Ming-Feng Tsai, PhD

Professional Titles

• Assistant Professor

Publications

• Quantitative assays to measure the transport activity of the mitochondrial calcium uniporter in cell lines or Xenopus oocytes. Rodriguez MX, Van Keuren AM, Tsai MF. STAR Protocols. 2: 100979 (2021).
• Tsai CW, Wu Y, Pao PC, Phillips CB, Williams C, Miller C, Ranaghan M, Tsai MF. Proteolytic control of the mitochondrial calcium uniporter complex. Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):4388-4393. PubMed PMID: 28396416
• Tsai CW, Tsai MF. Electrical recordings of the mitochondrial calcium uniporter in Xenopus oocytes. J Gen Physiol. 2018 Jul 2;150(7):1035-1043. PubMed PMID: 29891485
• Van Keuren AM, Tsai CW, Balderas E, Rodriguez MX, Chaudhuri D, Tsai MF. Mechanisms of EMRE-Dependent MCU Opening in the Mitochondrial Calcium Uniporter Complex. Cell Rep. 2020 Dec 8;33(10):108486. PubMed PMID: 33296646
• Fan M, Zhang J, Tsai CW, Orlando BJ, Rodriguez M, Xu Y, Liao M, Tsai MF, Feng L. Structure and mechanism of the mitochondrial Ca(2+) uniporter holocomplex. Nature. 2020 Jun;582(7810):129-133. PubMed PMID: 32494073
• Tsai CW, Rodriguez MX, Van Keuren AM, Phillips CB, Shushunov HM, Lee JE, Garcia AM, Ambardekar AV, Cleveland JC Jr, Reisz JA, Proenza C, Chatfield KC, Tsai MF. Mechanisms and significance of tissue-specific MICU regulation of the mitochondrial calcium uniporter complex. Mol Cell. 2022 Oct 6;82(19):3661-3676.e8. PubMed PMID: 36206740
• Tsai CW, Liu TY, Chao FY, Tu YC, Rodriguez XM, Van Keuren AM, Ma Z, Bankston J, & Tsai MF. Evidence supporting the MICU1 occlusion mechanism and against the potentiation model in the mitochondrial calcium uniporter complex. PNAS (2023) 120: e2217665120.

Practice Locations