Paula Hoffman, PhD

Publications

• Saba L, Hoffman PL, Hunter L, Tabakoff B The Marriage of Phenomics and Genetical/Genomics: A Systems Approach to Complex Trait Analysis. Systems Biol Psyc (In Press) (2010)
• Pronko S, Saba L, Hoffman PL, Tabakoff B Type 7 Adenylyl Cyclase-Mediated HPA Axis Responsiveness: Influence of Ethanol and Sex. J Pharmacol Exp Ther (In Press) (2010)
• Clapp P, Gibson ES, Dell'Acqua ML, Hoffman PL Phosphorylation regulates removal of synaptic NMDA receptors after withdrawal from chronic ethanol exposure. J Pharmacol Exp Ther 332:720-729 (2010)
• Saba LM, Bennett B, Hoffman PL, Barcomb K, Ishii T, Kechris K, Tabakoff B A systems genetic analysis of alcohol drinking by mice, rats and men: Influence of brain GABAergic transmission. Neuropharmacology (In Press) (2010)
• Pronko SP, Saba LM, Hoffman PL, Tabakoff B Type 7 adenylyl cyclase-mediated hypothalamic-pituitary-adrenal axis responsiveness: influence of ethanol and sex. J Pharmacol Exp Ther 334:44-52 (2010)
• Bennett B, Saba LM, Hornbaker CK, Kechris KJ, Hoffman PL, Tabakoff B Genetical Genomic Analysis of Complex Phenotypes Using the PhenoGen Website. Behav Genet (In Press) (2010)
• Clapp P, Gibson ES, Dell'Acqua ML, Hoffman PL Phosphorylation regulates removal of synaptic N-methyl-D-aspartate receptors after withdrawal from chronic ethanol exposure. J Pharmacol Exp Ther 332:720-729 (2010)
• 239. Procopio D.O., Saba L.M, Walter H., Lesch O., Skala K., Schlaff G., Vanderlinden L., Clapp P., Hoffman P.L. and Tabakoff B. Genetic markers of comorbid depression and alcoholism in women. Alcohol Clin Exp Res. 37:896-904 (2013) PMC3620932
• 240. Vanderlinden L.A., Saba L.M, Kechris K., Miles M.F., Hoffman P.L. and Tabakoff B. Whole brain and brain regional coexpression network interactions associated with predisposition to alcohol consumption. PLoS ONE 8:e68878 (2013). PMC3720886
• Vanderlinden, L.A., Saba, L.M., Printz, M.P., Flodman, P., Koob, G., Richardson, H.N., Hoffman, P.L. and Tabakoff, B. Is the alcohol deprivation effect genetically mediated? Studies with HXB/BXH recombinant inbred rat strains. Alcohol Clin Exp Res. 38:2148-2157 (2014).
• Hoffman, P.L., Saba, L.M., Flink, S., Grahame, N.J., Kechris, K. and Tabakoff, B. Genetics of gene expression characterizes response to selective breeding for alcohol preference. Genes, Brain Behav. 13: 743-757 (2014)
• Ru, Y., Kechris, K.J., Tabakoff, B., Hoffman, P.L., Radcliffe, R.A., Bowler, R., Mahaffey, S., Rossi, S., Calin, G.A., Bemis, L., and Theodorescu, D. The multiMiR R package and database: integration of microRNA-target interactions along with their disease and drug associations. Nucleic Acids Res. 42: e133 (2104)
• Vanderlinden, L.A., Saba, L.M., Bennett, B., Hoffman, P.L., and Tabakoff, B. Influence of sex on genetic regulation of “drinking in the dark” alcohol consumption. Mamm. Genome 26: 43-56 (2015)
• Tabakoff, B., Saba, L.M., Vanderlinden, L.M., and Hoffman, P.L. Genetical genomic systems analysis of alcohol consumption by mouse, rat and human. Int. Rev. Neurobiol.-Brain Transcriptome (in press).
• Vanderlinden, L.A., Saba, L.M., Bennett, B., Hoffman, P.L., and Tabakoff, B. Influence of sex on genetic regulation of “drinking in the dark” alcohol consumption. Mamm. Genome 26: 43-56 (2015)
• .Saba, L.M., Flink, S.C., Vanderlinden, L.A., Israel, Y., Tampier, L:., Colombo, G., Kiianmaa, K., Bell, R.L., Printz, M.P., Flodman, P., Koob, G., Richardson, H.N., Hoffman, P.L., and Tabakoff, B. The sequenced rat brain transcriptome, its use in identifying networks predisposing alcohol consumption. FEBS Journal 282: 3556-3578 (2015)
• Saba, L., Hoffman, P.L., and Tabakoff, B. Using baseline transcriptional connectomes in rat to identify genetic pathways associated with predisposition to complex traits. In: Systems Genetics: Models and Methods, Eds. Schugart, K. and Williams, R., Springer, New York (in press).
• Tabakoff, B.. Ren, W., Vanderlinden, L., Snell, L.D., Matheson, C.J., Wang, Z-J., Levinson, R., Smothers, C.T., Woodward, J.J., Honse, Y., Lovinger, L., Rush, A.M., Sather, W.A., Gustafson, D.L., and Hoffman, P.L. A novel substituted aminoquinoline (DCUKA) selectively targets voltage-sensitive sodium channel isoforms and NMDA receptor subtypes and alleviates chronic inflammatory and neuropathic pain. (submitted).
• 241. Tabakoff, B., and Hoffman P.L. The neurobiology of alcohol consumption and alcoholism: An integrative history. Pharmacol Biochem Behav 113: 20-37 (2013). PMC3867277
• Harrall KK, Kechris KJ, Tabakoff B, Hoffman PL, Hines LM, Tsukamoto H, Pravenec M, Printz M, Saba LM. Uncovering the liver's role in immunity through RNA co-expression networks. Mamm Genome. 2016 Oct;27(9-10):469-84. PubMed PMID: 27401171
• Tabakoff B, Ren W, Vanderlinden L, Snell LD, Matheson CJ, Wang ZJ, Levinson R, Smothers CT, Woodward JJ, Honse Y, Lovinger D, Rush AM, Sather WA, Gustafson DL, Hoffman PL. A novel substituted aminoquinoline selectively targets voltage-sensitive sodium channel isoforms and NMDA receptor subtypes and alleviates chronic inflammatory and neuropathic pain. Eur J Pharmacol. 2016 Aug 5;784:1-14. PubMed PMID: 27158117
• Saba L, Hoffman P, Tabakoff B. Using Baseline Transcriptional Connectomes in Rat to Identify Genetic Pathways Associated with Predisposition to Complex Traits. Methods Mol Biol. 2017;1488:299-317. PubMed PMID: 27933531
• 242. Hoffman, P.L., Saba, L.M., Flink, S., Grahame, N.J., Kechris, K. and Tabakoff, B. Genetics of gene expression characterizes response to selective breeding for alcohol preference. Genes, Brain and Behavior (in revision).
• 243. Vanderlinden, L.A., Saba, L.M., Printz, M.P., Flodman, P., Koob, G., Richardson, H.N., Hoffman, P.L. and Tabakoff, B. Is the alcohol deprivation effect genetically mediated? Studies with HXB/BXH recombinant inbred rat strains. Alcohol Clin Exp Res. (in revision).
• Hoffman PL, Saba LM, Vanderlinden LA, Tabakoff B. Voluntary exposure to a toxin: the genetic influence on ethanol consumption. Mamm Genome. 2017 Dec 1. [Epub ahead of print] PubMed PMID: 29196862
• Borghese CM, Herman M, Snell LD, Lawrence KJ, Lee HY, Backos DS, Vanderlinden LA, Harris RA, Roberto M, Hoffman PL, Tabakoff B. Novel Molecule Exhibiting Selective Affinity for GABA(A) Receptor Subtypes. Sci Rep. 2017 Jul 24;7(1):6230. PubMed PMID: 28740086
• Saba L, Hoffman P, Tabakoff B. Using Baseline Transcriptional Connectomes in Rat to Identify Genetic Pathways Associated with Predisposition to Complex Traits. Methods Mol Biol. 2017;1488:299-317. PubMed PMID: 27933531
• Tabakoff, B. Harrall, K., Saba L., Hoffman,P. Liver Influences on Alcohol Drinking Behavior. Experimental and Molecular Pathology
• Rudra P, Shi WJ, Russell P, Vestal B, Tabakoff B, Hoffman P, Kechris K, Saba L. Predictive modeling of miRNA-mediated predisposition to alcohol-related phenotypes in mouse. BMC Genomics. 2018 Aug 29;19(1):639. PubMed PMID: 30157779
• Tanabe J, Yamamoto DJ, Sutton B, Brown MS, Hoffman PL, Burnham EL, Glueck DH, Tabakoff B. Effects of Alcohol and Acetate on Cerebral Blood Flow: A Pilot Study. Alcohol Clin Exp Res. 2019 Oct;43(10):2070-2078. PubMed PMID: 31386214
• Tabakoff B, Smith H, Vanderlinden LA, Hoffman PL, Saba LM. Networking in Biology: The Hybrid Rat Diversity Panel. Methods Mol Biol. 2019;2018:213-231. PubMed PMID: 31228159
• Lusk R, Saba LM, Vanderlinden LA, Zidek V, Silhavy J, Pravenec M, Hoffman PL, Tabakoff B. Unsupervised, Statistically Based Systems Biology Approach for Unraveling the Genetics of Complex Traits: A Demonstration with Ethanol Metabolism. Alcohol Clin Exp Res. 2018 Jul;42(7):1177-1191. PubMed PMID: 29689131
• Saba, L., Hoffman,P.L., Homanics, G.E., Tabakoff, B. A Long Non-Coding RNA (Lrap) Modulates Brain Gene Expression and Levels of Alcohol Consumption in Rats FEBS J. (under revision)
• Hoffman PL, Saba LM, Vanderlinden LA, Tabakoff B. Voluntary exposure to a toxin: the genetic influence on ethanol consumption. Mamm Genome. 2018 Feb;29(1-2):128-140. PubMed PMID: 29196862
• Tabakoff B, Hoffman PL. Controlling the "Opioid Epidemic": A Novel Chemical Entity (NCE) to Reduce or Supplant Opiate Use for Chronic Pain. J Psychiatr Brain Sci. 2020;5. PubMed PMID: 33117893
• Saba LM, Hoffman PL, Homanics GE, Mahaffey S, Daulatabad SV, Janga SC, Tabakoff B. A long non-coding RNA (Lrap) modulates brain gene expression and levels of alcohol consumption in rats. Genes Brain Behav. 2020 Sep 6;:e12698. [Epub ahead of print] PubMed PMID: 32893479
• Alcoholic-Hepatitis, Links to Brain and Microbiome: Mechanisms, Clinical and Experimental Research. Neuman MG, Seitz HK, French SW, Malnick S, Tsukamoto H, Cohen LB, Hoffman P, Tabakoff B, Fasullo M, Nagy LE, Tuma PL, Schnabl B, Mueller S, Groebner JL, Barbara FA, Yue J, Nikko A, Alejandro M, Brittany T, Edward V, Harrall K, Saba L, Mihai O. Biomedicines. 2020 Mar 18;8(3):63. doi: 10.3390/biomedicines8030063. PMID: 32197424
• Effects of acetate on cerebral blood flow, systemic inflammation, and behavior in alcohol use disorder Jody Tanabe, M.D.a,c, Sarah Neff, B.S.b, Brianne Sutton, Ph.D.c, Sam Ellis, Pharm D.e, Luke Patten, MS.f, Mark S. Brown, Ph.D.a, Paula L. Hoffman, Ph.D.d, Boris Tabakoff, Ph.D.e, Ellen L. Burnham, M.D.b
• Tanabe J, Neff S, Sutton B, Ellis S, Patten L, Brown MS, Hoffman PL, Tabakoff B, Burnham EL. Effects of acetate on cerebral blood flow, systemic inflammation, and behavior in alcohol use disorder. Alcohol Clin Exp Res. 2021 May;45(5):922-933. PubMed PMID: 33682145
• Saba LM, Hoffman PL, Homanics GE, Mahaffey S, Daulatabad SV, Janga SC, Tabakoff B. A long non-coding RNA (Lrap) modulates brain gene expression and levels of alcohol consumption in rats. Genes Brain Behav. 2021 Feb;20(2):e12698. PubMed PMID: 32893479
• Hitzemann R, Bergeson SE, Berman AE, Bubier JA, Chesler EJ, Finn DA, Hein M, Hoffman P, Holmes A, Kisby BR, Lockwood D, Lodowski KH, McManus M, Owen JA, Ozburn AR, Panthagani P, Ponomarev I, Saba L, Tabakoff B, Walchale A, Williams RW, Phillips TJ. Sex Differences in the Brain Transcriptome Related to Alcohol Effects and Alcohol Use Disorder. Biol Psychiatry. 2021 May 1. [Epub ahead of print] PubMed PMID: 34274109
• Mahaffey, J, Mahaffey S, Vanderlinden LA, Saba,LM, Hoffman, PL, Pravenec, M, Tabakoff,B A Novel circRNA Highlights a Path to Cardiac Hypertrophy in Spontaneously Hypertensive Rats. Scientific Reports
• Ryan Lusk, Paula L. Hoffman, Spencer Mahaffey, Michal Pravenec, Boris Tabakoff, Laura M. Saba Beyond genes: Inclusion of alternative splicing and alternative polyadenylation to assess the genetic architecture of predisposition to voluntary alcohol consumption in brain of the HXB/BXH recombinant inbred rat panel . Frontiers in Genetics
• Tabakoff B, Hoffman PL. The role of the type 7 adenylyl cyclase isoform in alcohol use disorder and depression. Front Pharmacol. 2022;13:1012013. PubMed PMID: 36386206
• Pattee J, Vanderlinden LA, Mahaffey S, Hoffman P, Tabakoff B, Saba LM. Evaluation and characterization of expression quantitative trait analysis methods in the Hybrid Rat Diversity Panel. Front Genet. 2022;13:947423. PubMed PMID: 36186443
• Lusk R, Hoffman PL, Mahaffey S, Rosean S, Smith H, Silhavy J, Pravenec M, Tabakoff B, Saba LM. Beyond Genes: Inclusion of Alternative Splicing and Alternative Polyadenylation to Assess the Genetic Architecture of Predisposition to Voluntary Alcohol Consumption in Brain of the HXB/BXH Recombinant Inbred Rat Panel. Front Genet. 2022;13:821026. PubMed PMID: 35368676
• Hitzemann R, Bergeson SE, Berman AE, Bubier JA, Chesler EJ, Finn DA, Hein M, Hoffman P, Holmes A, Kisby BR, Lockwood D, Lodowski KH, McManus M, Owen JA, Ozburn AR, Panthagani P, Ponomarev I, Saba L, Tabakoff B, Walchale A, Williams RW, Phillips TJ. Sex Differences in the Brain Transcriptome Related to Alcohol Effects and Alcohol Use Disorder. Biol Psychiatry. 2022 Jan 1;91(1):43-52. PubMed PMID: 34274109
• Wood, C, Mahaffey, S, Mahaffey, J, Saba,L, Hoffman, PL, Pravanec, M, Tabakoff, B. Quantitative trait locus and kidney RNA coexpression identifies an interactive network of contributors to hypertension. In preparation