Sashi Kant, PhD
Research Instructor, Immunology and Microbiology

Publications

• Kant S, Till JKA, Liu L, Margolis A, Uppalapati S, Kim JS, and Vazquez-Torres A. Gre factors help Salmonella adapt to oxidative stress by improving transcription elongation and fidelity of metabolic genes. PLoS Biol.
• Kant S, Karl JA Till, Liu L, Kim JS, Vazquez-Torres A. Rescue of transcriptional pausing in metabolic genes jumpstarts Salmonella antioxidant defenses. 2022. bioRxiv. 2022.06.09.495436; doi: https://doi.org/10.1101/2022.06.09.495436.
• Kim JS, Born A, Till JKA, Liu L, Kant S, Henen M, Vogeli B, Vázquez-Torres A. Promiscuity of response regulators for thioredoxin steers bacterial virulence. 2022 Oct 20; Nat Commun. 13, 6210. https://doi.org/10.1038/s41467-022-33983-6.
• Kim JS, Liu L, Davenport B, Kant S, Morrison TE, and Vazquez-Torres A. Oxidative stress activates Salmonella pathogenicity island transcription in macrophages. J Biol Chem. 2022 Jun 14; 298(7): 102130. doi: 10.1016/j.jbc.2022.102130. Epub ahead of print. PMID: 35714768.
• Kant S, Pancholi V. Novel Tyrosine Kinase-Mediated Phosphorylation With Dual Specificity Plays a Key Role in the Modulation of Streptococcus pyogenes Physiology and Virulence. Front Microbiol. 2021;12:689246. PubMed PMID: 34950110
• Pandey S, Kant S, Khawary M, Tripathi D. Macrophages in Microbial Pathogenesis: Commonalities of Defense Evasion Mechanisms. Infect Immun. 2021 Nov 15;:IAI0029121. [Epub ahead of print] PubMed PMID: 34780281
• Wilkie T, Verma AK, Zhao H, Charan M, Ahirwar DK, Kant S, Pancholi V, Mishra S, Ganju RK. Lipopolysaccharide from the commensal microbiota of the breast enhances cancer growth: role of S100A7 and TLR4. Mol Oncol. 2021 May 9. [Epub ahead of print] PubMed PMID: 33969603
• Davuluri G, Welch N, Sekar J, Gangadhariah M, Alsabbagh Alchirazi K, Mohan ML, Kumar A, Kant S, Thapaliya S, Stine M, McMullen MR, McCullough RL, Stark GR, Nagy LE, Naga Prasad SV, Dasarathy S. Activated Protein Phosphatase 2A Disrupts Nutrient Sensing Balance Between Mechanistic Target of Rapamycin Complex 1 and Adenosine Monophosphate-Activated Protein Kinase, Causing Sarcopenia in Alcohol-Associated Liver Disease. Hepatology. 2021 May;73(5):1892-1908. PubMed PMID: 32799332
• Fitzsimmons LF, Liu L, Kant S, Kim JS, Till JK, Jones-Carson J, Porwollik S, McClelland M, Vazquez-Torres A. SpoT Induces Intracellular Salmonella Virulence Programs in the Phagosome. mBio. 2020 Feb 25;11(1). PubMed PMID: 32098823
• Davuluri G, Welch N, Sekar J, Gangadhariah M, Alsabbagh Alchirazi K, Mohan ML, Kumar A, Kant S, Thapaliya S, Stine M, McMullen MR, McCullough RL, Stark GR, Nagy LE, Naga Prasad SV, Dasarathy S. Activated protein phosphatase 2A disrupts nutrient sensing balance between mTORC1 and AMPK causing sarcopenia in alcoholic liver disease. Hepatology. 2020 Aug 16. [Epub ahead of print] PubMed PMID: 32799332
• Pandey S, Yadav B, Pandey A, Tripathi T, Khawary M, Kant S, Tripathi D. Lessons from SARS-CoV-2 Pandemic: Evolution, Disease Dynamics and Future. Biology (Basel). 2020 Jun 26;9(6). PubMed PMID: 32604825