Bryon Adinoff, MD

Clinical Professor, Psychiatry-Residency

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Medical School
  • MD, Michigan State University College of Human Medicine (1979)
Undergraduate School
  • BS, University of Michigan (MI) (1974)
Residency
  • Tulane University Program, Psychiatry (1983)
Fellowships
  • National Institutes of Health (NIH), Addiction Psychiatry (1986)
Languages
English
Department
Psychiatry-Residency

Professional Titles

  • Editor-in-Chief, American Journal of Drug and Alcohol Abuse

Recognitions

  • Distinguished Fellow, American Academy of Addiction Psychiatry (2017)
  • Dr. Kenneth Z. Altshuler Medical Leadership Award, Turtle Creek Manor, Dallas, TX (2005)
  • Elected Alumnus, Alpha Omega Alpha (2002)
  • PGY-I Outstanding Teacher of the Year, Psychiatry Residents’ Organization Southwestern Medical School (2000)
  • Public Service Award for the Prevention and Treatment of Substance Abuse, GEICO (1997)
  • Psychiatry Golden Apple Award, Psychiatry Clerkship, Medical University of South Carolina (1992)
    For teaching
  • Distinguished Life Fellow, American Psychiatric Association (2020)
  • Fellow, American College of Neuropsychopharmacology (2012)
  • Distinguished Professor of Alcohol and Drug Abuse Research, University of Texas Southwestern (1995)
    endowed professorship

Publications

  • Zhang A, Price JL, Leonard D, North CS, Suris A, Javors MA, Adinoff B. Alcohol Use Disorder Masks the Effects of Childhood Adversity, Lifetime Trauma, and Chronic Stress on Hypothalamic-Pituitary-Adrenal Axis Reactivity. Alcohol Clin Exp Res. 2020 Jun;44(6):1192-1203. PubMed PMID: 32491213
  • Sakoglu U, Mete M, Esquivel J, Rubia K, Briggs R, Adinoff B. Classification of cocaine-dependent participants with dynamic functional connectivity from functional magnetic resonance imaging data. J Neurosci Res. 2019 Jul;97(7):790-803. PubMed PMID: 30957276
  • Price JL, Frazier IR, Lewis B, Walker R, Javors MA, Nixon SJ, Adinoff B. Differences in pituitary-adrenal reactivity in Black and White men with and without alcohol use disorder. Psychoneuroendocrinology. 2019 Feb;100:180-189. PubMed PMID: 30347319
  • Adinoff B, Cooper ZD. Cannabis legalization: progress in harm reduction approaches for substance use and misuse. Am J Drug Alcohol Abuse. 2019;45(6):707-712. PubMed PMID: 31755837
  • Adinoff B, Reiman A. Implementing social justice in the transition from illicit to legal cannabis. Am J Drug Alcohol Abuse. 2019;45(6):673-688. PubMed PMID: 31634005
  • Naglich AC, Brown ES, Adinoff B. Systematic review of preclinical, clinical, and post-marketing evidence of bupropion misuse potential. Am J Drug Alcohol Abuse. 2019;45(4):341-354. PubMed PMID: 30601027
  • Naglich AC, Lin A, Wakhlu S, Adinoff BH. Systematic Review of Combined Pharmacotherapy for the Treatment of Alcohol Use Disorder in Patients Without Comorbid Conditions. CNS Drugs. 2018 Jan;32(1):13-31. PubMed PMID: 29273901
  • Ketcherside A, Filbey FM, Aubert PM, Seibyl JP, Price JL, Adinoff B. Brain intrinsic network connectivity in individuals with frequent tanning behavior. Am J Drug Alcohol Abuse. 2018;44(6):668-677. PubMed PMID: 29714526
  • Robinson SM, Adinoff B. The mixed message behind "Medication-Assisted Treatment" for substance use disorder. Am J Drug Alcohol Abuse. 2018;44(2):147-150. PubMed PMID: 28920715
  • Adinoff B, Leonard D, Price J, Javors MA, Walker R, Brown ES, Xiao H, Rao U. Adrenocortical sensitivity, moderated by ongoing stress, predicts drinking intensity in alcohol-dependent men. Psychoneuroendocrinology. 2017 Feb;76:67-76. PubMed PMID: 27888772
  • Adinoff B. The costs of prohibition. Am J Drug Alcohol Abuse. 2016 Nov;42(6):621-623. PubMed PMID: 27723372
  • Aubert PM, Seibyl JP, Price JL, Harris TS, Filbey FM, Jacobe H, Devous MD Sr, Adinoff B. Dopamine efflux in response to ultraviolet radiation in addicted sunbed users. Psychiatry Res Neuroimaging. 2016 May 30;251:7-14. PubMed PMID: 27085608
  • Brodrick JE, Brodrick CK, Adinoff B. Legal regimes surrounding naloxone access: considerations for prescribers. Am J Drug Alcohol Abuse. 2016 Mar;42(2):117-28. PubMed PMID: 26809471
  • Wilcox CE, Pommy JM, Adinoff B. Neural Circuitry of Impaired Emotion Regulation in Substance Use Disorders. Am J Psychiatry. 2016 Apr 1;173(4):344-61. PubMed PMID: 26771738
  • Adinoff B, Gu H, Merrick C, McHugh M, Jeon-Slaughter H, Lu H, Yang Y, Stein EA. Basal Hippocampal Activity and Its Functional Connectivity Predicts Cocaine Relapse. Biol Psychiatry. 2015 Oct 1;78(7):496-504. PubMed PMID: 25749098
  • Yang H, Spence JS, Briggs RW, Rao U, North C, Devous MD Sr, Xiao H, Adinoff B. Interaction between early life stress and alcohol dependence on neural stress reactivity. Addict Biol. 2015 May;20(3):523-33. PubMed PMID: 24602036
  • LoBue C, Cullum CM, Braud J, Walker R, Winhusen T, Suderajan P, Adinoff B. Optimal neurocognitive, personality and behavioral measures for assessing impulsivity in cocaine dependence. Am J Drug Alcohol Abuse. 2014 Nov;40(6):455-62. PubMed PMID: 25083938
  • Adinoff B, Devous MD, Williams MJ, Harris TS, Best SE, Dong H, Zielinski T. Differences in regional cerebral blood flow response to a 5HT3 antagonist in early- and late-onset cocaine-dependent subjects. Addict Biol. 2014 Mar;19(2):250-61. PubMed PMID: 22458709
  • McHugh MJ, Demers CH, Salmeron BJ, Devous MD Sr, Stein EA, Adinoff B. Cortico-amygdala coupling as a marker of early relapse risk in cocaine-addicted individuals. Front Psychiatry. 2014;5:16. PubMed PMID: 24578695
  • Burdick BV, Adinoff B. A proposal to evaluate mechanistic efficacy of hallucinogens in addiction treatment. Am J Drug Alcohol Abuse. 2013 Sep;39(5):291-7. PubMed PMID: 23968172
  • Adinoff B, Conley RR, Taylor SF, Chezem LL. Protecting confidentiality in human research. Am J Psychiatry. 2013 May;170(5):466-70. PubMed PMID: 23632832
  • Yang H, Devous MD, Briggs RW, Spence JS, Xiao H, Kreyling N, Adinoff B. Altered neural processing of threat in alcohol-dependent men. Alcohol Clin Exp Res. 2013 Dec;37(12):2029-38. PubMed PMID: 23888999
  • Yang H, Spence JS, Devous MD Sr, Briggs RW, Goyal A, Xiao H, Yadav H, Adinoff B. Striatal-limbic activation is associated with intensity of anticipatory anxiety. Psychiatry Res. 2012 Nov 30;204(2-3):123-31. PubMed PMID: 23137803
  • Harrington CR, Beswick TC, Graves M, Jacobe HT, Harris TS, Kourosh S, Devous MD Sr, Adinoff B. Activation of the mesostriatal reward pathway with exposure to ultraviolet radiation (UVR) vs. sham UVR in frequent tanners: a pilot study. Addict Biol. 2012 May;17(3):680-6. PubMed PMID: 21481104
  • Harrington CR, Beswick TC, Leitenberger J, Minhajuddin A, Jacobe HT, Adinoff B. Addictive-like behaviours to ultraviolet light among frequent indoor tanners. Clin Exp Dermatol. 2011 Jan;36(1):33-8. PubMed PMID: 20545951
  • Schepis TS, Rao U, Yadav H, Adinoff B. The limbic-hypothalamic-pituitary-adrenal axis and the development of alcohol use disorders in youth. Alcohol Clin Exp Res. 2011 Apr;35(4):595-605. PubMed PMID: 21223300
  • Kourosh AS, Harrington CR, Adinoff B. Tanning as a behavioral addiction. Am J Drug Alcohol Abuse. 2010 Sep;36(5):284-90. PubMed PMID: 20545604
  • Adinoff B, Talmadge C, Williams MJ, Schreffler E, Jackley PK, Krebaum SR. Time to Relapse Questionnaire (TRQ): a measure of sudden relapse in substance dependence. Am J Drug Alcohol Abuse. 2010 May;36(3):140-9. PubMed PMID: 20465371
  • Adinoff B, Devous M. Scientifically unfounded claims in diagnosing and treating patients. Am J Psychiatry. 2010 May;167(5):598. PubMed PMID: 20439400
  • Adinoff B, Devous MD Sr, Williams MJ, Best SE, Harris TS, Minhajuddin A, Zielinski T, Cullum M. Altered neural cholinergic receptor systems in cocaine-addicted subjects. Neuropsychopharmacology. 2010 Jun;35(7):1485-99. PubMed PMID: 20393457
  • Adinoff B, Devous MD Sr, Cooper DC, Best SE, Harris TS, Williams MJ. Neural response to lidocaine in healthy subjects. Psychiatry Res. 2009 Aug 30;173(2):135-42. PubMed PMID: 19560905
  • Adinoff B. Divided doses for methadone maintenance. Am J Psychiatry. 2008 Mar;165(3):303-5. PubMed PMID: 18316426
  • Williams MJ, Adinoff B. The role of acetylcholine in cocaine addiction. Neuropsychopharmacology. 2008 Jul;33(8):1779-97. PubMed PMID: 17928814
  • Schepis TS, Adinoff B, Rao U. Neurobiological processes in adolescent addictive disorders. Am J Addict. 2008 Jan-Feb;17(1):6-23. PubMed PMID: 18214718
  • Adinoff B, Rilling LM, Williams MJ, Schreffler E, Schepis TS, Rosvall T, Rao U. Impulsivity, neural deficits, and the addictions: the "oops" factor in relapse. J Addict Dis. 2007;26 Suppl 1:25-39. PubMed PMID: 19283972
  • Adinoff B, Junghanns K, Kiefer F, Krishnan-Sarin S. Suppression of the HPA axis stress-response: implications for relapse. Alcohol Clin Exp Res. 2005 Jul;29(7):1351-5. PubMed PMID: 16088999
  • Adinoff B, Krebaum SR, Chandler PA, Ye W, Brown MB, Williams MJ. Dissection of hypothalamic-pituitary-adrenal axis pathology in 1-month-abstinent alcohol-dependent men, part 2: response to ovine corticotropin-releasing factor and naloxone. Alcohol Clin Exp Res. 2005 Apr;29(4):528-37. PubMed PMID: 15834217
  • Adinoff B, Krebaum SR, Chandler PA, Ye W, Brown MB, Williams MJ. Dissection of hypothalamic-pituitary-adrenal axis pathology in 1-month-abstinent alcohol-dependent men, part 1: adrenocortical and pituitary glucocorticoid responsiveness. Alcohol Clin Exp Res. 2005 Apr;29(4):517-27. PubMed PMID: 15834216
  • Adinoff B. Neurobiologic processes in drug reward and addiction. Harv Rev Psychiatry. 2004 Nov-Dec;12(6):305-20. PubMed PMID: 15764467
  • Adinoff B, Ruether K, Krebaum S, Iranmanesh A, Williams MJ. Increased salivary cortisol concentrations during chronic alcohol intoxication in a naturalistic clinical sample of men. Alcohol Clin Exp Res. 2003 Sep;27(9):1420-7. PubMed PMID: 14506402
  • Adinoff B, Devous MD Sr, Best SM, George MS, Alexander D, Payne K. Limbic responsiveness to procaine in cocaine-addicted subjects. Am J Psychiatry. 2001 Mar;158(3):390-8. PubMed PMID: 11229979
  • Middaugh LD, McGroarty KK, Groseclose CH, Adinoff B. Cocaine discrimination: relationship to local anesthetics and monoamine uptake inhibitors in C57BL/6 mice. Psychopharmacology (Berl). 1998 Mar;136(1):44-9. PubMed PMID: 9537681
  • Fisher LA, Adinoff B. Itching to understand the phenomenon of craving in addiction. South Med J. 1998 Feb;91(2):217. PubMed PMID: 9496881
  • Adinoff B, Iranmanesh A, Veldhuis J, Fisher L. Disturbances of the stress response: the role of the HPA axis during alcohol withdrawal and abstinence. Alcohol Health Res World. 1998;22(1):67-72. PubMed PMID: 15706736
  • Adinoff B. Double-blind study of alprazolam, diazepam, clonidine, and placebo in the alcohol withdrawal syndrome: preliminary findings. Alcohol Clin Exp Res. 1994 Aug;18(4):873-8. PubMed PMID: 7978098
  • Adinoff B, Martin PR, Bone GH, Eckardt MJ, Roehrich L, George DT, Moss HB, Eskay R, Linnoila M, Gold PW. Hypothalamic-pituitary-adrenal axis functioning and cerebrospinal fluid corticotropin releasing hormone and corticotropin levels in alcoholics after recent and long-term abstinence. Arch Gen Psychiatry. 1990 Apr;47(4):325-30. PubMed PMID: 2157379
  • Adinoff B, Bone GH, Linnoila M. Acute ethanol poisoning and the ethanol withdrawal syndrome. Med Toxicol Adverse Drug Exp. 1988 May-Jun;3(3):172-96. PubMed PMID: 3041244
  • Adinoff B, Majchrowicz E, Martin PR, Linnoila M. The benzodiazepine antagonist Ro 15-1788 does not antagonize the ethanol withdrawal syndrome. Biol Psychiatry. 1986 Jun;21(7):643-9. PubMed PMID: 3011130

Professional Memberships

  • American College of Neuropsychopharmacology, Fellow
  • American Association of Addiction Psychiatry, Distinguished Fellow, Founding Member
  • American Psychiatric Association, Distinguished Life Fellow
  • Doctors for Cannabis Regulation, President, Founding Member
  • International Society of Addiction Journal Editors (ISAJE), Vice-President, Board Member

Specialty Information

Specialties
  • Psychiatry, Board Certification
  • Addiction Psychiatry, Board Certification (1993)
Clinical Interests
Drug Policy Reform Psychedelics as Treatment


School of Medicine

CU Anschutz
Fitzsimons Building

13001 East 17th Place

Aurora, CO 80045

303.724.5375

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