Eduardo Davila, PhD
Professor, Medicine-Medical Oncology

Publications

• Frontline chemoimmunotherapy with nivolumab and dose-adjusted EPOCH in peripheral T-cell lymphoma: a phase 1 trial. Haverkos B, Zain J, Kamdar M, Neuwelt A, Davila E, Bradeen X, Major A, Bair S, Jasem J, Smith C, Abbott D, Porcu P.
• Kent, A., Crump, L.S., and Davila, E. (2023). Beyond aß T cells: NK, iNKT, and ?dT cell biology in leukemic patients and potential for off-the-shelf adoptive cell therapies for AML. Frontiers in Immunology 14.
• Tobin, R.P., Cogswell, D.T., Cates, V.M., Davis, D.M., Borgers, J.S.W., Gulick, R.J.V., Katsnelson, E., Couts, K.L., Jordan, K.R., Gao, D.X., et al. (2023). Targeting MDSC Differentiation Using ATRA: A Phase I/II Clinical Trial Combining Pembrolizumab and All-Trans Retinoic Acid for Metastatic Melanoma. Clinical Cancer Research 29, 1209-1219.
• Tobin RP, Cogswell DT, Cates VM, Davis DM, Borgers JSW, Van Gulick RJ, Katsnelson E, Couts KL, Jordan KR, Gao D, Davila E, Medina TM, Lewis KD, Gonzalez R, McFarland RW, Robinson WA, McCarter MD. Targeting MDSC differentiation using ATRA: a phase I/II clinical trial combining pembrolizumab and all-trans retinoic acid for metastatic melanoma. Clin Cancer Res. 2022 Nov 15. [Epub ahead of print] PubMed PMID: 36378549
• Ciavattone NG, Wu L, O'Neill R, Qiu J, Davila E, Cao X. MyD88 Costimulation in Donor CD8( ) T Cells Enhances the Graft-versus-Tumor Effect in Murine Hematopoietic Cell Transplantation. J Immunol. 2021 Feb 15;206(4):892-903. PubMed PMID: 33408257
• Naturally Occurring Genetic Alterations in Proximal TCR Signaling and Implications for Cancer Immunotherapy Andrew Kent 1 2 3, Natalie V Longino 1 2 3 4, Allison Christians 1 2 3, Eduardo Davila 1 2 3 4 PMID: 34012443 PMCID: PMC8126620
• Soluble Sema4D in Plasma of Head and Neck Squamous Cell Carcinoma Patients Is Associated With Underlying Non-Inflamed Tumor Profile Rania H Younis 1 2 3, Ioana Ghita 1, Manar Elnaggar 1 3, Risa Chaisuparat 4, Vasileios Ionas Theofilou 1 5, Donita Dyalram 2 6, Robert A Ord 2 6, Eduardo Davila 7, Luke J Tallon 8, John C Papadimitriou 9, Tonya J Webb 2 10, Søren M Bentzen 2 11, Joshua E Lubek 2 6 PMID: 33776991 PMCID: PMC7991916
• MyD88 Costimulation in Donor CD8 + T Cells Enhances the Graft-versus-Tumor Effect in Murine Hematopoietic Cell Transplantation Nicholas G Ciavattone 1, Long Wu 1 2, Rachel O'Neill 1 2, Jingxin Qiu 3, Eduardo Davila 4, Xuefang Cao 5 2 PMID: 33408257 PMCID: PMC8691539
• Testing Cancer Immunotherapy in a Human Immune System Mouse Model: Correlating Treatment Responses to Human Chimerism, Therapeutic Variables and Immune Cell Phenotypes Juan A Marín-Jiménez 1, Anna Capasso 2, Matthew S Lewis 3, Stacey M Bagby 4, Sarah J Hartman 4, Jeremy Shulman 3, Natalie M Navarro 4, Hui Yu 4 5, Chris J Rivard 4 5, Xiaoguang Wang 3, Jessica C Barkow 3, Degui Geng 4, Adwitiya Kar 6, Ashley Yingst 7, Dejene M Tufa 7, James T Dolan 8, Patrick J Blatchford 9, Brian M Freed 3 10, Raul M Torres 3 5, Eduardo Davila 4 5, Jill E Slansky 3 5, Roberta Pelanda 3 5, S Gail Eckhardt 2, Wells A Messersmith 4 5, Jennifer R Diamond 4 5, Christopher H Lieu 4, Michael R Verneris 7, Jing H Wang 3 5, Katja Kiseljak-Vassiliades 5 6, Todd M Pitts 4 5, Julie Lang 3 PMID: 33854497 PMCID: PMC8040953
• Geng D, Ciavattone N, Lasola JJ, Shrestha R, Sanchez A, Guo J, Vlk A, Younis R, Wang L, Brown AJ, Zhang Y, Velasco-Gonzalez C, Tan AC, Davila E. Induction of IRAK-M in melanoma induces caspase-3 dependent apoptosis by reducing TRAF6 and calpastatin levels. Commun Biol. 2020 Jun 12;3(1):306. PubMed PMID: 32533049
• Guo J, Muse E, Christians AJ, Swanson SJ, Davila E. An Anticancer Drug Cocktail of Three Kinase Inhibitors Improved Response to a Dendritic Cell-Based Cancer Vaccine. Cancer Immunol Res. 2019 Sep;7(9):1523-1534. PubMed PMID: 31266784
• Suk Lee Y, Davila E, Zhang T, Milmoe HP, Vogel SN, Bromberg JS, Scalea JR. Myeloid-derived suppressor cells are bound and inhibited by anti-thymocyte globulin. Innate Immun. 2019 Jan;25(1):46-59. PubMed PMID: 30782043
• Connolly NP, Shetty AC, Stokum JA, Hoeschele I, Siegel MB, Miller CR, Kim AJ, Ho CY, Davila E, Simard JM, Devine SE, Rossmeisl JH, Holland EC, Winkles JA, Woodworth GF. Cross-species transcriptional analysis reveals conserved and host-specific neoplastic processes in mammalian glioma. Sci Rep. 2018 Jan 19;8(1):1180. PubMed PMID: 29352201
• Kapoor S, Natarajan K, Baldwin PR, Doshi KA, Lapidus RG, Mathias TJ, Scarpa M, Trotta R, Davila E, Kraus M, Huszar D, Tron AE, Perrotti D, Baer MR. Concurrent Inhibition of Pim and FLT3 Kinases Enhances Apoptosis of FLT3-ITD Acute Myeloid Leukemia Cells through Increased Mcl-1 Proteasomal Degradation. Clin Cancer Res. 2018 Jan 1;24(1):234-247. PubMed PMID: 29074603
• Scalea JR, Lee YS, Davila E, Bromberg JS. Myeloid-Derived Suppressor Cells and Their Potential Application in Transplantation. Transplantation. 2018 Mar;102(3):359-367. PubMed PMID: 29189485