Tamara Timic Stamenic, PhD
Sr. Instructor, Anesthesiology
My research goal is to improve preventive and treatment strategies for opioid misuse and use disorder by investigating involvement of thalamic voltage-gated (T-type) calcium channels in the morphine effects. My present work is focused on discovering changes in thalamocortical oscillations, sleep disturbances and thalamic excitability after repeated morphine administration. During PhD studies, I was determining the activity of alpha5 selective GABAA receptor modulators in animal models of schizophrenia. During Postdoctoral Fellowship, I established the importance of T-type calcium channels in thalamocortical oscillations that underlie clinically important effects of anesthesia.
Santrac A, Batinic B, Stamenic TT, Arandelovic J, Sharmin D, Knutson DE, Cook JM, Savic MM. Positive modulation of a5GABAA receptors leads to dichotomous effects in rats on memory pattern and GABRA5 expression in prefrontal cortex and hippocampus. Behav Brain Res. 2022 Jan 7;416:113578. PubMed PMID: 34508769
Timic Stamenic T, Manzella FM, Maksimovic S, Krishnan K, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Further Evidence that Inhibition of Neuronal Voltage-Gated Calcium Channels Contributes to the Hypnotic Effect of Neurosteroid Analogue, 3ß-OH. Front Pharmacol. 2022;13:850658. PubMed PMID: 35677453
Timic Stamenic T, Todorovic SM. Thalamic T-Type Calcium Channels as Targets for Hypnotics and General Anesthetics. Int J Mol Sci. 2022 Feb 21;23(4). PubMed PMID: 35216466
Coulter I, Timic Stamenic T, Eggan P, Fine BR, Corrigan T, Covey DF, Yang L, Pan JQ, Todorovic SM. Different roles of T-type calcium channel isoforms in hypnosis induced by an endogenous neurosteroid epipregnanolone. Neuropharmacology. 2021 Oct 1;197:108739. PubMed PMID: 34339750
Timic Stamenic T, Feseha S, Manzella FM, Wallace D, Wilkey D, Corrigan T, Fiedler H, Doerr P, Krishnan K, Raol YH, Covey DF, Jevtovic-Todorovic V, Todorovic SM. The T-type calcium channel isoform Ca(v)3.1 is a target for the hypnotic effect of the anaesthetic neurosteroid (3ß,5ß,17ß)-3-hydroxyandrostane-17-carbonitrile. Br J Anaesth. 2021 Jan;126(1):245-255. PubMed PMID: 32859366