Joseph Hippensteel, MD

Professional Titles

• Assistant Professor

Research Interests

My research interests focus on the cognitive consequences (i.e., acutely as delirium and chronically as long-term cognitive dysfunction) of sepsis and other critical illness. I perform both basic and translational research in this realm seeking to identify the relevance of brain-penetrating heparan sulfate and chondroitin sulfate in these conditions. Ultimately, I seek to develop novel biomarkers and/or therapeutics for these understudied problems.

Publications

• Andonian BJ, Hippensteel JA, Abuabara K, Boyle EM, Colbert JF, Devinney MJ, Faye AS, Kochar B, Lee J, Litke R, Nair D, Sattui SE, Sheshadri A, Sherman AN, Singh N, Zhang Y, LaHue SC. Inflammation and aging-related disease: A transdisciplinary inflammaging framework. Geroscience. 2024.
• Palakshappa JA, Batt JAE, Bodine SC, Connolly BA, Doles J, Falvey JR, Ferrante LE, Files DC, Harhay MO, Harrell K, Hippensteel JA, Iwashyna TJ, Jackson JC, Lane-Fall MB, Monje M, Moss M, Needham DM, Semler MW, Lahiri S, Larsson L, Sevin CM, Sharshar T, Singer B, Stevens T, Taylor SP, Gomez CR, Zhou G, Girard TD, Hough CL. Tackling Brain and Muscle Dysfunction in Acute Respiratory Distress Syndrome Survivors: NHLBI Workshop Report. Am J Respir Crit Care Med. 2024 Jun 1;209(11):1304-1313. doi: 10.1164/rccm.202311-2130WS. PMID: 38477657; PMCID: PMC11146564.
• Hippensteel JA, Aggarwal NR, Mikkelsen ME. A New Era in Critical Care Trials: Linking ICU Practice to Long-Term Outcomes. [Editorial] Am J Respir Crit Care Med. 2024 Apr 1;209(7):782-784. doi: 10.1164/rccm.202402-0349ED. PMID: 38387023; PMCID: PMC10995568.
• Katsandres SC, Hall J, Danielson K, Sakr S, Dean SG, Carlbom DJ, Wurfel MM, Bhatraju PK, Hippensteel JA, Schmidt EP, Oshima K, Counts CR, Sayre MR, Henning DJ, Johnson NJ. Inflammation, endothelial injury, and the acute respiratory distress syndrome after out-of-hospital cardiac arrest. Resusc Plus. 2024 Mar 5;17:100590. doi: 10.1016/j.resplu.2024.100590. PMID: 38463638; PMCID: PMC10924201.
• Sallee CJ, Maddux BJ, Hippensteel JA, Markovic D, Oshima K, Schwingshackl A, Mourani PM, Schmidt EP, Sapru A. Circulating Heparan Sulfate Profiles in Pediatric Acute Respiratory Distress Syndrome. Shock. 2024.
• Oshima K, Siddiqui N, Orfila JE, Carter D, Laing J, Han X, Zakharevich I, Iozzo RV, Ghasabyan A, Moore H, Zhang F, Linhardt RJ, Moore EE, Quillinan N, Schmidt EP, Herson PS, Hippensteel JA. A role for decorin in improving motor deficits after traumatic brain injury. Matrix Biol. 2024 Jan;125:88-99. doi: 10.1016/j.matbio.2023.12.005. Epub 2023 Dec 21. PMID: 38135163; PMCID: PMC10922985.
• Sallee CJ, Hippensteel JA, Miller KR, Oshima K, Pham AT, Richter RP, Belperio J, Sierra YL, Schwingshackl A, Mourani PM, Schmidt EP, Sapru A, Maddux AB. Endothelial Glycocalyx Degradation Patterns in Sepsis-Associated Pediatric Acute Respiratory Distress Syndrome: A Single Center Retrospective Observational Study. J Intensive Care Med. 2024 Mar;39(3):277-287. doi: 10.1177/08850666231200162. Epub 2023 Sep 6. PMID: 37670670; PMCID: PMC10845819.
• Karlsson R, Grønset MN, Chuang C, Hippensteel JA, Miller RL. Methods and Materials for Studying Proteoglycans and Glycosaminoglycans. [Chapter] Glycoprotein Analysis: New Developments in Mass Spectrometry. Royal Society of Chemistry. 2024.
• Rockstrom M, Balaban E, Fakhri S, Peterson RA, Jin Y, Jolley SE, Erlandson KM, Hippensteel JA. Predictors of adverse outcomes in aged patients critically ill with COVID-19: a retrospective study. J Investig Med. 2023 Apr;71(4):315-320. PubMed PMID: 36655809
• Colbert JF, Kirsch JM, Erzen CL, Langouët-Astrié CJ, Thompson GE, McMurtry SA, Kofonow JM, Robertson CE, Kovacs EJ, Sullivan RC, Hippensteel JA, Sawant NV, De Nisco NJ, McCollister BD, Schwartz RS, Horswill AR, Frank DN, Duerkop BA, Schmidt EP. Aging-Associated Augmentation of Gut Microbiome Virulence Capability Drives Sepsis Severity. mBio. 2023 Jun 27;14(3):e0005223. PubMed PMID: 37102874
• Taylor LJ, Jolley SE, Ramani C, Mayer KP, Etchill EW, Mart MF, Fakhri S, Peterson S, Colborn K, Sevin CM, Kadl A, Enfield K, Whitman GJR, Zwischenberger JB, Rove JY. Early posthospitalization recovery after extracorporeal membrane oxygenation in survivors of COVID-19. J Thorac Cardiovasc Surg. 2023 Sep;166(3):842-851.e1. PubMed PMID: 35431034
• Sallee CJ, Hippensteel JA, Miller KR, Oshima K, Pham AT, Richter RP, Belperio J, Sierra YL, Schwingshackl A, Mourani PM, Schmidt EP, Sapru A, Maddux AB. Endothelial Glycocalyx Degradation Patterns in Sepsis-Associated Pediatric Acute Respiratory Distress Syndrome: A Single Center Retrospective Observational Study. J Intensive Care Med. 2023 Sep 6;:8850666231200162. [Epub ahead of print] PubMed PMID: 37670670
• Oshima K, Siddiqui N, Orfila JE, Carter D, Laing J, Han X, Zakharevich I, Iozzo RV, Ghasabayan A, Moore H, Zhang F, Linhardt RJ, Moore EE, Quillinan N, Schmidt EP, Herson PS, Hippensteel JA. A role for decorin in improving motor deficits after traumatic brain injury. Matrix Biol. 2023 Dec 20. [Epub ahead of print] PubMed PMID: 38135163
• Vasunilashorn SM, Lunardi N, Newman JC, Crosby G, Acker L, Abel T, Bhatnagar S, Cunningham C, de Cabo R, Dugan L, Hippensteel JA, Ishizawa Y, Lahiri S, Marcantonio ER, Xie Z, Inouye SK, Terrando N, Eckenhoff RG. Preclinical and translational models for delirium: Recommendations for future research from the NIDUS delirium network. Alzheimers Dement. 2023 May;19(5):2150-2174. PubMed PMID: 36799408
• Sullivan RC, Rockstrom MD, Schmidt EP, Hippensteel JA. Endothelial glycocalyx degradation during sepsis: Causes and consequences. Matrix Biol Plus. 2021 Dec;12:100094. PubMed PMID: 34917925
• Bai X, Hippensteel J, Leavitt A, Maloney JP, Beckham D, Garcia C, Li Q, Freed BM, Ordway D, Sandhaus RA, Chan ED. Hypothesis: Alpha-1-antitrypsin is a promising treatment option for COVID-19. Med Hypotheses. 2021 Jan;146:110394. PubMed PMID: 33239231
• Mayer KP, Jolley SE, Etchill EW, Fakhri S, Hoffman J, Sevin CM, Zwischenberger JB, Rove JY. Long-term recovery of survivors of coronavirus disease (COVID-19) treated with extracorporeal membrane oxygenation: The next imperative. JTCVS Open. 2021 Mar;5:163-168. PubMed PMID: 34173554
• Hippensteel JA, LaRiviere WB, Colbert JF, Langouët-Astrié CJ, Schmidt EP. Heparin as a Therapy for COVID-19: Current Evidence and Future Possibilities. Am J Physiol Lung Cell Mol Physiol. 2020 Jun 10. [Epub ahead of print] PubMed PMID: 32519894
• Hippensteel JA, Burnham EL, Jolley SE. Prevalence of Venous Thromboembolism in Critically Ill Patients with COVID-19. Br J Haematol. 2020 Jun 2. [Epub ahead of print] PubMed PMID: 32484907
• Hippensteel JA, LaRiviere WB, Colbert JF, Langouët-Astrié CJ, Schmidt EP. Heparin as a therapy for COVID-19: current evidence and future possibilities. Am J Physiol Lung Cell Mol Physiol. 2020 Aug 1;319(2):L211-L217. PubMed PMID: 32519894
• Hippensteel JA, Burnham EL, Jolley SE. Prevalence of venous thromboembolism in critically ill patients with COVID-19. Br J Haematol. 2020 Aug;190(3):e134-e137. PubMed PMID: 32484907
• Bai X, Hippensteel J, Leavitt A, Maloney JP, Beckham D, Garcia C, Li Q, Freed BM, Ordway D, Sandhaus RA, Chan ED. Hypothesis: Alpha-1-antitrypsin is a promising treatment option for COVID-19. Medical hypotheses. 2020 Nov 12:110394.
• Hippensteel JA, Uchimido R, Tyler PD, Burke RC, Han X, Zhang F, McMurtry SA, Colbert JF, Lindsell CJ, Angus DC, Kellum JA, Yealy DM, Linhardt RJ, Shapiro NI, Schmidt EP. Intravenous fluid resuscitation is associated with septic endothelial glycocalyx degradation. Crit Care. 2019 Jul 23;23(1):259. PubMed PMID: 31337421
• Kwiecinski JM, Crosby HA, Valotteau C, Hippensteel JA, Nayak MK, Chauhan AK, Schmidt EP, Dufrêne YF, Horswill AR. Staphylococcus aureus adhesion in endovascular infections is controlled by the ArlRS-MgrA signaling cascade. PLoS Pathog. 2019 May;15(5):e1007800. PubMed PMID: 31116795
• Zhang X, Han X, Xia K, Xu Y, Yang Y, Oshima K, Haeger SM, Perez MJ, McMurtry SA, Hippensteel JA, Ford JA, Herson PS, Liu J, Schmidt EP, Linhardt RJ. Circulating heparin oligosaccharides rapidly target the hippocampus in sepsis, potentially impacting cognitive functions. Proc Natl Acad Sci U S A. 2019 May 7;116(19):9208-9213. PubMed PMID: 31010931
• Hippensteel JA, Anderson BJ, Orfila JE, McMurtry SA, Dietz RM, Su G, Ford JA, Oshima K, Yang Y, Zhang F, Han X, Yu Y, Liu J, Linhardt RJ, Meyer NJ, Herson PS, Schmidt EP. Circulating heparan sulfate fragments mediate septic cognitive dysfunction. J Clin Invest. 2019 Apr 1;129(4):1779-1784. PubMed PMID: 30720464
• Mayer KP, Jolley SE, Etchill EW, Fakhri S, Hoffman J, Sevin CM, Zwischenberger JB, Rove JY. Long-term Recovery of Survivors of COVID-19 Treated with ECMO: The Next Imperative. Jtcvs Open. 2020 Nov 25.

Practice Locations

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

Hospital Affiliation

• University of Colorado Hospital

Specialty Information

Specialties

• Pulmonary Disease and Critical Care Medicine, Board Certification (2018)