Arianne Theiss, PhD

Associate Professor, Medicine-Gastroenterology


Publications

  • Jackson DN, Theiss AL. Gut bacteria signaling to mitochondria in intestinal inflammation and cancer. Gut Microbes. 2019 Mar 26;:1-20. [Epub ahead of print] PubMed PMID: 30913966
  • Alula KM, Delgado-Deida Y, Jackson DN, Venuprasad K, Theiss AL. Nuclear partitioning of Prohibitin 1 inhibits Wnt/ß-catenin-dependent intestinal tumorigenesis. Oncogene. 2020 Nov 3. [Epub ahead of print] PubMed PMID: 33144683
  • Delgado-Deida Y, Alula KM, Theiss AL. The influence of mitochondrial-directed regulation of Wnt signaling on tumorigenesis. Gastroenterol Rep (Oxf). 2020 Jun;8(3):215-223. PubMed PMID: 32665853
  • Jackson DN, Alula KM, Delgado-Deida Y, Tabti R, Turner K, Wang X, Venuprasad K, Souza RF, Désaubry L, Theiss AL. The Synthetic Small Molecule FL3 Combats Intestinal Tumorigenesis via Axin1-Mediated Inhibition of Wnt/ß-Catenin Signaling. Cancer Res. 2020 Sep 1;80(17):3519-3529. PubMed PMID: 32665357
  • Mukherjee S, Kumar R, Tsakem Lenou E, Basrur V, Kontoyiannis DL, Ioakeimidis F, Mosialos G, Theiss AL, Flavell RA, Venuprasad K. Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinal inflammation. Nat Immunol. 2020 Jun;21(6):626-635. PubMed PMID: 32424362
  • Kathania M, Tsakem EL, Theiss AL, Venuprasad K. Gut Microbiota Contributes to Spontaneous Colitis in E3 Ligase Itch-Deficient Mice. J Immunol. 2020 Apr 15;204(8):2277-2284. PubMed PMID: 32169841
  • Jackson DN, Panopoulos M, Neumann WL, Turner K, Cantarel BL, Thompson-Snipes L, Dassopoulos T, Feagins LA, Souza RF, Mills JC, Blumberg RS, Venuprasad K, Thompson WE, Theiss AL. Mitochondrial dysfunction during loss of prohibitin 1 triggers Paneth cell defects and ileitis. Gut. 2020 Nov;69(11):1928-1938. PubMed PMID: 32111635
  • Jackson DN, Theiss AL. Gut bacteria signaling to mitochondria in intestinal inflammation and cancer. Gut Microbes. 2020 May 3;11(3):285-304. PubMed PMID: 30913966
  • Kumar R, Theiss AL, Venuprasad K. ROR?t protein modifications and IL-17-mediated inflammation. Trends Immunol. 2021 Nov;42(11):1037-1050. PubMed PMID: 34635393
  • Ho GT, Theiss AL. Mitochondria and Inflammatory Bowel Diseases: Toward a Stratified Therapeutic Intervention. Annu Rev Physiol. 2021 Oct 6. [Epub ahead of print] PubMed PMID: 34614372
  • Alula KM, Jackson DN, Smith AD, Kim DS, Turner K, Odstrcil E, Kaipparettu BA, Dassopoulos T, Venuprasad K, Feagins LA, Theiss AL. Targeting Mitochondrial Damage as a Therapeutic for Ileal Crohn's Disease. Cells. 2021 May 29;10(6). PubMed PMID: 34072441
  • Theiss AL. Autophagy and Cancer: Current Biology & Drug Development In Inflammation, Infection, and Microbiome in Cancers: Evidence, Mechanisms, and Implications, Physiology in Health and Disease Series. New York, NY: Springer Nature.
  • Venuprasad K, Theiss AL. NLRP6 in host defense and intestinal inflammation. Cell Rep. 2021 Apr 27;35(4):109043. PubMed PMID: 33910012
  • Kumar R, Singh AK, Starokadomskyy P, Luo W, Theiss AL, Burstein E, Venuprasad K. Cutting Edge: Hypoxia-Induced Ubc9 Promoter Hypermethylation Regulates IL-17 Expression in Ulcerative Colitis. J Immunol. 2021 Mar 1;206(5):936-940. PubMed PMID: 33504619
  • Kumar J, Kumar R, Kumar Singh A, Tsakem EL, Kathania M, Riese MJ, Theiss AL, Davila ML, Venuprasad K. Deletion of Cbl-b inhibits CD8( ) T-cell exhaustion and promotes CAR T-cell function. J Immunother Cancer. 2021 Jan;9(1). PubMed PMID: 33462140
  • Alula KM, Delgado-Deida Y, Jackson DN, Venuprasad K, Theiss AL. Nuclear partitioning of Prohibitin 1 inhibits Wnt/ß-catenin-dependent intestinal tumorigenesis. Oncogene. 2021 Jan;40(2):369-383. PubMed PMID: 33144683
  • Kathania M, Kumar R, Lenou ET, Basrur V, Theiss AL, Chernoff J, Venuprasad K. Pak2-mediated phosphorylation promotes ROR?t ubiquitination and inhibits colonic inflammation. Cell Rep. 2022 Sep 13;40(11):111345. PubMed PMID: 36103814
  • Ho GT, Theiss AL. Mitochondria and Inflammatory Bowel Diseases: Toward a Stratified Therapeutic Intervention. Annu Rev Physiol. 2022 Feb 10;84:435-459. PubMed PMID: 34614372
  • Mukherjee S, Kumar R, Theiss AL, Venuprasad K. Advances in the analysis of protein ubiquitination, In Advances in Protein Molecular and Structural Biology Methods. Elsevier. 2022; 635-640.
  • Tsakem E, Mukherjee S, Theiss AL, Venuprasad K. “Cellular signaling, molecular activation, and regulation of the NLRP6 inflammasome” In Inflammasome Biology. Elsevier. 2023; in press.
  • Adams JC, Price OJ, Rogers N, Rounds S, Taruno A, Theiss AL, Uchida S, Wright DC. Physiological Reports celebrates its first 10?years. Physiol Rep. 2023 Dec;11(23):e15874. PubMed PMID: 38016666
  • Alula KM, Dowdell AS, LeBere B, Lee JS, Levens CL, Kuhn KA, Kaipparettu BA, Thompson WE, Blumberg RS, Colgan SP, Theiss AL. Interplay of gut microbiota and host epithelial mitochondrial dysfunction is necessary for the development of spontaneous intestinal inflammation in mice. Microbiome. 2023 Nov 17;11(1):256. PubMed PMID: 37978573
  • Alula KM, Theiss AL. Autophagy in Crohn's Disease: Converging on Dysfunctional Innate Immunity. Cells. 2023 Jul 4;12(13). PubMed PMID: 37443813
  • Theiss AL. Ptpn2: A Critical Regulator of Paneth Cell Homeostasis. Cell Mol Gastroenterol Hepatol. 2023;16(1):163-164. PubMed PMID: 37098410
  • Alula KM, Delgado-Deida Y, Callahan R, Till A, Underwood L, Thompson WE, Souza RF, Dassopoulos T, Onyiah J, Venuprasad K, Theiss AL. Inner mitochondrial membrane protein Prohibitin 1 mediates Nix-induced, Parkin-independent mitophagy. Sci Rep. 2023 Jan 2;13(1):18. PubMed PMID: 36593241

Public Speaking
Yes