Leslie Berg, PhD

Professional Titles

• Professor and Chair

Publications

• Yee EJ, Gilbert D, Kaplan J, van Dyk L, Kim SS, Berg L, Clambey E, Wani S, McCarter MD, Stewart CL. Immune Landscape of Epstein-Barr Virus-Associated Gastric Cancer: Analysis From a Western Academic Institution. J Surg Res. 2024 Apr;296:742-750. PubMed PMID: 38368775
• Neurath MF, Berg LJ. VAV1 as a putative therapeutic target in autoimmune and chronic inflammatory diseases. Trends Immunol. 2024 Aug;45(8):580-596. PubMed PMID: 39060140
• Berg, LJ. (2024). Understanding T lymphocytes’ inner workings to harness therapeutic potential. Open Access Government, January 2024. DOI: 10.56367/OAG-041-11145
• Berg, LJ and Pugh-Bernard, A. (2023). Investigating immunity: uncovering the mechanisms of the immune system. Futurum Careers (futurumcareers.com), May 25, 2023. https://doi.org/10.33424/FUTURUM391
• Berg, LJ. (2023). Understanding T lymphocytes’ inner workings to harness therapeutic potential. Open Access Government, in press.
• Janeway's Immunobiology
• K Murphy, C Weaver, and L Berg. Janeway’s Immunobiology, 10th edition. W.W. Norton & Company, Inc., 2022.
• 86. Forconi, CS, DH Mulama, PS Lakshmi, J Foley, J Oteino, JD Kurtis, L Berg, JM Ong’echa, C Munz, and AM Moormann. Interplay between IL-10, IFN-?, IL-17A and PD-1 expressing EBNA1-specific CD4+ and CD8+ T cell responses in the etiologic pathway to endemic Burkitt lymphoma, Cancers, in press.
• Riggs JB, Medina EM, Perrenoud LJ, Bonilla DL, Clambey ET, van Dyk LF, Berg LJ. Optimized Detection of Acute MHV68 Infection With a Reporter System Identifies Large Peritoneal Macrophages as a Dominant Target of Primary Infection. Front Microbiol. 2021;12:656979. PubMed PMID: 33767688
• Gallagher MP, Conley JM, Vangala P, Garber M, Reboldi A, Berg LJ. Hierarchy of signaling thresholds downstream of the T cell receptor and the Tec kinase ITK. Proc Natl Acad Sci U S A. 2021 Aug 31;118(35). PubMed PMID: 34452995
• Cho HS, Ha S, Shin HM, Reboldi A, Hall JA, Huh JR, Usherwood EJ, Berg LJ. CD8( ) T Cells Require ITK-Mediated TCR Signaling for Migration to the Intestine. Immunohorizons. 2020 Feb 7;4(2):57-71. PubMed PMID: 32034085
• Conley JM, Gallagher MP, Rao A, Berg LJ. Activation of the Tec Kinase ITK Controls Graded IRF4 Expression in Response to Variations in TCR Signal Strength. J Immunol. 2020 Jul 15;205(2):335-345. PubMed PMID: 32493815
• Gallagher MP, Conley JM, Vangala P, Reboldi A, Garber, M, Berg LJ. The Tec kinase ITK differentially optimizes NFAT, NF-?B, and MAPK signaling during early T cell activation to regulate graded gene induction doi: https://doi.org/10.1101/2020.11.12.380725
• Riggs JR, Medina EM, Perrenoud LJ, Clambey ET, VanDyk LF, Berg LJ. Optimized detection of acute MHV68 infection with a reporter system identifies large peritoneal macrophages as a dominant target of primary infection. doi: https://doi.org/10.1101/2020.11.17.387969
• Conley JM, Berg LJ. TCR signaling: it's all about the numbers. Nat Immunol. 2019 Oct 7. [Epub ahead of print] PubMed PMID: 31591572
• Cho HS, Reboldi A, Hall JA, Berg LJ. The Tec kinase ITK is essential for ILC2 survival and epithelial integrity in the intestine. Nat Commun. 2019 Feb 15;10(1):784. PubMed PMID: 30770814
• Janeway's Immunobiology
• Kolli, N, A Andreotti, A Reboldi, LJ Berg, J Kang. (2024). Expanding the Tec kinase inhibitor landscape by emergent small molecule mediated modulation of ITK, manuscript submitted.
• 90. Stanley, M, S Shanmuganadam, A Calcino, J Cappello, D Searle, T Lea-Henry, S He, R Jin, SE Boyken, MB Downes, E Wang, J Chow, TXN Huynh, P Gonzalez-Figueroa, J Roco, S Zachariah, P Puri, A Jain, J Cockburn, IL Bales, G Hart, TD Andrews, D Tscharke, AMD Lorenzo, C Hayter, MN Fadia, R Singer, C Perera, B Corry, A Andreotti, L Berg, N Shen, K Morrisroe, CG Vinuesa, M Field, GD Walters, V Athanasopoulos, SH Jiang. (2024). ITK gain of function genetic variation drives human autoimmunity and is responsive to T cell inhibition, manuscript submitted.
• Perrenoud, et al. Analysis of T-cell receptor induced calcium influx in primary murine T cells by full spectrum flow cytometry, Journal of Visualized Experiments, in press.
• Yee, EJ, D Gilbert, J Kaplan, L van Dyk, S Kim, L Berg, E Clambey, S Wani, MM McCarter, and CL Stewart. (2023). Evaluation of the Immune Landscape of Epstein-Barr Virus associated Gastric Cancer: Analysis from a Western, Academic Institution, manuscript submitted.
• Kolli, N, A Andreotti, A Reboldi, LJ Berg, J Kang. (2023). Expanding the Tec kinase inhibitor landscape by emergent small molecule mediated modulation of ITK, manuscript submitted.

Practice Locations

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000