My research interests include investigating the role of mucosal barrier in gastrointestinal disease. I am particularly interested in the role of metabolic components in the diet on homeostasis in the GI tract.
Publications
Curtis VF, Cartwright IM, Lee JS, Wang RX, Kao DJ, Lanis JM, Burney KM, Welch N, Hall CHT, Goldberg MS, Campbell EL, Colgan SP. Neutrophils as sources of dinucleotide polyphosphates and metabolism by epithelial ENPP1 to influence barrier function via adenosine signaling. Mol Biol Cell. 2018 Nov 1;29(22):2687-2699. PubMed PMID: 30188771
Hall CHT, Lee JS, Murphy EM, Gerich ME, Dran R, Glover LE, Abdulla ZI, Skelton MR, Colgan SP. Creatine Transporter, Reduced in Colon Tissues From Patients With Inflammatory Bowel Diseases, Regulates Energy Balance in Intestinal Epithelial Cells, Epithelial Integrity, and Barrier Function. Gastroenterology. 2020 Sep;159(3):984-998.e1. PubMed PMID: 32433978
Constant BD, Dutmer CM, Arnold MA, Hall C, Abbott JK, de Zoeten EF. Cytotoxic T-Lymphocyte-Associated Antigen 4 Haploinsufficiency Mimics Difficult-to-Treat Inflammatory Bowel Disease. Clin Gastroenterol Hepatol. 2021 May 7. [Epub ahead of print] PubMed PMID: 33965572
Cartwright IM, Dowdell AS, Lanis JM, Brink KR, Mu A, Kostelecky RE, Schaefer REM, Welch N, Onyiah JC, Hall CHT, Gerich ME, Tabor JJ, Colgan SP. Mucosal acidosis elicits a unique molecular signature in epithelia and intestinal tissue mediated by GPR31-induced CREB phosphorylation. Proc Natl Acad Sci U S A. 2021 May 18;118(20). PubMed PMID: 33972436
Wallimann T, Hall CHT, Colgan SP, Glover LE. Creatine Supplementation for Patients with Inflammatory Bowel Diseases: A Scientific Rationale for a Clinical Trial. Nutrients. 2021 Apr 23;13(5). PubMed PMID: 33922654
Hall CHT, de Zoeten EF. Understanding very early onset inflammatory bowel disease (VEOIBD) in relation to inborn errors of immunity. Immunol Rev. 2023 Dec 19. [Epub ahead of print] PubMed PMID: 38115672
Hall CHT, Lanis JM, Dowdell AS, Murphy EM, Bhagavatula G, Neuhart RM, Vijaya Sai KY, Colgan SP. Fundamental role for the creatine kinase pathway in protection from murine colitis. Mucosal Immunol. 2023 Dec;16(6):817-825. PubMed PMID: 37716510
Steiner CA, Koch SD, Evanoff T, Welch N, Kostelecky R, Callahan R, Murphy EM, Nguyen TT, Hall CHT, Lu S, de Zoeten EF, Weiser-Evans MCM, Cartwright IM, Colgan SP. The TNF(?ARE) Mouse as a Model of Intestinal Fibrosis. Am J Pathol. 2023 Aug;193(8):1013-1028. PubMed PMID: 37169343
Colgan SP, Wang RX, Hall CHT, Bhagavatula G, Lee JS. Revisiting the "starved gut" hypothesis in inflammatory bowel disease. Immunometabolism (Cobham). 2023 Jan;5(1):e0016. PubMed PMID: 36644501