Samuel DeStefano, MD
Assistant Professor, Neurology

Department: Neurology

Professional Titles

  • Director, Highlands Ranch Epilepsy Monitoring Unit
  • Director, Tuberous Sclerosis clinic
  • Director, Adult Epilepsy Fellowship Program


  • Affiliate Bioengineering Faculty (2022)
    College of Engineering and Applied Science, University of Colorado - Denver
    Mentoring undergraduate and graduate bioengineering students in neurology and epilepsy related design projects


  • Nuthalapati P, Thomas L, Donahue MA, Moura LMVR, DeStefano S, Simpson JR, Buchhalter J, Fureman BE, Pellinen J. Improving Seizure Frequency Documentation and Classification. Neurol Clin Pract. 2023 Dec;13(6):e200212. doi: 10.1212/CPJ.0000000000200212. Epub 2023 Oct 19. PMID: 37873534; PMCID: PMC10586801.
  • DeStefano S, Pellinen J, Sillau S, Buchhalter J. Standardization of seizure response times and data collection in an epilepsy monitoring unit. Epilepsy Res. 2022 Feb;180:106869. PubMed PMID: 35101657
  • Standardization of Seizure Response Times and Data Collection in an Epilepsy Monitoring Unit
  • Patient, Physician and Clinic Staff Perspectives and Quality Assessment of Telehealth for New Patient Epilepsy Ambulatory Visits 
  • Management of post-operative delirium following stereoelectroencephalography electrode placement for drug resistant epilepsy: Lessons learned from two case reports. Epilepsy Behav Rep. 2021
  • Hixon AM, Brown MG, McDermott D, Destefano S, Abosch A, Kahn L, Ojemann S, Drees C. RNS modifications to eliminate stimulation-triggered signs or symptoms (STS): Case series and practical guide. Epilepsy Behav. 2020
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Professional Memberships

  • American Epilepsy Society, member
  • American Academy of Neurology, member

Practice Locations

UCHealth Neurosciences Center - Anschutz Medical Campus
1635 Aurora Ct
4th Floor
Aurora, CO 80045

UCHealth Anschutz Outpatient Pavilion - Anschutz Medical Campus
1635 Aurora Ct
Aurora, CO 80045

UCHealth Anschutz Inpatient Pavilion 2 - Anschutz Medical Campus
12505 E. 16th Ave
Aurora, CO 80045

UCHealth Lone Tree Medical Center
9548 Park Meadows Drive
Lone Tree, CO 80124

Hospital Affiliation
  • University of Colorado Hospital

Specialty Information

  • Neurology, Board Certification (2017)
  • Epilepsy, Board Certification (2018)
Conditions & Treatments
  • Brain and Nervous System
  • Brain and Nervous System - Epilepsy
Clinical Interests
Specialty Clinics: Tuberous Sclerosis (TS) clinic, Epilepsy Monitoring Unit (EMU), Clinical Trials

Care Philosophy
I strongly believe that patients should understand their own disease as well as their doctors. I strive to provide quality care while educating my patients throughout the diagnostic and treatment process.

General Information

Department: Neurology
Contact Us
CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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