Leland Shapiro, MD

Publications

• Lewis E, Shapiro L, Bowers OJ, Dinarello CA. alpha1-Antitrypsin monotherapy prolongs islet allograft survival in mice. Proc. Natl. Acad. Sci .USA. 102:12153-12158, 2005)
• Petrache I, Fijalkowska I, Zhen L, Medler TR, Brown E, Cruz P, Choe KH, Taraseviciene-Stewart L, Scerbavicius R, Shapiro L, Zhang B, Song S, Hicklin D, Voelkel NF, Flotte T, Tuder RM. A Novel Anti-apoptotic Role for Alpha-1 Antitrypsin in the Prevention of Pulmonary Emphysema. Am J Resp Crit Care Med, 2006, IN PRESS
• Normal alpha-1-antitrypsin (AAT) function protects against pulmonary disease due to rapidly-growing mycobacteria: epidemiological linkage of disease to AAT anomalies and AAT-suppression of infectivity in vitro. Chan ED, Kaminska AM, Gill W, Chmura K, Feldman NE, Bai X, Floyd CM, Fulton KE, Huitt GA, Iseman MD, Shapiro L
• Sailer CA, Pott GB, Dinarello CA, MaWhinney S, Forster JE, Larson-Duran JK, Landay A, Al-Harthi L, Schooley RT, Benson CA, Judson FN, Thompson M, Palella FJ, Shapiro L. Whole-blood interleukin 18 level during early HIV-1 infection is associated with reduced CXCR4 co-receptor expression and interferon gamma levels. J Infect Dis, vol 195,pp734-738, 2007.
• Chan ED, Kaminska AM, GIll W, Chmura K, Feldman NE, Bai X, FLoyd CM, Fulton KE, Huitt GA, Strand MJ, Iseman MD, Shapiro L. Alpha-1-antitrypsin (AAT) anomalies are associated with lung disease due to rapidly growing mycobacteria and AAT inhibits Mycobacterium abscessus infection of macrophages. Scand J Infect Dis, IN PRESS.
• Petrache I, Fijalkowska I, Zhen L, Medler TR, Brown E, Cruz P, Choe K-H, Taraseviciene-Stewart L, Scerbavicius R, Shapiro L, Zhang B, Song S, Hicklin D, Voelkel NF, Flotte T, Tuder R. A novel antiapoptotic effect role for alpha-1-antitrypsin in the prevention of pulmonary emphysema. Am J Resp Crit Care Med. vol 173, pp1222-1228, 2006.
• Sailer CA, Pott GB, Dinarello CA, MaWhinney S, Forster JE, Larson-Duran JK, Landay A, Al-Harthi L, Schooley RT, Benson CA, Judson FN, Thompson M, Palella FJ, Shapiro L. Whole blood interleukin-18 level during early HIV-1 infection is associated with reduced CXCR4 coreceptor expression and interferon-? levels. J. Infect. Dis. 195:734-738, 2007.
• Pott GB, Sailer CA, Porat R, Peskind RL, Fuchs AC, Angel JB, LeBeaut A, Grint PC, Dinarello CA, Shapiro/L. Effect of a four-week course of interleukin-10 on cytokine in a placebo-controlled stud of HIV-1-infected subjects. European Cytokine Network. 18: 49-58
• Chan ED, Kaminska AM, Gil W, Chmura K, Feldman NE, Bai X, Floyd CM, Fulton KE, Huitt GA, Strand MJ, Iseman MD, Shapiro L. Alpha-1-antitrypsin (AAT) anomalies are associated with lung diseases due to rapidly growing mycobacteria and AAT inhibits Mycobacterium abscessus infection of macrophages. Scandinavian J. Infect. Dis. 39: 690-696, 2007
• Sailer CA and Shapiro L. Reply to Torre. J Infect Dis,; 196(5): 804-5, 2007
• Hiremath J, Thanikachalam S, Parikh K, Shanmugasundaram S, Bangera S, Shapiro L, Pott GB, Vnencak-Jones CL, Arneson C, Wade M, White RJ. Exercise improvement and plasma biomarker changes with intravenous treprostinil therapy for pulmonary arterial hypertension; a placebo-controlled trial. Journal of Heart and Lung transplantation, 29; 137-149, 2010
• ALPHA-1-ANTITRYPSIN INHIBITS INFLUENZA IN VITRO, REDUCES INFLUENZA DISEASE IN VIVO, AND GENETIC DEFICIENCY IS A RISK FACTOR FOR HUMAN INFLUENZA INFECTION K. Scott Beard1,2, Sam MaWhinney3, Martin Zamora2, Rebecca Oberley-Deegan4. James D Crapo4, Gregory B. Pott1,2, Claudia Nold-Petry2, Andrew Churg5, Eli C. Lewis2, Charles L. Edelstein2, Charles A. Dinarello2, and Leland Shapiro1,2. Cytokine, vol48, p38, 2009
• ACTIVATED COLLAGEN ACCELERATES WOUND REPAIR AND MODULATES CYTOKINE PRODUCTION IN WHOLE BLOOD AND PBMC CULTURES. Gregory B. Pott1,2, K. Scott Beard1,2, Matthew Regulski3, and Leland Shapiro1,2., Cytokine, vol48, p93, 2009
• Clin Invest Med. 2010 Dec 1;33(6):E384-9. HIV infection is associated with reduced serum alpha-1-antitrypsin concentrations. Bryan CL, Beard KS, Pott GB, Rahkola J, Gardner EM, Janoff EN, Shapiro L.
• J Immunol. 2011 Mar 1;186(5):3148-55. Epub 2011 Jan 24. HIV replication in CD4+ T lymphocytes in the presence and absence of follicular dendritic cells: inhibition of replication mediated by a-1-antitrypsin through altered I?Ba ubiquitination. Zhou X, Shapiro L, Fellingham G, Willardson BM, Burton GF
• Mycopathologia. 2016 Dec;181(11-12):807-814. Epub 2016 Aug 8. Risk Factors for Cryptococcal Meningitis: A Single United States Center Experience. Henao-Martínez AF1, Gross L2, Mcnair B2, McCollister B3, DeSanto K4, Montoya JG5, Shapiro L6, Beckham JD3.
• Cryptococcosis and cryptococcal meningitis: New predictors and clinical outcomes at a united states academic medical center
• Kashef Hamadani BH, Franco-Paredes C2,, McCollister B, Shapiro L2,, Beckham JD2, Henao-Martínez AF. Cryptococcosis and cryptococcal meningitis: New predictors and clinical outcomes at a United States academic medical centre. Mycoses. 2018. May; 61(5): 314-320
• Preventing SARS-CoV-2 infection by blocking a tissue serine protease. Jankousky KC, Schultz J, Windham S, Henao-Martínez AF, Franco-Paredes C, Shapiro L. Ther Adv Infect Dis. 2020 Jun 10;7:2049936120933076. doi: 10.1177/2049936120933076. eCollection 2020 Jan-Dec. PMID: 32577236
• Empiric Therapies for COVID-19: Destined to Fail by Ignoring the Lessons of History. Canfield GS, Schultz JS, Windham S, Scherger S, Henao-Martinez AF, Shapiro L, Franco-Paredes C, Chastain DB, Wand T, Krsak M. J Hosp Med. 2020 Jul 1;15(7):434-436. doi: 10.12788/jhm.3469. Epub 2020 Jun 17. PMID: 32584243
• Diagnostic utility of a Ferritin-to-Procalcitonin Ratio to differentiate patients with COVID-19 from those with Bacterial Pneumonia: A multicenter study. Gharamti AA, Mei F, Jankousky KC, Huang J, Hyson P, Chastain DB, Fan J, Osae S, Zhang WW, Montoya JG, Erlandson KM, Scherger SJ, Franco-Paredes C, Henao-Martínez AF, Shapiro L. medRxiv. 2020 Oct 22:2020.10.20.20216309. doi: 10.1101/2020.10.20.20216309. Preprint. PMID: 33106821
• Lower Mortality Associated With Adjuvant Corticosteroid Therapy in Non-HIV-Infected Patients With Pneumocystis jirovecii Pneumonia: A Single-Institution Retrospective US Cohort Study. Mundo W, Morales-Shnaider L, Tewahade S, Wagner E, Archuleta S, Bandali M, Chadalawada S, Johnson SC, Franco-Paredes C, Shapiro L, Henao-Martínez AF. Open Forum Infect Dis. 2020 Aug 13;7(9):ofaa354. doi: 10.1093/ofid/ofaa354. eCollection 2020 Sep. PMID: 33005696
• Risk of Chronic Cardiomyopathy Among Patients With the Acute Phase or Indeterminate Form of Chagas Disease: A Systematic Review and Meta-analysis. Chadalawada S, Sillau S, Archuleta S, Mundo W, Bandali M, Parra-Henao G, Rodriguez-Morales AJ, Villamil-Gomez WE, Suárez JA, Shapiro L, Hotez PJ, Woc-Colburn L, DeSanto K, Rassi A Jr, Franco-Paredes C, Henao-Martínez AF. JAMA Netw Open. 2020 Aug 3;3(8):e2015072. doi: 10.1001/jamanetworkopen.2020.15072. PMID: 32865573
• Rethinking interleukin-6 blockade for treatment of COVID-19. Scherger S, Henao-Martínez A, Franco-Paredes C, Shapiro L. Med Hypotheses. 2020 Nov;144:110053. doi: 10.1016/j.mehy.2020.110053. Epub 2020 Jun 27. PMID: 32758889
• 37928695
• 36938147

Practice Locations

Denver Veterans Affairs Medical Center
1055 Clermont St
Denver, CO 80220
1-888-336-8262

Hospital Affiliation

• University of Colorado Hospital
• Veterans Affairs Medical Center

Specialty Information

Specialties

• Infectious Disease, Board Certification (1996)
• Internal Medicine, Board Certification

Conditions & Treatments

• Infections - Bacterial Infections
• Infections - Viral Infections
• Infections