Lisa Spencer, PhD

Associate Professor, Pediatrics-Gastroenterology, Hepatology and Nutrition

FacultyPhoto

Professional Titles

  • Scientific Director, Gastrointestinal Eosinophilic Diseases Program

Publications

  • Dunn JLM, Spencer LA. Pathophysiology of Non-Esophageal Eosinophilic Gastrointestinal Disorders. Immunol Allergy Clin North Am. 2024 May;44(2):299-309. PubMed PMID: 38575225
  • Schworer SA, Olbrich CL, Larsen LD, Howard E, Liu L, Koyama K, Spencer LA. Notch 2 signaling contributes to intestinal eosinophil adaptations in steady-state and tissue burden following oral allergen challenge. J Leukoc Biol. 2024 May 24. [Epub ahead of print] PubMed PMID: 38789100
  • Khoury P, Roufosse F, Kuang FL, Ackerman SJ, Akuthota P, Bochner BS, Johansson MW, Mathur SK, Ogbogu PU, Spencer LA, Wechsler ME, Zimmermann N, Klion AD. Biologic Therapy in Rare Eosinophil-Associated Disorders: Remaining Questions and Translational Research Opportunities. J Leukoc Biol. 2024 Mar 8. [Epub ahead of print] PubMed PMID: 38457125
  • Shearn CT, Anderson AL, Devereaux MW, Koch SD, Larsen LD, Spencer LA, Orlicky DJ, Colgan SP, Steiner CA, Sokol RJ. Overexpression of TNFa in TNF?ARE /- mice increases hepatic periportal inflammation and alters bile acid signaling in mice. Hepatol Commun. 2024 Dec 1;8(12). PubMed PMID: 39585296
  • Wright BL, Abonia JP, Abud EM, Aceves SS, Ackerman SJ, Braskett M, Chang JW, Chehade M, Constantine GM, Davis CM, Dellon ES, Doyle AD, Durban R, Hill DA, Jensen ET, Kewalramani A, Khoury P, Klion AD, Kottyan L, Kuang FL, McGowan EC, Ruffner MA, Spencer LA, Spergel JM, Uchida AM, Wechsler JB, Pesek RD. Advances and ongoing challenges in eosinophilic gastrointestinal disorders presented at the CEGIR/TIGERs Symposium at the 2024 American Academy of Allergy, Asthma & Immunology meeting. J Allergy Clin Immunol. 2024 Oct;154(4):882-892. PubMed PMID: 39111348
  • Schworer SA, Olbrich CL, Larsen LD, Howard E, Liu L, Koyama K, Spencer LA. Notch 2 signaling contributes to intestinal eosinophil adaptations in steady state and tissue burden following oral allergen challenge. J Leukoc Biol. 2024 Jul 25;116(2):379-391. PubMed PMID: 38789100
  • Dunn JLM, Spencer LA. Pathophysiology of Non-Esophageal Eosinophilic Gastrointestinal Disorders. Immunol Allergy Clin North Am. 2024 May;44(2):299-309. PubMed PMID: 38575225
  • Khoury P, Roufosse F, Kuang FL, Ackerman SJ, Akuthota P, Bochner BS, Johansson MW, Mathur SK, Ogbogu PU, Spencer LA, Wechsler ME, Zimmermann N, Klion AD. Biologic therapy in rare eosinophil-associated disorders: remaining questions and translational research opportunities. J Leukoc Biol. 2024 Jul 25;116(2):307-320. PubMed PMID: 38457125
  • Quinn L, Nguyen B, Menard-Katcher C, Spencer L. IgG4 cells are increased in the gastrointestinal tissue of pediatric patients with active eosinophilic gastritis and duodenitis and decrease in remission. Dig Liver Dis. 2023 Jan;55(1):53-60. PubMed PMID: 36064648
  • Menard-Katcher C, Liu C, Galbraith MD, Benson T, Burger C, Dobias D, Larsen L, O'Brien C, Spencer LA, Furuta GT, Masterson JC. Fibrostenotic eosinophilic esophagitis phenotype is defined by a proliferative gene signature. Allergy. 2023 Feb;78(2):579-583. PubMed PMID: 36273270
  • Menard-Katcher C, Liu C, Galbraith MD, Benson T, Burger C, Dobias D, Larsen L, O'Brien C, Spencer LA, Furuta GT, Masterson JC. Fibrostenotic Eosinophilic Esophagitis phenotype is defined by a proliferative gene signature. Allergy. 2022 Oct 22. [Epub ahead of print] PubMed PMID: 36273270
  • Larsen LD, Dockstader K, Olbrich CL, Cartwright IM, Spencer LA. Modulation of surface CD11c expression tracks plasticity in murine intestinal tissue eosinophils. J Leukoc Biol. 2022 May;111(5):943-952. PubMed PMID: 35141942
  • Quinn L, Nguyen B, Menard-Katcher C, Spencer L. IgG4 cells are increased in the gastrointestinal tissue of pediatric patients with active eosinophilic gastritis and duodenitis and decrease in remission. Dig Liver Dis. 2022 Sep 2. [Epub ahead of print] PubMed PMID: 36064648
  • Masterson JC, Menard-Katcher C, Larsen LD, Furuta GT, Spencer LA. Heterogeneity of Intestinal Tissue Eosinophils: Potential Considerations for Next-Generation Eosinophil-Targeting Strategies. Cells. 2021 Feb 17;10(2). PubMed PMID: 33671475
  • Olbrich CL, Larsen LD, Spencer LA. Assessing Phenotypic Heterogeneity in Intestinal Tissue Eosinophils. Methods Mol Biol. 2021;2241:243-255. PubMed PMID: 33486741
  • Olbrich CL, Bivas-Benita M, Xenakis JJ, Maldonado S, Cornwell E, Fink J, Yuan Q, Gill N, Mansfield R, Dockstader K, Spencer LA. Remote allergen exposure elicits eosinophil infiltration into allergen nonexposed mucosal organs and primes for allergic inflammation. Mucosal Immunol. 2020 Sep;13(5):777-787. PubMed PMID: 32518365
  • Olbrich CL, Simerly L, de Zoeten EF, Furuta GT, Spencer LA. Climbing New Mountains: How Antibodies Blocking a4ß7 Integrins Tamed Eosinophilic Inflammation of the Intestinal Tract. Dig Dis Sci. 2019 Aug;64(8):2068-2071. PubMed PMID: 31273593
  • Ueki S, Miyabe Y, Yamamoto Y, Fukuchi M, Hirokawa M, Spencer LA, Weller PF. Charcot-Leyden Crystals in Eosinophilic Inflammation: Active Cytolysis Leads to Crystal Formation. Curr Allergy Asthma Rep. 2019 Jun 15;19(8):35. PubMed PMID: 31203469
  • Ueki S, Tokunaga T, Melo RCN, Saito H, Honda K, Fukuchi M, Konno Y, Takeda M, Yamamoto Y, Hirokawa M, Fujieda S, Spencer LA, Weller PF. Charcot-Leyden crystal formation is closely associated with eosinophil extracellular trap cell death. Blood. 2018 Nov 15;132(20):2183-2187. PubMed PMID: 30154112
  • Xenakis JJ, Howard ED, Smith KM, Olbrich CL, Huang Y, Anketell D, Maldonado S, Cornwell EW, Spencer LA. Resident intestinal eosinophils constitutively express antigen presentation markers and include two phenotypically distinct subsets of eosinophils. Immunology. 2018 Jun;154(2):298-308. PubMed PMID: 29281125
  • Khoury P, Akuthota P, Ackerman SJ, Arron JR, Bochner BS, Collins MH, Kahn JE, Fulkerson PC, Gleich GJ, Gopal-Srivastava R, Jacobsen EA, Leiferman KM, Francesca LS, Mathur SK, Minnicozzi M, Prussin C, Rothenberg ME, Roufosse F, Sable K, Simon D, Simon HU, Spencer LA, Steinfeld J, Wardlaw AJ, Wechsler ME, Weller PF, Klion AD. Revisiting the NIH Taskforce on the Research needs of Eosinophil-Associated Diseases (RE-TREAD). J Leukoc Biol. 2018 Jul;104(1):69-83. PubMed PMID: 29672914
  • Sallis BF, Erkert L, Moñino-Romero S, Acar U, Wu R, Konnikova L, Lexmond WS, Hamilton MJ, Dunn WA, Szepfalusi Z, Vanderhoof JA, Snapper SB, Turner JR, Goldsmith JD, Spencer LA, Nurko S, Fiebiger E. An algorithm for the classification of mRNA patterns in eosinophilic esophagitis: Integration of machine learning. J Allergy Clin Immunol. 2018 Apr;141(4):1354-1364.e9. PubMed PMID: 29273402
  • Weller PF, Spencer LA. Functions of tissue-resident eosinophils. Nat Rev Immunol. 2017 Dec;17(12):746-760. PubMed PMID: 28891557
  • Smith KM, Rahman RS, Spencer LA. Humoral Immunity Provides Resident Intestinal Eosinophils Access to Luminal Antigen via Eosinophil-Expressed Low-Affinity Fc? Receptors. J Immunol. 2016 Nov 1;197(9):3716-3724. PubMed PMID: 27683752
  • Ueki S, Tokunaga T, Fujieda S, Honda K, Hirokawa M, Spencer LA, Weller PF. Eosinophil ETosis and DNA Traps: a New Look at Eosinophilic Inflammation. Curr Allergy Asthma Rep. 2016 Jul;16(8):54. PubMed PMID: 27393701
  • Carmo LA, Bonjour K, Ueki S, Neves JS, Liu L, Spencer LA, Dvorak AM, Weller PF, Melo RC. CD63 is tightly associated with intracellular, secretory events chaperoning piecemeal degranulation and compound exocytosis in human eosinophils. J Leukoc Biol. 2016 Aug;100(2):391-401. PubMed PMID: 26965633
  • Liu LY, Wang H, Xenakis JJ, Spencer LA. Notch signaling mediates granulocyte-macrophage colony-stimulating factor priming-induced transendothelial migration of human eosinophils. Allergy. 2015 Jul;70(7):805-12. PubMed PMID: 25846339
  • Bettigole SE, Lis R, Adoro S, Lee AH, Spencer LA, Weller PF, Glimcher LH. The transcription factor XBP1 is selectively required for eosinophil differentiation. Nat Immunol. 2015 Aug;16(8):829-37. PubMed PMID: 26147683
  • Ueki S, Melo RC, Ghiran I, Spencer LA, Dvorak AM, Weller PF. Eosinophil extracellular DNA trap cell death mediates lytic release of free secretion-competent eosinophil granules in humans. Blood. 2013 Mar 14;121(11):2074-83. PubMed PMID: 23303825
  • Melo RC, Liu L, Xenakis JJ, Spencer LA. Eosinophil-derived cytokines in health and disease: unraveling novel mechanisms of selective secretion. Allergy. 2013 Mar;68(3):274-84. PubMed PMID: 23347072
  • Shamri R, Melo RC, Young KM, Bivas-Benita M, Xenakis JJ, Spencer LA, Weller PF. CCL11 elicits secretion of RNases from mouse eosinophils and their cell-free granules. FASEB J. 2012 May;26(5):2084-93. PubMed PMID: 22294786
  • Akuthota P, Melo RC, Spencer LA, Weller PF. MHC Class II and CD9 in human eosinophils localize to detergent-resistant membrane microdomains. Am J Respir Cell Mol Biol. 2012 Feb;46(2):188-95. PubMed PMID: 21885678
  • Shamri R, Xenakis JJ, Spencer LA. Eosinophils in innate immunity: an evolving story. Cell Tissue Res. 2011 Jan;343(1):57-83. PubMed PMID: 21042920
  • Spencer LA, Weller PF. Eosinophils and Th2 immunity: contemporary insights. Immunol Cell Biol. 2010 Mar-Apr;88(3):250-6. PubMed PMID: 20065995
  • Neves JS, Perez SA, Spencer LA, Melo RC, Weller PF. Subcellular fractionation of human eosinophils: isolation of functional specific granules on isoosmotic density gradients. J Immunol Methods. 2009 May 15;344(1):64-72. PubMed PMID: 19328806
  • Radke AL, Reynolds LE, Melo RC, Dvorak AM, Weller PF, Spencer LA. Mature human eosinophils express functional Notch ligands mediating eosinophil autocrine regulation. Blood. 2009 Mar 26;113(13):3092-101. PubMed PMID: 19171875
  • Melo RC, Spencer LA, Perez SA, Neves JS, Bafford SP, Morgan ES, Dvorak AM, Weller PF. Vesicle-mediated secretion of human eosinophil granule-derived major basic protein. Lab Invest. 2009 Jul;89(7):769-81. PubMed PMID: 19398958
  • Spencer LA, Szela CT, Perez SA, Kirchhoffer CL, Neves JS, Radke AL, Weller PF. Human eosinophils constitutively express multiple Th1, Th2, and immunoregulatory cytokines that are secreted rapidly and differentially. J Leukoc Biol. 2009 Jan;85(1):117-23. PubMed PMID: 18840671
  • Neves JS, Perez SA, Spencer LA, Melo RC, Reynolds L, Ghiran I, Mahmudi-Azer S, Odemuyiwa SO, Dvorak AM, Moqbel R, Weller PF. Eosinophil granules function extracellularly as receptor-mediated secretory organelles. Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18478-83. PubMed PMID: 19017810
  • Melo RC, Spencer LA, Dvorak AM, Weller PF. Mechanisms of eosinophil secretion: large vesiculotubular carriers mediate transport and release of granule-derived cytokines and other proteins. J Leukoc Biol. 2008 Feb;83(2):229-36. PubMed PMID: 17875811
  • Akuthota P, Wang HB, Spencer LA, Weller PF. Immunoregulatory roles of eosinophils: a new look at a familiar cell. Clin Exp Allergy. 2008 Aug;38(8):1254-63. PubMed PMID: 18727793
  • Spencer LA, Melo RC, Perez SA, Bafford SP, Dvorak AM, Weller PF. Cytokine receptor-mediated trafficking of preformed IL-4 in eosinophils identifies an innate immune mechanism of cytokine secretion. Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3333-8. PubMed PMID: 16492782
  • Melo RC, Perez SA, Spencer LA, Dvorak AM, Weller PF. Intragranular vesiculotubular compartments are involved in piecemeal degranulation by activated human eosinophils. Traffic. 2005 Oct;6(10):866-79. PubMed PMID: 16138901
  • Melo RC, Spencer LA, Perez SA, Ghiran I, Dvorak AM, Weller PF. Human eosinophils secrete preformed, granule-stored interleukin-4 through distinct vesicular compartments. Traffic. 2005 Nov;6(11):1047-57. PubMed PMID: 16190985
  • Spencer LA, Melo RC, Perez SA, Weller PF. A gel-based dual antibody capture and detection method for assaying of extracellular cytokine secretion: EliCell. Methods Mol Biol. 2005;302:297-314. PubMed PMID: 15937360
  • Spencer LA, Porte P, Zetoff C, Rajan TV. Mice genetically deficient in immunoglobulin E are more permissive hosts than wild-type mice to a primary, but not secondary, infection with the filarial nematode Brugia malayi. Infect Immun. 2003 May;71(5):2462-7. PubMed PMID: 12704117
  • Olbrich CL, Larsen LD, Spencer LA. Methods in Molecular Biology (Vol. 2241) GM Walsh (Ed); Springer, Chapter 19, Assessing Phenotypic Heterogeneity in Intestinal tissue Eosinophils.
  • Berdnikovs S, Spencer LA, and Lewkowich IP. Cytokines in Allergic Inflammation (Chapter 5). In: Middleton's Allergy, 10th edition, 2024.
  • Dunn ,JLM, Spencer LA. Pathophysiology of non-EoE EGIDs. Immunology and Allergy Clinics of North America. In Press.

Professional Memberships

  • American Academy of Allergy, Asthma, and Immunology (AAAAI), Fellow
  • International Eosinophil Society, Secretary/Treasurer
  • Collegium Internationale Allergologicum (CIA), Inducted member
  • Society for Leukocyte Biology, Member
Public Speaking
Yes



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