN, Kim R, Menon KV. Comparative analysis of the safety and efficacy of transcatheter arterial chemoembolization and yttrium-90 radioembolization in patients with unresectable hepatocellular carcinoma. J Vasc Interv Radiol. 2011 Dec;22(12):1697-705. PubMed PMID: 21983055
Haskal ZJ, Trerotola S, Dolmatch B, Schuman E, Altman S, Mietling S, Berman S, McLennan G, Trimmer C, Ross J, Vesely T. Stent graft versus balloon angioplasty for failing dialysis-access grafts. N Engl J Med. 2010 Feb 11;362(6):494-503. PubMed PMID: 20147715
Georgiades CS, Rodriguez R, Littrup PJ, Frangakis CE, Leveille R, Ahrar K, Atwell TD, Cadeddu J, Trimmer C, Durack JC, Hammers HJ, Meng MV, Raman S, Solomon SB, Zagoria RJ, McLennan G, Laberge JM, Gervais DA, Kee ST. Development of a research agenda for percutaneous renal tumor ablation: proceedings from a multidisciplinary research consensus panel. J Vasc Interv Radiol. 2010 Dec;21(12):1807-16. PubMed PMID: 21111363
Ju S, McLennan G, Bennett SL, Liang Y, Bonnac L, Pankiewicz KW, Jayaram HN. Technical aspects of imaging and transfemoral arterial treatment of N1-S1 tumors in rats: an appropriate model to test the biology and therapeutic response to transarterial treatments of liver cancers. J Vasc Interv Radiol. 2009 Mar;20(3):410-4. PubMed PMID: 19167243
de Ryk J, Namati E, Weydert J, Thiesse J, McLennan G. New imaging approaches for understanding lung cancer response to treatment. Clin Pharmacol Ther. 2008 Oct;84(4):517-22. PubMed PMID: 18769370
Babs'kyi AM, Ju S, Topper S, Bennett S, Atthe B, McLennan G, Bansal N. [Noninvasive monitoring of the hepatocellular carcinoma growth by the method of 1H and 23Na nuclear magnetic resonance]. Ukr Biokhim Zh (1999). 2008 Jul-Aug;80(4):130-7. PubMed PMID: 19140459
Stecker MS, Johnson MS, Ying J, McLennan G, Agarwal DM, Namyslowski J, Ahmad I, Shah H, Butty S, Casciani T. Time to hemostasis after traction removal of tunneled cuffed central venous catheters. J Vasc Interv Radiol. 2007 Oct;18(10):1232-9; quiz 1240. PubMed PMID: 17911513
Hendee WR, Banovac F, Carson PL, DeFronzo RA, Eckelman WC, Fullerton GD, Larson SM, McLennan G, Welch MJ. Biomedical imaging research opportunities workshop IV: a white paper. Med Phys. 2007 Feb;34(2):673-9. PubMed PMID: 17388185
Vascular and Interventional Radiology, Board Certification (2002, 2018)
Conditions & Treatments
Heart and Circulation - Aneurysms
Heart and Circulation
Heart and Circulation - Aneurysms
Heart and Circulation - Angioplasty
Heart and Circulation - Peripheral Artery Disease
Heart and Circulation - Vascular Malformations
Cancers - Biliary Cancer
Cancers
Cancers - Colorectal Cancer
Cancers - Lung Cancer
Cancers - Kidney Cancer
Cancers - Pancreatic Cancer
Cancers - Anal Cancer
Cancers - Gastroenterologic Cancer (Colon, Stomach, Esophageal, Liver)
Circulatory System and Blood Vessel Health - Abdominal aortic aneurysm
Circulatory System and Blood Vessel Health
Circulatory System and Blood Vessel Health - Acute mesenteric ischemia
Circulatory System and Blood Vessel Health - Aneurysms
Circulatory System and Blood Vessel Health - Angioplasty
Circulatory System and Blood Vessel Health - Aortic dissection
Circulatory System and Blood Vessel Health - Carotid artery disease
Circulatory System and Blood Vessel Health - Chronic mesenteric ischemia
Circulatory System and Blood Vessel Health - Chronic mesenteric ischemia
Circulatory System and Blood Vessel Health - Claudication
Circulatory System and Blood Vessel Health - Critical Limb-threatening ischemia
Circulatory System and Blood Vessel Health - Dialysis access
Circulatory System and Blood Vessel Health - Limb Salvage
Circulatory System and Blood Vessel Health - Lower extremity rest pain
Circulatory System and Blood Vessel Health - Peripheral arterial disease (PAD)
Circulatory System and Blood Vessel Health - Peripheral Artery Disease
Circulatory System and Blood Vessel Health - Renal artery stenosis
Circulatory System and Blood Vessel Health - TOS - Thoracic Outlet Syndrome
Circulatory System and Blood Vessel Health - Varicose Veins
Circulatory System and Blood Vessel Health - Vascular Malformations
Circulatory System and Blood Vessel Health - Vascular Surgery
Bones, Joints and Muscles - Spine Injuries
Bones, Joints and Muscles
Bones, Joints and Muscles - Back Pain
Kidneys and Urinary System - Prostate Disease
Kidneys and Urinary System
Men's Health - Prostate Conditions
Men's Health
Men's Health - Infertility and Reproductive Medicine
Women's Health
Radiology - Interventional
Radiology
Hereditary Hemorrhagic Telangiectasia (HHT)
Critical Care
Lungs and Breathing - Pulmonary Embolism
Lungs and Breathing
Lungs and Breathing - Pulmonary Hypertension
Digestive System
Bones, Joints and Muscles - Knee Injuries and Disorders
Cancers - Bone Cancer
Clinical Interests
Management of vascular diseases including leg pain, leg ulcers, varicose veins, aneurysms, carotid stenosis, Pulmonary Emboli, Deep vein clots & leg swelling.
Cancer Therapy for liver, lung, kidney, pancreas & bone cancers
Management of prostate enlargement
Management of fibroids & pelvic pain
Management of pain related to knee arthritis with embolization
Care Philosophy
Interventional Radiology will provide patients with the best opportunity to get care for complex diseases like cancer, vascular disease, prostate problems,
Personal Interests
I have recently moved from the midwest to Denver having taken the leadership role of Section Chief & Vice Chairman for Clinical research without ever having been in the state. I am very excited to be here & these first few weeks have been exhillarating.
Volunteer Activities
I have dedicated my time to furthering the educational & scientific missions of the Interventional Radiology community. It is a small community but by making research and education a major focus, I have been able to build programs that advance medical care & bring minimally invasive therapies to more people.
Public Speaking Yes
I have given numerous talks nationally & internationally about the impact of Interventional Radiology on the transformation of modern healthcare. This includes talks related to Cancer therapy, Vascular disease management, management of dialysis access problems, Treatments for broken spines from osteoporosis, and pelvic pain & fibroids in women.
General Information
Medical Schools:
MD, Virginia Commonwealth University School of Medicine
(1993)