Lisa Spencer, PhD

Department

Pediatrics-Gastroenterology, Hepatology and Nutrition

Professional Titles

Scientific Director, Gastrointestinal Eosinophilic Diseases Program

Publications

Dunn JLM, Spencer LA. Pathophysiology of Non-Esophageal Eosinophilic Gastrointestinal Disorders. Immunol Allergy Clin North Am. 2024 May;44(2):299-309. PubMed PMID: 38575225
Schworer SA, Olbrich CL, Larsen LD, Howard E, Liu L, Koyama K, Spencer LA. Notch 2 signaling contributes to intestinal eosinophil adaptations in steady-state and tissue burden following oral allergen challenge. J Leukoc Biol. 2024 May 24. [Epub ahead of print] PubMed PMID: 38789100
Khoury P, Roufosse F, Kuang FL, Ackerman SJ, Akuthota P, Bochner BS, Johansson MW, Mathur SK, Ogbogu PU, Spencer LA, Wechsler ME, Zimmermann N, Klion AD. Biologic Therapy in Rare Eosinophil-Associated Disorders: Remaining Questions and Translational Research Opportunities. J Leukoc Biol. 2024 Mar 8. [Epub ahead of print] PubMed PMID: 38457125
Shearn CT, Anderson AL, Devereaux MW, Koch SD, Larsen LD, Spencer LA, Orlicky DJ, Colgan SP, Steiner CA, Sokol RJ. Overexpression of TNFa in TNF?ARE /- mice increases hepatic periportal inflammation and alters bile acid signaling in mice. Hepatol Commun. 2024 Dec 1;8(12). PubMed PMID: 39585296
Wright BL, Abonia JP, Abud EM, Aceves SS, Ackerman SJ, Braskett M, Chang JW, Chehade M, Constantine GM, Davis CM, Dellon ES, Doyle AD, Durban R, Hill DA, Jensen ET, Kewalramani A, Khoury P, Klion AD, Kottyan L, Kuang FL, McGowan EC, Ruffner MA, Spencer LA, Spergel JM, Uchida AM, Wechsler JB, Pesek RD. Advances and ongoing challenges in eosinophilic gastrointestinal disorders presented at the CEGIR/TIGERs Symposium at the 2024 American Academy of Allergy, Asthma & Immunology meeting. J Allergy Clin Immunol. 2024 Oct;154(4):882-892. PubMed PMID: 39111348
Schworer SA, Olbrich CL, Larsen LD, Howard E, Liu L, Koyama K, Spencer LA. Notch 2 signaling contributes to intestinal eosinophil adaptations in steady state and tissue burden following oral allergen challenge. J Leukoc Biol. 2024 Jul 25;116(2):379-391. PubMed PMID: 38789100
Dunn JLM, Spencer LA. Pathophysiology of Non-Esophageal Eosinophilic Gastrointestinal Disorders. Immunol Allergy Clin North Am. 2024 May;44(2):299-309. PubMed PMID: 38575225
Khoury P, Roufosse F, Kuang FL, Ackerman SJ, Akuthota P, Bochner BS, Johansson MW, Mathur SK, Ogbogu PU, Spencer LA, Wechsler ME, Zimmermann N, Klion AD. Biologic therapy in rare eosinophil-associated disorders: remaining questions and translational research opportunities. J Leukoc Biol. 2024 Jul 25;116(2):307-320. PubMed PMID: 38457125
Menard-Katcher C, Liu C, Galbraith MD, Benson T, Burger C, Dobias D, Larsen L, O'Brien C, Spencer LA, Furuta GT, Masterson JC. Fibrostenotic eosinophilic esophagitis phenotype is defined by a proliferative gene signature. Allergy. 2023 Feb;78(2):579-583. PubMed PMID: 36273270
Quinn L, Nguyen B, Menard-Katcher C, Spencer L. IgG4 cells are increased in the gastrointestinal tissue of pediatric patients with active eosinophilic gastritis and duodenitis and decrease in remission. Dig Liver Dis. 2023 Jan;55(1):53-60. PubMed PMID: 36064648
Menard-Katcher C, Liu C, Galbraith MD, Benson T, Burger C, Dobias D, Larsen L, O'Brien C, Spencer LA, Furuta GT, Masterson JC. Fibrostenotic Eosinophilic Esophagitis phenotype is defined by a proliferative gene signature. Allergy. 2022 Oct 22. [Epub ahead of print] PubMed PMID: 36273270
Larsen LD, Dockstader K, Olbrich CL, Cartwright IM, Spencer LA. Modulation of surface CD11c expression tracks plasticity in murine intestinal tissue eosinophils. J Leukoc Biol. 2022 May;111(5):943-952. PubMed PMID: 35141942
Quinn L, Nguyen B, Menard-Katcher C, Spencer L. IgG4 cells are increased in the gastrointestinal tissue of pediatric patients with active eosinophilic gastritis and duodenitis and decrease in remission. Dig Liver Dis. 2022 Sep 2. [Epub ahead of print] PubMed PMID: 36064648
Masterson JC, Menard-Katcher C, Larsen LD, Furuta GT, Spencer LA. Heterogeneity of Intestinal Tissue Eosinophils: Potential Considerations for Next-Generation Eosinophil-Targeting Strategies. Cells. 2021 Feb 17;10(2). PubMed PMID: 33671475
Olbrich CL, Larsen LD, Spencer LA. Assessing Phenotypic Heterogeneity in Intestinal Tissue Eosinophils. Methods Mol Biol. 2021;2241:243-255. PubMed PMID: 33486741
Olbrich CL, Bivas-Benita M, Xenakis JJ, Maldonado S, Cornwell E, Fink J, Yuan Q, Gill N, Mansfield R, Dockstader K, Spencer LA. Remote allergen exposure elicits eosinophil infiltration into allergen nonexposed mucosal organs and primes for allergic inflammation. Mucosal Immunol. 2020 Sep;13(5):777-787. PubMed PMID: 32518365
Olbrich CL, Simerly L, de Zoeten EF, Furuta GT, Spencer LA. Climbing New Mountains: How Antibodies Blocking a4ß7 Integrins Tamed Eosinophilic Inflammation of the Intestinal Tract. Dig Dis Sci. 2019 Aug;64(8):2068-2071. PubMed PMID: 31273593
Ueki S, Miyabe Y, Yamamoto Y, Fukuchi M, Hirokawa M, Spencer LA, Weller PF. Charcot-Leyden Crystals in Eosinophilic Inflammation: Active Cytolysis Leads to Crystal Formation. Curr Allergy Asthma Rep. 2019 Jun 15;19(8):35. PubMed PMID: 31203469
Ueki S, Tokunaga T, Melo RCN, Saito H, Honda K, Fukuchi M, Konno Y, Takeda M, Yamamoto Y, Hirokawa M, Fujieda S, Spencer LA, Weller PF. Charcot-Leyden crystal formation is closely associated with eosinophil extracellular trap cell death. Blood. 2018 Nov 15;132(20):2183-2187. PubMed PMID: 30154112
Xenakis JJ, Howard ED, Smith KM, Olbrich CL, Huang Y, Anketell D, Maldonado S, Cornwell EW, Spencer LA. Resident intestinal eosinophils constitutively express antigen presentation markers and include two phenotypically distinct subsets of eosinophils. Immunology. 2018 Jun;154(2):298-308. PubMed PMID: 29281125
Khoury P, Akuthota P, Ackerman SJ, Arron JR, Bochner BS, Collins MH, Kahn JE, Fulkerson PC, Gleich GJ, Gopal-Srivastava R, Jacobsen EA, Leiferman KM, Francesca LS, Mathur SK, Minnicozzi M, Prussin C, Rothenberg ME, Roufosse F, Sable K, Simon D, Simon HU, Spencer LA, Steinfeld J, Wardlaw AJ, Wechsler ME, Weller PF, Klion AD. Revisiting the NIH Taskforce on the Research needs of Eosinophil-Associated Diseases (RE-TREAD). J Leukoc Biol. 2018 Jul;104(1):69-83. PubMed PMID: 29672914
Sallis BF, Erkert L, Moñino-Romero S, Acar U, Wu R, Konnikova L, Lexmond WS, Hamilton MJ, Dunn WA, Szepfalusi Z, Vanderhoof JA, Snapper SB, Turner JR, Goldsmith JD, Spencer LA, Nurko S, Fiebiger E. An algorithm for the classification of mRNA patterns in eosinophilic esophagitis: Integration of machine learning. J Allergy Clin Immunol. 2018 Apr;141(4):1354-1364.e9. PubMed PMID: 29273402
Weller PF, Spencer LA. Functions of tissue-resident eosinophils. Nat Rev Immunol. 2017 Dec;17(12):746-760. PubMed PMID: 28891557
Smith KM, Rahman RS, Spencer LA. Humoral Immunity Provides Resident Intestinal Eosinophils Access to Luminal Antigen via Eosinophil-Expressed Low-Affinity Fc? Receptors. J Immunol. 2016 Nov 1;197(9):3716-3724. PubMed PMID: 27683752
Ueki S, Tokunaga T, Fujieda S, Honda K, Hirokawa M, Spencer LA, Weller PF. Eosinophil ETosis and DNA Traps: a New Look at Eosinophilic Inflammation. Curr Allergy Asthma Rep. 2016 Jul;16(8):54. PubMed PMID: 27393701
Carmo LA, Bonjour K, Ueki S, Neves JS, Liu L, Spencer LA, Dvorak AM, Weller PF, Melo RC. CD63 is tightly associated with intracellular, secretory events chaperoning piecemeal degranulation and compound exocytosis in human eosinophils. J Leukoc Biol. 2016 Aug;100(2):391-401. PubMed PMID: 26965633
Liu LY, Wang H, Xenakis JJ, Spencer LA. Notch signaling mediates granulocyte-macrophage colony-stimulating factor priming-induced transendothelial migration of human eosinophils. Allergy. 2015 Jul;70(7):805-12. PubMed PMID: 25846339
Bettigole SE, Lis R, Adoro S, Lee AH, Spencer LA, Weller PF, Glimcher LH. The transcription factor XBP1 is selectively required for eosinophil differentiation. Nat Immunol. 2015 Aug;16(8):829-37. PubMed PMID: 26147683
Ueki S, Melo RC, Ghiran I, Spencer LA, Dvorak AM, Weller PF. Eosinophil extracellular DNA trap cell death mediates lytic release of free secretion-competent eosinophil granules in humans. Blood. 2013 Mar 14;121(11):2074-83. PubMed PMID: 23303825
Melo RC, Liu L, Xenakis JJ, Spencer LA. Eosinophil-derived cytokines in health and disease: unraveling novel mechanisms of selective secretion. Allergy. 2013 Mar;68(3):274-84. PubMed PMID: 23347072
Shamri R, Melo RC, Young KM, Bivas-Benita M, Xenakis JJ, Spencer LA, Weller PF. CCL11 elicits secretion of RNases from mouse eosinophils and their cell-free granules. FASEB J. 2012 May;26(5):2084-93. PubMed PMID: 22294786
Akuthota P, Melo RC, Spencer LA, Weller PF. MHC Class II and CD9 in human eosinophils localize to detergent-resistant membrane microdomains. Am J Respir Cell Mol Biol. 2012 Feb;46(2):188-95. PubMed PMID: 21885678
Shamri R, Xenakis JJ, Spencer LA. Eosinophils in innate immunity: an evolving story. Cell Tissue Res. 2011 Jan;343(1):57-83. PubMed PMID: 21042920
Spencer LA, Weller PF. Eosinophils and Th2 immunity: contemporary insights. Immunol Cell Biol. 2010 Mar-Apr;88(3):250-6. PubMed PMID: 20065995
Neves JS, Perez SA, Spencer LA, Melo RC, Weller PF. Subcellular fractionation of human eosinophils: isolation of functional specific granules on isoosmotic density gradients. J Immunol Methods. 2009 May 15;344(1):64-72. PubMed PMID: 19328806
Radke AL, Reynolds LE, Melo RC, Dvorak AM, Weller PF, Spencer LA. Mature human eosinophils express functional Notch ligands mediating eosinophil autocrine regulation. Blood. 2009 Mar 26;113(13):3092-101. PubMed PMID: 19171875
Melo RC, Spencer LA, Perez SA, Neves JS, Bafford SP, Morgan ES, Dvorak AM, Weller PF. Vesicle-mediated secretion of human eosinophil granule-derived major basic protein. Lab Invest. 2009 Jul;89(7):769-81. PubMed PMID: 19398958
Spencer LA, Szela CT, Perez SA, Kirchhoffer CL, Neves JS, Radke AL, Weller PF. Human eosinophils constitutively express multiple Th1, Th2, and immunoregulatory cytokines that are secreted rapidly and differentially. J Leukoc Biol. 2009 Jan;85(1):117-23. PubMed PMID: 18840671
Neves JS, Perez SA, Spencer LA, Melo RC, Reynolds L, Ghiran I, Mahmudi-Azer S, Odemuyiwa SO, Dvorak AM, Moqbel R, Weller PF. Eosinophil granules function extracellularly as receptor-mediated secretory organelles. Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18478-83. PubMed PMID: 19017810
Melo RC, Spencer LA, Dvorak AM, Weller PF. Mechanisms of eosinophil secretion: large vesiculotubular carriers mediate transport and release of granule-derived cytokines and other proteins. J Leukoc Biol. 2008 Feb;83(2):229-36. PubMed PMID: 17875811
Akuthota P, Wang HB, Spencer LA, Weller PF. Immunoregulatory roles of eosinophils: a new look at a familiar cell. Clin Exp Allergy. 2008 Aug;38(8):1254-63. PubMed PMID: 18727793
Spencer LA, Melo RC, Perez SA, Bafford SP, Dvorak AM, Weller PF. Cytokine receptor-mediated trafficking of preformed IL-4 in eosinophils identifies an innate immune mechanism of cytokine secretion. Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3333-8. PubMed PMID: 16492782
Melo RC, Perez SA, Spencer LA, Dvorak AM, Weller PF. Intragranular vesiculotubular compartments are involved in piecemeal degranulation by activated human eosinophils. Traffic. 2005 Oct;6(10):866-79. PubMed PMID: 16138901
Melo RC, Spencer LA, Perez SA, Ghiran I, Dvorak AM, Weller PF. Human eosinophils secrete preformed, granule-stored interleukin-4 through distinct vesicular compartments. Traffic. 2005 Nov;6(11):1047-57. PubMed PMID: 16190985
Spencer LA, Melo RC, Perez SA, Weller PF. A gel-based dual antibody capture and detection method for assaying of extracellular cytokine secretion: EliCell. Methods Mol Biol. 2005;302:297-314. PubMed PMID: 15937360
Spencer LA, Porte P, Zetoff C, Rajan TV. Mice genetically deficient in immunoglobulin E are more permissive hosts than wild-type mice to a primary, but not secondary, infection with the filarial nematode Brugia malayi. Infect Immun. 2003 May;71(5):2462-7. PubMed PMID: 12704117
Olbrich CL, Larsen LD, Spencer LA. Methods in Molecular Biology (Vol. 2241) GM Walsh (Ed); Springer, Chapter 19, Assessing Phenotypic Heterogeneity in Intestinal tissue Eosinophils.
Dunn ,JLM, Spencer LA. Pathophysiology of non-EoE EGIDs. Immunology and Allergy Clinics of North America. In Press.
Berdnikovs S, Spencer LA, and Lewkowich IP. Cytokines in Allergic Inflammation (Chapter 5). In: Middleton's Allergy, 10th edition, 2024.

View All (49 Total)

Professional Memberships

American Academy of Allergy, Asthma, and Immunology (AAAAI), Fellow
International Eosinophil Society, Secretary/Treasurer
Collegium Internationale Allergologicum (CIA), Inducted member
Society for Leukocyte Biology, Member

Public Speaking
Yes

Associate Professor, Pediatrics-Gastroenterology, Hepatology and Nutrition

Department

Professional Titles

Publications

Professional Memberships

School of Medicine

CU Anschutz

Fitzsimons Building