Leslie Berg, PhD

Professional Titles

• Professor and Chair

Publications

• Conley JM, Berg LJ. TCR signaling: it's all about the numbers. Nat Immunol. 2019 Oct 7. [Epub ahead of print] PubMed PMID: 31591572
• Cho HS, Reboldi A, Hall JA, Berg LJ. The Tec kinase ITK is essential for ILC2 survival and epithelial integrity in the intestine. Nat Commun. 2019 Feb 15;10(1):784. PubMed PMID: 30770814
• Janeway's Immunobiology
• Cho HS, Ha S, Shin HM, Reboldi A, Hall JA, Huh JR, Usherwood EJ, Berg LJ. CD8( ) T Cells Require ITK-Mediated TCR Signaling for Migration to the Intestine. Immunohorizons. 2020 Feb 7;4(2):57-71. PubMed PMID: 32034085
• Conley JM, Gallagher MP, Rao A, Berg LJ. Activation of the Tec Kinase ITK Controls Graded IRF4 Expression in Response to Variations in TCR Signal Strength. J Immunol. 2020 Jul 15;205(2):335-345. PubMed PMID: 32493815
• Gallagher MP, Conley JM, Vangala P, Reboldi A, Garber, M, Berg LJ. The Tec kinase ITK differentially optimizes NFAT, NF-?B, and MAPK signaling during early T cell activation to regulate graded gene induction doi: https://doi.org/10.1101/2020.11.12.380725
• Riggs JR, Medina EM, Perrenoud LJ, Clambey ET, VanDyk LF, Berg LJ. Optimized detection of acute MHV68 infection with a reporter system identifies large peritoneal macrophages as a dominant target of primary infection. doi: https://doi.org/10.1101/2020.11.17.387969
• Riggs JB, Medina EM, Perrenoud LJ, Bonilla DL, Clambey ET, van Dyk LF, Berg LJ. Optimized Detection of Acute MHV68 Infection With a Reporter System Identifies Large Peritoneal Macrophages as a Dominant Target of Primary Infection. Front Microbiol. 2021;12:656979. PubMed PMID: 33767688
• Gallagher MP, Conley JM, Vangala P, Garber M, Reboldi A, Berg LJ. Hierarchy of signaling thresholds downstream of the T cell receptor and the Tec kinase ITK. Proc Natl Acad Sci U S A. 2021 Aug 31;118(35). PubMed PMID: 34452995
• Janeway's Immunobiology
• 86. Forconi, CS, DH Mulama, PS Lakshmi, J Foley, J Oteino, JD Kurtis, L Berg, JM Ong’echa, C Munz, and AM Moormann. Interplay between IL-10, IFN-?, IL-17A and PD-1 expressing EBNA1-specific CD4+ and CD8+ T cell responses in the etiologic pathway to endemic Burkitt lymphoma, Cancers, in press.
• Perrenoud, et al. Analysis of T-cell receptor induced calcium influx in primary murine T cells by full spectrum flow cytometry, Journal of Visualized Experiments, in press.
• Yee, EJ, D Gilbert, J Kaplan, L van Dyk, S Kim, L Berg, E Clambey, S Wani, MM McCarter, and CL Stewart. (2023). Evaluation of the Immune Landscape of Epstein-Barr Virus associated Gastric Cancer: Analysis from a Western, Academic Institution, manuscript submitted.
• Kolli, N, A Andreotti, A Reboldi, LJ Berg, J Kang. (2023). Expanding the Tec kinase inhibitor landscape by emergent small molecule mediated modulation of ITK, manuscript submitted.
• Berg, LJ and Pugh-Bernard, A. (2023). Investigating immunity: uncovering the mechanisms of the immune system. Futurum Careers (futurumcareers.com), May 25, 2023. https://doi.org/10.33424/FUTURUM391
• Berg, LJ. (2023). Understanding T lymphocytes’ inner workings to harness therapeutic potential. Open Access Government, in press.
• Yee EJ, Gilbert D, Kaplan J, van Dyk L, Kim SS, Berg L, Clambey E, Wani S, McCarter MD, Stewart CL. Immune Landscape of Epstein-Barr Virus-Associated Gastric Cancer: Analysis From a Western Academic Institution. J Surg Res. 2024 Apr;296:742-750. PubMed PMID: 38368775
• Neurath MF, Berg LJ. VAV1 as a putative therapeutic target in autoimmune and chronic inflammatory diseases. Trends Immunol. 2024 Aug;45(8):580-596. PubMed PMID: 39060140
• Berg, LJ. (2024). Understanding T lymphocytes’ inner workings to harness therapeutic potential. Open Access Government, January 2024. DOI: 10.56367/OAG-041-11145
• Kolli, N, A Andreotti, A Reboldi, LJ Berg, J Kang. (2024). Expanding the Tec kinase inhibitor landscape by emergent small molecule mediated modulation of ITK, manuscript submitted.
• 90. Stanley, M, S Shanmuganadam, A Calcino, J Cappello, D Searle, T Lea-Henry, S He, R Jin, SE Boyken, MB Downes, E Wang, J Chow, TXN Huynh, P Gonzalez-Figueroa, J Roco, S Zachariah, P Puri, A Jain, J Cockburn, IL Bales, G Hart, TD Andrews, D Tscharke, AMD Lorenzo, C Hayter, MN Fadia, R Singer, C Perera, B Corry, A Andreotti, L Berg, N Shen, K Morrisroe, CG Vinuesa, M Field, GD Walters, V Athanasopoulos, SH Jiang. (2024). ITK gain of function genetic variation drives human autoimmunity and is responsive to T cell inhibition, manuscript submitted.
• K Murphy, C Weaver, and L Berg. Janeway’s Immunobiology, 10th edition. W.W. Norton & Company, Inc., 2022.

Practice Locations

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000