Joshua Thurman, MD

Thurman JM, Serkova NJ. Nanosized contrast agents to noninvasively detect kidney inflammation by magnetic resonance imaging. Adv Chronic Kidney Dis. 2013 Nov;20(6):488-99. PubMed PMID: 24206601

Pickering MC, D'Agati VD, Nester CM, Smith RJ, Haas M, Appel GB, Alpers CE, Bajema IM, Bedrosian C, Braun M, Doyle M, Fakhouri F, Fervenza FC, Fogo AB, Frémeaux-Bacchi V, Gale DP, Goicoechea de Jorge E, Griffin G, Harris CL, Holers VM, Johnson S, Lavin PJ, Medjeral-Thomas N, Paul Morgan B, Nast CC, Noel LH, Peters DK, Rodríguez de Córdoba S, Servais A, Sethi S, Song WC, Tamburini P, Thurman JM, Zavros M, Cook HT. C3 glomerulopathy: consensus report. Kidney Int. 2013 Dec;84(6):1079-89. PubMed PMID: 24172683

McCullough JW, Renner B, Thurman JM. The role of the complement system in acute kidney injury. Semin Nephrol. 2013 Nov;33(6):543-56. PubMed PMID: 24161039

Zou L, Feng Y, Li Y, Zhang M, Chen C, Cai J, Gong Y, Wang L, Thurman JM, Wu X, Atkinson JP, Chao W. Complement factor B is the downstream effector of TLRs and plays an important role in a mouse model of severe sepsis. J Immunol. 2013 Dec 1;191(11):5625-35. PubMed PMID: 24154627

Renner B, Klawitter J, Goldberg R, McCullough JW, Ferreira VP, Cooper JE, Christians U, Thurman JM. Cyclosporine induces endothelial cell release of complement-activating microparticles. J Am Soc Nephrol. 2013 Nov;24(11):1849-62. PubMed PMID: 24092930

Berman N, Lectura M, Thurman JM, Reinecke J, Raff AC, Melamed ML, Quan Z, Evans T, Meyer TW, Hostetter TH. A zebrafish model for uremic toxicity: role of the complement pathway. Blood Purif. 2013;35(4):265-9. PubMed PMID: 23689420

Fuquay R, Renner B, Kulik L, McCullough JW, Amura C, Strassheim D, Pelanda R, Torres R, Thurman JM. Renal ischemia-reperfusion injury amplifies the humoral immune response. J Am Soc Nephrol. 2013 Jun;24(7):1063-72. PubMed PMID: 23641055

Thurman JM, Kulik L, Orth H, Wong M, Renner B, Sargsyan SA, Mitchell LM, Hourcade DE, Hannan JP, Kovacs JM, Coughlin B, Woodell AS, Pickering MC, Rohrer B, Holers VM. Detection of complement activation using monoclonal antibodies against C3d. J Clin Invest. 2013 May 1;123(5):2218-30. PubMed PMID: 23619360

Thurman JM, Rohrer B. Noninvasive detection of complement activation through radiologic imaging. Adv Exp Med Biol. 2013;735:271-82. PubMed PMID: 23402034

Strassheim D, Renner B, Panzer S, Fuquay R, Kulik L, Ljubanovic D, Holers VM, Thurman JM. IgM contributes to glomerular injury in FSGS. J Am Soc Nephrol. 2013 Feb;24(3):393-406. PubMed PMID: 23393315

Bohra R, Klepacki J, Klawitter J, Klawitter J, Thurman JM, Christians U. Proteomics and metabolomics in renal transplantation-quo vadis?. Transpl Int. 2013 Mar;26(3):225-41. PubMed PMID: 23350848

Hu X, Holers VM, Thurman JM, Schoeb TR, Ramos TN, Barnum SR. Therapeutic inhibition of the alternative complement pathway attenuates chronic EAE. Mol Immunol. 2013 Jul;54(3-4):302-8. PubMed PMID: 23337717

Leinhase I, Schmidt OI, Thurman JM, Hossini AM, Rozanski M, Taha ME, Scheffler A, John T, Smith WR, Holers VM, Stahel PF. Pharmacological complement inhibition at the C3 convertase level promotes neuronal survival, neuroprotective intracerebral gene expression, and neurological outcome after traumatic brain injury. Exp Neurol, 2006 Mar 16

Thurman JM and Holers VM. Complement deficient mice as model systems for kidney diseases. In Complement and Kidney Disease. P.F. Zipfel, editor. Basel: Birkhauser Verlag AG.

Activation of the Alternative Pathway of Complement after Renal Ischemia/Reperfusion Induces the Production of Multiple Chemotactic Factors. Joshua M. Thurman, Pamela A Royer, Jian Zhou, Richard J. Quigg, and V. Michael Holers ASN meeting, Philadelphia, November 2005.

BMC Neurosci. 2006 Jul 14;7:55. Links Reduced neuronal cell death after experimental brain injury in mice lacking a functional alternative pathway of complement activation.Leinhase I, Holers VM, Thurman JM, Harhausen D, Schmidt OI, Pietzcker M, Taha ME, Rittirsch D, Huber-Lang M, Smith WR, Ward PA, Stahel PF.

Klawitter J, Klawitter J, Schmitz V, Shokati T, Epshtein E, Thurman JM, Christians U. Mycophenolate Mofetil Enhances the Negative Effects of Sirolimus and Tacrolimus on Rat Kidney Cell Metabolism. PLOS ONE. 2014 Jan 30;9(1):e86202. PMCID3907404.

Locatelli M, Buelli S, Pezzotta A, Corna D, Perico L, Tomasoni S, Rottoli D, Rizzo P, Conti D, Thurman JM, Remuzzi G, Zoja C, Morigi M. Shiga-toxin promotes podocyte injury in experimental HUS via alternative pathway complement activation. J Am Soc Nephrol. 2014 Aug;25(8):1786-98.

Banda NK, Thurman JM, Kraus D, Wood A, Carroll MC, Arend WP, Holers VM. Related Articles, Links Alternative complement pathway activation is essential for inflammation and joint destruction in the passive transfer model of collagen-induced arthritis. J Immunol. 2006 Aug 1;177(3):1904-12.

Thurman JM. New Anti-Complement Drugs: Not So Far Away. Blood. 2014 Mar 27;123(13):1975-6. PMCID3968382.

Tong HH, Lambert G, Li YX, Thurman JM, Stahl GL, Douthitt K, He Y and Clancy C. Deletion of the complement C5a receptor alleviates the severity of acute pneumococcal otitis media following influenza A virus infection in mice. PLOS ONE. 2014 Apr 16;9(4):e96160. PMCID3989264.

Thurman JM. Complement in Kidney Disease: Core Curriculum. Am J Kidney Dis. 2015 Jan;65(1):156-68.

Byrne SN, Hammond KJ, Chan CY, Rogers LJ, Beaugie C, Rana S, Marsh-Wakefield F, Thurman JM, Halliday GM. The alternative complement component factor B regulates UV-induced oedema, systemic suppression of contact and delayed hypersensitivity, and mast cell infiltration into the skin. Photochem Photobiol Sci. 2015 Feb 3.

Girardi G, Yarilin D, Thurman JM, Holers VM, Salmon JE. Related Articles, Links Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction. J Exp Med. 2006 Sep 4;203(9):2165-75. Epub 2006 Aug 21.

13. Panzer SE, Thurman JM. The Patient with Glomerular Disease or Vasculitis. In: Robert W. Schrier, ed. Manual of Nephrology, Eigth ed., Philadelphia: Lippincott Williams & Wilkins. 2014.

Thurman JM. Complement in Kidney Disease: Core Curriculum. Am J Kidney Dis. 2015, 65(1):156-68. PMCID4272665

Byrne SN, Hammond KJ, Chan CY, Rogers LJ, Beaugie C, Rana S, Marsh-Wakefield F, Thurman JM, Halliday GM. The alternative complement component factor B regulates UV-induced oedema, systemic suppression of contact and delayed hypersensitivity, and mast cell infiltration into the skin. Photochem Photobiol Sci. 2015, 14(4):801-6.

Evgin L, Acuna SA, Tanese de Souza C, Marguerie M, Lemay CG, Ilkow CS, Findlay SC, Falls T, Parato KA, Hanwell D, Goldstein A, Lopez R, Lafrance S, Breitbach CJ, Kirn D, Atkins H, Auer RC, Thurman JM, Stahl GL, Lambris JD, Bell J, and McCart JA. Complement inhibition prevents oncolytic vaccinia virus neutralization in immune humans and cynomolgus macaques. Molecular Therapy. 2015, Jun;23(6):1066-76.

Panzer SE, Laskowski J, Renner B, Kulik L, Ljubanovic D, Hasebroock KM, Zhong W, Pickering MC, Holers VM, Thurman JM. IgM Exacerbates Glomerular Disease Progression in Complement Induced Glomerulopathy. Kidney International. 2015 Sep;88(3):528-37.

Klepacki J, Klawitter J, Klawitter J, Thurman JM, Christians U. A High-Performance Liquid Chromatography- Tandem Mass Spectrometry- Based Targeted Metabolomics Kidney Dysfunction Marker Panel in Human Urine. Clinica Chimica Acta. 2015, 446:43-53.

Thurman JM. Getting Over Our Immune-Complex - C5a Receptor Blockade is the Answer. Cellular & Molecular Immun. 2015, in press.

Thurman JM, Wong M, Frazer-Abel A, Giclas PC, Radeva MK, Gipson DS, Kaskel F, Friedman A, Moxey-Mims MM, Vento SM, Trachtman H. Complement Activation in Patients with Focal Segmental Glomerulosclerosis. PLoS One. 2015, in press.

Thurman JM, Serkova NJ. Non-invasive imaging to monitor lupus nephritis and neuropsychiatric systemic lupus erythematosus. F1000Research. 2015, 4:153.

Wehrmann F, Lavelle J, Collins C, Tinega A, Thurman JM, Burnham EL, and Simonian PL. ?d T cells protect against LPS induced lung injury. Journal of Leukocyte Biology. 2015, 2015 Oct 1. pii: jlb.4A0115-017RR.

Stites E, Le Quintrec M, Thurman JM. The Complement System and Antibody Mediated Transplant Rejection. J. Immunol. 2015 Dec 15;195(12):5525-31.

Li D, Zou L, Feng Y, Xu G, Gong Y, Ouyang W, Thurman JM, Chao W. Complement factor B production in renal tubular cells and its role in sodium transporter expression during polymicrobial sepsis. Critical Care Medicine. 2015, in press.

Hannan JP, Laskowski J, Thurman JM, Hageman GS, Holers VM. Mapping the Complement Factor H-Related Protein 1 (CFHR1):C3b/C3d Interactions. PLoS One. 2016 Nov 4;11(11):e0166200. PubMed PMID: 27814381

Thurman JM, Nemenoff RA. Never make assumptions: the complicated role of complement in urinary tract infections. Kidney Int. 2016 Sep;90(3):469-71. PubMed PMID: 27521106

Thurman JM, Nester CM. All Things Complement. Clin J Am Soc Nephrol. 2016 Jun 23. [Epub ahead of print] PubMed PMID: 27340286

Thurman JM, Le Quintrec M. Targeting the complement cascade: novel treatments coming down the pike. Kidney Int. 2016 Oct;90(4):746-52. PubMed PMID: 27325183

Holers VM, Tomlinson S, Kulik L, Atkinson C, Rohrer B, Banda N, Thurman JM. New therapeutic and diagnostic opportunities for injured tissue-specific targeting of complement inhibitors and imaging modalities. Semin Immunol. 2016 Jun;28(3):260-7. PubMed PMID: 27282113

Blatt AZ, Saggu G, Kulkarni KV, Cortes C, Thurman JM, Ricklin D, Lambris JD, Valenzuela JG, Ferreira VP. Properdin-Mediated C5a Production Enhances Stable Binding of Platelets to Granulocytes in Human Whole Blood. J Immunol. 2016 Jun 1;196(11):4671-80. PubMed PMID: 27183616

Laskowski J, Renner B, Le Quintrec M, Panzer S, Hannan JP, Ljubanovic D, Ruseva MM, Borza DB, Antonioli AH, Pickering MC, Holers VM, Thurman JM. Distinct roles for the complement regulators factor H and Crry in protection of the kidney from injury. Kidney Int. 2016 Jul;90(1):109-22. PubMed PMID: 27165610

Li D, Zou L, Feng Y, Xu G, Gong Y, Zhao G, Ouyang W, Thurman JM, Chao W. Complement Factor B Production in Renal Tubular Cells and Its Role in Sodium Transporter Expression During Polymicrobial Sepsis. Crit Care Med. 2016 May;44(5):e289-99. PubMed PMID: 26757165

Renner B, Tong HH, Laskowski J, Jonscher K, Goetz L, Woolaver R, Hannan J, Li YX, Hourcade D, Pickering MC, Holers VM, Thurman JM. Annexin A2 Enhances Complement Activation by Inhibiting Factor H. J Immunol. 2016 Feb 1;196(3):1355-65. PubMed PMID: 26729803

Wehrmann F, Lavelle JC, Collins CB, Tinega AN, Thurman JM, Burnham EL, Simonian PL. ?d T cells protect against LPS-induced lung injury. J Leukoc Biol. 2016 Feb;99(2):373-86. PubMed PMID: 26428678

Thurman JM. Related Articles, Links Triggers of inflammation after renal ischemia/reperfusion. Clin Immunol. 2006 Oct 23; [Epub ahead of print] PMID: 17064966 [PubMed - as supplied by publisher]

Thorgersen EB, Ghebremariam YT, Thurman JM, Fung M, Nielsen EW, Holers VM, Kotwal GJ, Mollnes TE. Related Articles, Links Candidate inhibitors of porcine complement. Mol Immunol. 2007 Mar;44(8):1837-44. Epub 2006 Nov 15. PMID: 17109963 [PubMed - in process]

Hoke TS, Douglas IS, Klein CL, He Z, Fang W, Thurman JM, Tao Y, Dursun B, Voelkel NF, Edelstein CL, Faubel S. Related Articles, Links Acute renal failure after bilateral nephrectomy is associated with cytokine-mediated pulmonary injury. J Am Soc Nephrol. 2007 Jan;18(1):155-64. Epub 2006 Dec 13. PMID: 17167117 [PubMed - in process]

C3a is Required for the Production of CXC Chemokines by Tubular Epithelial Cells after Renal Ishemia/Reperfusion1 Joshua M. Thurman,*2 Amanda M. Lenderink,* Pamela A. Royer,* Kathrin E. Coleman,* Jian Zhou,† John D. Lambris,‡ Raphael A. Nemenoff,* Richard J. Quigg,† and V. Michael Holers* J Immunology, in press.

Antonioli AH, White J, Crawford F, Renner B, Marchbank KJ, Hannan JP, Thurman JM, Marrack P, Holers VM. Modulation of the Alternative Pathway of Complement by Murine Factor H-Related Proteins. J Immunol. 2018 Jan 1;200(1):316-326. PubMed PMID: 29187587

Thurman JM, Laskowski J. Complement factor H-related proteins in IgA nephropathy-sometimes a gentle nudge does the trick. Kidney Int. 2017 Oct;92(4):790-793. PubMed PMID: 28938951

1.Parikh, C., Gibney, E., and Thurman, J. In Press. The Long-Term Outcome of Glomerular Diseases. In Diseases of the kidney and urinary tract. R. Schrier, editor. Philadelphia: Lippincott Williams & Wilkins

Kwak JW, Laskowski J, Li HY, McSharry MV, Sippel TR, Bullock BL, Johnson AM, Poczobutt JM, Neuwelt AJ, Malkoski SP, Weiser-Evans MC, Lambris JD, Clambey ET, Thurman JM, Nemenoff RA. Complement Activation via a C3a Receptor Pathway Alters CD4( ) T Lymphocytes and Mediates Lung Cancer Progression. Cancer Res. 2018 Jan 1;78(1):143-156. PubMed PMID: 29118090

Klawitter J, Pennington A, Klawitter J, Thurman JM, Christians U. Mitochondrial cyclophilin D ablation is associated with the activation of Akt/p70S6K pathway in the mouse kidney. Sci Rep. 2017 Sep 5;7(1):10540. PubMed PMID: 28874678

Lenderink AM, Ljubanovic D, Gilkeson GS, Holers VM, Thurman JM. The Alternative Pathway of Complement is Activated in the Glomeruli and Tubulointerstitium of Mice with Adriamycin Nephropathy. Am J Physiol Renal Physiol. 2007 Aug;293(2):F555-64.

Smith RJ, Alexander J, Barlow PN, Botto M, Cassavant TL, Cook HT, de Córdoba SR, Hageman GS, Jokiranta TS, Kimberling WJ, Lambris JD, Lanning LD, Levidiotis V, Licht C, Lutz HU, Meri S, Pickering MC, Quigg RJ, Rops AL, Salant DJ, Sethi S, Thurman JM, Tully HF, Tully SP, van der Vlag J, Walker PD, Würzner R, Zipfel PF; Dense Deposit Disease Focus Group. New Approaches to the Treatment of Dense Deposit Disease. J Am Soc Nephrol. 2007 Sep;18(9):2447-56. Epub 2007 Aug 5.

Thurman JM, Frazer-Abel A, Holers VM. The Evolving Landscape for Complement Therapeutics in Rheumatic and Autoimmune Diseases. Arthritis Rheumatol. 2017 Nov;69(11):2102-2113. PubMed PMID: 28732131

Jorgensen TN, Roper E, Thurman JM, Marrack P, Kotzin BL. Type I interferon signaling is involved in the spontaneous development of lupus-like disease in B6.Nba2 and (B6.Nba2 x NZW)F(1) mice. Genes Immun. 2007 Sep 20; [Epub ahead of print].

Thurman JM. Many drugs for many targets: novel treatments for complement-mediated glomerular disease. Nephrol Dial Transplant. 2017 Jan 1;32(suppl_1):i57-i64. PubMed PMID: 28391332

Babu AN, Murakawa T, Thurman JM, Miller EJ, Henson P, Zamora MR, Voelkel NF, Nicolls MR. Microvascular Destruction Identifies Allografts which cannot be Rescued from Airway Fibrosis. J Clin Invest 2007, 117(12):3774.

Sesarman A, Sidonia M, Chiriac MT, Olaru F, Sitaru AG, Thurman JM, Zillikens D, Sitaru C. Binding of avian IgY to type VII collagen does not activate complement and leucocytes and fails to induce subepidermal blistering in mice.Br J Dermatol. 2008 Jan 17; [Epub ahead of print]

Mol Immunol. 2008 Jun;45(11):3125-32. Epub 2008 May 1. Links Evidence for non-traditional activation of complement factor C3 during murine liver regeneration. Clark A, Weymann A, Hartman E, Turmelle Y, Carroll M, Thurman JM, Holers VM, Hourcade DE, Rudnick DA.

Casiraghi F, Azzollini N, Todeschini M, Fiori S, Cavinato RA, Cassis P, Solini S, Pezzuto F, Mister M, Thurman JM, Benigni A, Remuzzi G, Noris M. Complement Alternative Pathway Deficiency in Recipients Protects Kidney Allograft From Ischemia/Reperfusion Injury and Alloreactive T Cell Response. Am J Transplant. 2017 Sep;17(9):2312-2325. PubMed PMID: 28276660

Singh MV, Kapoun A, Higgins L, Kutschke W, Thurman JM, Zhang R, Singh M, Yang J, Guan X, Lowe JS, Weiss RM, Zimmermann K, Yull FE, Blackwell TS, Mohler PJ, Anderson ME. Ca2+/calmodulin-dependent kinase II triggers cell membrane injury by inducing complement factor B gene expression in the mouse heart. J Clin Invest. 2009 Apr;119(4):986-9632.

Thurman JM, Renner B, Kunchithapautham K, Ferreira VP, Pangburn MK, Ablonczy Z, Tomlinson S, Holers VM, Rohrer B. Oxidative stress renders retinal pigment epithelial cells susceptible to complement-mediated injury. J Biol Chem. 2009 Jun 19;284(25):16939-47.

Thurman JM, Marians R, Emlen W, Wood S, Smith C, Akana H, Holers VM, Lesser M, Kline M, Hoffman C, Christen E, Trachtman H. Alternative pathway of complement in children with diarrhea-associated hemolytic uremic syndrome. Clin J Am Soc Nephrol. 2009 Dec;4(12):1920-4.

Rubtsova K, Rubtsov AV, Thurman JM, Mennona JM, Kappler JW, Marrack P. B cells expressing the transcription factor T-bet drive lupus-like autoimmunity. J Clin Invest. 2017 Apr 3;127(4):1392-1404. PubMed PMID: 28240602

Banda NK, Levitt B, Glogowska MJ, Thurman JM, Takahashi K, Stahl GL, Tomlinson S, Arend WP, Holers VM. Targeted inhibition of the complement alternative pathway with complement receptor 2 and factor H attenuates collagen antibody-induced arthritis in mice. J Immunol. 2009 Nov 1;183(9):5928-37.

Kataria A, Levine D, Wertenteil S, Vento S, Xue J, Rajendiran K, Kannan K, Thurman JM, Morrison D, Brody R, Urbina E, Attina T, Trasande L, Trachtman H. Exposure to bisphenols and phthalates and association with oxidant stress, insulin resistance, and endothelial dysfunction in children. Pediatr Res. 2017 Jun;81(6):857-864. PubMed PMID: 28099427

Tong HH, Li YX, Stahl GL, Thurman JM. Enhanced susceptibility of complement-deficient C1qa, factor B and factor B/C2 mice to acute pneumococcal otitis media. Infect Immun. 2010 Jan 11. [Epub ahead of print]

Thurman JM. Getting over our Immune-Complex - C5a receptor blockade is the answer. Cell Mol Immunol. 2017 Mar;14(3):319-320. PubMed PMID: 26144251

Thurman JM. Complement Biomarkers of Hemolytic Uremic Syndrome-If Not One Thing, Maybe Another. Mayo Clin Proc. 2018 Oct;93(10):1337-1339. PubMed PMID: 30286826

Tomlinson S, Thurman JM. Tissue-targeted complement therapeutics. Mol Immunol. 2018 Oct;102:120-128. PubMed PMID: 30220307

Jalal D, Renner B, Laskowski J, Stites E, Cooper J, Valente K, You Z, Perrenoud L, Le Quintrec M, Muhamed I, Christians U, Klawitter J, Lindorfer MA, Taylor RP, Holers VM, Thurman JM. Endothelial Microparticles and Systemic Complement Activation in Patients With Chronic Kidney Disease. J Am Heart Assoc. 2018 Jul 13;7(14). PubMed PMID: 30006493

Foss CA, Kulik L, Ordonez AA, Jain SK, Michael Holers V, Thurman JM, Pomper MG. SPECT/CT Imaging of Mycobacterium tuberculosis Infection with [(125)I]anti-C3d mAb. Mol Imaging Biol. 2018 Jul 11. [Epub ahead of print] PubMed PMID: 29998399

Luo W, Olaru F, Miner JH, Beck LH Jr, van der Vlag J, Thurman JM, Borza DB. Alternative Pathway Is Essential for Glomerular Complement Activation and Proteinuria in a Mouse Model of Membranous Nephropathy. Front Immunol. 2018;9:1433. PubMed PMID: 29988342

Serkova NJ, Renner B, Larsen BA, Stoldt CR, Hasebroock KM, Bradshaw-Pierce EL, Holers VM, and Thurman JM. Targeted Iron Oxide Nanoparticles for Molecular MR Imaging of Renal Inflammation in Mice. Radiology 2009 (in press).

Thurman JM, Wiseman A, The Patient with Glomerulonephritis or Vasculitis. In: Robert W. Schrier, ed. Manual of Nephrology, Seventh ed., Philadelphia: Lippincott Williams & Wilkins. 2009.

Thurman JM, Renner B, Kunchithapautham K, Holers VM, Rohrer B. Aseptic injury to epithelial cells alters cell surface complement regulation in a tissue specific fashion. In: Retinal Degenerations: Mechanisms and Experimental Therapy (LaVail MM, Hollyfield JG, Anderson R, eds.) Advances in Experimental Medicine & Biology, Kluwer Academic/Plenum Publishers, New York. In press, 2010.

Rohrer B, Long Q, Coughlin B, Renner B, Huang Y, Kunchithapautham K, Ferreira V, Pangburn M, Gilkeson GS, Thurman J, Tomlinson S, Holers VM. A targeted inhibitor of the alternative complement pathway reduces RPE injury and angiogenesis in models of age-related macular degeneration. In: Current Topics on Complement and Eye Diseases (Lambris J, ed.) Springer Publishing Company, New York, NY. In press 2010

Thurman JM, Renner B, Kunchithapautham K, Holers VM, Rohrer B. Aseptic injury to epithelial cells alters cell surface complement regulation in a tissue specific fashion. Adv Exp Med Biol. 2010;664:151-8.

Mihai S, Hirose M, Wang Y, Thurman JM, Holers VM, Morgan BP, Köhl J, Zillikens D, Ludwig RJ, Nimmerjahn F. Specific Inhibition of Complement Activation Significantly Ameliorates Autoimmune Blistering Disease in Mice. Front Immunol. 2018;9:535. PubMed PMID: 29616034

Okamoto T, Mathai SK, Hennessy CE, Hancock LA, Walts AD, Stefanski AL, Brown KK, Lynch DA, Cosgrove GP, Groshong SD, Cool CD, Schwarz MI, Banda NK, Thurman JM, Yang IV, Holers VM, Schwartz DA. The relationship between complement C3 expression and the MUC5B genotype in pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2018 Jul 1;315(1):L1-L10. PubMed PMID: 29565179

Thurman JM. A Patient with Hemolytic Uremic Syndrome and Kidney Failure. Clin J Am Soc Nephrol. 2018 Jun 7;13(6):933-936. PubMed PMID: 29459381

Goetz L, Laskowski J, Renner B, Pickering MC, Kulik L, Klawitter J, Stites E, Christians U, van der Vlag J, Ravichandran K, Holers VM, Thurman JM. Complement factor H protects mice from ischemic acute kidney injury but is not critical for controlling complement activation by glomerular IgM. Eur J Immunol. 2018 May;48(5):791-802. PubMed PMID: 29389016

Antonioli AH, White J, Crawford F, Renner B, Marchbank KJ, Hannan JP, Thurman JM, Marrack P, Holers VM. Modulation of the Alternative Pathway of Complement by Murine Factor H-Related Proteins. J Immunol. 2018 Jan 1;200(1):316-326. PubMed PMID: 29187587

Dalton K, Smith M, and Thurman JM. The development of membranous lupus nephritis during treatment with mycophenolate mofetil for proliferative renal disease. NDT Plus. 2010 sqf046.

Tchepeleva SN, Thurman JM, Ruff K, Perkins SJ, Morel L, Boackle SA. An Allelic Variant of Crry in the Murine Sle1c Lupus Susceptibility Interval Is Not Impaired in Its Ability To Regulate Complement Activation. J Immunol. 2010 Aug 15;185(4):2331-9.

Rohrer B, Long Q, Coughlin B, Renner B, Huang Y, Kunchithapautham K, Ferreira VP, Pangburn MK, Gilkeson GS, Thurman JM, Tomlinson S, Holers VM. A Targeted Inhibitor of the Complement Alternative Pathway Reduces RPE Injury and Angiogenesis in Models of Age-Related Macular Degeneration. Adv Exp Med Biol. 2010;703:137-49.

Renner B, Coleman K, Goldberg R, Amura C, Pierce K, Molina H, Ferreira VP, Cortes C, Pangburn MK, Holers VM, and Thurman JM. The Complement Inhibitors Crry and Factor H are Critical for Preventing Autologous Complement Activation on Renal Tubular Epithelial Cells. J Immunol. 2010 Sep 1;185(5):3086-94.

Goldberg R, Nakagawa T, Johnson RJ, Thurman JM. The Role of Endothelial Cell Injury in Thrombotic Microangiopathy. Am J Kidney Dis. 2010 Dec;56(6):1168-74.

Renner B, Strassheim D, Amura CR, Kulik L, Ljubanovic D, Glogowska MJ, Takahashi K, Carroll MC, Holers VM, Thurman JM. B Cell Subsets Contribute to Both Renal Injury and Renal Protection after Ischemia/Reperfusion. J Immunol. 2010 Oct 1;185(7):4393-400.

Kwak JW, Laskowski J, Li HY, McSharry MV, Sippel TR, Bullock BL, Johnson AM, Poczobutt JM, Neuwelt AJ, Malkoski SP, Weiser-Evans MC, Lambris JD, Clambey ET, Thurman JM, Nemenoff RA. Complement Activation via a C3a Receptor Pathway Alters CD4( ) T Lymphocytes and Mediates Lung Cancer Progression. Cancer Res. 2018 Jan 1;78(1):143-156. PubMed PMID: 29118090

Thurman JM, Renner B. Dynamic control of the complement system by tissues-specific modulation of regulatory proteins. Lab Investigation. 2011 Jan;91(1):4-11.

Shaw CD, Storek MJ, Young KA, Kovacs JM, Thurman JM, Holers VM, Hannan JP. Delineation of the complement receptor type 2-c3d complex by site-directed mutagenesis and molecular docking. J Mol Biol. 2010 Dec 10;404(4):697-710.

8. Rohrer B, Long Q, Coughlin B, Renner B, Huang Y, Kunchithapautham K, Ferreira V, Pangburn M, Gilkeson GS, Thurman J, Tomlinson S, Holers VM. A targeted inhibitor of the alternative complement pathway reduces RPE injury and angiogenesis in models of age-related macular degeneration. In: Current Topics on Complement and Eye Diseases (Lambris J, ed.) Springer Publishing Company, New York, NY. 2010.

9. Thurman JM, Goldberg R. The Glomerulopathies. In: Schrier RW, ed. Renal and Electrolyte Disorders, Seventh Ed., Lippincott Williams & Wilkins, Philadelphia, PA. 2010.

Kulik L, Laskowski J, Renner B, Woolaver R, Zhang L, Lyubchenko T, You Z, Thurman JM, Holers VM. Targeting the Immune Complex-Bound Complement C3d Ligand as a Novel Therapy for Lupus. J Immunol. 2019 Nov 15. [Epub ahead of print] PubMed PMID: 31732528

Grafals M, Thurman JM. The Role of Complement in Organ Transplantation. Front Immunol. 2019;10:2380. PubMed PMID: 31636644

Frid MG, McKeon BA, Thurman JM, Maron BA, Li M, Zhang H, Kumar S, Sullivan T, Laskowsky J, Fini MA, Hu S, Tuder RM, Gandjeva A, Wilkins MR, Rhodes CJ, Ghataorhe P, Leopold JA, Wang RS, Holers VM, Stenmark KR. Immunoglobulin-Driven Complement Activation Regulates Pro-Inflammatory Remodeling in Pulmonary Hypertension. Am J Respir Crit Care Med. 2019 Sep 23. [Epub ahead of print] PubMed PMID: 31545648

Laskowski J, Philbrook HT, Parikh CR, Thurman JM. Urine complement activation fragments are increased in patients with kidney injury after cardiac surgery. Am J Physiol Renal Physiol. 2019 Sep 1;317(3):F650-F657. PubMed PMID: 31313951

Thurman JM, Panzer SE, Le Quintrec M. The role of complement in antibody mediated transplant rejection. Mol Immunol. 2019 Aug;112:240-246. PubMed PMID: 31195225

Klawitter J, Klawitter J, Pennington A, Kirkpatrick B, Roda G, Kotecha NC, Thurman JM, Christians U. Cyclophilin D knockout protects the mouse kidney against cyclosporin A-induced oxidative stress. Am J Physiol Renal Physiol. 2019 Sep 1;317(3):F683-F694. PubMed PMID: 31188033

Thurman JM, Yapa R. Complement Therapeutics in Autoimmune Disease. Front Immunol. 2019;10:672. PubMed PMID: 31001274

10. Jefferson JA, Thurman JM, Schrier RW. Pathophysiology and Etiology of Acute Kidney Injury. In: J Floege, RJ Johnson, J Feehally, eds. Comprehensive Clinical Nephrology, Fourth Ed., Elsevier Saunders, St. Louis, MO. 2010.

Renner B, Ferreira VP, Cortes C, Goldberg R, Ljubanovic D, Pangburn MK, Pickering MC, Tomlinson S, Holland-Neidermyer A, Strassheim D, Holers VM, Thurman JM. Factor H Controls Complement Activation in the Renal Tubulointerstitium after Ischemic Injury. Kidney International. 2011. Jul;80(2):165-73.

Li Q, Li YX, Stahl GL, Thurman JM, He Y, Tong HH. Essential role of factor B of the alternative complement pathway in complement activation and opsonophagocytosis during acute pneumococcal otitis media in mice. Infect Immun. 2011 Jul;79(7):2578-85.

Stites E, Renner B, Laskowski J, Le Quintrec M, You Z, Freed B, Cooper J, Jalal D, Thurman JM. Complement fragments are biomarkers of antibody-mediated endothelial injury. Mol Immunol. 2020 Feb;118:142-152. PubMed PMID: 31884386

Panzer SE, Laskowski J, Renner B, Kulik L, Ljubanovic D, Huber KM, Zhong W, Pickering MC, Holers VM, Thurman JM. IgM exacerbates glomerular disease progression in complement-induced glomerulopathy. Kidney Int. 2015 Sep;88(3):528-37. PubMed PMID: 25945405

Klepacki J, Klawitter J, Klawitter J, Thurman JM, Christians U. A high-performance liquid chromatography-tandem mass spectrometry-based targeted metabolomics kidney dysfunction marker panel in human urine. Clin Chim Acta. 2015 Jun 15;446:43-53. PubMed PMID: 25871999

Evgin L, Acuna SA, Tanese de Souza C, Marguerie M, Lemay CG, Ilkow CS, Findlay CS, Falls T, Parato KA, Hanwell D, Goldstein A, Lopez R, Lafrance S, Breitbach CJ, Kirn D, Atkins H, Auer RC, Thurman JM, Stahl GL, Lambris JD, Bell JC, McCart JA. Complement inhibition prevents oncolytic vaccinia virus neutralization in immune humans and cynomolgus macaques. Mol Ther. 2015 Jun;23(6):1066-1076. PubMed PMID: 25807289

Thurman JM. Complement in kidney disease: core curriculum 2015. Am J Kidney Dis. 2015 Jan;65(1):156-68. PubMed PMID: 25441433

Stites E, Le Quintrec M, Thurman JM. The Complement System and Antibody-Mediated Transplant Rejection. J Immunol. 2015 Dec 15;195(12):5525-31. PubMed PMID: 26637661

Byrne SN, Hammond KJ, Chan CY, Rogers LJ, Beaugie C, Rana S, Marsh-Wakefield F, Thurman JM, Halliday GM. The alternative complement component factor B regulates UV-induced oedema, systemic suppression of contact and delayed hypersensitivity, and mast cell infiltration into the skin. Photochem Photobiol Sci. 2015 Apr;14(4):801-6. PubMed PMID: 25645888

Thurman JM, Wong M, Renner B, Frazer-Abel A, Giclas PC, Joy MS, Jalal D, Radeva MK, Gassman J, Gipson DS, Kaskel F, Friedman A, Trachtman H. Complement Activation in Patients with Focal Segmental Glomerulosclerosis. PLoS One. 2015;10(9):e0136558. PubMed PMID: 26335102

Thurman JM, Serkova NJ. Non-invasive imaging to monitor lupus nephritis and neuropsychiatric systemic lupus erythematosus. F1000Res. 2015;4:153. PubMed PMID: 26309728

Thurman JM. New anti-complement drugs: not so far away. Blood. 2014 Mar 27;123(13):1975-6. PubMed PMID: 24677397

Locatelli M, Buelli S, Pezzotta A, Corna D, Perico L, Tomasoni S, Rottoli D, Rizzo P, Conti D, Thurman JM, Remuzzi G, Zoja C, Morigi M. Shiga toxin promotes podocyte injury in experimental hemolytic uremic syndrome via activation of the alternative pathway of complement. J Am Soc Nephrol. 2014 Aug;25(8):1786-98. PubMed PMID: 24578132

Tong HH, Lambert G, Li YX, Thurman JM, Stahl GL, Douthitt K, Clancy C, He Y, Bowman AS. Deletion of the complement C5a receptor alleviates the severity of acute pneumococcal otitis media following influenza A virus infection in mice. PLoS One. 2014;9(4):e95160. PubMed PMID: 24740152

Amura CR, Renner B, Lyubchenko T, Faubel S, Simonian PL, Thurman JM. Complement activation and toll-like receptor-2 signaling contribute to cytokine production after renal ischemia/reperfusion. Mol Immunol. 2012 Oct;52(3-4):249-57. PubMed PMID: 22750071

Klawitter J, Klawitter J, Schmitz V, Brunner N, Crunk A, Corby K, Bendrick-Peart J, Leibfritz D, Edelstein CL, Thurman JM, Christians U. Low-salt diet and cyclosporine nephrotoxicity: changes in kidney cell metabolism. J Proteome Res. 2012 Nov 2;11(11):5135-44. PubMed PMID: 23057591

Thurman JM. Factor friction: protective and pathogenic roles for complement factors in immune complex glomerulonephritis. Kidney Int. 2012 Nov;82(9):945-7. PubMed PMID: 23064186

Li Q, Li YX, Douthitt K, Stahl GL, Thurman JM, Tong HH. Role of the alternative and classical complement activation pathway in complement mediated killing against Streptococcus pneumoniae colony opacity variants during acute pneumococcal otitis media in mice. Microbes Infect. 2012 Nov;14(14):1308-18. PubMed PMID: 22975410

Larson JD, Thurman JM, Rubtsov AV, Claypool D, Marrack P, van Dyk LF, Torres RM, Pelanda R. Murine gammaherpesvirus 68 infection protects lupus-prone mice from the development of autoimmunity. Proc Natl Acad Sci U S A. 2012 May 1;109(18):E1092-100. PubMed PMID: 22474381

Thurman JM. Therapeutic regulation of complement in patients with renal disease - where is the promise?. Clin Nephrol. 2012 May;77(5):413-23. PubMed PMID: 22551888

Thurman JM, Tchepeleva SN, Haas M, Panzer S, Boackle SA, Glogowska MJ, Quigg RJ, Holers VM. Complement alternative pathway activation in the autologous phase of nephrotoxic serum nephritis. Am J Physiol Renal Physiol. 2012 Jun 15;302(12):F1529-36. PubMed PMID: 22492944

Sargsyan SA, Thurman JM. Molecular imaging of autoimmune diseases and inflammation. Mol Imaging. 2012 Jun;11(3):251-64. PubMed PMID: 22554489

Takeda K, Thurman JM, Tomlinson S, Okamoto M, Shiraishi Y, Ferreira VP, Cortes C, Pangburn MK, Holers VM, Gelfand EW. The critical role of complement alternative pathway regulator factor H in allergen-induced airway hyperresponsiveness and inflammation. J Immunol. 2012 Jan 15;188(2):661-7. PubMed PMID: 22174452

Sargsyan SA, Serkova NJ, Renner B, Hasebroock KM, Larsen B, Stoldt C, McFann K, Pickering MC, Thurman JM. Detection of glomerular complement C3 fragments by magnetic resonance imaging in murine lupus nephritis. Kidney Int. 2012 Jan;81(2):152-9. PubMed PMID: 21956190

Kunchithapautham K, Bandyopadhyay M, Dahrouj M, Thurman JM, Rohrer B. Sublytic membrane-attack-complex activation and VEGF secretion in retinal pigment epithelial cells. Adv Exp Med Biol. 2012;723:23-30. PubMed PMID: 22183311

Kenyon KD, Cole C, Crawford F, Kappler JW, Thurman JM, Bratton DL, Boackle SA, Henson PM. IgG autoantibodies against deposited C3 inhibit macrophage-mediated apoptotic cell engulfment in systemic autoimmunity. J Immunol. 2011 Sep 1;187(5):2101-11. PubMed PMID: 21813769

Renner B, Ferreira VP, Cortes C, Goldberg R, Ljubanovic D, Pangburn MK, Pickering MC, Tomlinson S, Holland-Neidermyer A, Strassheim D, Holers VM, Thurman JM. Binding of factor H to tubular epithelial cells limits interstitial complement activation in ischemic injury. Kidney Int. 2011 Jul;80(2):165-73. PubMed PMID: 21544060

Li Q, Li YX, Stahl GL, Thurman JM, He Y, Tong HH. Essential role of factor B of the alternative complement pathway in complement activation and opsonophagocytosis during acute pneumococcal otitis media in mice. Infect Immun. 2011 Jul;79(7):2578-85. PubMed PMID: 21502587

Thurman JM, Renner B. Dynamic control of the complement system by modulated expression of regulatory proteins. Lab Invest. 2011 Jan;91(1):4-11. PubMed PMID: 20921948

Renner B, Coleman K, Goldberg R, Amura C, Holland-Neidermyer A, Pierce K, Orth HN, Molina H, Ferreira VP, Cortes C, Pangburn MK, Holers VM, Thurman JM. The complement inhibitors Crry and factor H are critical for preventing autologous complement activation on renal tubular epithelial cells. J Immunol. 2010 Sep 1;185(5):3086-94. PubMed PMID: 20675597

Renner B, Strassheim D, Amura CR, Kulik L, Ljubanovic D, Glogowska MJ, Takahashi K, Carroll MC, Holers VM, Thurman JM. B cell subsets contribute to renal injury and renal protection after ischemia/reperfusion. J Immunol. 2010 Oct 1;185(7):4393-400. PubMed PMID: 20810984

Serkova NJ, Renner B, Larsen BA, Stoldt CR, Hasebroock KM, Bradshaw-Pierce EL, Holers VM, Thurman JM. Renal inflammation: targeted iron oxide nanoparticles for molecular MR imaging in mice. Radiology. 2010 May;255(2):517-26. PubMed PMID: 20332377

Tong HH, Li YX, Stahl GL, Thurman JM. Enhanced susceptibility to acute pneumococcal otitis media in mice deficient in complement C1qa, factor B, and factor B/C2. Infect Immun. 2010 Mar;78(3):976-83. PubMed PMID: 20065024

Shaw CD, Storek MJ, Young KA, Kovacs JM, Thurman JM, Holers VM, Hannan JP. Delineation of the complement receptor type 2-C3d complex by site-directed mutagenesis and molecular docking. J Mol Biol. 2010 Dec 10;404(4):697-710. PubMed PMID: 20951140

Goldberg RJ, Nakagawa T, Johnson RJ, Thurman JM. The role of endothelial cell injury in thrombotic microangiopathy. Am J Kidney Dis. 2010 Dec;56(6):1168-74. PubMed PMID: 20843591

Tchepeleva SN, Thurman JM, Ruff K, Perkins SJ, Morel L, Boackle SA. An allelic variant of Crry in the murine Sle1c lupus susceptibility interval is not impaired in its ability to regulate complement activation. J Immunol. 2010 Aug 15;185(4):2331-9. PubMed PMID: 20660348

Dalton K, Smith M, Thurman JM. The development of membranous lupus nephritis during treatment with mycophenolate mofetil for proliferative renal disease. NDT Plus. 2010 Aug;3(4):346-8. PubMed PMID: 25949427

Rohrer B, Long Q, Coughlin B, Renner B, Huang Y, Kunchithapautham K, Ferreira VP, Pangburn MK, Gilkeson GS, Thurman JM, Tomlinson S, Holers VM. A targeted inhibitor of the complement alternative pathway reduces RPE injury and angiogenesis in models of age-related macular degeneration. Adv Exp Med Biol. 2010;703:137-49. PubMed PMID: 20711712

Thurman JM, Renner B, Kunchithapautham K, Holers VM, Rohrer B. Aseptic injury to epithelial cells alters cell surface complement regulation in a tissue specific fashion. Adv Exp Med Biol. 2010;664:151-8. PubMed PMID: 20238013

Banda NK, Levitt B, Glogowska MJ, Thurman JM, Takahashi K, Stahl GL, Tomlinson S, Arend WP, Holers VM. Targeted inhibition of the complement alternative pathway with complement receptor 2 and factor H attenuates collagen antibody-induced arthritis in mice. J Immunol. 2009 Nov 1;183(9):5928-37. PubMed PMID: 19828624

Thurman JM, Renner B, Kunchithapautham K, Ferreira VP, Pangburn MK, Ablonczy Z, Tomlinson S, Holers VM, Rohrer B. Oxidative stress renders retinal pigment epithelial cells susceptible to complement-mediated injury. J Biol Chem. 2009 Jun 19;284(25):16939-47. PubMed PMID: 19386604

Thurman JM, Marians R, Emlen W, Wood S, Smith C, Akana H, Holers VM, Lesser M, Kline M, Hoffman C, Christen E, Trachtman H. Alternative pathway of complement in children with diarrhea-associated hemolytic uremic syndrome. Clin J Am Soc Nephrol. 2009 Dec;4(12):1920-4. PubMed PMID: 19820137

Singh MV, Kapoun A, Higgins L, Kutschke W, Thurman JM, Zhang R, Singh M, Yang J, Guan X, Lowe JS, Weiss RM, Zimmermann K, Yull FE, Blackwell TS, Mohler PJ, Anderson ME. Ca2+/calmodulin-dependent kinase II triggers cell membrane injury by inducing complement factor B gene expression in the mouse heart. J Clin Invest. 2009 Apr;119(4):986-96. PubMed PMID: 19273909

Sesarman A, Mihai S, Chiriac MT, Olaru F, Sitaru AG, Thurman JM, Zillikens D, Sitaru C. Binding of avian IgY to type VII collagen does not activate complement and leucocytes and fails to induce subepidermal blistering in mice. Br J Dermatol. 2008 Mar;158(3):463-71. PubMed PMID: 18205879

Clark A, Weymann A, Hartman E, Turmelle Y, Carroll M, Thurman JM, Holers VM, Hourcade DE, Rudnick DA. Evidence for non-traditional activation of complement factor C3 during murine liver regeneration. Mol Immunol. 2008 Jun;45(11):3125-32. PubMed PMID: 18452991

Thurman JM, Parikh CR. Peeking into the black box: new biomarkers for acute kidney injury. Kidney Int. 2008 Feb;73(4):379-81. PubMed PMID: 18235520

Smith RJ, Alexander J, Barlow PN, Botto M, Cassavant TL, Cook HT, de Córdoba SR, Hageman GS, Jokiranta TS, Kimberling WJ, Lambris JD, Lanning LD, Levidiotis V, Licht C, Lutz HU, Meri S, Pickering MC, Quigg RJ, Rops AL, Salant DJ, Sethi S, Thurman JM, Tully HF, Tully SP, van der Vlag J, Walker PD, Würzner R, Zipfel PF. New approaches to the treatment of dense deposit disease. J Am Soc Nephrol. 2007 Sep;18(9):2447-56. PubMed PMID: 17675665

Mihai S, Chiriac MT, Takahashi K, Thurman JM, Holers VM, Zillikens D, Botto M, Sitaru C. The alternative pathway of complement activation is critical for blister induction in experimental epidermolysis bullosa acquisita. J Immunol. 2007 May 15;178(10):6514-21. PubMed PMID: 17475881

Thorgersen EB, Ghebremariam YT, Thurman JM, Fung M, Nielsen EW, Holers VM, Kotwal GJ, Mollnes TE. Candidate inhibitors of porcine complement. Mol Immunol. 2007 Mar;44(8):1827-34. PubMed PMID: 17109963

Hoke TS, Douglas IS, Klein CL, He Z, Fang W, Thurman JM, Tao Y, Dursun B, Voelkel NF, Edelstein CL, Faubel S. Acute renal failure after bilateral nephrectomy is associated with cytokine-mediated pulmonary injury. J Am Soc Nephrol. 2007 Jan;18(1):155-64. PubMed PMID: 17167117

Thurman JM, Lenderink AM, Royer PA, Coleman KE, Zhou J, Lambris JD, Nemenoff RA, Quigg RJ, Holers VM. C3a is required for the production of CXC chemokines by tubular epithelial cells after renal ishemia/reperfusion. J Immunol. 2007 Feb 1;178(3):1819-28. PubMed PMID: 17237432

Babu AN, Murakawa T, Thurman JM, Miller EJ, Henson PM, Zamora MR, Voelkel NF, Nicolls MR. Microvascular destruction identifies murine allografts that cannot be rescued from airway fibrosis. J Clin Invest. 2007 Dec;117(12):3774-85. PubMed PMID: 18060031

Jørgensen TN, Roper E, Thurman JM, Marrack P, Kotzin BL. Type I interferon signaling is involved in the spontaneous development of lupus-like disease in B6.Nba2 and (B6.Nba2 x NZW)F(1) mice. Genes Immun. 2007 Dec;8(8):653-62. PubMed PMID: 17882225

Lenderink AM, Liegel K, Ljubanovic D, Coleman KE, Gilkeson GS, Holers VM, Thurman JM. The alternative pathway of complement is activated in the glomeruli and tubulointerstitium of mice with adriamycin nephropathy. Am J Physiol Renal Physiol. 2007 Aug;293(2):F555-64. PubMed PMID: 17522263

Thurman JM. Triggers of inflammation after renal ischemia/reperfusion. Clin Immunol. 2007 Apr;123(1):7-13. PubMed PMID: 17064966

Girardi G, Yarilin D, Thurman JM, Holers VM, Salmon JE. Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction. J Exp Med. 2006 Sep 4;203(9):2165-75. PubMed PMID: 16923853

Kenyon KD, Cole C, Crawford F, Kappler JW, Thurman JM, Bratton DL, Boackle SA, Henson PM., IgG Autoantibodies against Deposited C3 Inhibit Macrophage-Mediated Apoptotic Cell Engulfment in Systemic Autoimmunity. J Immunol. 2011 Sep 1;187(5):2101-11.

Thurman JM, Laskowski J, Nemenoff RA. Complement and Cancer-A Dysfunctional Relationship?. Antibodies (Basel). 2020 Nov 5;9(4). PubMed PMID: 33167384

Poppelaars F, Thurman JM. Complement-mediated kidney diseases. Mol Immunol. 2020 Dec;128:175-187. PubMed PMID: 33137606

Chen JY, Galwankar NS, Emch HN, Menon SS, Cortes C, Thurman JM, Merrill SA, Brodsky RA, Ferreira VP. Properdin Is a Key Player in Lysis of Red Blood Cells and Complement Activation on Endothelial Cells in Hemolytic Anemias Caused by Complement Dysregulation. Front Immunol. 2020;11:1460. PubMed PMID: 32793201

Thurman JM. Therapeutic Regulation of Complement in Patients with Renal Disease - Where is the Promise? Clinical Nephrology. 2011 (in press).

Angeletti A, Cantarelli C, Petrosyan A, Andrighetto S, Budge K, D'Agati VD, Hartzell S, Malvi D, Donadei C, Thurman JM, Galešic-Ljubanovic D, He JC, Xiao W, Campbell KN, Wong J, Fischman C, Manrique J, Zaza G, Fiaccadori E, La Manna G, Fribourg M, Leventhal J, Da Sacco S, Perin L, Heeger PS, Cravedi P. Loss of decay-accelerating factor triggers podocyte injury and glomerulosclerosis. J Exp Med. 2020 Sep 7;217(9). PubMed PMID: 32717081

Sargsyan, SA, Thurman JM. Molecular imaging of inflammation. Molecular Imaging. 2011 (in press).

Sargsyan SA, Serkova NJ, Renner B, Hasebroock KM, Larsen B, Stoldt C, Mcfann K, Pickering MC, Thurman JM. MRI-based detection of glomerular complement C3 fragments as a biomarker of lupus nephritis. Kidney International. Kidney Int. 2011 Sep 28.

Wang Q, Rozelle AL, Lepus CM, Scanzello CR, Song JJ, Larsen DM, Crish JF, Bebek G, Ritter SY, Lindstrom TM, Hwang I, Wong HH, Punzi L, Encarnacion A, Shamloo M, Goodman SB, Wyss-Coray T, Goldring SR, Banda NK, Thurman JM, Gobezie R, Crow MK, Holers VM, Lee DM, Robinson WH. Identification of a central role for complement in osteoarthritis. Nature Medicine. 2011 Nov 6;17(12):1674-9.

Takeda K, Thurman JM, Tomlinson S, Okamoto M, Shiraishi Y, Ferreira VP, Cortes C, Pangburn MK, Holers VM, Gelfand EW. The Critical Role of Complement Alternative Pathway Regulator Factor H in Allergen-Induced Airway Hyperresponsiveness (AHR) and Inflammation. J Immunol. 2011 Dec 14. [Epub ahead of print]

Kunchithapautham K, Bandyopadhyay M, Dahrouj M, Thurman JM, Rohrer B. Sublytic membrane-attack-complex activation and VEGF secretion in retinal pigment epithelial cells. Adv Exp Med Biol. 2012;723:23-30.

12. Rohrer B, Bandyopadhyay M, Kunchithapautham K, Thurman JM. Complement pathways and oxidative stress in Models of Age-Related Macular Degeneration. In: Oxidative Stress and Oxygen Free Radicals in the Retina and Choroid. Springer. 2011 (in press).

Thurman JM. Complement and the Kidney: An Overview. Adv Chronic Kidney Dis. 2020 Mar;27(2):86-94. PubMed PMID: 32553250

Kunchithapautham K, Bandyopadhyay M, Dahrouj M, Thurman JM, Rohrer B. Sublytic membrane-attack-complex activation and VEGF secretion in retinal pigment epithelial cells. Adv Exp Med Biol. 2012;723:23-30.

Frid MG, Thurman JM, Hansen KC, Maron BA, Stenmark KR. Inflammation, immunity, and vascular remodeling in pulmonary hypertension; Evidence for complement involvement?. Glob Cardiol Sci Pract. 2020 Apr 30;2020(1):e202001. PubMed PMID: 32478115

Larson JD, Thurman JM, Rubtsov AV, Claypool D, Marrack P, van Dyk LF, Torres RM, Pelanda R. Murine gammaherpesvirus 68 infection protects lupus-prone mice from the development of autoimmunity. Proc Natl Acad Sci U S A. 2012 May 1;109(18):E1092-100. PMC3345002

Thurman JM, Tchepeleva SN, Haas M, Boackle SA, Glogowska JM, Quigg RJ, Holers VM. Complement alternative pathway activation in the autologous phase of nephrotoxic serum nephritis. Am J Physiol Renal Physiol. 2012 Jun; 302(12):F1529-36. PMC3378099

Laskowski J, Renner B, Pickering MC, Serkova NJ, Smith-Jones PM, Clambey ET, Nemenoff RA, Thurman JM. Complement factor H-deficient mice develop spontaneous hepatic tumors. J Clin Invest. 2020 Aug 3;130(8):4039-4054. PubMed PMID: 32369457

Thurman JM. Therapeutic Regulation of Complement in Patients with Renal Disease - Where is the Promise? Clinical Nephrology. 2012 May;77(5):413-23.

Sargsyan SA, Thurman JM. Molecular imaging of inflammation. Mol Imaging. 2012 Jun 1;11(3):251-64.

Amura CR, Renner B, Lyubchenko T, Faubel S, Simonian PL, Thurman JM. Complement Activation and Toll-Like Receptor-2 Signaling Contribute to Cytokine Production After Renal Ischemia/Reperfusion. Molecular Immunology. 2012. Oct;52(3-4):249-57.

Thurman JM. Factor friction – Protective and pathogenic roles for complement factors in immune-complex glomerulonephritis. Kidney International. 2012. Nov;82(9):945-7.

Stites E, Renner B, Laskowski J, Le Quintrec M, You Z, Freed B, Cooper J, Jalal D, Thurman JM. Complement fragments are biomarkers of antibody-mediated endothelial injury. Mol Immunol. 2020 Feb;118:142-152. PubMed PMID: 31884386

Li Q, Li YX, Douthitt K, Stahl GL, Thurman JM and Tong HH. Role of the alternative and classical complement activation pathway in complement mediated killing against Streptococcus pneumoniae colony opacity variants during acute pneumococcal otitis media in mice. Microbes and Infection. 2012 Aug 30. pii: S1286-4579(12)00212-2.

Frid MG, McKeon BA, Thurman JM, Maron BA, Li M, Zhang H, Kumar S, Sullivan T, Laskowsky J, Fini MA, Hu S, Tuder RM, Gandjeva A, Wilkins MR, Rhodes CJ, Ghataorhe P, Leopold JA, Wang RS, Holers VM, Stenmark KR. Immunoglobulin-driven Complement Activation Regulates Proinflammatory Remodeling in Pulmonary Hypertension. Am J Respir Crit Care Med. 2020 Jan 15;201(2):224-239. PubMed PMID: 31545648

Thurman JM, Rohrer B. Noninvasive detection of complement activation through radiologic imaging. Adv Exp Med Biol. 2013;734:271-82.

Klawitter J, Klawitter J, Schmitz V, Brunner N, Crunk A, Corby K, Bendrick-Peart J, Leibfritz D, Edelstein C, Thurman JM, Christians U. Low-Salt Diet and Cyclosporine Nephrotoxicity: Changes in Kidney Cell Metabolism. Journal of Proteome Research. 2012. Nov 2;11(11):5135-44.

Bohra R, Klepacki J, Klawitter J, Klawitter J, Thurman JM, Christians U. Proteomics and Metabolomics in Renal Transplantation-Quo Vadis? Transplant International 2012. In press.

Thurman JM. Rhabdomyolysis and complement-once again, epithelial cells take center stage. Kidney Int. 2021 Mar;99(3):537-539. PubMed PMID: 33637198

Strassheim D, Renner B, Panzer S, Fuquay R, Kulik L, Ljubanovic D, Holers VM, Thurman JM. IgM contributes to glomerular injury in focal segmental glomerulosclerosis. J Am Soc Nephrol. 2013. In press.

Laskowski J, Thurman JM. Complement Detection in Mouse Kidneys by Immunofluorescence. Methods Mol Biol. 2021;2227:179-189. PubMed PMID: 33847942

Hu X, Holers VM, Thurman JM, Schoeb TR, Ramos TN, Barnum SR. Therapeutic Inhibition of the Alternative Complement Pathway Attenuates Chronic EAE. Molecular Immunology. In press.

Berman N, Lectura M, Thurman JM, Reinecke J, Raff AC, Melamed ML, Quan Z, Evans T, Meyer TW, and Hostetter TH. A Zebrafish Model for Uremic Toxicity: Role of the Complement Pathway. Blood Purification. In press.

Bomback AS, Appel GB, Gipson DS, Hladunewich MA, Lafayette R, Nester CM, Parikh SV, Smith RJH, Trachtman H, Heeger PS, Ram S, Rovin BH, Ali S, Arceneaux N, Ashoor I, Bailey-Wickins L, Barratt J, Beck L, Cattran DC, Cravedi P, Erkan E, Fervenza F, Frazer-Abel AA, Fremeaux-Bacchi V, Fuller L, Gbadegesin R, Hogan JJ, Kiryluk K, le Quintrec-Donnette M, Licht C, Mahan JD, Pickering MC, Quigg R, Rheault M, Ronco P, Sarwal MM, Sethna C, Spino C, Stegall M, Vivarelli M, Feldman DL, Thurman JM. Improving Clinical Trials for Anticomplement Therapies in Complement-Mediated Glomerulopathies: Report of a Scientific Workshop Sponsored by the National Kidney Foundation. Am J Kidney Dis. 2021 Sep 24. [Epub ahead of print] PubMed PMID: 34571062

Fuquay R, Renner B, Kulik L, McCullough JW, Amura C, Strassheim D, Pelanda R, Torres R, Thurman JM. Renal Ischemia-Reperfusion Injury Amplifies the Humoral Immune Response. J Am Soc Nephrol. In press, 2013.

Trachtman H, Laskowski J, Lee C, Renner B, Feemster A, Parikh S, Panzer SE, Zhong W, Cravedi P, Cantarelli C, Kulik L, You Z, Satchell S, Rovin B, Liu F, Kalled SL, Holers VM, Jalal D, Thurman JM. Natural antibody and complement activation characterize patients with idiopathic nephrotic syndrome. Am J Physiol Renal Physiol. 2021 Oct 1;321(4):F505-F516. PubMed PMID: 34459222

Thurman JM, Kulik L, Orth HN, Wong MH, Renner B, Sargsyan SA, Mitchell LM, Hourcade D, Hannan JP, Kovacs JM, Coughlin B, Woodell AS, Pickering MC, Rohrer B, Holers VM. Detection of complement activation using monoclonal antibodies to C3d. The Journal of clinical investigation. In press, 2013.

Thurman, JM, Schrier, RW, Nephrotic Syndrome. In: Mustafa Nur Elhuda, ed. Textbook of Glomerular Diseases, 4th ed. SEHA Dialysis Services, Abu Dhabi, UAE.

Fogueri U, Charkoftaki G, Roda G, Tuey S, Ibrahim M, Persaud I, Wempe MF, Brown JM, Thurman JM, Anchordoquy TJ, Joy MS. An evaluation of a novel nanoformulation of imatinib mesylate in a mouse model of lupus nephritis. Drug Deliv Transl Res. 2021 Jul 28. [Epub ahead of print] PubMed PMID: 34322850

Thurman JM, Berl T. Disorders of water metabolism. In: DB Mount et al., eds. Core Concepts in the Disorders of Fluid, Electrolytes and Acid-Base Balance. Springer. New York, NY. 2012.

Stenmark KR, Frid MG, Gerasimovskaya E, Zhang H, McCarthy MK, Thurman JM, Morrison TE. Mechanisms of SARS-CoV-2-induced lung vascular disease: potential role of complement. Pulm Circ. 2021 Apr-Jun;11(2):20458940211015799. PubMed PMID: 34046161

Vivarelli M, van de Kar N, Labbadia R, Diomedi-Camassei F, Thurman JM. A clinical approach to children with C3 glomerulopathy. Pediatr Nephrol. 2021 May 18. [Epub ahead of print] PubMed PMID: 34002292

Jalal D, Sanford B, Renner B, Ten Eyck P, Laskowski J, Cooper J, Sun M, Zakharia Y, Spitz D, Dokun A, Attanasio M, Jones K, Thurman JM. Detection of pro angiogenic and inflammatory biomarkers in patients with CKD. Sci Rep. 2021 Apr 22;11(1):8786. PubMed PMID: 33888746

Tuey SM, Atilano-Roque A, Charkoftaki G, Thurman JM, Nolin TD, Joy MS. Influence of vitamin D treatment on functional expression of drug disposition pathways in human kidney proximal tubule cells during simulated uremia. Xenobiotica. 2021 Jun;51(6):657-667. PubMed PMID: 33870862

Laskowski J, Thurman JM. Complement Detection in Mouse Kidneys by Immunofluorescence. Methods Mol Biol. 2021;2227:179-189. PubMed PMID: 33847942

Thurman JM. Rhabdomyolysis and complement-once again, epithelial cells take center stage. Kidney Int. 2021 Mar;99(3):537-539. PubMed PMID: 33637198

Thurman JM. BLISS in the Treatment of Lupus Nephritis. Clin J Am Soc Nephrol. 2021 Jun;16(6):969-971. PubMed PMID: 33536242

Alternative pathway diagnostics. Thurman JM, Fremeaux-Bacchi V. Immunol Rev. 2022 Oct 28. doi: 10.1111/imr.13156. Online ahead of print.

The complement system in pediatric acute kidney injury. Stenson EK, Kendrick J, Dixon B, Thurman JM. Pediatr Nephrol. 2022 Oct 6:1-15. doi: 10.1007/s00467-022-05755-3. Online ahead of print.

The Immune System and Idiopathic Nephrotic Syndrome. Campbell RE, Thurman JM. Clin J Am Soc Nephrol. 2022 Oct 5:CJN.07180622. doi: 10.2215/CJN.07180622. Online ahead of print.

Factor H related proteins modulate complement activation on kidney cells. Renner B, Laskowski J, Poppelaars F, Ferreira VP, Blaine J, Antonioli AH, Hannan JP, Kovacs JM, van Kooten C, You Z, Pickering MC, Holers VM, Thurman JM. Kidney Int. 2022 Sep 3:S0085-2538(22)00692-5. doi: 10.1016/j.kint.2022.07.035. Online ahead of print.

Development and Optimization of Bifunctional Fusion Proteins to Locally Modulate Complement Activation in Diseased Tissue. Fahnoe KC, Liu F, Morgan JG, Ryan ST, Storek M, Stark EG, Taylor FR, Holers VM, Thurman JM, Wawersik S, Kalled SL, Violette SM. Front Immunol. 2022 Jun 16;13:869725. doi: 10.3389/fimmu.2022.869725. eCollection 2022.

Extracellular vesicles derived from patients with antibody-mediated rejection induce tubular senescence and endothelial to mesenchymal transition in renal cells. Franzin R, Stasi A, Sallustio F, Bruno S, Merlotti G, Quaglia M, Grandaliano G, Pontrelli P, Thurman JM, Camussi G, Stallone G, Cantaluppi V, Gesualdo L, Castellano G. Am J Transplant. 2022 Sep;22(9):2139-2157. doi: 10.1111/ajt.17097. Epub 2022 Jul 5.

Minimal Change Disease Is Associated With Endothelial Glycocalyx Degradation and Endothelial Activation. Bauer C, Piani F, Banks M, Ordoñez FA, de Lucas-Collantes C, Oshima K, Schmidt EP, Zakharevich I, Segarra A, Martinez C, Roncal-Jimenez C, Satchell SC, Bjornstad P, Lucia MS, Blaine J, Thurman JM, Johnson RJ, Cara-Fuentes G. Kidney Int Rep. 2021 Dec 16;7(4):797-809. doi: 10.1016/j.ekir.2021.11.037. eCollection 2022 Apr.

Peterson JN, Boackle SA, Taitano SH, Sang A, Lang J, Kelly M, Rahkola JT, Miranda AM, Sheridan RM, Thurman JM, Rao VK, Torres RM, Pelanda R. Elevated Detection of Dual Antibody B Cells Identifies Lupus Patients With B Cell-Reactive VH4-34 Autoantibodies. Front Immunol. 2022;13:795209. PubMed PMID: 35185888

Schriek P, Ching AC, Moily NS, Moffat J, Beattie L, Steiner TM, Hosking LM, Thurman JM, Holers VM, Ishido S, Lahoud MH, Caminschi I, Heath WR, Mintern JD, Villadangos JA. Marginal zone B cells acquire dendritic cell functions by trogocytosis. Science. 2022 Feb 11;375(6581):eabf7470. PubMed PMID: 35143312

Bomback AS, Appel GB, Gipson DS, Hladunewich MA, Lafayette R, Nester CM, Parikh SV, Smith RJH, Trachtman H, Heeger PS, Ram S, Rovin BH, Ali S, Arceneaux N, Ashoor I, Bailey-Wickins L, Barratt J, Beck L, Cattran DC, Cravedi P, Erkan E, Fervenza F, Frazer-Abel AA, Fremeaux-Bacchi V, Fuller L, Gbadegesin R, Hogan JJ, Kiryluk K, le Quintrec-Donnette M, Licht C, Mahan JD, Pickering MC, Quigg R, Rheault M, Ronco P, Sarwal MM, Sethna C, Spino C, Stegall M, Vivarelli M, Feldman DL, Thurman JM. Improving Clinical Trials for Anticomplement Therapies in Complement-Mediated Glomerulopathies: Report of a Scientific Workshop Sponsored by the National Kidney Foundation. Am J Kidney Dis. 2022 Apr;79(4):570-581. PubMed PMID: 34571062

Petr V, Thurman JM. The role of complement in kidney disease. Nat Rev Nephrol. 2023 Dec;19(12):771-787. PubMed PMID: 37735215

Antonucci L, Thurman JM, Vivarelli M. Complement inhibitors in pediatric kidney diseases: new therapeutic opportunities. Pediatr Nephrol. 2023 Sep 21. [Epub ahead of print] PubMed PMID: 37733095

Whelan R, Feemster A, Laskowski J, Renner B, Kulik L, Poppelaars F, Lee C, Holers VM, Thurman JM. Female but Not Male Mice Deficient in Soluble IgM Are Susceptible to Chemically Induced Glomerular Injury. J Immunol. 2023 Oct 15;211(8):1240-1248. PubMed PMID: 37682538

Yandamuri SS, Filipek B, Obaid AH, Lele N, Thurman JM, Makhani N, Nowak RJ, Guo Y, Lucchinetti CF, Flanagan EP, Longbrake EE, O'Connor KC. MOGAD patient autoantibodies induce complement, phagocytosis, and cellular cytotoxicity. JCI Insight. 2023 Jun 8;8(11). PubMed PMID: 37097758

Kulik L, Renner B, Laskowski J, Thurman JM, Michael Holers V. Highly pathogenic natural monoclonal antibody B4-IgM recognizes a post-translational modification comprised of acetylated N-terminal methionine followed by aspartic or glutamic acid. Mol Immunol. 2023 May;157:112-128. PubMed PMID: 37018938

Renner B, Poppelaars F, Laskowski J, Serkova NJ, Kulik L, Holers VM, Thurman JM. Noninvasive Detection of iC3b/C3d Deposits in the Kidney Using a Novel Bioluminescent Imaging Probe. J Am Soc Nephrol. 2023 Jul 1;34(7):1151-1154. PubMed PMID: 36995143

Stenson EK, Edelstein CL, You Z, Miyazaki-Anzai S, Thurman JM, Dixon BP, Zappitelli M, Goldstein SL, Akcan Arikan A, Kendrick J. Urine Complement Factor Ba Is Associated with AKI in Critically Ill Children. Kidney360. 2023 Mar 1;4(3):326-332. PubMed PMID: 36758197

Kleczko EK, Poczobutt JM, Navarro AC, Laskowski J, Johnson AM, Korpela SP, Gurule NJ, Heasley LE, Hopp K, Weiser-Evans MCM, Gottlin EB, Bushey RT, Campa MJ, Patz EF Jr, Thurman JM, Nemenoff RA. Upregulation of complement proteins in lung cancer cells mediates tumor progression. Front Oncol. 2022;12:1045690. PubMed PMID: 36686777

Trinidad CNB, Thurman JM. Breaking the Barrier-Glomerular C5b-9 as a Prognostic Marker in Membranous Nephropathy. Kidney Int Rep. 2023 Jan;8(1):14-16. PubMed PMID: 36644344

Harrison RA, Harris CL, Thurman JM. The complement alternative pathway in health and disease-activation or amplification?. Immunol Rev. 2023 Jan;313(1):6-14. PubMed PMID: 36424888

Thurman JM, Harrison RA. The susceptibility of the kidney to alternative pathway activation-A hypothesis. Immunol Rev. 2023 Jan;313(1):327-338. PubMed PMID: 36369971

Thurman JM, Fremeaux-Bacchi V. Alternative pathway diagnostics. Immunol Rev. 2023 Jan;313(1):225-238. PubMed PMID: 36305168

Stenson EK, Kendrick J, Dixon B, Thurman JM. The complement system in pediatric acute kidney injury. Pediatr Nephrol. 2023 May;38(5):1411-1425. PubMed PMID: 36203104

Campbell RE, Thurman JM. The Immune System and Idiopathic Nephrotic Syndrome. Clin J Am Soc Nephrol. 2022 Dec;17(12):1823-1834. PubMed PMID: 36198505

Renner B, Laskowski J, Poppelaars F, Ferreira VP, Blaine J, Antonioli AH, Hannan JP, Kovacs JM, van Kooten C, You Z, Pickering MC, Holers VM, Thurman JM. Factor H related proteins modulate complement activation on kidney cells. Kidney Int. 2022 Dec;102(6):1331-1344. PubMed PMID: 36063874

Fahnoe KC, Liu F, Morgan JG, Ryan ST, Storek M, Stark EG, Taylor FR, Holers VM, Thurman JM, Wawersik S, Kalled SL, Violette SM. Development and Optimization of Bifunctional Fusion Proteins to Locally Modulate Complement Activation in Diseased Tissue. Front Immunol. 2022;13:869725. PubMed PMID: 35784298

Franzin R, Stasi A, Sallustio F, Bruno S, Merlotti G, Quaglia M, Grandaliano G, Pontrelli P, Thurman JM, Camussi G, Stallone G, Cantaluppi V, Gesualdo L, Castellano G. Extracellular vesicles derived from patients with antibody-mediated rejection induce tubular senescence and endothelial to mesenchymal transition in renal cells. Am J Transplant. 2022 Sep;22(9):2139-2157. PubMed PMID: 35583104

Trachtman H, Laskowski J, Lee C, Renner B, Feemster A, Parikh S, Panzer SE, Zhong W, Cravedi P, Cantarelli C, Kulik L, You Z, Satchell S, Rovin B, Liu F, Kalled SL, Holers VM, Jalal D, Thurman JM. Natural antibody and complement activation characterize patients with idiopathic nephrotic syndrome. Am J Physiol Renal Physiol. 2021 Oct 1;321(4):F505-F516. PubMed PMID: 34459222

Fogueri U, Charkoftaki G, Roda G, Tuey S, Ibrahim M, Persaud I, Wempe MF, Brown JM, Thurman JM, Anchordoquy TJ, Joy MS. An evaluation of a novel nanoformulation of imatinib mesylate in a mouse model of lupus nephritis. Drug Deliv Transl Res. 2022 Jun;12(6):1445-1454. PubMed PMID: 34322850

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