Jacob Basak, MD, PhD

Professional Titles

• Faculty, Neuronal Injury Program

Recognitions

• Dr. Traystman Developing Clinician Scientist Endowed Fellow, The University of Colorado Department of Anesthesia (2019)
• Kosaka Best of Meeting Award, International Anesthesia Research Society (2019)
• Resident Travel Award, Association of University Anesthesiologists (2019)
• Mentored Research Training Grant Recipient, Foundation for Anesthesia Education and Research (2022)
• Second Century Early Faculty Independence Award, American Heart Association (2024)
• Junior Faculty Research Award for Laboratory Science, Association of University Anesthesiologists (AUA) (2024)
• Golden Stethoscope Award, University of Colorado School of Medicine (2024)

Publications

• Basak JM, Verghese PB, Yoon H, Kim J, Holtzman DM. Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Aß uptake and degradation by astrocytes. J Biol Chem. 2012 Apr 20;287(17):13959-71. PubMed PMID: 22383525
• Kim J, Eltorai AE, Jiang H, Liao F, Verghese PB, Kim J, Stewart FR, Basak JM, Holtzman DM. Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aß amyloidosis. J Exp Med. 2012 Nov 19;209(12):2149-56. PubMed PMID: 23129750
• Wildsmith KR, Basak JM, Patterson BW, Pyatkivskyy Y, Kim J, Yarasheski KE, Wang JX, Mawuenyega KG, Jiang H, Parsadanian M, Yoon H, Kasten T, Sigurdson WC, Xiong C, Goate A, Holtzman DM, Bateman RJ. In vivo human apolipoprotein E isoform fractional turnover rates in the CNS. PLoS One. 2012;7(6):e38013. PubMed PMID: 22675504
• Kim J, Jiang H, Park S, Eltorai AE, Stewart FR, Yoon H, Basak JM, Finn MB, Holtzman DM. Haploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-ß amyloidosis. J Neurosci. 2011 Dec 7;31(49):18007-12. PubMed PMID: 22159114
• Basak JM, Kim J. Differential effects of ApoE isoforms on dendritic spines in vivo: linking an Alzheimer's disease risk factor with synaptic alterations. J Neurosci. 2010 Mar 31;30(13):4526-7. PubMed PMID: 20357102
• Lee J, Basak JM, Demehri S, Kopan R. Bi-compartmental communication contributes to the opposite proliferative behavior of Notch1-deficient hair follicle and epidermal keratinocytes. Development. 2007 Aug;134(15):2795-806. PubMed PMID: 17611229
• Yamada K, Hashimoto T, Yabuki C, Nagae Y, Tachikawa M, Strickland DK, Liu Q, Bu G, Basak JM, Holtzman DM, Ohtsuki S, Terasaki T, Iwatsubo T. The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid beta peptides in an in vitro model of the blood-brain barrier cells. J Biol Chem. 2008 Dec 12;283(50):34554-62. PubMed PMID: 18940800
• Kim J, Basak JM, Holtzman DM. The role of apolipoprotein E in Alzheimer's disease. Neuron. 2009 Aug 13;63(3):287-303. PubMed PMID: 19679070
• Kim J, Castellano JM, Jiang H, Basak JM, Parsadanian M, Pham V, Mason SM, Paul SM, Holtzman DM. Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance. Neuron. 2009 Dec 10;64(5):632-44. PubMed PMID: 20005821
• Basak JM, Ferreiro A, Cohen LS, Sheehan PW, Nadarajah CJ, Kanan MF, Sukhum KV, Dantas G, Musiek ES. Bacterial sepsis increases hippocampal fibrillar amyloid plaque load and neuroinflammation in a mouse model of Alzheimer's disease. Neurobiol Dis. 2021 Feb 5;152:105292. [Epub ahead of print] PubMed PMID: 33556539
• Basak JM, Kim J, Pyatkivskyy Y, Wildsmith KR, Jiang H, Parsadanian M, Patterson BW, Bateman RJ, Holtzman DM. Measurement of apolipoprotein E and amyloid ß clearance rates in the mouse brain using bolus stable isotope labeling. Mol Neurodegener. 2012 Apr 18;7:14. PubMed PMID: 22512932
• Kim J, Yoon H, Basak J, Kim J. Apolipoprotein E in synaptic plasticity and Alzheimer's disease: potential cellular and molecular mechanisms. Mol Cells. 2014 Nov;37(11):767-76. PubMed PMID: 25358504
• Basak JM, Falk M, Mitchell DN, Coakley KA, Quillinan N, Orfila JE, Herson PS. Targeting BACE1-mediated production of amyloid beta improves hippocampal synaptic function in an experimental model of ischemic stroke. J Cereb Blood Flow Metab. 2023 Feb 22;:271678X231159597. [Epub ahead of print] PubMed PMID: 37150606
• Basak JM, Falk M, Mitchell DN, Coakley KA, Quillinan N, Orfila JE, Herson PS. Targeting BACE1-mediated production of amyloid beta improves hippocampal synaptic function in an experimental model of ischemic stroke. J Cereb Blood Flow Metab. 2023 Feb 22;:271678X231159597. [Epub ahead of print] PubMed PMID: 37150606

Professional Memberships

• The Society of Critical Care Anesthesiologists, Member
• The American Society of Anesthesiologists, Member
• Society of Critical Care Medicine, Member
• International Anesthesia Research Society, Member
• Association of University Anesthesiologists, Associate Member

Practice Locations

• University of Colorado Hospital

Specialty Information

• Critical Care Medicine, Board Certification (2019)
• Anesthesiology, Board Certification (2019)

• Critical Care