Tasha Garcia, PhD

Professional Titles

• Assistant Professor

Research Interests

Publications

• Lewis CV, Garcia AM, Burciaga SD, Posey JN, Jordan M, Nguyen TN, Stenmark KR, Mickael C, Sul C, Delaney C, Nozik ES. Redistribution of SOD3 expression due to R213G polymorphism affects pulmonary interstitial macrophage reprogramming in response to hypoxia. Physiol Genomics. 2024 Nov 1;56(11):776-790. PubMed PMID: 39311838
• Garcia AM, Toni LS, Miyano CA, Sparagna GC, Jonscher R, Phillips EK, Karimpour-Fard A, Chapman HL, Baybayon-Grandgeorge AN, Pietra AE, Selner E, Chatfield KC, Stauffer BL, Sucharov CC, Miyamoto SD. Cardiac Transcriptome Remodeling and Impaired Bioenergetics in Single-Ventricle Congenital Heart Disease. JACC Basic Transl Sci. 2023 Mar;8(3):258-279. PubMed PMID: 37034285
• Pires Da Silva J, Padilla PA, Garcia AM. Editorial: The intersection of gene regulation and metabolism in cardiovascular disease. Front Genet. 2023;14:1253690. PubMed PMID: 37701624
• Garcia AM, Toni LS, Miyano CA, Sparagna GC, Jonscher R, Phillips EK, Karimpour-Fard A, Chapman HL, Baybayon-Grandgeorge AN, Pietra AE, Selner E, Chatfield KC, Stauffer BL, Sucharov CC, Miyamoto SD. Cardiac Transcriptome Remodeling and Impaired Bioenergetics in Single-Ventricle Congenital Heart Disease. JACC Basic Transl Sci. 2023 Mar;8(3):258-279. PubMed PMID: 37034285
• Tsai CW, Rodriguez MX, Van Keuren AM, Phillips CB, Shushunov HM, Lee JE, Garcia AM, Ambardekar AV, Cleveland JC Jr, Reisz JA, Proenza C, Chatfield KC, Tsai MF. Mechanisms and significance of tissue-specific MICU regulation of the mitochondrial calcium uniporter complex. Mol Cell. 2022 Oct 6;82(19):3661-3676.e8. PubMed PMID: 36206740
• Baybayon-Grandgeorge AN, Pietra AE, Miyamoto SD, Garcia AM. Medical Therapies for Heart Failure in Hypoplastic Left Heart Syndrome. J Cardiovasc Dev Dis. 2022 May 12;9(5). PubMed PMID: 35621863
• Pires Da Silva J, Baybayon-Grandgeorge AN, Pietra AE, and Garcia AM, “Serum metabolic profiling identifies key differences between patients with single ventricle heart disease and healthy controls.” Int. J. Transl. Med., 2022 (https://www.mdpi.com/2673-8937/2/1/8)
• Sparagna GS, Jonscher RL, Shuff SR, Phillips EK, Wilson CE, Woulfe KC, Garcia AM, Stauffer BL, and Chatfield KC, “Linoleate-Enrichment of Mitochondrial Cardiolipin Molecular Species Is Developmentally Regulated and a Determinant of Metabolic Phenotype,” Biology, 2022 (https://www.mdpi.com/2079-7737/12/1/32)
• Jeffrey DA, Pires Da Silva J, Garcia AM, Jiang X, Karimpour-Fard A, Toni LS, Lanzicher T, Peña B, Miyano CA, Nunley K, Korst A, Sbaizero O, Taylor MR, Miyamoto SD, Stauffer BL, Sucharov CC. Serum circulating proteins from pediatric patients with dilated cardiomyopathy cause pathologic remodeling and cardiomyocyte stiffness. JCI Insight. 2021 Oct 8;6(19). PubMed PMID: 34383712
• Wall JB, Garcia AM, Jacobsen RM, Miyamoto SD. Important Considerations in Pediatric Heart Failure. Curr Cardiol Rep. 2020 Sep 10;22(11):141. PubMed PMID: 32910348
• Rubinstein J, Woo JG, Garcia AM, Alsaied T, Li J, Lunde PK, Moore RA, Laasmaa M, Sammons A, Mays WA, Miyamoto SD, Louch WE, Veldtman GR. Probenecid Improves Cardiac Function in Subjects with a Fontan Circulation and Augments Cardiomyocyte Calcium Homeostasis. Pediatr Cardiol. 2020 Dec;41(8):1675-1688. PubMed PMID: 32770262
• Ohlstrom D, Hernandez-Lagunas L, Garcia AM, Allawzi A, Karimpour-Fard A, Sucharov CC, Nozik-Grayck E. MicroRNA regulation postbleomycin due to the R213G extracellular superoxide dismutase variant is predicted to suppress inflammatory and immune pathways. Physiol Genomics. 2020 Jun 1;52(6):245-254. PubMed PMID: 32421439
• Garcia AM, Beatty JT, Nakano SJ. Heart failure in single right ventricle congenital heart disease: physiological and molecular considerations. Am J Physiol Heart Circ Physiol. 2020 Apr 1;318(4):H947-H965. PubMed PMID: 32108525
• Garcia AM, McPhaul JC, Sparagna GC, Jeffrey DA, Jonscher R, Patel SS, Sucharov CC, Stauffer BL, Miyamoto SD, Chatfield KC. Alteration of cardiolipin biosynthesis and remodeling in single right ventricle congenital heart disease. Am J Physiol Heart Circ Physiol. 2020 Apr 1;318(4):H787-H800. PubMed PMID: 32056460
• Nakano SJ, Walker JS, Walker LA, Li X, Du Y, Miyamoto SD, Sucharov CC, Garcia AM, Mitchell MB, Ambardekar AV, Stauffer BL. Increased myocyte calcium sensitivity in end-stage pediatric dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 2019 Dec 1;317(6):H1221-H1230. PubMed PMID: 31625780
• Garcia AM, Allawzi A, Tatman P, Hernandez-Lagunas L, Swain K, Mouradian G, Bowler R, Karimpour-Fard A, Sucharov CC, Nozik-Grayck E. R213G polymorphism in SOD3 protects against bleomycin-induced inflammation and attenuates induction of proinflammatory pathways. Physiol Genomics. 2018 Sep 1;50(9):807-816. PubMed PMID: 30004839
• Garcia AM, Nakano SJ, Karimpour-Fard A, Nunley K, Blain-Nelson P, Stafford NM, Stauffer BL, Sucharov CC, Miyamoto SD. Phosphodiesterase-5 Is Elevated in Failing Single Ventricle Myocardium and Affects Cardiomyocyte Remodeling In Vitro. Circ Heart Fail. 2018 Sep;11(9):e004571. PubMed PMID: 30354365
• Nakano SJ, Siomos AK, Garcia AM, Nguyen H, SooHoo M, Galambos C, Nunley K, Stauffer BL, Sucharov CC, Miyamoto SD. Fibrosis-Related Gene Expression in Single Ventricle Heart Disease. J Pediatr. 2017 Dec;191:82-90.e2. PubMed PMID: 29050751
• Garcia AM, Ladage ML, Dumesnil DR, Zaman K, Shulaev V, Azad RK, Padilla PA. Glucose induces sensitivity to oxygen deprivation and modulates insulin/IGF-1 signaling and lipid biosynthesis in Caenorhabditis elegans. Genetics. 2015 May;200(1):167-84. PubMed PMID: 25762526
• Padilla PA, Garcia AM, Ladage ML, Toni LS. Caenorhabditis elegans: an old genetic model can learn new epigenetic tricks. Integr Comp Biol. 2014 Jul;54(1):52-60. PubMed PMID: 24861810
• Garcia AM, Toni LS, Miyano CA, Sparagna GS, Jonscher R, Phillips EK, Karimpour-Fard A, Chapman HL, Baybayon-Grandgeorge AN, Pietra AE, Selner E, Chatfield KC, Stauffer BL, Sucharov CC, and Miyamoto SD, “Cardiac Transcriptome Remodeling and Impaired Bioenergetics in Single Ventricle Congenital Heart Disease,” J Am Coll Cardiol Basic Trans Science, 2022 (Epublished DOI: https://www.jacc.org/doi/abs/10.1016/j.jacbts.2022.09.013)