Catherine Musselman, PhD

Publications

• Musselman CA, Kutateladze TG. Targeting epigenetic readers. Nat Chem Biol. 2026 Jan 9. [Epub ahead of print] PubMed PMID: 41513857
• Fuchs HA, Peng Y, Ayyapan S, Rosas R, Zhang H, Panchenko AR, Musselman CA. G34R cancer mutation alters the conformational ensemble and dynamics of the histone H3.3 tails. Nucleic Acids Res. 2026 Jan 14;54(2). PubMed PMID: 41533587
• Becht DC, Biswas S, Xu C, Xuan H, Khalil M, Cai L, Musselman CA, Liu X, Affar EB, Shi X, Wang GG, Kutateladze TG. Multiple transactivation domains of EZH2 bind to the TAZ2 domain of p300 and stimulate the acetyltransferase function of p300. Biochem J. 2025 Jul 2;482(13):955-968. PubMed PMID: 40534232
• Keogh MC, Almouzni G, Andrews AJ, Armache KJ, Arrowsmith CH, Baek SH, Bedford MT, Bernstein E, Côté J, David Y, Denu JM, Fierz B, Garcia BA, Glass KC, Gozani O, Helin K, Henikoff S, Jensen ON, Josefowicz SZ, Kelleher NL, Kutateladze TG, Lindner HH, Lu C, Luger K, Mallick P, Musselman CA, Muir TW, Paša-Tolic L, Schneider R, Shi X, Shi Y, Sidoli S, Smith LM, Tyler JK, Wolberger C, Workman JL, Strahl BD, Young NL. A needed nomenclature for nucleosomes. Mol Cell. 2025 Oct 2;85(19):3554-3561. PubMed PMID: 41043390
• Marunde MR, Popova IK, Hall NW, Vaidya A, Bone JR, Boone BA, Brown PJ, Ezell RJ, Firestone TM, Fuchs HA, Gibson E, Gillespie ZB, Gloor SL, Hickman AR, Howard SA, Husby NL, Hsiung VT, Johnstone AL, Khan LF, Krajewski K, Lee AS, McAnarney ET, Maier KE, Maryanski DN, McCuiston JL, Noll KE, Novitzky K, Patteson EF, Rodriguez KL, Sanchez JC, Schachner LF, Smith CE, Sun L, Taylor HF, Watson R, Willis HE, Musselman CA, Venters BJ, Cheek MA, Meiners MJ, Sun ZW, Kelleher NL, Cowles MW, Weinzapfel EN, Keogh MC, Burg JM. Nucleosome context regulates chromatin reader preference. Nucleic Acids Res. 2025 Oct 28;53(20). PubMed PMID: 41182902
• Emmons-Bell M, Forsyth G, Sundquist A, Oldeman S, Gardikioti A, de Souza R, Coene J, Kamel MH, Ayyapan S, Fuchs HA, Verhelst S, Smeeton J, Musselman CA, Schvartzman JM. Polyamines regulate cell fate by altering the activity of histone-modifying enzymes. bioRxiv. 2024 Jul 2. PubMed PMID: 39005392
• Marunde MR, Fuchs HA, Burg JM, Popova IK, Vaidya A, Hall NW, Weinzapfel EN, Meiners MJ, Watson R, Gillespie ZB, Taylor HF, Mukhsinova L, Onuoha UC, Howard SA, Novitzky K, McAnarney ET, Krajewski K, Cowles MW, Cheek MA, Sun ZW, Venters BJ, Keogh MC, Musselman CA. Nucleosome conformation dictates the histone code. Elife. 2024 Feb 6;13. PubMed PMID: 38319148
• Akbari E, Park EJ, Singh AK, Vinayak V, Virk RKA, Wereszczynksi J, Musselman CA. Multiscale genome organization symposium - annual biophysical society meeting 2023. Biophys Rev. 2023 Jun;15(3):313-315. PubMed PMID: 37396443
• Ghoneim M, Musselman CA. Protocol to prepare doubly labeled fluorescent nucleosomes for single-molecule fluorescence microscopy. STAR Protoc. 2023 Apr 19;4(2):102229. [Epub ahead of print] PubMed PMID: 37083320
• De Silva SM, Dhiman A, Sood S, Mercedes KF, Simmons WJ, Henen MA, Vögeli B, Dykhuizen EC, Musselman CA. PBRM1 bromodomains associate with RNA to facilitate chromatin association. Nucleic Acids Res. 2023 May 8;51(8):3631-3649. PubMed PMID: 36808431
• Ghoneim M, Musselman CA. Single-Molecule Characterization of Cy3.5 -Cy5.5 Dye Pair for FRET Studies of Nucleic Acids and Nucleosomes. J Fluoresc. 2023 Mar;33(2):413-421. PubMed PMID: 36435903
• Ghoneim M, Musselman CA. Single-Molecule Characterization of Cy3.5 -Cy5.5 Dye Pair for FRET Studies of Nucleic Acids and Nucleosomes. J Fluoresc. 2022 Nov 26. [Epub ahead of print] PubMed PMID: 36435903
• Musselman CA, Valkov E. Dynamic views of molecular recognition in protein-nucleic acid complexes. Curr Opin Struct Biol. 2022 Dec;77:102500. PubMed PMID: 36402027
• Musselman CA, Kutateladze TG. Visualizing Conformational Ensembles of the Nucleosome by NMR. ACS Chem Biol. 2022 Mar 18;17(3):495-502. PubMed PMID: 35196453
• Suh JL, Bsteh D, Hart B, Si Y, Weaver TM, Pribitzer C, Lau R, Soni S, Ogana H, Rectenwald JM, Norris JL, Cholensky SH, Sagum C, Umana JD, Li D, Hardy B, Bedford MT, Mumenthaler SM, Lenz HJ, Kim YM, Wang GG, Pearce KH, James LI, Kireev DB, Musselman CA, Frye SV, Bell O. Reprogramming CBX8-PRC1 function with a positive allosteric modulator. Cell Chem Biol. 2022 Apr 21;29(4):555-571.e11. PubMed PMID: 34715055
• Musselman, C.A.*, Kutateladze, T.G., Visualizing Conformational Ensembles of the Nucleosome by NMR, 17(3), 495-502, 2022
• Suh JL, Bsteh D, Hart B, Si Y, Weaver TM, Pribitzer C, Lau R, Soni S, Ogana H, Rectenwald JM, Norris JL, Cholensky SH, Sagum C, Umana JD, Li D, Hardy B, Bedford MT, Mumenthaler SM, Lenz HJ, Kim YM, Wang GG, Pearce KH, James LI, Kireev DB, Musselman CA, Frye SV, Bell O. Reprogramming CBX8-PRC1 function with a positive allosteric modulator. Cell Chem Biol. 2021 Oct 26. [Epub ahead of print] PubMed PMID: 34715055
• Morrison EA, Baweja L, Poirier MG, Wereszczynski J, Musselman CA. Nucleosome composition regulates the histone H3 tail conformational ensemble and accessibility. Nucleic Acids Res. 2021 May 7;49(8):4750-4767. PubMed PMID: 33856458
• Musselman CA, Kutateladze TG. Characterization of functional disordered regions within chromatin-associated proteins. iScience. 2021 Feb 19;24(2):102070. PubMed PMID: 33604523
• Ghoneim M, Fuchs HA, Musselman CA. Histone Tail Conformations: A Fuzzy Affair with DNA. Trends Biochem Sci. 2021 Jul;46(7):564-578. PubMed PMID: 33551235
• Lupo BE, Chu P, Harms MJ, Morrison EA, Musselman CA. Evolutionary Conservation of Structural and Functional Coupling between the BRM AT-Hook and Bromodomain. J Mol Biol. 2021 Jul 9;433(14):166845. PubMed PMID: 33539881
• Sanchez JC, Zhang L, Evoli S, Schnicker NJ, Nunez-Hernandez M, Yu L, Wereszczynski J, Pufall MA, Musselman CA. The molecular basis of selective DNA binding by the BRG1 AT-hook and bromodomain. Biochim Biophys Acta Gene Regul Mech. 2020 Aug;1863(8):194566. PubMed PMID: 32376391
• Wang S, Denton KE, Hobbs KF, Weaver T, McFarlane JMB, Connelly KE, Gignac MC, Milosevich N, Hof F, Paci I, Musselman CA, Dykhuizen EC, Krusemark CJ. Optimization of Ligands Using Focused DNA-Encoded Libraries To Develop a Selective, Cell-Permeable CBX8 Chromodomain Inhibitor. ACS Chem Biol. 2020 Jan 17;15(1):112-131. PubMed PMID: 31755685
• Wang S, Denton KE, Hobbs KF, Weaver T, McFarlane JMB, Connelly KE, Gignac MC, Milosevich N, Hof F, Paci I, Musselman CA, Dykhuizen EC, Krusemark CJ. Optimization of Ligands Using Focused DNA-Encoded Libraries To Develop a Selective, Cell-Permeable CBX8 Chromodomain Inhibitor. ACS Chem Biol. 2020 Jan 17;15(1):112-131. PubMed PMID: 31755685
• Musselman, CA. Chromatin and epigenetic signaling pathways. In Chromatin Signaling and Neurological Disorders, Binda, O. (Ed.), Elsevier, 1-23, 2019
• Sanchez, J.C., Zhang, L., Evoli, S., Schnicker, N.J., Nunez-Hernandez, M., Yu, L., Wereszczynski, J.*, Pufall, M.A.*, Musselman, C.A.*, The Molecular Basis of Specific DNA Binding by the BRG1 AT-hook and Bromodomain, bioRxiv, 854000, 2019
• Wiles, E.T., McNaught, K.J., De Silva, S.M., Kaur, G., Selker, J.M., Ornnsby, T., Aravin, L., Musselman, C.A., Selker, E.U., Evolutionarily Ancient BAH-PHD Protein Mediates Polycomb Silencing, bioRxiv, 868117, 2019
• Connelly KE, Weaver TM, Alpsoy A, Gu BX, Musselman CA*, Dykhuizen EC*. Engagement of DNA and H3K27me3 by the CBX8 chromodomain drives chromatin association. Nucleic Acids Res. 2019 Mar 18;47(5):2289-2305. PubMed PMID: 30597065
• Weaver TM, Liu J, Connelly KE, Coble C, Varzavand K, Dykhuizen EC, Musselman CA*. The EZH2 SANT1 domain is a histone reader providing sensitivity to the modification state of the H4 tail. Sci Rep. 2019 Jan 30;9(1):987. PubMed PMID: 30700785
• Musselman CA*, Kutateladze TG*. Strategies for Generating Modified Nucleosomes: Applications within Structural Biology Studies. ACS Chem Biol. 2019 Apr 19;14(4):579-586. PubMed PMID: 30817115
• Li Y, Xie N, Chen R, Lee AR, Lovnicki J, Morrison EA, Fazli L, Zhang Q, Musselman CA, Wang Y, Huang J, Gleave ME, Collins C, Dong X. RNA Splicing of the BHC80 Gene Contributes to Neuroendocrine Prostate Cancer Progression. Eur Urol. 2019 Aug;76(2):157-166. PubMed PMID: 30910347
• Musselman CA, Kutateladze TG. The PHD finger of Spp1 mediates histone modification cross-talk. Biochem J. 2019 Aug 28;476(16):2351-2354. PubMed PMID: 31462441
• Ghoneim, M., Fuchs, H.A., Musselman, C.A.*, Histone tail conformations: A fuzzy affair with DNA, Trends in Biochemical Sciences,
• Musselman, C.A.*, Kutateladze, T.G., Characterization of functional disordered regions within chromatin associated proteins, iScience
• Lupo, B.E., Chu, P., Harms, M.J., Morrison, E.A., Musselman, C.A.*, Evolutionary conservation of structural and functional coupling between the BRM AT-hook and bromodomain, Journal of Molecular Biology

Practice Locations

UCHealth Anschutz Outpatient Pavilion - Anschutz Medical Campus
1635 Aurora Ct
Aurora, CO 80045
720-848-0000