Katrina Claw, PhD

Professional Titles

• Assistant Professor

Recognitions

• Genomic Innovator Award, NHGRI (2020)
  Pharmacogenomic approaches to drug metabolism in American Indian/Alaska Native People

Research Interests

My research focuses broadly on personalizing medicine, using genetic information and biomarkers for tailored treatment, in relation to pharmacogenomics as well as understanding the ethical, cultural, and social implications of genomic research with populations historically underrepresented in health research. My current research includes studying cytochrome P450 genetic variation in Indigenous communities (e.g., American Indian and Alaska Native peoples), with a focus on CYP2A6 variation in relation to nicotine metabolism and smoking cessation, as well as understanding the ways in which adaptations to diverse local environments may have impacted modern pharmacogenomic variation and evolutionary medicine. My other projects include exploring the perspectives of tribal members on genetic research with tribes and developing guidelines and policies in partnership with tribes. All of my projects strive to use community based participatory research approach and include cultural and Indigenous knowledge.

Publications

• Claw KG, Beans JA, Lee SB, Avey JP, Stapleton PA, Scherer SE, El-Boraie A, Tyndale RF, Nickerson DA, Dillard DA, Thummel KE, Robinson RF. Pharmacogenomics of nicotine metabolism: novel CYP2A6 and CYP2B6 genetic variation patterns in Alaska Native and American Indian populations. Nicotine Tob Res. 2019 Jun 25. [Epub ahead of print] PubMed PMID: 31241144
• Dalton R, Lee SB, Claw KG, Prasad B, Phillips BR, Shen DD, Wong LH, Fade M, McDonald MG, Dunham MJ, Fowler DM, Rettie AE, Schuetz E, Thornton TA, Nickerson DA, Gaedigk A, Thummel KE, Woodahl EL. Interrogation of CYP2D6 Structural Variant Alleles Improves the Correlation Between CYP2D6 Genotype and CYP2D6-Mediated Metabolic Activity. Clin Transl Sci. 2020 Jan;13(1):147-156. PubMed PMID: 31536170
• Fohner AE, Dalton R, Skagen K, Jackson K, Claw KG, Hopkins SE, Robinson R, Khan BA, Prasad B, Schuetz EG, Nickerson DA, Thornton TA, Dillard DA, Boyer BB, Thummel KE, Woodahl EL. Characterization of CYP3A pharmacogenetic variation in American Indian and Alaska Native communities, targeting CYP3A4*1G allele function. Clin Transl Sci. 2021 Jan 27. [Epub ahead of print] PubMed PMID: 33503331
• Hiratsuka VY, Hahn MJ, Woodbury RB, Hull SC, Wilson DR, Bonham VL, Dillard DA, Avey JP, Beckel-Mitchener AC, Blome J, Claw K, Ferucci ED, Gachupin FC, Ghazarian A, Hindorff L, Jooma S, Trinidad SB, Troyer J, Walajahi H. Alaska Native genomic research: perspectives from Alaska Native leaders, federal staff, and biomedical researchers. Genet Med. 2020 Dec;22(12):1935-1943. PubMed PMID: 32839571
• Wagner JK, Colwell C, Claw KG, Stone AC, Bolnick DA, Hawks J, Brothers KB, Garrison NA. Fostering Responsible Research on Ancient DNA. Am J Hum Genet. 2020 Aug 6;107(2):183-195. PubMed PMID: 32763189
• Begay RL, Garrison NA, Sage F, Bauer M, Knoki-Wilson U, Begay DH, Becenti-Pigman B, Claw KG. Weaving the Strands of Life ( Iiná Bitl'ool ): History of Genetic Research Involving Navajo People. Hum Biol. 2020 Jul 9;91(3):189-208. PubMed PMID: 32549035
• Tsosie KS, Claw KG. Indigenizing Science and Reasserting Indigeneity in Research. Hum Biol. 2020 Jul 9;91(3):137-140. PubMed PMID: 32549033
• Bhatt DK, Basit A, Zhang H, Gaedigk A, Lee SB, Claw KG, Mehrotra A, Chaudhry AS, Pearce RE, Gaedigk R, Broeckel U, Thornton TA, Nickerson DA, Schuetz EG, Amory JK, Leeder JS, Prasad B. Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex. Drug Metab Dispos. 2018 Jun;46(6):888-896. PubMed PMID: 29602798
• Dalton R, Lee SB, Claw KG, Prasad B, Phillips BR, Shen DD, Wong LH, Fade M, McDonald MG, Dunham MJ, Fowler DM, Rettie AE, Schuetz E, Thornton TA, Nickerson DA, Gaedigk A, Thummel KE, Woodahl EL. Interrogation of CYP2D6 Structural Variant Alleles Improves the Correlation Between CYP2D6 Genotype and CYP2D6-Mediated Metabolic Activity. Clin Transl Sci. 2020 Jan;13(1):147-156. PubMed PMID: 31536170
• Claw KG, Beans JA, Lee SB, Avey JP, Stapleton PA, Scherer SE, El-Boraie A, Tyndale RF, Nickerson DA, Dillard DA, Thummel KE, Robinson RF. Pharmacogenomics of Nicotine Metabolism: Novel CYP2A6 and CYP2B6 Genetic Variation Patterns in Alaska Native and American Indian Populations. Nicotine Tob Res. 2020 May 26;22(6):910-918. PubMed PMID: 31241144
• Tanner JA, Zhu AZ, Claw KG, Prasad B, Korchina V, Hu J, Doddapaneni H, Muzny DM, Schuetz EG, Lerman C, Thummel KE, Scherer SE, Tyndale RF. Novel CYP2A6 diplotypes identified through next-generation sequencing are associated with in-vitro and in-vivo nicotine metabolism. Pharmacogenet Genomics. 2018 Jan;28(1):7-16. PubMed PMID: 29232328
• James RD, West KM, Claw KG, EchoHawk A, Dodge L, Dominguez A, Taualii M, Forquera R, Thummel K, Burke W. Responsible Research With Urban American Indians and Alaska Natives. Am J Public Health. 2018 Dec;108(12):1613-1616. PubMed PMID: 30359103
• Wong T, Wang Z, Chapron BD, Suzuki M, Claw KG, Gao C, Foti RS, Prasad B, Chapron A, Calamia J, Chaudhry A, Schuetz EG, Horst RL, Mao Q, de Boer IH, Thornton TA, Thummel KE. Polymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D(3)-3- O -Sulfate, a Major Circulating Vitamin D Metabolite in Humans. Drug Metab Dispos. 2018 Apr;46(4):367-379. PubMed PMID: 29343609
• Xu M, Bhatt DK, Yeung CK, Claw KG, Chaudhry AS, Gaedigk A, Pearce RE, Broeckel U, Gaedigk R, Nickerson DA, Schuetz E, Rettie AE, Leeder JS, Thummel KE, Prasad B. Genetic and Nongenetic Factors Associated with Protein Abundance of Flavin-Containing Monooxygenase 3 in Human Liver. J Pharmacol Exp Ther. 2017 Nov;363(2):265-274. PubMed PMID: 28819071
• Claw KG, Dundas N, Parrish MS, Begay RL, Teller TL, Garrison NA, Sage F. Perspectives on Genetic Research: Results From a Survey of Navajo Community Members. Front Genet. 2021;12:734529. PubMed PMID: 34925442
• Tsosie KS, Claw KG, Garrison NA. Considering "Respect for Sovereignty" Beyond the Belmont Report and the Common Rule: Ethical and Legal Implications for American Indian and Alaska Native Peoples. Am J Bioeth. 2021 Oct;21(10):27-30. PubMed PMID: 34554064
• Schaefer KR, Avey JP, Todd MR, Beans JA, Dillard DA, Shireman LM, Thornton TA, Tyndale RF, Thummel KE, Robinson RF, Claw KG. Nicotine metabolism and its association with CYP2A6 genotype among Indigenous people in Alaska who smoke. Clin Transl Sci. 2021 Nov;14(6):2474-2486. PubMed PMID: 34520119
• El-Boraie A, Tanner JA, Zhu AZX, Claw KG, Prasad B, Schuetz EG, Thummel KE, Fukunaga K, Mushiroda T, Kubo M, Benowitz NL, Lerman C, Tyndale RF. Functional characterization of novel rare CYP2A6 variants and potential implications for clinical outcomes. Clin Transl Sci. 2022 Jan;15(1):204-220. PubMed PMID: 34476898
• Fohner AE, Dalton R, Skagen K, Jackson K, Claw KG, Hopkins SE, Robinson R, Khan BA, Prasad B, Schuetz EG, Nickerson DA, Thornton TA, Dillard DA, Boyer BB, Thummel KE, Woodahl EL. Characterization of CYP3A pharmacogenetic variation in American Indian and Alaska Native communities, targeting CYP3A4*1G allele function. Clin Transl Sci. 2021 Jul;14(4):1292-1302. PubMed PMID: 33503331
• Fleskes RE, Bader AC, Tsosie KS, Wagner JK, Claw KG, Garrison NA. Ethical Guidance in Human Paleogenomics: New and Ongoing Perspectives. Annu Rev Genomics Hum Genet. 2022 Aug 31;23:627-652. PubMed PMID: 35537469
• El-Boraie A, Tanner JA, Zhu AZX, Claw KG, Prasad B, Schuetz EG, Thummel KE, Fukunaga K, Mushiroda T, Kubo M, Benowitz NL, Lerman C, Tyndale RF. Functional characterization of novel rare CYP2A6 variants and potential implications for clinical outcomes. Clin Transl Sci. 2022 Jan;15(1):204-220. PubMed PMID: 34476898
• Claw KG, Lippert D, Bardill J, Cordova A, Fox K, Yracheta JM, Bader AC, Bolnick DA, Malhi RS, TallBear K, Garrison NA. Chaco Canyon Dig Unearths Ethical Concerns. Hum Biol. 2017 Jul;89(3):177-180. PubMed PMID: 29745246
• Tanner JA, Prasad B, Claw KG, Stapleton P, Chaudhry A, Schuetz EG, Thummel KE, Tyndale RF. Predictors of Variation in CYP2A6 mRNA, Protein, and Enzyme Activity in a Human Liver Bank: Influence of Genetic and Nongenetic Factors. J Pharmacol Exp Ther. 2017 Jan;360(1):129-139. PubMed PMID: 27815364
• Claw KG, George RD, Swanson WJ. Detecting coevolution in mammalian sperm-egg fusion proteins. Mol Reprod Dev. 2014 Jun;81(6):531-8. PubMed PMID: 24644026
• Claw KG, Nashoba A. Indigenous diversity in Australia's DNA tapestry unlocked for genetic equity. Nature. 2023 Dec;624(7992):536-537. PubMed PMID: 38093045
• Wroblewski TH, Witt KE, Lee SB, Malhi RS, Peede D, Huerta-Sánchez E, Villanea FA, Claw KG. Pharmacogenetic Variation in Neanderthals and Denisovans and Implications for Human Health and Response to Medications. Genome Biol Evol. 2023 Dec 1;15(12). PubMed PMID: 38051947
• Maldonado BL, Piqué DG, Kaplan RC, Claw KG, Gignoux CR. Genetic risk prediction in Hispanics/Latinos: milestones, challenges, and social-ethical considerations. J Community Genet. 2023 Dec;14(6):543-553. PubMed PMID: 37962783
• Lasisi T, Claw KG, Fox K, Zaidi AA. Editorial: The ethics and challenges of studying the genetics of marginalized populations. Front Genet. 2023;14:1260457. PubMed PMID: 37674477
• Avey JP, Schaefer KR, Noonan CJ, Trinidad SB, Muller CJ, Claw KG, Dillard DA, Todd MR, Beans JA, Tyndale RF, Robinson RF, Thummel KE. Identification of Sociodemographic, Clinical, and Genetic Factors to Aid Alaska Native and American Indian People to Successfully Quit Smoking. Nicotine Tob Res. 2024 Jan 1;26(1):79-86. PubMed PMID: 37527452
• Claw KG, Swanson WJ. Evolution of the egg: new findings and challenges. Annu Rev Genomics Hum Genet. 2012;13:109-25. PubMed PMID: 22703177
• (6) National Academies of Sciences, Engineering, and Medicine. 2023. Using Population Descriptors in Genetics and Genomics Research: A New Framework for an Evolving Field. Washington, DC: The National Academies Press. https://doi.org/10.17226/26902.
• (7) American Society of Human Genetics. 2023. Facing Our History – Building an Equitable Future Initiative. url: https://www.ashg.org/wp-content/uploads/2023/01/Facing_Our_History-Building_an_Equitable_Future_Final_Report_January_2023.pdf
• Claw KG, Tito RY, Stone AC, Verrelli BC. Haplotype structure and divergence at human and chimpanzee serotonin transporter and receptor genes: implications for behavioral disorder association analyses. Mol Biol Evol. 2010 Jul;27(7):1518-29. PubMed PMID: 20118193
• Perry GH, Dominy NJ, Claw KG, Lee AS, Fiegler H, Redon R, Werner J, Villanea FA, Mountain JL, Misra R, Carter NP, Lee C, Stone AC. Diet and the evolution of human amylase gene copy number variation. Nat Genet. 2007 Oct;39(10):1256-60. PubMed PMID: 17828263

Professional Memberships

• ASHG, Member
• SACNAS, Lifetime member
• SMBE, Member
• AISES, member

Practice Locations

UCHealth Anschutz Outpatient Pavilion - Anschutz Medical Campus
1635 Aurora Ct
Aurora, CO 80045
720-848-0000