Bradford Siegele, MD, JD

Professional Titles

• Assistant Professor

Recognitions

• Robert H. Fennell, Jr., M.D. Award for Excellence in Education, University of Colorado Department of Pathology (2016)

Research Interests

My research interests are primarily focused on characterizing and investigating tools for diagnosis of pediatric, adolescent/young adult, and adult leukemias and lymphomas.

Publications

• Iyasere CA, Takvorian RW, Simeone FJ, Siegele BJ. Case 28-2018: A 39-Year-Old Man with Epistaxis, Pain and Erythema of the Forearm, and Pancytopenia. N Engl J Med. 2018 Sep 13;379(11):1072-1081. PubMed PMID: 30207921
• Martin D, Degese MS, Vitale-Cross L, Iglesias-Bartolome R, Valera JLC, Wang Z, Feng X, Yeerna H, Vadmal V, Moroishi T, Thorne RF, Zaida M, Siegele B, Cheong SC, Molinolo AA, Samuels Y, Tamayo P, Guan KL, Lippman SM, Lyons JG, Gutkind JS. Assembly and activation of the Hippo signalome by FAT1 tumor suppressor. Nat Commun. 2018 Jul 9;9(1):2372. PubMed PMID: 29985391
• Siegele BJ, Nardi V. Laboratory testing in BCR-ABL1-like (Philadelphia-like) B-lymphoblastic leukemia/lymphoma. Am J Hematol. 2018 Jul;93(7):971-977. PubMed PMID: 29696694
• Rosenblatt SD, Wolter NE, Siegele B, Brodsky JR. Primary parotid lymphoma presenting as a recurrent cystic mass: A case report. Laryngoscope. 2018 Apr;128(4):998-1001. PubMed PMID: 28771798
• Winters AC, Gutman JA, Purev E, Nakic M, Tobin J, Chase S, Kaiser J, Lyle L, Boggs C, Halsema K, Schowinsky JT, Rosser J, Ewalt MD, Siegele B, Rana V, Schuster S, Abbott D, Stevens BM, Jordan CT, Smith C, Pollyea DA. Real-world experience of venetoclax with azacitidine for untreated patients with acute myeloid leukemia. Blood Adv. 2019 Oct 22;3(20):2911-2919. PubMed PMID: 31648312
• Myers, KC, Furutani, E, Weller, E, Siegele, B., Galvin, A, Arsenault, V, Alter, B, Boulad, F, Bueso-Ramos, C, Burroughs, L, Castillo, P, Connelly, J, Davies, S, DiNardo, C, Hanif, I, Ho, R, Karras, N, Manalang, M, McReynolds, L, Nakano, T, Nalepa, G, Norkin, M, Oberley, M, Orgel, E, Pastore, Y, Rosenthal, J, Walkovich, K, Larson, J, Malsch, M, Elghetany, T, Fleming, M, Shimamura, A. Clinical Features and Outcomes of Myeloid Malignancies in Shwachman-Diamond Syndrome. Lancet Haematology.
• Myers KC, Furutani E, Weller E, Siegele B, Galvin A, Arsenault V, Alter BP, Boulad F, Bueso-Ramos C, Burroughs L, Castillo P, Connelly J, Davies SM, DiNardo CD, Hanif I, Ho RH, Karras N, Manalang M, McReynolds LJ, Nakano TA, Nalepa G, Norkin M, Oberley MJ, Orgel E, Pastore YD, Rosenthal J, Walkovich K, Larson J, Malsch M, Elghetany MT, Fleming MD, Shimamura A. Clinical features and outcomes of patients with Shwachman-Diamond syndrome and myelodysplastic syndrome or acute myeloid leukaemia: a multicentre, retrospective, cohort study. Lancet Haematol. 2020 Mar;7(3):e238-e246. PubMed PMID: 31879230
• PTEN Hamartoma Tumor Syndrome Presenting as Isolated Soft Tissue Vascular Anomalies. J Vasc. Anomalies. 2021;2(2):e011.
• Blades CM, Mason AC, Kulungowski AM, Annam A, Duis J, Bruckner AL, Siegele BJ, Hill LRS, Nakano TA. Atypical PIK3CA Positive Hemangioma Refractory to Propranolol. Journal of Vascular Anomalies (2022), 3(3), e044.
• Rankin AW, Siegele B, Gross TG. Discordance between detection of MYC rearrangement by immunohistochemistry versus fluorescent in situ hybridization in Burkitt lymphoma. Pediatr Blood Cancer. 2022 Dec;69(12):e29804. PubMed PMID: 35670760
• Ramos-Gonzalez G, Crum R, Allain A, Agur T, O'Melia L, Staffa S, Burchett SK, Siegele B, Weinberg O, Rodig NM, Fawaz R, Singh TP, Freiberger DA, Bae Kim H. Presentation and outcomes of post-transplant lymphoproliferative disorder at a single institution pediatric transplant center. Pediatr Transplant. 2022 Aug;26(5):e14268. PubMed PMID: 35304794
• Siegele BJ, Stemmer-Rachamimov AO, Lilljebjorn H, Fioretos T, Winters AC, Dal Cin P, Treece A, Gaskell A, Nardi V. N-terminus DUX4-immunohistochemistry is a reliable methodology for the diagnosis of DUX4-fused B-lymphoblastic leukemia/lymphoma (N-terminus DUX4 IHC for DUX4-fused B-ALL). Genes Chromosomes Cancer. 2022 Aug;61(8):449-458. PubMed PMID: 35218117
• Bishop JA, Thompson LDR, Siegele B, Gagan J, Mansour M, Chernock RD, Rooper LM. Mucoepidermoid carcinoma may be devoid of squamoid cells by immunohistochemistry: expanding the histologic and immunohistochemical spectrum of MAML2- rearranged salivary gland tumours. Histopathology. 2023 Jan;82(2):305-313. PubMed PMID: 36208053
• Quinn, LA, Plost, GR, Siegele, B, Feldman, AG, de Zoeten, E. “Inflammatory Bowel Disease Presenting With Retiform Purpura.” JPGN Reports. 2022, 3(3) e232.
• Diagnostic Pediatric Pathology: Hematopoietic and Histiocytic Disorders
• Bishop JA, Thompson LDR, Siegele B, Gagan J, Mansour M, Chernock RD, Rooper LM. Mucoepidermoid carcinoma may be devoid of squamoid cells by immunohistochemistry: expanding the histologic and immunohistochemical spectrum of MAML2- rearranged salivary gland tumours. Histopathology. 2023 Jan;82(2):305-313. PubMed PMID: 36208053
• Winters AC, Minhajuddin M, Stevens BM, Major A, Bosma G, Abbott D, Miltgen N, Yuan J, Treece AL, Siegele BJ, Ewalt MD, Gutman JA, Jordan CT, Pollyea DA. Multi-gene measurable residual disease assessed by digital polymerase chain reaction has clinical and biological utility in acute myeloid leukemia patients receiving venetoclax/azacitidine. Haematologica. 2023 Dec 14. [Epub ahead of print] PubMed PMID: 38105738

Professional Memberships

• Society for Pediatric Pathology, Member
• College of American Pathologists, Member
• American Society for Clinical Pathology, Member

Practice Locations

UCHealth Anschutz Inpatient Pavilion - Anschutz Medical Campus
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

Children's Hospital Colorado Anschutz Medical Campus
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hospital Affiliation

• University of Colorado Hospital
• Children's Hospital Colorado

Specialty Information

Specialties

• Anatomic and Clinical, Board Certification (2016)
• Pediatric Pathology, Board Certification (2017)
• Hematology, Board Certification (2018)

Conditions & Treatments

• Cancers - Leukemia (Adult Acute)
• Cancers
• Cancers - Leukemia (Adult Chronic)
• Cancers - Leukemia (Childhood)
• Cancers - Lymphoma
• Cancers - Myelodysplastic Syndrome
• Cancers - Myeloma
• Cancers - Pediatric Cancer
• Cancers - Sarcoma
• Cancers - Cancer Pathology
• Cancers - Aplastic Anemia
• Blood / Lymphatic System
• Child and Teen Health - Pediatric Diseases and Conditions
• Child and Teen Health
• Child and Teen Health - Teen Health