Edward Lau, PhD
Assistant Professor, Medicine-Cardiology

Graduate School :
  • PhD, University of California, Los Angeles
Undergraduate School:
  • BA, University of California–Berkeley (CA)
Department: Medicine-Cardiology

Research Interests

I am interested in understanding intercellular communications and crosstalk in the heart using human induced pluripotent stem cell models and bioinformatics methods. Please see our website for details https://www.laulab.net.


  • Srivastava H, Lippincott MJ, Currie J, Canfield R, Lam MPY, Lau E. Protein prediction models support widespread post-transcriptional regulation of protein abundance by interacting partners. PLoS Comput Biol. 2022 Nov;18(11):e1010702. PubMed PMID: 36356032
  • Paik DT, Kim H, Lau E. Editorial: Intercellular communication and crosstalk in cardiac development and disease. Front Cardiovasc Med. 2022;9:1053539. PubMed PMID: 36277794
  • Eaton DM, Berretta RM, Lynch JE, Travers JG, Pfeiffer RD, Hulke ML, Zhao H, Hobby ARH, Schena G, Johnson JP, Wallner M, Lau E, Lam MPY, Woulfe KC, Tucker NR, McKinsey TA, Wolfson MR, Houser SR. Sex-specific responses to slow progressive pressure overload in a large animal model of HFpEF. Am J Physiol Heart Circ Physiol. 2022 Oct 1;323(4):H797-H817. PubMed PMID: 36053749
  • Han Y, Wennersten SA, Wright JM, Ludwig RW, Lau E, Lam MPY. Proteogenomics reveals sex-biased aging genes and coordinated splicing in cardiac aging. Am J Physiol Heart Circ Physiol. 2022 Sep 1;323(3):H538-H558. PubMed PMID: 35930447
  • Srivastava H, Pozzoli M, Lau E. Defining the Roles of Cardiokines in Human Aging and Age-Associated Diseases. Front Aging. 2022;3:884321. PubMed PMID: 35821831
  • Wei TT, Chandy M, Nishiga M, Zhang A, Kumar KK, Thomas D, Manhas A, Rhee S, Justesen JM, Chen IY, Wo HT, Khanamiri S, Yang JY, Seidl FJ, Burns NZ, Liu C, Sayed N, Shie JJ, Yeh CF, Yang KC, Lau E, Lynch KL, Rivas M, Kobilka BK, Wu JC. Cannabinoid receptor 1 antagonist genistein attenuates marijuana-induced vascular inflammation. Cell. 2022 Jun 23;185(13):2387-2389. PubMed PMID: 35750035
  • Hammond DE, Simpson DM, Franco C, Wright Muelas M, Waters J, Ludwig RW, Prescott MC, Hurst JL, Beynon RJ, Lau E. Harmonizing Labeling and Analytical Strategies to Obtain Protein Turnover Rates in Intact Adult Animals. Mol Cell Proteomics. 2022 Jul;21(7):100252. PubMed PMID: 35636728
  • Wei TT, Chandy M, Nishiga M, Zhang A, Kumar KK, Thomas D, Manhas A, Rhee S, Justesen JM, Chen IY, Wo HT, Khanamiri S, Yang JY, Seidl FJ, Burns NZ, Liu C, Sayed N, Shie JJ, Yeh CF, Yang KC, Lau E, Lynch KL, Rivas M, Kobilka BK, Wu JC. Cannabinoid receptor 1 antagonist genistein attenuates marijuana-induced vascular inflammation. Cell. 2022 May 12;185(10):1676-1693.e23. PubMed PMID: 35489334
  • Veitch S, Njock MS, Chandy M, Siraj MA, Chi L, Mak H, Yu K, Rathnakumar K, Perez-Romero CA, Chen Z, Alibhai FJ, Gustafson D, Raju S, Wu R, Zarrin Khat D, Wang Y, Caballero A, Meagher P, Lau E, Pepic L, Cheng HS, Galant NJ, Howe KL, Li RK, Connelly KA, Husain M, Delgado-Olguin P, Fish JE. MiR-30 promotes fatty acid beta-oxidation and endothelial cell dysfunction and is a circulating biomarker of coronary microvascular dysfunction in pre-clinical models of diabetes. Cardiovasc Diabetol. 2022 Feb 24;21(1):31. PubMed PMID: 35209901
  • Han Y, Thomas CT, Wennersten SA, Lau E, Lam MPY. Shotgun Proteomics Sample Processing Automated by an Open-Source Lab Robot. J Vis Exp. 2021 Oct 28;(176). PubMed PMID: 34779440
  • Han Y, Li LZ, Kastury NL, Thomas CT, Lam MPY, Lau E. Transcriptome features of striated muscle aging and predictability of protein level changes. Mol Omics. 2021 Oct 11;17(5):796-808. PubMed PMID: 34328155
  • Woulfe KC, Jeffrey DA, Pires Da Silva J, Wilson CE, Mahaffey JH, Lau E, Slavov D, Hailu F, Karimpour-Fard A, Dockstader K, Bristow MR, Stauffer BL, Miyamoto SD, Sucharov CC. Serum response factor deletion 5 regulates phospholamban phosphorylation and calcium uptake. J Mol Cell Cardiol. 2021 Oct;159:28-37. PubMed PMID: 34139234
  • Chour T, Tian L, Lau E, Thomas D, Itzhaki I, Malak O, Zhang JZ, Qin X, Wardak M, Liu Y, Chandy M, Black KE, Lam MP, Neofytou E, Wu JC. Method for selective ablation of undifferentiated human pluripotent stem cell populations for cell-based therapies. JCI Insight. 2021 Apr 8;6(7). PubMed PMID: 33830086
  • Han Y, Wood SD, Wright JM, Dostal V, Lau E, Lam MPY. Computation-assisted targeted proteomics of alternative splicing protein isoforms in the human heart. J Mol Cell Cardiol. 2021 May;154:92-96. PubMed PMID: 33549679
  • Ludwig RW, Lau E. JCAST: Sample-specific protein isoform databases for mass spectrometry-based proteomics experiments. Software Impacts. 2021; 10, 100163
  • Han Y, Wright JM, Lau E, Lam MPY. Determining Alternative Protein Isoform Expression Using RNA Sequencing and Mass Spectrometry. STAR Protoc. 2020 Dec 18;1(3):100138. PubMed PMID: 33377032
  • Chandy M, Rhee JW, Ozen MO, Williams DR, Pepic L, Liu C, Zhang H, Malisa J, Lau E, Demirci U, Wu JC. Atlas of Exosomal microRNAs Secreted From Human iPSC-Derived Cardiac Cell Types. Circulation. 2020 Nov 3;142(18):1794-1796. PubMed PMID: 33136510
  • Dostal V, Wood SD, Thomas CT, Han Y, Lau E, Lam MPY. Proteomic signatures of acute oxidative stress response to paraquat in the mouse heart. Sci Rep. 2020 Oct 28;10(1):18440. PubMed PMID: 33116222
  • Rhee JW, Yi H, Thomas D, Lam CK, Belbachir N, Tian L, Qin X, Malisa J, Lau E, Paik DT, Kim Y, Choi BS, Sayed N, Sallam K, Liao R, Wu JC. Modeling Secondary Iron Overload Cardiomyopathy with Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Cell Rep. 2020 Jul 14;32(2):107886. PubMed PMID: 32668256
  • Zhang JX, Lau E, Paik DT, Zhuge Y, Wu JC. High-throughput Preparation of DNA, RNA, and Protein from Cryopreserved Human iPSCs for Multi-omics Analysis. Curr Protoc Stem Cell Biol. 2020 Sep;54(1):e114. PubMed PMID: 32584494
  • Lau E, Paik DT, Wu JC. Systems-Wide Approaches in Induced Pluripotent Stem Cell Models. Annu Rev Pathol. 2019 Jan 24;14:395-419. PubMed PMID: 30379619
  • Seeger T, Shrestha R, Lam CK, Chen C, McKeithan WL, Lau E, Wnorowski A, McMullen G, Greenhaw M, Lee J, Oikonomopoulos A, Lee S, Yang H, Mercola M, Wheeler M, Ashley EA, Yang F, Karakikes I, Wu JC. A Premature Termination Codon Mutation in MYBPC3 Causes Hypertrophic Cardiomyopathy via Chronic Activation of Nonsense-Mediated Decay. Circulation. 2019 Feb 5;139(6):799-811. PubMed PMID: 30586709
  • Lau E, Han Y, Williams DR, Thomas CT, Shrestha R, Wu JC, Lam MPY. Splice-Junction-Based Mapping of Alternative Isoforms in the Human Proteome. Cell Rep. 2019 Dec 10;29(11):3751-3765.e5. PubMed PMID: 31825849
  • Lee J, Termglinchan V, Diecke S, Itzhaki I, Lam CK, Garg P, Lau E, Greenhaw M, Seeger T, Wu H, Zhang JZ, Chen X, Gil IP, Ameen M, Sallam K, Rhee JW, Churko JM, Chaudhary R, Chour T, Wang PJ, Snyder MP, Chang HY, Karakikes I, Wu JC. Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy. Nature. 2019 Aug;572(7769):335-340. PubMed PMID: 31316208
  • Olmeta-Schult F, Segal LM, Tyner S, Moon TA, Chow RD, Chakrabarty P, Pacesa M, Podgornaia AI, Chen J, Singh B, Cao B, Sidhu RRS, Tan BWQ, Sood P, Parker S, Scult MA, Van Haute D, Konstantinides N, Schwendimann BA, Srivastava S, Fiorenza R, Dutton-Regester K, Hale R, Polat EO, Lau E, Mayer AL, White ER. NextGen VOICES: Research resolutions. Science. 2018 Jan 5;359(6371):26-28. PubMed PMID: 29301998
  • Lee AS, Inayathullah M, Lijkwan MA, Zhao X, Sun W, Park S, Hong WX, Parekh MB, Malkovskiy AV, Lau E, Qin X, Pothineni VR, Sanchez-Freire V, Zhang WY, Kooreman NG, Ebert AD, Chan CKF, Nguyen PK, Rajadas J, Wu JC. Prolonged survival of transplanted stem cells after ischaemic injury via the slow release of pro-survival peptides from a collagen matrix. Nat Biomed Eng. 2018 Feb;2(2):104-113. PubMed PMID: 29721363
  • Lau E, Venkatraman V, Thomas CT, Wu JC, Van Eyk JE, Lam MPY. Identifying High-Priority Proteins Across the Human Diseasome Using Semantic Similarity. J Proteome Res. 2018 Dec 7;17(12):4267-4278. PubMed PMID: 30256117
  • Lau E, Wu JC. Omics, Big Data, and Precision Medicine in Cardiovascular Sciences. Circ Res. 2018 Apr 27;122(9):1165-1168. PubMed PMID: 29700063
  • Lam MP, Venkatraman V, Xing Y, Lau E, Cao Q, Ng DC, Su AI, Ge J, Van Eyk JE, Ping P. Data-Driven Approach To Determine Popular Proteins for Targeted Proteomics Translation of Six Organ Systems. J Proteome Res. 2016 Nov 4;15(11):4126-4134. PubMed PMID: 27356587
  • Gramolini A, Lau E, Liu PP. Identifying Low-Abundance Biomarkers: Aptamer-Based Proteomics Potentially Enables More Sensitive Detection in Cardiovascular Diseases. Circulation. 2016 Jul 26;134(4):286-9. PubMed PMID: 27444931
  • Lam MP, Lau E, Ng DC, Wang D, Ping P. Cardiovascular proteomics in the era of big data: experimental and computational advances. Clin Proteomics. 2016;13:23. PubMed PMID: 27980500
  • Lau E, Watson KE, Ping P. Connecting the Dots: From Big Data to Healthy Heart. Circulation. 2016 Aug 2;134(5):362-4. PubMed PMID: 27481999
  • Kudelko M, Chan CW, Sharma R, Yao Q, Lau E, Chu IK, Cheah KS, Tanner JA, Chan D. Label-Free Quantitative Proteomics Reveals Survival Mechanisms Developed by Hypertrophic Chondrocytes under ER Stress. J Proteome Res. 2016 Jan 4;15(1):86-99. PubMed PMID: 26587667
  • Lam MP, Venkatraman V, Cao Q, Wang D, Dincer TU, Lau E, Su AI, Xing Y, Ge J, Ping P, Van Eyk JE. Prioritizing Proteomics Assay Development for Clinical Translation. J Am Coll Cardiol. 2015 Jul 14;66(2):202-4. PubMed PMID: 26160638
  • Chan XC, Black CM, Lin AJ, Ping P, Lau E. Mitochondrial protein turnover: methods to measure turnover rates on a large scale. J Mol Cell Cardiol. 2015 Jan;78:54-61. PubMed PMID: 25451168
  • Lau E, Huang D, Cao Q, Dincer TU, Black CM, Lin AJ, Lee JM, Wang D, Liem DA, Lam MP, Ping P. Spatial and temporal dynamics of the cardiac mitochondrial proteome. Expert Rev Proteomics. 2015 Apr;12(2):133-46. PubMed PMID: 25752359
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Practice Locations

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045

Specialty Information

  • Psychology

General Information

Graduate Schools:
  • PhD, University of California, Los Angeles (0001)
Undergraduate Schools:
  • BA, University of California–Berkeley (CA) (0001)
Department: Medicine-Cardiology
Contact Us
CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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