Vijaya Knight, MD, PhD

Professional Titles

• Associate Professor
• Director, Clinical & Translational Allergy and Immunology Laboratory

Publications

• Knight V, Wolf ML, Trikha A, Curran-Everett D, Hiserote M, Harbeck RJ. A comparison of specific IgE and skin prick test results to common environmental allergens using the HYTEC™ 288. J Immunol Methods. 2018 Nov;462:9-12. PubMed PMID: 30031799
• Castro G, Merkel PA, Giclas HE, Gibula A, Andersen GE, Corash LM, Lin JS, Green J, Knight V, Stassinopoulos A. Amotosalen/UVA treatment inactivates T cells more effectively than the recommended gamma dose for prevention of transfusion-associated graft-versus-host disease. Transfusion. 2018 Jun;58(6):1506-1515. PubMed PMID: 29607502
• The utility of flow cytometry for the diagnosis of primary immunodeficiencies. Vijaya Knight. Int J Lab Hematol. 2019;41(Suppl. 1):63–72. https://doi.org/10.1111/ijlh.13010
• Functional Analysis of Anti-cytokine Autoantibodies Using Flow Cytometry. Patricia A. Merkel, Terri Lebo and Vijaya Knight. Front. Immunol., 12 July 2019 | https://doi.org/10.3389/fimmu.2019.01517
• DomBourian MG, Annen K, Huey L, Andersen G, Merkel PA, Jung S, Dominguez SR, Knight V. Analysis of COVID-19 convalescent plasma for SARS-CoV-2 IgG using two commercial immunoassays. J Immunol Methods. 2020 Aug 20;:112837. [Epub ahead of print] PubMed PMID: 32828791
• Wang M, Strand MJ, Lanser BJ, Santos C, Bendelja K, Fish J, Esterl EA, Ashino S, Abbott JK, Knight V, Gelfand EW. Expression and activation of the steroidogenic enzyme CYP11A1 is associated with IL-13 production in T cells from peanut allergic children. PLoS One. 2020;15(6):e0233563. PubMed PMID: 32497050
• Knight V, Long T, Meng QH, Linden MA, Rhoads DD. Variability in the Laboratory Measurement of Cytokines: A Longitudinal Summary of a College of American Pathologists Proficiency Testing Survey. Arch Pathol Lab Med. 2020 May 13. [Epub ahead of print] PubMed PMID: 32401053
• Wortmann SB, Van Hove JLK, Derks TGJ, Chevalier N, Knight V, Koller A, Oussoren E, Mayr JA, van Spronsen FJ, Lagler FB, Gaughan S, Van Schaftingen E, Veiga-da-Cunha M. Treating neutropenia and neutrophil dysfunction in glycogen storage disease type Ib with an SGLT2 inhibitor. Blood. 2020 Aug 27;136(9):1033-1043. PubMed PMID: 32294159
• Merkel PA, Lebo T, Knight V. Functional Analysis of Anti-cytokine Autoantibodies Using Flow Cytometry. Front Immunol. 2019;10:1517. PubMed PMID: 31354706
• Knight, V.; Heimall, J.R.; Wright, N.; Dutmer, C.M.; Boyce, T.G.; Torgerson, T.R.; Abraham, R.S. Follow-Up for an Abnormal Newborn Screen for Severe Combined Immunodeficiencies (NBS SCID): A Clinical Immunology Society (CIS) Survey of Current Practices. Int. J. Neonatal Screen. 2020, 6, 52.
• Presence and short-term persistence of SARS-CoV-2 neutralizing antibodies in COVID-19 convalescent plasma donors. Kyle Annen, Thomas E Morrison, Melkon G DomBourian, Mary K McCarthy, Leah Huey, Patricia A Merkel, Gillian Andersen, Eileen Schwartz, Vijaya Knight medRxiv 2020.09.01.20185942; doi: https://doi.org/10.1101/2020.09.01.20185942
• Multiplexed, Microscale, Microarray-based Serological Assay for Antibodies Against All Human-Relevant Coronaviruses Erica D Dawson, Laura R Kuck, Rebecca H Blair, Amber W Taylor, Evan Toth, Vijaya Knight, Kathy L Rowlen medRxiv 2020.09.03.20179598; doi: https://doi.org/10.1101/2020.09.03.20179598
• Meehan RT, Amigues IA, Knight V. Precision Medicine for Rheumatoid Arthritis: The Right Drug for the Right Patient-Companion Diagnostics. Diagnostics (Basel). 2021 Jul 29;11(8). PubMed PMID: 34441297
• Izadi N, Knight V, Strand M, Hill HR, Peterson LK, Hauk PJ. An enzyme-linked immunospot assay to evaluate Pneumovax response when on intravenous immunoglobulin. Ann Allergy Asthma Immunol. 2021 Aug 12. [Epub ahead of print] PubMed PMID: 34391898
• Huey L, Andersen G, Merkel PA, Morrison TE, McCarthy M, DomBourian MG, Annen K, Dawson ED, Rowlen KL, Knight V. Evaluation of a multiplexed coronavirus antigen array for detection of SARS-CoV-2 specific IgG in COVID-19 convalescent plasma. J Immunol Methods. 2021 Oct;497:113104. PubMed PMID: 34303688
• Knight V, Heimall JR, Chong H, Nandiwada SL, Chen K, Lawrence MG, Sadighi Akha AA, Kumánovics A, Jyonouchi S, Ngo SY, Vinh DC, Hagin D, Forbes Satter LR, Marsh RA, Chiang SCC, Willrich MAV, Frazer-Abel AA, Rider NL. A Toolkit and Framework for Optimal Laboratory Evaluation of Individuals with Suspected Primary Immunodeficiency. J Allergy Clin Immunol Pract. 2021 Sep;9(9):3293-3307.e6. PubMed PMID: 34033983
• Schultz JS, McCarthy MK, Rester C, Sabourin KR, Annen K, DomBourian M, Eisenmesser E, Frazer-Abel A, Knight V, Jaenisch T, Morrison TE, Rochford R, Kedl RM. Development and Validation of a Multiplex Microsphere Immunoassay Using Dried Blood Spots for SARS-CoV-2 Seroprevalence: Application in First Responders in Colorado, USA. J Clin Microbiol. 2021 May 19;59(6). PubMed PMID: 33795412
• Dawson ED, Kuck LR, Blair RH, Taylor AW, Toth E, Knight V, Rowlen KL. Multiplexed, microscale, microarray-based serological assay for antibodies against all human-relevant coronaviruses. J Virol Methods. 2021 May;291:114111. PubMed PMID: 33640374
• Knight V, Askar MZ, Ntrivalas E, Nandiwada SL, Peterson LK, Tebo AE, Kadkhoda K, Schmitz JL, Naides SJ, Snyder MR, Sadighi Akha AA. Highlights of the 33rd annual scientific meeting of the Association of Medical Laboratory Immunologists (AMLI). J Immunol Methods. 2021 May;492:112994. PubMed PMID: 33626382
• Tacker DH, Bashleben C, Long TC, Theel ES, Knight V, Kadkhoda K, Rhoads DD, Linden MA, Fink SL. Interlaboratory Agreement of Anti-Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Serologic Assays in the Expedited College of American Pathologists Proficiency Testing Program. Arch Pathol Lab Med. 2021 May 1;145(5):536-542. PubMed PMID: 33461214
• Annen K, Morrison TE, DomBourian MG, McCarthy MK, Huey L, Merkel PA, Andersen G, Schwartz E, Knight V. Presence and short-term persistence of SARS-CoV-2 neutralizing antibodies in COVID-19 convalescent plasma donors. Transfusion. 2021 Apr;61(4):1148-1159. PubMed PMID: 33452828
• Chauhan L, Pattee J, Ford J, Thomas C, Lesteberg K, Richards E, Bernas CA, Loi M, Dumont L, Annen K, Berg M, Zirbes M, Knight V, Miller A, Jenkins TC, Bennett TD, Monkowski D, Boxer RS, Beckham JD. A Multi-center, Prospective, Observational-cohort controlled study of Clinical Outcomes following COVID-19 Convalescent plasma therapy in hospitalized COVID-19 patients. Clin Infect Dis. 2021 Sep 21. [Epub ahead of print] PubMed PMID: 34549274
• Hu G, Hauk PJ, Zhang N, Elsegeiny W, Guardia CM, Kullas A, Crosby K, Deterding RR, Schedel M, Reynolds P, Abbott JK, Knight V, Pittaluga S, Raffeld M, Rosenzweig SD, Bonifacino JS, Uzel G, Williamson PR, Gelfand EW. Autophagy-associated immune dysregulation and hyperplasia in a patient with compound heterozygous mutations in ATG9A . Autophagy. 2022 Jul 15;:1-14. [Epub ahead of print] PubMed PMID: 35838483
• Abbott JK, Chan SK, MacBeth M, Crooks JL, Hancock C, Knight V, Gelfand EW. Fluctuations in quality of life and immune responses during intravenous immunoglobulin infusion cycles. PLoS One. 2022;17(3):e0265852. PubMed PMID: 35316278
• Knight V. Immunodeficiency and Autoantibodies to Cytokines. J Appl Lab Med. 2022 Jan 5;7(1):151-164. PubMed PMID: 34996092
• Windsor WJ, Knight V, Merkel PA, Lamb MM, Tucker HR, Carson K, Howard KM, Yates JL, Santiago ML, McCarthy MK, Morrison TE, Kedl RM, Frazer-Abel A, Guo K, Andersen G, Huey L, Barrett BS, Colón-Franco JM, Lee WT, Chu MC. COVID-19 Serology Control Panel Using the Dried-Tube Specimen Method. Am J Trop Med Hyg. 2022 Jan 7;106(2):562-565. PubMed PMID: 34996045
• Ataya A, Knight V, Carey BC, Lee E, Tarling EJ, Wang T. The Role of GM-CSF Autoantibodies in Infection and Autoimmune Pulmonary Alveolar Proteinosis: A Concise Review. Front Immunol. 2021;12:752856. PubMed PMID: 34880857
• Meehan RT, Gill MT, Hoffman ED, Coeshott CM, Galvan MD, Wolf ML, Amigues IA, Kastsianok LM, Regan EA, Crooks JL, Czuczman GJ, Knight V. Ultrasound-Guided Injections of HYADD4 for Knee Osteoarthritis Improves Pain and Functional Outcomes at 3, 6, and 12 Months without Changes in Measured Synovial Fluid, Serum Collagen Biomarkers, or Most Synovial Fluid Biomarker Proteins at 3 Months. J Clin Med. 2023 Aug 25;12(17). PubMed PMID: 37685608
• Knight V, Snyder MR. Editorial introduction for "B cell immunodeficiencies" Journal of Immunological Methods special edition. J Immunol Methods. 2023 Aug;519:113505. PubMed PMID: 37290738
• Hu G, Hauk PJ, Zhang N, Elsegeiny W, Guardia CM, Kullas A, Crosby K, Deterding RR, Schedel M, Reynolds P, Abbott JK, Knight V, Pittaluga S, Raffeld M, Rosenzweig SD, Bonifacino JS, Uzel G, Williamson PR, Gelfand EW. Autophagy-associated immune dysregulation and hyperplasia in a patient with compound heterozygous mutations in ATG9A. Autophagy. 2023 Feb;19(2):678-691. PubMed PMID: 35838483
• O'Brien SC, Cole LD, Albanese BA, Mahon A, Knight V, Williams N, Severson R, Burakoff A, Alden NB, Dominguez SR. SARS-CoV-2 Seroprevalence Compared with Confirmed COVID-19 Cases among Children, Colorado, USA, May-July 2021. Emerg Infect Dis. 2023 May;29(5):929-936. PubMed PMID: 36972709
• Shumate KA, Williams SN, Khatri AB, Knight V. Addition of CD14 improves discrimination of lymphocytes in the TBNK phenotyping panel. Cytometry B Clin Cytom. 2024 May 17. [Epub ahead of print] PubMed PMID: 38757910
• Vaddi A, Hulsebus HJ, O'Neill EL, Knight V, Chan ED. A narrative review of the controversy on the risk of mycobacterial infections with immune checkpoint inhibitor use: does Goldilocks have the answer?. J Thorac Dis. 2024 Feb 29;16(2):1601-1624. PubMed PMID: 38505086
• Baxter RM, Cabrera-Martinez B, Ghosh T, Rester C, Moreno MG, Borko TL, Selva S, Fleischer CL, Haakonsen N, Mayher A, Bowhay E, Evans C, Miller TM, Huey L, McWilliams J, van Bokhoven A, Deane KD, Knight V, Jordan KR, Ghosh D, Klarquist J, Kedl RM, Piquet AL, Hsieh EWY. SARS-CoV-2 Vaccine-Elicited Immunity after B Cell Depletion in Multiple Sclerosis. Immunohorizons. 2024 Mar 1;8(3):254-268. PubMed PMID: 38483384
• Starich O, Rieck JM, Tarter WJ, Hochheimer CJ, Knight V, Abbott JK. Composition of the CD27 Memory-B-Cell Compartment Delineates Immunoglobulin Deficiency Endotypes. Res Sq. 2024 Jan 9. PubMed PMID: 38260264
• O'Brien RL, Knight V, Harbeck RJ, Fernández Pérez ER. Alternative assays for identifying the inciting antigen in hypersensitivity pneumonitis. J Allergy Clin Immunol Pract. 2024 May;12(5):1387-1390.e2. PubMed PMID: 38224871
• Principles of Diagnostic Tests Vijaya Knight and Mandakolathur R. Murali. Chapter in: Textbook of Diagnostic and Therapeutic Procedures in Allergy, Edited By Pudupakkam K. Vedanthan, Harold S. Nelson, Hugo Van Bever, Mandakolathur R Murali
• Routine Laboratory Tests Vijaya Knight and Mandakolathur R. Murali. Chapter in: Textbook of Diagnostic and Therapeutic Procedures in Allergy Edited By Pudupakkam K. Vedanthan, Harold S. Nelson, Hugo Van Bever, Mandakolathur R Murali
• Laboratory Analysis of Primary Immunodeficiency Vijaya Knight and Mandakolathur R. Murali. Chapter in: Textbook of Diagnostic and Therapeutic Procedures in Allergy Edited By Pudupakkam K. Vedanthan, Harold S. Nelson, Hugo Van Bever, Mandakolathur R Murali

Practice Locations

Children's Hospital Colorado Anschutz Medical Campus
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hospital Affiliation

• Children's Hospital Colorado

Specialty Information

Specialties

• (D)ABMLI, Board Certification (2012)