My research interests are primary focused on vitreoretinal diseases and surgery including imaging biomarkers for retinal disease, proliferative vitreoretinopathy, retinal vascular diseases, and surgical outcomes of vitreoretinal pathology.
Teaching
Assistant Professor
(2020)
School of Medicine,
Ophthalmology
Vitreoretinal Disease and Surgery
Publications
Scott RA, Lu VI, Grove N, Patnaik JL, Manoharan N. Rates of diabetic retinopathy among cluster analysis-identified type 2 diabetic mellitus subgroups. Graefes Arch Clin Exp Ophthalmol. 2023 Oct 16. [Epub ahead of print] PubMed PMID: 37843564
Gill ZS, Marin AI, Caldwell AS, Mehta N, Grove N, Seibold LK, Puente MA, De Carlo Forest TE, Oliver SCN, Patnaik JL, Manoharan N. Limited English Proficiency Is Associated With Diabetic Retinopathy in Patients Presenting for Cataract Surgery. Transl Vis Sci Technol. 2023 Oct 3;12(10):4. PubMed PMID: 37796496
Lu VI, Patnaik JL, Scott RA, Lynch AM, Smith JM, Mandava N, Manoharan N. Risk Factors and Outcomes of Delayed Presentation of Diabetic Retinopathy Patients to a County Hospital. Transl Vis Sci Technol. 2023 Sep 1;12(9):8. PubMed PMID: 37676677
Rajeswaren V, Wagner BD, Patnaik JL, Mandava N, Mathias MT, Manoharan N, De Carlo Forest TE, Gnanaraj R, Lynch AM, Palestine AG. Interleukin-4 Plasma Levels Stratified by Sex in Intermediate Age-Related Macular Degeneration and Geographic Atrophy. Transl Vis Sci Technol. 2023 Aug 1;12(8):1. PubMed PMID: 37526620
Lynch AM, McReynolds AJ, Wittel RJ, Mathias MT, Manoharan N, Emerick LM, Brocious ML, Patnaik JL. The use of social and digital media to recruit patients with early and intermediate age-related macular degeneration. Clin Exp Ophthalmol. 2023 May-Jun;51(4):398-401. PubMed PMID: 37062710
Fonteh CN, Palestine AG, Wagner BD, Patnaik JL, Mathias MT, Manoharan N, Mandava N, Baldermann R, De Carlo T, Lynch AM. RANTES (CCL5) in Patients With Geographic Atrophy Age-Related Macular Degeneration. Transl Vis Sci Technol. 2023 Jan 3;12(1):19. PubMed PMID: 36633873
Milner DC, Le C, Marin AI, Smith JM, Manoharan N. Outcomes of chronic macula-off retinal detachment repair. Graefes Arch Clin Exp Ophthalmol. 2023 Mar;261(3):709-714. PubMed PMID: 36289075
Khanani AM, Patel SS, Staurenghi G, Tadayoni R, Danzig CJ, Eichenbaum DA, Hsu J, Wykoff CC, Heier JS, Lally DR, Monés J, Nielsen JS, Sheth VS, Kaiser PK, Clark J, Zhu L, Patel H, Tang J, Desai D, Jaffe GJ. Efficacy and safety of avacincaptad pegol in patients with geographic atrophy (GATHER2): 12-month results from a randomised, double-masked, phase 3 trial. Lancet. 2023 Oct 21;402(10411):1449-1458. PubMed PMID: 37696275
Milner DC, Le C, Marin AI, Smith JM, Manoharan N. Outcomes of chronic macula-off retinal detachment repair. Graefes Arch Clin Exp Ophthalmol. 2022 Oct 27;:1-6. [Epub ahead of print] PubMed PMID: 36289075
Fonteh CN, Mathias MT, Mandava N, Manoharan N, Lynch AM, Navo R, Patnaik JL. Mental health and visual acuity in patients with age-related macular degeneration. BMC Ophthalmol. 2022 Oct 2;22(1):391. PubMed PMID: 36183081
Sidhu S, Lynch AM, Mandava N, Manoharan N, Mathias MT, Patnaik JL. Gender Differences in Visual Functioning Questionnaire Scores among Patients with Age-Related Macular Degeneration. Ophthalmic Epidemiol. 2022 Jul 17;:1-10. [Epub ahead of print] PubMed PMID: 35848204
Marin AI, Poppelaars F, Wagner BD, Palestine AG, Patnaik JL, Holers VM, Frazer-Abel AA, Mathias MT, Manoharan N, Fonteh CN, Mandava N, Lynch AM. Sex and Age-Related Differences in Complement Factors Among Patients With Intermediate Age-Related Macular Degeneration. Transl Vis Sci Technol. 2022 May 2;11(5):22. PubMed PMID: 35594041
Ramtohul P, Iovino C, Au A, Bacci T, Pichi F, Corradetti G, Corvi F, Manoharan N, Marin AI, Tadayoni R, Sadda S, Freund KB, Sarraf D. Clinical and Morphologic Characteristics of Perivenular Fernlike Leakage on Ultrawide-field Fluorescein Angiography. Ophthalmol Retina. 2022 Nov;6(11):1070-1079. PubMed PMID: 35545196
Chehaibou I, Manoharan N, Govetto A, Tsui I, Hubschman JP. SPONTANEOUS LAMELLAR MACULAR HOLES CLOSURE. Retin Cases Brief Rep. 2022 Jul 1;16(4):397-400. PubMed PMID: 32910024
Fonteh CN, Mathias MT, Mandava N, Manoharan N, Lynch AM, Navo R, Patnaik JL. Mental health and visual acuity in patients with age-related macular degeneration. BMC Ophthalmol. 2022 Oct 2;22(1):391. PubMed PMID: 36183081
Chehaibou I, Manoharan N, Govetto A, Tsui I, Hubschman JP. SPONTANEOUS LAMELLAR MACULAR HOLES CLOSURE. Retin Cases Brief Rep. 2022 Jul 1;16(4):397-400. PubMed PMID: 32910024
Ramtohul P, Iovino C, Au A, Bacci T, Pichi F, Corradetti G, Corvi F, Manoharan N, Marin AI, Tadayoni R, Sadda S, Freund KB, Sarraf D. Clinical and Morphologic Characteristics of Perivenular Fernlike Leakage on Ultrawide-field Fluorescein Angiography. Ophthalmol Retina. 2022 Nov;6(11):1070-1079. PubMed PMID: 35545196
Marin AI, Poppelaars F, Wagner BD, Palestine AG, Patnaik JL, Holers VM, Frazer-Abel AA, Mathias MT, Manoharan N, Fonteh CN, Mandava N, Lynch AM. Sex and Age-Related Differences in Complement Factors Among Patients With Intermediate Age-Related Macular Degeneration. Transl Vis Sci Technol. 2022 May 2;11(5):22. PubMed PMID: 35594041
Sidhu S, Lynch AM, Mandava N, Manoharan N, Mathias MT, Patnaik JL. Gender Differences in Visual Functioning Questionnaire Scores among Patients with Age-Related Macular Degeneration. Ophthalmic Epidemiol. 2022 Jul 17;:1-10. [Epub ahead of print] PubMed PMID: 35848204
Kothari N, Chu A, Huang JM, Lin F, Lin BR, Manoharan N, Gui W, Huang AS, Tsui I. Arm-mounted optical coherence tomography angiography in extremely low birth weight neonates with retinopathy of prematurity. Am J Ophthalmol Case Rep. 2020 Jun;18:100624. PubMed PMID: 32154434
Chehaibou I, Manoharan N, Govetto A, Francone AA, Sarraf D, Hubschman JP. Comparison of vitreoretinal disorders in fellow eyes of lamellar macular holes versus epiretinal membrane foveoschisis. Graefes Arch Clin Exp Ophthalmol. 2020 Dec;258(12):2611-2619. PubMed PMID: 33009974
Chehaibou I, Manoharan N, Govetto A, Tsui I, Hubschman JP. SPONTANEOUS LAMELLAR MACULAR HOLES CLOSURE. Retin Cases Brief Rep. 2020 Sep 7. [Epub ahead of print] PubMed PMID: 32910024
Chehaibou I, Manoharan N, Govetto A, Francone AA, Sarraf D, Hubschman JP. Comparison of vitreoretinal disorders in fellow eyes of lamellar macular holes versus epiretinal membrane foveoschisis. Graefes Arch Clin Exp Ophthalmol. 2020 Dec;258(12):2611-2619. PubMed PMID: 33009974
Chehaibou I, Manoharan N, Govetto A, Tsui I, Hubschman JP. SPONTANEOUS LAMELLAR MACULAR HOLES CLOSURE. Retin Cases Brief Rep. 2020 Sep 7. [Epub ahead of print] PubMed PMID: 32910024
Olson JL, Velez-Montoya R, Mackin A, Manoharan N, Mueller N, Erlanger M. Vitreous protein binding with nanopore dialysis membrane device. Biomed Microdevices. 2020 Jul 4;22(3):46. PubMed PMID: 32623529
Olson JL, Velez-Montoya R, Mackin A, Manoharan N, Mueller N, Erlanger M. Vitreous protein binding with nanopore dialysis membrane device. Biomed Microdevices. 2020 Jul 4;22(3):46. PubMed PMID: 32623529
Kothari N, Chu A, Huang JM, Lin F, Lin BR, Manoharan N, Gui W, Huang AS, Tsui I. Arm-mounted optical coherence tomography angiography in extremely low birth weight neonates with retinopathy of prematurity. Am J Ophthalmol Case Rep. 2020 Jun;18:100624. PubMed PMID: 32154434
Kothari N, Chu A, Huang JM, Lin F, Lin BR, Manoharan N, Gui W, Huang AS, Tsui I. Arm-mounted optical coherence tomography angiography in extremely low birth weight neonates with retinopathy of prematurity. Am J Ophthalmol Case Rep. 2020 Jun;18:100624. PubMed PMID: 32154434
Kothari, N., Manoharan, N. and Tsui, I., 2020. Pediatric Flourescein Angiography. In: M. Hartnett, ed., Pediatric Retina, 3rd ed. LWW.
Brittany M. Wong, Alison Chu, Nicholas N Zoppi, Niranjan Manoharan, Artemiy Kokhanov, Alex S. Huang, Irena Tsui; Cystoid macular edema on optical coherence tomography correlated with worse intraventricular hemorrhage in preterm neonates. Invest. Ophthalmol. Vis. Sci. 2020;61(7):2170.
Manoharan N, Patnaik JL, Olson JL. INCREASED COMPLEMENT LEVELS IN HUMAN VITREOUS ASPIRATES OF PROLIFERATIVE DIABETIC RETINOPATHY AND RETINAL DETACHMENT EYES. Retina. 2019 Nov;39(11):2212-2218. PubMed PMID: 30148749
Manoharan N, Patnaik JL, Olson JL. INCREASED COMPLEMENT LEVELS IN HUMAN VITREOUS ASPIRATES OF PROLIFERATIVE DIABETIC RETINOPATHY AND RETINAL DETACHMENT EYES. Retina. 2019 Nov;39(11):2212-2218. PubMed PMID: 30148749
Rabina G, Chehaibou I, Manoharan N, Ip M. New Drug Application for Brilliant Blue G Accepted. Ocular Surgery News. July 2019.
Chehaibou, I, Manoharan N, Hubschman, JP. Findings From the Fellow Eyes of Lamellar Macula Hole: A Bilateral Degenerative Condition? ARVO Annual Meeting. 2019 April; Vancouver, Canada.
Manoharan N, Patnaik JL, Bonnell LN, SooHoo JR, Pantcheva MB, Kahook MY, Wagner BD, Lynch AM, Seibold LK. Refractive outcomes of phacoemulsification cataract surgery in glaucoma patients. J Cataract Refract Surg. 2018 Mar;44(3):348-354. PubMed PMID: 29605284
Haines NR, Manoharan N, Olson JL, D'Alessandro A, Reisz JA. Metabolomics Analysis of Human Vitreous in Diabetic Retinopathy and Rhegmatogenous Retinal Detachment. J Proteome Res. 2018 Jul 6;17(7):2421-2427. PubMed PMID: 29877085
Manoharan N, Subramanian PS. A case of non-arteritic anterior ischemic optic neuropathy after completion of Harvoni therapy. Am J Ophthalmol Case Rep. 2017 Jun;6:55-57. PubMed PMID: 29260058
Manoharan N, Pecen PE, Cherof AM, Oliver SCN, Palestine AG. Comparison of Oral Versus Intravenous Fluorescein Widefield Angiography in Ambulatory Pediatric Patients. Journal of VitreoRetinal Diseases. 2017;1(3):191-196.
Malarkannan S, Awasthi A, Rajasekaran K, Kumar P, Schuldt KM, Bartoszek A, Manoharan N, Goldner NK, Umhoefer CM, Thakar MS. IQGAP1: a regulator of intracellular spacetime relativity. J Immunol. 2012 Mar 1;188(5):2057-63. PubMed PMID: 22345702
Vitreoretinal Diseases and Surgery, Specialized Training
(0001)
Conditions & Treatments
Eyes and Vision
Eyes and Vision - Diabetic Eye Disease
Eyes and Vision - Eye Disease
Eyes and Vision - Macular Degeneration
Eyes and Vision - Retinal Detachment
Failed Prior Surgery
Surgery - Eye and/or Orbital Surgery
Surgery
Endocrine System (Hormones) - Diabetic Retinopathy
Endocrine System (Hormones)
Clinical Interests
Dr. Manoharan specializes in the medical and surgical management of all vitreoretinal diseases, including expertise in macular degeneration, diabetic retinopathy, retinal vein and artery occlusion, retinal detachment, macular hole, macular pucker, and eye trauma.
Public Speaking Yes
General Information
Medical Schools:
MD, Medical College of Wisconsin
(2014)
Undergraduate Schools:
BS, University of California–San Diego (CA)
(2010)
Internships:
Aurora Health Care Program
(2015)
Residency Programs:
University of Colorado, Ophthalmology (2018)
Fellowships:
UCLA Medical Center Program, Vitreoretinal Disease and Surgery
(2020)