Joseph Hippensteel, MD
Assistant Professor, Medicine-Pulmonary Sciences & Critical Care

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Medical School:
  • MD, University of Wisconsin School of Medicine and Public Health (2012)
Graduate School :
  • MS, University of Wisconsin - Madison (2008)
Undergraduate School:
  • BS, University of Wisconsin–Madison (WI) (2007)
Internship:
  • University of California (San Francisco) Program (2013)
Residency:
  • University of California (San Francisco) Program, Internal Medicine (2015)
Fellowships:
  • University of Colorado, Pulmonary Disease and Critical Care Medicine (2019)
Department: Medicine-Pulmonary Sciences & Critical Care

Professional Titles

  • Assistant Professor

Research Interests

My research interests focus on the cognitive consequences (i.e., acutely as delirium and chronically as long-term cognitive dysfunction) of sepsis and other critical illness. I perform both basic and translational research in this realm seeking to identify the relevance of brain-penetrating heparan sulfate and chondroitin sulfate in these conditions. Ultimately, I seek to develop novel biomarkers and/or therapeutics for these understudied problems.

Publications

  • Sullivan RC, Rockstrom MD, Schmidt EP, Hippensteel JA. Endothelial glycocalyx degradation during sepsis: Causes and consequences. Matrix Biol Plus. 2021 Dec;12:100094. PubMed PMID: 34917925
  • Bai X, Hippensteel J, Leavitt A, Maloney JP, Beckham D, Garcia C, Li Q, Freed BM, Ordway D, Sandhaus RA, Chan ED. Hypothesis: Alpha-1-antitrypsin is a promising treatment option for COVID-19. Med Hypotheses. 2021 Jan;146:110394. PubMed PMID: 33239231
  • Mayer KP, Jolley SE, Etchill EW, Fakhri S, Hoffman J, Sevin CM, Zwischenberger JB, Rove JY. Long-term recovery of survivors of coronavirus disease (COVID-19) treated with extracorporeal membrane oxygenation: The next imperative. JTCVS Open. 2021 Mar;5:163-168. PubMed PMID: 34173554
  • Hippensteel JA, LaRiviere WB, Colbert JF, Langouët-Astrié CJ, Schmidt EP. Heparin as a Therapy for COVID-19: Current Evidence and Future Possibilities. Am J Physiol Lung Cell Mol Physiol. 2020 Jun 10. [Epub ahead of print] PubMed PMID: 32519894
  • Hippensteel JA, Burnham EL, Jolley SE. Prevalence of Venous Thromboembolism in Critically Ill Patients with COVID-19. Br J Haematol. 2020 Jun 2. [Epub ahead of print] PubMed PMID: 32484907
  • Hippensteel JA, LaRiviere WB, Colbert JF, Langouët-Astrié CJ, Schmidt EP. Heparin as a therapy for COVID-19: current evidence and future possibilities. Am J Physiol Lung Cell Mol Physiol. 2020 Aug 1;319(2):L211-L217. PubMed PMID: 32519894
  • Hippensteel JA, Burnham EL, Jolley SE. Prevalence of venous thromboembolism in critically ill patients with COVID-19. Br J Haematol. 2020 Aug;190(3):e134-e137. PubMed PMID: 32484907
  • Bai X, Hippensteel J, Leavitt A, Maloney JP, Beckham D, Garcia C, Li Q, Freed BM, Ordway D, Sandhaus RA, Chan ED. Hypothesis: Alpha-1-antitrypsin is a promising treatment option for COVID-19. Medical hypotheses. 2020 Nov 12:110394.
  • Hippensteel JA, Uchimido R, Tyler PD, Burke RC, Han X, Zhang F, McMurtry SA, Colbert JF, Lindsell CJ, Angus DC, Kellum JA, Yealy DM, Linhardt RJ, Shapiro NI, Schmidt EP. Intravenous fluid resuscitation is associated with septic endothelial glycocalyx degradation. Crit Care. 2019 Jul 23;23(1):259. PubMed PMID: 31337421
  • Kwiecinski JM, Crosby HA, Valotteau C, Hippensteel JA, Nayak MK, Chauhan AK, Schmidt EP, Dufrêne YF, Horswill AR. Staphylococcus aureus adhesion in endovascular infections is controlled by the ArlRS-MgrA signaling cascade. PLoS Pathog. 2019 May;15(5):e1007800. PubMed PMID: 31116795
  • Zhang X, Han X, Xia K, Xu Y, Yang Y, Oshima K, Haeger SM, Perez MJ, McMurtry SA, Hippensteel JA, Ford JA, Herson PS, Liu J, Schmidt EP, Linhardt RJ. Circulating heparin oligosaccharides rapidly target the hippocampus in sepsis, potentially impacting cognitive functions. Proc Natl Acad Sci U S A. 2019 May 7;116(19):9208-9213. PubMed PMID: 31010931
  • Hippensteel JA, Anderson BJ, Orfila JE, McMurtry SA, Dietz RM, Su G, Ford JA, Oshima K, Yang Y, Zhang F, Han X, Yu Y, Liu J, Linhardt RJ, Meyer NJ, Herson PS, Schmidt EP. Circulating heparan sulfate fragments mediate septic cognitive dysfunction. J Clin Invest. 2019 Apr 1;129(4):1779-1784. PubMed PMID: 30720464
  • Mayer KP, Jolley SE, Etchill EW, Fakhri S, Hoffman J, Sevin CM, Zwischenberger JB, Rove JY. Long-term Recovery of Survivors of COVID-19 Treated with ECMO: The Next Imperative. Jtcvs Open. 2020 Nov 25.
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Practice Locations

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

Hospital Affiliation
  • University of Colorado Hospital

Specialty Information

Specialties
  • Pulmonary Disease and Critical Care Medicine, Board Certification (2018)

General Information

Medical Schools:
  • MD, University of Wisconsin School of Medicine and Public Health (2012)
Graduate Schools:
  • MS, University of Wisconsin - Madison (2008)
Undergraduate Schools:
  • BS, University of Wisconsin–Madison (WI) (2007)
Internships:
  • University of California (San Francisco) Program (2013)
Residency Programs:
  • University of California (San Francisco) Program, Internal Medicine (2015)
Fellowships:
  • University of Colorado, Pulmonary Disease and Critical Care Medicine (2019)
Department: Medicine-Pulmonary Sciences & Critical Care
SOM Resources
CU Resources
Contact Us
CU Anschutz
Fitzsimons Building
13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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