Jessica Christenson, PhD

Publications

• Rogers TJ, Christenson JL, Greene LI, O'Neill KI, Williams MM, Gordon MA, Nemkov T, D'Alessandro A, Degala GD, Shin J, Tan AC, Cittelly DM, Lambert JR, Richer JK. Reversal of Triple-Negative Breast Cancer EMT by miR-200c Decreases Tryptophan Catabolism and a Program of Immunosuppression. Mol Cancer Res. 2018 Sep 13. [Epub ahead of print] PubMed PMID: 30213797
• Greene LI, Bruno TC, Christenson JL, D'Alessandro A, Culp-Hill R, Torkko K, Borges VF, Slansky JE, Richer JK. A Role for Tryptophan-2,3-dioxygenase in CD8 T-cell Suppression and Evidence of Tryptophan Catabolism in Breast Cancer Patient Plasma. Mol Cancer Res. 2018 Aug 24. [Epub ahead of print] PubMed PMID: 30143553
• Christenson JL, Trepel JB, Ali HY, Lee S, Eisner JR, Baskin-Bey ES, Elias AD, Richer JK. Harnessing a Different Dependency: How to Identify and Target Androgen Receptor-Positive Versus Quadruple-Negative Breast Cancer. Horm Cancer. 2018 Apr;9(2):82-94. PubMed PMID: 29340907
• Smith LP, Bitler BG, Richer JK, Christenson JL (2019) Tryptophan catabolism in epithelial ovarian carcinoma. Trends in Cancer Research 14: 1-9.
• Beadnell T, Borriello L, Christenson JL, Fornetti J, Guldner I, Hanna A, Kyjacova L, Marinak-Whately K, de Melo Martins PC, Rotinen M, Te Boekhorst V, Cox T (2019) Meeting report: Metastasis Research Society 17th Biennial conference on metastasis. Clinical and Experimental Metastasis 36: 119-137. PMID: 30673912.
• Rosas E, Roberts JT, O’Neill K, Christenson JL, Williams MM, Hanamura T, Spoelstra NS, Vahrenkamp JM, Gertz J, Richer JK (2020) A positive feedback loop between TGFß and androgen receptor supports triple-negative breast cancer anoikis resistance. Endocrinology online ahead of print. PMID: 33294922.
• Williams MM, Spoelstra NS, Arnesen S, O'Neill KI, Christenson JL, Reese J, Torkko KC, Goodspeed A, Rosas E, Hanamura T, Sams SB, Li Z, Oesterreich S, Riggins RB, Jacobsen BM, Elias A, Gertz J, Richer JK (2020) Steroid hormone receptor and infiltrating immune cell status reveals therapeutic vulnerabilities of ESR1 mutant breast cancer. Cancer Research online ahead of print. PMID: 33184106.
• Christenson JL, O’Neill KI, Williams MM, Spoelstra N, Jones KL, Trahan GD, Reese JM, Van Patten E, Elias, AD, Eisner JR, Richer JK (2021) Activity of combined androgen receptor antagonism and cell cycle inhibition in androgen receptor-positive triple-negative breast cancer. Under review at Molecular Cancer Therapeutics.
• Williams MM, Hafeez SA, Christenson JL, O'Neill KI, Hammond NG, Richer JK. Reversing an Oncogenic Epithelial-to-Mesenchymal Transition Program in Breast Cancer Reveals Actionable Immune Suppressive Pathways. Pharmaceuticals (Basel). 2021 Nov 2;14(11). PubMed PMID: 34832904
• Hanamura T, Christenson JL, O'Neill KI, Rosas E, Spoelstra NS, Williams MM, Richer JK. Secreted indicators of androgen receptor activity in breast cancer pre-clinical models. Breast Cancer Res. 2021 Nov 4;23(1):102. PubMed PMID: 34736512
• Williams MM, Christenson JL, O'Neill KI, Hafeez SA, Ihle CL, Spoelstra NS, Slansky JE, Richer JK. MicroRNA-200c restoration reveals a cytokine profile to enhance M1 macrophage polarization in breast cancer. NPJ Breast Cancer. 2021 May 27;7(1):64. PubMed PMID: 34045467
• Christenson JL, O'Neill KI, Williams MM, Spoelstra NS, Jones KL, Trahan GD, Reese J, Van Patten ET, Elias A, Eisner JR, Richer JK. Activity of Combined Androgen Receptor Antagonism and Cell Cycle Inhibition in Androgen Receptor Positive Triple Negative Breast Cancer. Mol Cancer Ther. 2021 Jun;20(6):1062-1071. PubMed PMID: 33722849
• Rosas E, Roberts JT, O'Neill KI, Christenson JL, Williams MM, Hanamura T, Spoelstra NS, Vahrenkamp JM, Gertz J, Richer JK. A Positive Feedback Loop Between TGFß and Androgen Receptor Supports Triple-negative Breast Cancer Anoikis Resistance. Endocrinology. 2021 Feb 1;162(2). PubMed PMID: 33294922
• Williams MM, Spoelstra NS, Arnesen S, O'Neill KI, Christenson JL, Reese J, Torkko KC, Goodspeed A, Rosas E, Hanamura T, Sams SB, Li Z, Oesterreich S, Riggins RB, Jacobsen BM, Elias A, Gertz J, Richer JK. Steroid Hormone Receptor and Infiltrating Immune Cell Status Reveals Therapeutic Vulnerabilities of ESR1 -Mutant Breast Cancer. Cancer Res. 2021 Feb 1;81(3):732-746. PubMed PMID: 33184106
• Christenson JL, Williams MM, Richer JK. The underappreciated role of resident epithelial cell populations in metastatic progression: contributions of the lung alveolar epithelium. Am J Physiol Cell Physiol. 2022 Dec 1;323(6):C1777-C1790. PubMed PMID: 36252127
• Camp FA, Brunetti TM, Williams MM, Christenson JL, Sreekanth V, Costello JC, Hay ZLZ, Kedl RM, Richer JK, Slansky JE. Antigens expressed by breast cancer cells undergoing EMT stimulate cytotoxic CD8+ T cell immunity. Cancers (Basel). 2022 Sep 9;14(18). PubMed PMID: 36139558
• Fernandez NB, Sosa SM, Roberts JT, Recouvreux MS, Rocha-Viegas L, Christenson JL, Spoelstra NS, Couto FL, Raimondi AR, Richer JK, Rubinstein N. RUNX1 is regulated by androgen receptor to promote cancer stem markers and chemotherapy resistance in triple negative breast cancer. bioRxiv. 11.12.516193; doi: https://doi.org/10.1101/2022.11.12.516193.
• Fernández NB, Sosa SM, Roberts JT, Recouvreux MS, Rocha-Viegas L, Christenson JL, Spoelstra NS, Couto FL, Raimondi AR, Richer JK, Rubinstein N. RUNX1 Is Regulated by Androgen Receptor to Promote Cancer Stem Markers and Chemotherapy Resistance in Triple Negative Breast Cancer. Cells. 2023 Jan 29;12(3). PubMed PMID: 36766786
• Kuo LW, Crump L, O’Neill K, Williams M, Christenson J, Spoelstra N, Roy M, Argabright A, Reisz J, D’Alessandro A, Boorgula M, Goodspeed A, Bickerdike M, Bitler B, Richer J. Blocking tryptophan catabolism reduces triple-negative breast cancer invasive capacity. Cancer Research Communications 2024; 4: 2699-2713.
• Pham-Danis C, Chia SB, Scarborough HA, Danis E, Nemkov T, Zaberezhnyy V, Christenson JL, Kleczko EK, Navarro A, Goodspeed A, Bonney EA, Dinarello CA, Marchetti C, Nemenoff R, Hansen K, DeGregori J. Inflammation promotes aging-associated oncogenesis in the lung. Aging and Cancer 2024.