Zachary Macchi, MD
Assistant Professor, Neurology
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Medical School:
Department: Neurology
Medical School:
- MD, University of Kansas School of Medicine (2015)
- BA/BS, University of Kansas (KS) (2011)
- University of Colorado (University Hospital) Program (2016)
- University of Colorado (University Hospital) Program, Chief Resident, Neurology (2019)
- University of Colorado (University Hospital) Program, Behavioral Neurology and Neuropsychiatry (2020)
- University of Colorado, Palliative Care & Aging Research Fellowship (T32) (2022)
Department: Neurology
Professional Titles
- Assistant Professor
Research Interests
Currently my research is focused on behavioral disturabnces, specifically aggression, directed towards caregivers from patients experiencing Parkinson's disease and related parkinsonian disorders. My aims for this work include: 1) examining factors which contribute the development of aggression in patient-caregiver PDRD dyads and 2) development of caregiver interventions for use in outpatient management of PDRD.
Publications
- Macchi ZA, Carlisle TC, Filley CM. Prognosis in substance abuse-related acute toxic leukoencephalopathy: A scoping review. J Neurol Sci. 2022 Sep 13;442:120420. [Epub ahead of print] PubMed PMID: 36156344
- Bock M, Katz M, Sillau S, Adjepong K, Yaffe K, Ayele R, Macchi ZA, Pantilat S, Miyasaki JM, Kluger B. What's in the Sauce? The Specific Benefits of Palliative Care for Parkinson's Disease. J Pain Symptom Manage. 2022 Jun;63(6):1031-1040. PubMed PMID: 35114353
- Macchi ZA, Lum HD. Advance care planning in neurologic illness. Handb Clin Neurol. 2022;190:129-148. PubMed PMID: 36055711
- Bock M, Katz M, Sillau S, Adjepong K, Yaffe K, Ayele R, Macchi ZA, Pantilat S, Miyasaki JM, Kluger B. What's in the Sauce? The Specific Benefits of Palliative Care for Parkinson's Disease. J Pain Symptom Manage. 2022 Jun;63(6):1031-1040. PubMed PMID: 35114353
- Macchi, Z.A., Seshadri, S., Ayele, R., Bock, M., Long, J., Coats, H., Miyasaki, J., Pantilat, S.Z., Katz, M., Santos, E.J., Sillau, S.H., Lum, H.D. and Kluger, B.M. (2022), Aggression Towards Caregivers in Parkinson's Disease and Related Disorders: A Mixed Methods Study. Mov Disord Clin Pract. https://doi.org/10.1002/mdc3.13555
- Hale E, Macchi ZA, Pressman P. Delirium Following Anticholinergic Use in Hospitalized Patients with Dementia. The Neurohospitalist. 2022.
- Ayele R, Macchi ZA, Dini M, Bock M, Katz M, Pantilat SZ, Jones J, Kluger BM. Experience of Community Neurologists Providing Care for Patients With Neurodegenerative Illness During the COVID-19 Pandemic. Neurology. 2021 Sep 7;97(10):e988-e995. PubMed PMID: 34489348
- Macchi ZA, Kletenik I, Olvera C, Holden SK. Psychiatric Comorbidities in Functional Movement Disorders: A Retrospective Cohort Study. Mov Disord Clin Pract. 2021 Jul;8(5):725-732. PubMed PMID: 34307745
- Macchi ZA, Ayele R, Dini M, Lamira J, Katz M, Pantilat SZ, Jones J, Kluger BM. Lessons from the COVID-19 pandemic for improving outpatient neuropalliative care: A qualitative study of patient and caregiver perspectives. Palliat Med. 2021 Jul;35(7):1258-1266. PubMed PMID: 34006157
- Macchi ZA, Miyasaki J, Katz M, Galifianakis N, Sillau S, Kluger BM. Prevalence and Cumulative Incidence of Caregiver-Reported Aggression in Advanced Parkinson Disease and Related Disorders. Neurol Clin Pract. 2021 Dec;11(6):e826-e833. PubMed PMID: 34992965
- Macchi ZA, Tarolli CG, Kluger BM. Palliative Care in Movement Disorders: an Evolving Field. Curr Neurol Neurosci Rep. 2021 Jan 28;21(3):5. PubMed PMID: 33506431
- Macchi ZA, Koljack CE, Miyasaki JM, Katz M, Galifianakis N, Prizer LP, Sillau SH, Kluger BM. Patient and caregiver characteristics associated with caregiver burden in Parkinson's disease: a palliative care approach. Ann Palliat Med. 2020 Feb;9(Suppl 1):S24-S33. PubMed PMID: 31735048
- Macchi ZA, Kleinschmidt-DeMasters BK, Orjuela KD, Pastula DM, Piquet AL, Baca CB. Glioblastoma as an autoimmune limbic encephalitis mimic: A case and review of the literature. J Neuroimmunol. 2020 Mar 7;342:577214. [Epub ahead of print] PubMed PMID: 32182452
- Macchi Z, Wang Y, Moore D, Katz J, Saperstein D, Walk D, Simpson E, Genge A, Bertorini T, Fernandes JA, Swenson A, Elman L, Dimachkie M, Herbelin L, Miller J, Lu J, Wilkins H, Swerdlow RH, Statland J, Barohn R. A multi-center screening trial of rasagiline in patients with amyotrophic lateral sclerosis: Possible mitochondrial biomarker target engagement. Amyotroph Lateral Scler Frontotemporal Degener. 2015;16(5-6):345-52. PubMed PMID: 25832828
Practice Locations
UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000
CU Memory Disorders Clinic - Central Park
3055 Roslyn Street
Suite 120
Denver, CO 80238
720-848-2080
Hospital Affiliation
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000
CU Memory Disorders Clinic - Central Park
3055 Roslyn Street
Suite 120
Denver, CO 80238
720-848-2080
Hospital Affiliation
- University of Colorado Hospital
Specialty Information
Specialties
- Neurology, Board Certification (2019)
- Behavioral Neurology & Neuropsychiatry, Board Certification (2020)
- Brain and Nervous System
- Brain and Nervous System - Alzheimer's Disease
- Brain and Nervous System - Epilepsy
- Brain and Nervous System - Movement Disorders
- Brain and Nervous System - Multiple Sclerosis
- Brain and Nervous System - Neuromuscular Diseases
- Brain and Nervous System - Parkinson's Disease
- Brain and Nervous System - Stroke
- Brain and Nervous System - Traumatic and Acquired Brain Injuries
- Brain and Nervous System - Trauma / Nerve Injuries
Clinical Interests
My clinical interests include the diagnosis neurodegenerative conditions and the management of cognitive and neuropsychiatric symptoms, specifically through the lens of a palliative care approach.
Care Philosophy
My aim is to provide comprehensive care for both patients and their loved ones. I believe in approaching patient care with the goal of providing diagnosis and appropriate treatment as well as improving quality of life.
My clinical interests include the diagnosis neurodegenerative conditions and the management of cognitive and neuropsychiatric symptoms, specifically through the lens of a palliative care approach.
Care Philosophy
My aim is to provide comprehensive care for both patients and their loved ones. I believe in approaching patient care with the goal of providing diagnosis and appropriate treatment as well as improving quality of life.
Personal Interests
In my spare time I enjoy skiing, camping, backpacking, trail running, and relaxing with my family and two dogs.
Public Speaking
Yes
I have spoken in both academic and patient-centered settings, mainly for discussing topics relevant to dementia and neurodegeneration as well as to share my research.
In my spare time I enjoy skiing, camping, backpacking, trail running, and relaxing with my family and two dogs.
Public Speaking
Yes
I have spoken in both academic and patient-centered settings, mainly for discussing topics relevant to dementia and neurodegeneration as well as to share my research.
General Information
Medical Schools:
- MD, University of Kansas School of Medicine (2015)
Undergraduate Schools:
- BA/BS, University of Kansas (KS) (2011)
Internships:
- University of Colorado (University Hospital) Program (2016)
Residency Programs:
- University of Colorado (University Hospital) Program, Chief Resident, Neurology (2019)
Fellowships:
- University of Colorado (University Hospital) Program, Behavioral Neurology and Neuropsychiatry (2020)
- University of Colorado, Palliative Care & Aging Research Fellowship (T32) (2022)
Languages: English
Department: Neurology