Zhirui Wang, PhD

Publications

• Wang Z, Louras NJ, Lellouch AG, Pratts SG, Zhang H, Wang H, Huang CA, Cetrulo CL Jr, Madsen JC, Sachs DH, Wang Z. Dosing optimization of CCR4 immunotoxin for improved depletion of CCR4( ) Treg in nonhuman primates. Mol Oncol. 2018 Aug;12(8):1374-1382. PubMed PMID: 29873181
• Navarro-Alvarez N, Goncalves B, Andrews AR, Wang Z, Wang Z, Harrington E, Shah J, Sachs DH, Eliaz I, Huang CA. The effects of galectin-3 depletion apheresis on induced skin inflammation in a porcine model. J Clin Apher. 2018 Aug;33(4):486-493. PubMed PMID: 29572917
• Fan X, Wang P, Sun Y, Jiang J, Du H, Wang Z, Duan Z, Lei H, Li H. Induction of apoptosis by an oleanolic acid derivative in SMMC-7721 human hepatocellular carcinoma cells is associated with mitochondrial dysfunction. Oncol Lett. 2018 Mar;15(3):2821-2828. PubMed PMID: 29467861
• Wang Z, Huang CA. A PD-1-specific toxin suppresses autoimmunity. Nat Biomed Eng. 2019 Apr;3(4):253-254. PubMed PMID: 30952985
• Fan K, Du W, Wang Z, Khan A, Li H, Jiang J. Anti-Invasion and Antimetastatic Effects of Porcine Recombinant NK-lysin on SMMC-7721 Human Hepatocellular Carcinoma Cells. Biomed Res Int. 2019;2019:5318729. PubMed PMID: 31119174
• Navarro-Alvarez N, Goncalves B, Andrews AR, Wang Z, Wang Z, Harrington E, Shah J, Sachs DH, Eliaz I, Huang CA. The effects of galectin-3 depletion apheresis on induced skin inflammation in a porcine model. J Clin Apher. 2018 Aug;33(4):486-493. PubMed PMID: 29572917
• Fan X, Wang P, Sun Y, Jiang J, Du H, Wang Z, Duan Z, Lei H, Li H. Induction of apoptosis by an oleanolic acid derivative in SMMC-7721 human hepatocellular carcinoma cells is associated with mitochondrial dysfunction. Oncol Lett. 2018 Mar;15(3):2821-2828. PubMed PMID: 29467861
• Wang Z, Louras NJ, Lellouch AG, Pratts SG, Zhang H, Wang H, Huang CA, Cetrulo CL Jr, Madsen JC, Sachs DH, Wang Z. Dosing optimization of CCR4 immunotoxin for improved depletion of CCR4( ) Treg in nonhuman primates. Mol Oncol. 2018 Aug;12(8):1374-1382. PubMed PMID: 29873181
• Sivanandham R, Kleinman AJ, Sette P, Brocca-Cofano E, Kilapandal Venkatraman SM, Policicchio BB, He T, Xu C, Swarthout J, Wang Z, Pandrea I, Apetrei C. Nonhuman Primate Testing of the Impact of Different Regulatory T Cell Depletion Strategies on Reactivation and Clearance of Latent Simian Immunodeficiency Virus. J Virol. 2020 Sep 15;94(19). PubMed PMID: 32669326
• Wang H, Wang Z, Zhang H, Qi Z, Johnson AC, Mathes D, Pomfret EA, Rubin E, Huang CA, Wang Z. Bispecific human IL2-CCR4 immunotoxin targets human cutaneous T-cell lymphoma. Mol Oncol. 2020 May;14(5):991-1000. PubMed PMID: 32107846
• Fan K, Du W, Wang Z, Khan A, Li H, Jiang J. Anti-Invasion and Antimetastatic Effects of Porcine Recombinant NK-lysin on SMMC-7721 Human Hepatocellular Carcinoma Cells. Biomed Res Int. 2019;2019:5318729. PubMed PMID: 31119174
• Wang Z, Huang CA. A PD-1-specific toxin suppresses autoimmunity. Nat Biomed Eng. 2019 Apr;3(4):253-254. PubMed PMID: 30952985
• Qi Z, Qiu Y, Wang Z, Zhang H, Lu L, Liu Y, Mathes D, Pomfret EA, Gao D, Lu SL, Wang Z. A novel diphtheria toxin-based bivalent human EGF fusion toxin for treatment of head and neck squamous cell carcinoma. Mol Oncol. 2021 Apr;15(4):1054-1068. PubMed PMID: 33540470
• Chang XX, Fan K, Meng W, Guo J, Zhao D, Yin W, Li H, Wang Z. Truncated Diphtheria Toxin DT390 Enhances the Humoral Immunogenicity of Porcine Circovirus Type 2 Capsid Antigen in Mice. Viral Immunol. 2021 Sep;34(7):448-456. PubMed PMID: 33902339
• Kim S, Shukla RK, Yu H, Baek A, Cressman SG, Golconda S, Lee GE, Choi H, Reneau JC, Wang Z, Huang CA, Liyanage NPM, Kim S. CD3e-immunotoxin spares CD62L(lo) Tregs and reshapes organ-specific T-cell composition by preferentially depleting CD3e(hi) T cells. Front Immunol. 2022;13:1011190. PubMed PMID: 36389741
• Zhong Q, Sun Y, Khan A, Guo J, Wang Z, Sun N, Li H. 4,7-Didehydro-neophysalin B Protects Rat Lung Epithelial Cells against Hydrogen Peroxide-Induced Oxidative Damage through Nrf2-Mediated Signaling Pathway. Oxid Med Cell Longev. 2022;2022:4189083. PubMed PMID: 36132230
• Kim S, Shukla RK, Kim E, Cressman SG, Yu H, Baek A, Choi H, Kim A, Sharma A, Wang Z, Huang CA, Reneau JC, Boyaka PN, Liyanage NPM, Kim S. Comparison of CD3e Antibody and CD3e-sZAP Immunotoxin Treatment in Mice Identifies sZAP as the Main Driver of Vascular Leakage. Biomedicines. 2022 May 24;10(6). PubMed PMID: 35740248
• Chang XX, Fan K, Meng W, Guo J, Zhao D, Yin W, Li H, Wang Z. Truncated Diphtheria Toxin DT390 Enhances the Humoral Immunogenicity of Porcine Circovirus Type 2 Capsid Antigen in Mice. Viral Immunol. 2021 Sep;34(7):448-456. PubMed PMID: 33902339
• Qi Z, Qiu Y, Wang Z, Zhang H, Lu L, Liu Y, Mathes D, Pomfret EA, Gao D, Lu SL, Wang Z. A novel diphtheria toxin-based bivalent human EGF fusion toxin for treatment of head and neck squamous cell carcinoma. Mol Oncol. 2021 Apr;15(4):1054-1068. PubMed PMID: 33540470
• Yue Qiu, Zeng Qi, Zhaohui Wang, Yu Cao, Ling Lu, Huiping Zhang, David Mathes, Elizabeth A. Pomfret, Shi-Long Lu and Zhirui Wang (2022) EGF-IL2 bispecific and bivalent EGF fusion toxin efficacy against syngeneic head and neck cancer mouse models. Accepted by ONCOLOGY REPORTS. 
• Wang Z, Ramakrishna R, Wang Y, Qiu Y, Ma J, Mintzlaff D, Zhang H, Li B, Hammell B, Lucia MS, Pomfret E, Su AA, Washington KM, Mathes DW, Wang Z. Toxicology, pharmacokinetics, and immunogenicity studies of CCR4-IL2 bispecific immunotoxin in rats and minipigs. Eur J Pharmacol. 2024 Apr 5;968:176408. PubMed PMID: 38367684
• Ma J, Wang Z, Mintzlaff D, Zhang H, Ramakrishna R, Davila E, Witkowski MT, Lucia MS, Schwartz MS, Pomfret EA, Mathes DW, Wang Z. Bivalent CD47 Immunotoxin for Targeted Therapy of T-Cell Acute Lymphoblastic Leukemia. Blood. 2024.
• Wang Z, Ma J, Zhang H, Ramakrishna R, Mintzlaff D, Mathes DW, Pomfret EA, Lucia MS, Gao D, Haverkos BM, Wang Z. CCR4-IL2 bispecific immunotoxin is more effective than brentuximab for targeted therapy of cutaneous T-cell lymphoma in a mouse CTCL model. FEBS Open Bio. 2023 Jul;13(7):1309-1319. PubMed PMID: 37157185
• Qiu Y, Qi Z, Wang Z, Cao Y, Lu L, Zhang H, Mathes D, Pomfret EA, Lu SL, Wang Z. EGF-IL2 bispecific and bivalent EGF fusion toxin efficacy against syngeneic head and neck cancer mouse models. Oncol Rep. 2023 Feb;49(2). PubMed PMID: 36579667