Mia Smith, DVM, PhD

Publications

• Smith MJ, Rihanek M, Coleman BM, Gottlieb PA, Sarapura VD, Cambier JC. Activation of thyroid antigen-reactive B cells in recent onset autoimmune thyroid disease patients. J Autoimmun. 2018 May;89:82-89. PubMed PMID: 29233566
• Smith MJ, Rihanek M, Wasserfall C, Mathews CE, Atkinson MA, Gottlieb PA, Cambier JC. Loss of B-Cell Anergy in Type 1 Diabetes Is Associated With High-Risk HLA and Non-HLA Disease Susceptibility Alleles. Diabetes. 2018 Apr;67(4):697-703. PubMed PMID: 29343548
• Takeda K, Webb TL, Ning F, Shiraishi Y, Regan DP, Chow L, Smith MJ, Ashino S, Guth AM, Hopkins S, Gelfand EW, Dow S. Mesenchymal Stem Cells Recruit CCR2( ) Monocytes To Suppress Allergic Airway Inflammation. J Immunol. 2018 Feb 15;200(4):1261-1269. PubMed PMID: 29352000
• Smith MJ, Hinman RM, Getahun A, Kim S, Packard TA, Cambier JC. Silencing of high-affinity insulin-reactive B lymphocytes by anergy and impact of the NOD genetic background in mice. Diabetologia. 2018 Dec;61(12):2621-2632. PubMed PMID: 30255377
• Smith MJ, Cambier JC, Gottlieb PA. Endotypes in T1D: B lymphocytes and early onset. Curr Opin Endocrinol Diabetes Obes. 2020 Aug;27(4):225-230. PubMed PMID: 32618634
• Smith MJ, Ford BR, Rihanek M, Coleman BM, Getahun A, Sarapura VD, Gottlieb PA, Cambier JC. Elevated PTEN expression maintains anergy in human B cells and reveals unexpectedly high repertoire autoreactivity. JCI Insight. 2019 Feb 7;4(3). [Epub ahead of print] PubMed PMID: 30728334
• Stensland ZC, Smith MJ. Enrichment and Detection of Antigen-Binding B Cells for Mass Cytometry. Magnetochemistry. 2021 Jul;7(7). PubMed PMID: 34295938
• Stensland ZC, Cambier JC, Smith MJ. Therapeutic Targeting of Autoreactive B Cells: Why, How, and When?. Biomedicines. 2021 Jan 16;9(1). PubMed PMID: 33467130
• Smith MJ, Cambier JC, Gottlieb PA. Endotypes in T1D: B lymphocytes and early onset. Curr Opin Endocrinol Diabetes Obes. 2020 Aug;27(4):225-230. PubMed PMID: 32618634
• Stensland ZC, Coleman B, Rihanek M, Baxter R, Gottlieb PA, Hsieh EW, Sarapura V, Simmons K, Cambier JC, Smith MJ. Peripheral immunophenotyping of autoimmune thyroid disease patients reveals alterations in immune cell subsets in pediatric vs adult-onset AITD. iScience. (in revision)
• Castleman MJ, Stumpf MM, Therrien NR, Smith MJ, Lesteberg KE, Palmer BE, Maloney JP, Janssen WJ, Mould KJ, Beckham JD, Pelanda R, Torres RM. Autoantibodies elicited with SARS-CoV-2 infection are linked to alterations in double negative B cells. Front Immunol. 2022;13:988125. PubMed PMID: 36131937
• Castleman MJ, Stumpf MM, Therrien NR, Smith MJ, Lesteberg KE, Palmer BE, Maloney JP, Janssen WJ, Mould KJ, Beckham JD, Pelanda R, Torres RM. SARS-CoV-2 infection relaxes peripheral B cell tolerance. J Exp Med. 2022 Jun 6;219(6). PubMed PMID: 35420627
• Stensland ZC, Coleman BM, Rihanek M, Baxter RM, Gottlieb PA, Hsieh EWY, Sarapura VD, Simmons KM, Cambier JC, Smith MJ. Peripheral immunophenotyping of AITD subjects reveals alterations in immune cells in pediatric vs adult-onset AITD. iScience. 2022 Jan 21;25(1):103626. PubMed PMID: 35005561
• Stensland ZC, Magera CA, Broncucia H, Gomez BD, Rios-Guzman NM, Wells KL, Nicholas CA, Rihanek M, Hunter MJ, Toole KP, Gottlieb PA, Smith MJ. Identification of an anergic BND cell-derived activated B cell population (BND2) in young-onset type 1 diabetes patients. J Exp Med. 2023 Aug 7;220(8). PubMed PMID: 37184563
• Nicholas CA, Smith MJ. Application of single-cell RNA sequencing methods to develop B cell targeted treatments for autoimmunity. Front Immunol. 2023;14:1103690. PubMed PMID: 37520578
• Baxter RM, Wang CS, Garcia-Perez JE, Kong DS, Coleman BM, Larchenko V, Schuyler RP, Jackson C, Ghosh T, Rudra P, Paul D, Claassen M, Rochford R, Cambier JC, Ghosh D, Cooper JC, Smith MJ, Hsieh EWY. Expansion of extrafollicular B and T cell subsets in childhood-onset systemic lupus erythematosus. Front Immunol. 2023;14:1208282. PubMed PMID: 37965329
• Smith MJ, Boldison J, Wong FS. The Role of B Lymphocytes in Type 1 Diabetes. Cold Spring Harb Perspect Med. 2024 Aug 12. [Epub ahead of print] PubMed PMID: 39134387
• Nicholas CA, Tensun FA, Evans SA, Toole KP, Broncucia H, Hesselberth JR, Gottlieb PA, Wells KL, Smith MJ. Islet-antigen reactive B cells display a unique phenotype and BCR repertoire in autoantibody positive and recent-onset type 1 diabetes patients. bioRxiv. 2024 Jun 25. PubMed PMID: 38979376