Srividhya Iyer, PhD
Assistant Professor, Orthopedics
Professional Titles
- Assistant Professor
Publications
- Kim HN, Chang J, Iyer S, Han L, Campisi J, Manolagas SC, Zhou D, Almeida M. Elimination of senescent osteoclast progenitors has no effect on the age-associated loss of bone mass in mice. Aging Cell. 2019 Jun;18(3):e12923. PubMed PMID: 30773784
- Elevation of the unfolded protein response increases RANKL expression Iyer S, Melendez-Suchi C, Han L, Baldini G, Almeida M, Jilka RL. Faseb Bioadvances. doi.org/10.1096/fba.2019-00032
- Delivery of phosphoethanolamine blunts stress in hepatoma cells exposed to elevated palmitate by targeting the endoplasmic reticulum. Trentzsch M, Nyamugenda E, Miles T, Griffin H, Russell S, Koss B, Cooney K, Phelan K, Tackett A, S Iyer, and Gunnar Boysen. Cell Death Diff. In Press
- Kim HN, Xiong J, MacLeod RS, Iyer S, Fujiwara Y, Cawley KM, Han L, He Y, Thostenson JD, Ferreira E, Jilka RL, Zhou D, Almeida M, O'Brien CA. Osteocyte RANKL is required for cortical bone loss with age and is induced by senescence. JCI Insight. 2020 Oct 2;5(19). PubMed PMID: 32870816
- Kim HN, Ponte F, Nookaew I, Ucer Ozgurel S, Marques-Carvalho A, Iyer S, Warren A, Aykin-Burns N, Krager K, Sardao VA, Han L, de Cabo R, Zhao H, Jilka RL, Manolagas SC, Almeida M. Estrogens decrease osteoclast number by attenuating mitochondria oxidative phosphorylation and ATP production in early osteoclast precursors. Sci Rep. 2020 Jul 20;10(1):11933. PubMed PMID: 32686739
- Iyer S, Melendez-Suchi C, Han L, Baldini G, Almeida M, Jilka RL. Elevation of the unfolded protein response increases RANKL expression. FASEB Bioadv. 2020 Apr;2(4):207-218. PubMed PMID: 32259048
- Ponte F, Kim HN, Iyer S, Han L, Almeida M, Manolagas SC. Cxcl12 Deletion in Mesenchymal Cells Increases Bone Turnover and Attenuates the Loss of Cortical Bone Caused by Estrogen Deficiency in Mice. J Bone Miner Res. 2020 Aug;35(8):1441-1451. PubMed PMID: 32154948
- Trentzsch M, Nyamugenda E, Miles TK, Griffin H, Russell S, Koss B, Cooney KA, Phelan KD, Tackett AJ, Iyer S, Boysen G, Baldini G. Delivery of phosphatidylethanolamine blunts stress in hepatoma cells exposed to elevated palmitate by targeting the endoplasmic reticulum. Cell Death Discov. 2020;6:8. PubMed PMID: 32123584
- Kim HN, Ponte F, Warren A, Ring R, Iyer S, Han L, Almeida M. A decrease in NAD( ) contributes to the loss of osteoprogenitors and bone mass with aging. NPJ Aging Mech Dis. 2021 Apr 1;7(1):8. PubMed PMID: 33795658
- Ponte F, Kim HN, Warren A, Iyer S, Han L, Mannen E, Gomez-Acevedo H, Nookaew I, Almeida M, Manolagas SC. Mmp13 deletion in mesenchymal cells increases bone mass and may attenuate the cortical bone loss caused by estrogen deficiency. Sci Rep. 2022 Jun 17;12(1):10257. PubMed PMID: 35715555
- Iyer S, Adams DJ. Bone and the Unfolded Protein Response: In Sickness and in Health. Calcif Tissue Int. 2023 Jul;113(1):96-109. PubMed PMID: 37243756