Kate Hamlington Smith, PhD

Research Interests

My research program has four overarching goals: 1. Advance the dissemination and implementation of lung function measurement techniques to improve low-burden monitoring of respiratory disease progression and treatment responses. 2. Investigate the impact of personal- and community-level environmental factors on respiratory morbidity and lung function in early childhood to identify modifiable exposures that decrease susceptibility to respiratory illness and exacerbation. 3. Understand the longitudinal relationships between lung function and airway endotype trajectories during early childhood to identify periods of exposure susceptibility and optimal timepoints for treatment of asthma and wheezing illnesses. 4. Provide education to learners at all levels including faculty, fellows, residents, medical students, undergraduates, and clinical staff on lung physiology, lung function measurements, environmental triggers of asthma, clinical study design, novel analytical approaches, and data management.

Publications

• Navanandan N, Hagopian E, Brinton JT, Tanverdi M, Edid A, Linn C, Sulbaran H, Florin TA, Mistry RD, Seibold MA, Szefler SJ, Liu AH, Hamlington KL. Oscillometry Measures the Response to Acute Asthma Therapy in the Pediatric Emergency Department. Ann Am Thorac Soc. 2025 Dec;22(12):1900-1910. PubMed PMID: 40705565
• Jackson A, DeBoer E, Hamlington KL, Wolter-Warmerdam K, Maybee J. Caregivers of children with Down Syndrome adapt their child's diet and experience barriers and impacts on quality of life. Int J Pediatr Otorhinolaryngol. 2025 Sep;196:112441. PubMed PMID: 40639047
• Hamlington KL, Cooper EH, Wolter-Warmerdam K, Vielkind ML, Brinton JT, Keck A, Bresselsmith RJ, Maybee J, Jackson A, Hickey F, DeBoer EM. Oscillometry Phenotypes in Children With Down Syndrome. Pediatr Pulmonol. 2025 Apr;60(4):e71069. PubMed PMID: 40152070
• Skeen EH, Hamlington KL, De Keyser HH, Liu AH, Szefler SJ. Managing childhood asthma with an eye toward environmental, social, and behavioral features. Ann Allergy Asthma Immunol. 2025 May;134(5):516-524. PubMed PMID: 40010666
• Hamlington KL, Liu AH. Airway inflammation, asthma, and soot. Pediatr Res. 2025 Jan;97(1):13-14. PubMed PMID: 39181983
• Navanandan N, Jackson ND, Hamlington KL, Everman JL, Pruesse E, Secor EA, Stewart Z, Diener K, Hardee I, Edid A, Sulbaran H, Mistry RD, Florin TA, Yoder AC, Moore CM, Szefler SJ, Liu AH, Seibold MA. Viral Determinants of Childhood Asthma Exacerbation Severity and Treatment Response. J Allergy Clin Immunol Pract. 2025 Jan;13(1):95-104.e5. PubMed PMID: 39368548
• Moore CM, Thornburg J, Secor EA, Hamlington KL, Schiltz AM, Freeman KL, Everman JL, Fingerlin TE, Liu AH, Seibold MA. Comparative analysis of ambient, in-home, and personal exposures reveals associations between breathing zone pollutant levels and asthma exacerbations in high-risk children. Respir Res. 2025 Jan 27;26(1):40. PubMed PMID: 39871239
• Hamlington KL, Navanandan N, Seibold MA, Liu AH. Oscillometry and Parent-Reported Respiratory Symptom Control in Toddlers with Recurrent Wheeze: The WINDOWS Study. [abstract]. Am J Respir Crit Care Med 2025;211:A1049. Oral Presentation.
• Navanandan N, Hagopian E, Brinton JT, Tanverdi MS, Linn C, Sulbaran H, Florin TA, Mistry RD, Szefler SJ, Liu AH, Hamlington KL. Oscillometry Measures the Response to Acute Asthma Therapy in the Pediatric Emergency Department. [abstract]. Am J Respir Crit Care Med 2025;211:A3069.
• Johnson E, Paracha A, Liu AH, Awan M, Navanandan N, Hamlington KL. Home Environment Risk Factors In Toddlers With Recurrent Wheeze: The Windows Study. [abstract]. Am J Respir Crit Care Med 2025;211:A2878.
• Tanverdi M, Cerna Sanchez JA, Maclean S, Navanandan N, Javed F, Liu AH, Hamlington KL. Measuring Oscillometry During Recovery after Emergency Department Treatment for Asthma Exacerbations in Children. [abstract]. Am J Respir Crit Care Med 2025;211:A2573.
• Everman JL, Secor EA, Hamlington KL, Diener K, Jackson ND, Stewart Z, Pruesse E, Hardee I, Moore CM, Navanandan N, Liu AH, Seibold MA. Unique airway immune responses and epithelial pathobiology underlie viral wheezing illnesses in young children. [abstract]. Am J Respir Crit Care Med 2025;211:A5173.
• Tanyaratsrisakul S, Bochkov YA, White V, Lee H, Loeffler J, Everman J, Schiltz AM, Freeman KL, Hamlington KL, Secor EA, Jackson ND, Chu HW, Liu AH, Ledford JG, Kraft M, Seibold MA, Voelker DR, Numata M. Surfactant Protein A Inhibits Human Rhinovirus C Binding and Infection of Airway Epithelial Cells from Pediatric Asthma. Viruses. 2024 Oct 30;16(11). PubMed PMID: 39599822
• Navanandan N, Jackson ND, Hamlington KL, Everman JL, Pruesse E, Secor EA, Stewart Z, Diener K, Hardee I, Edid A, Sulbaran H, Mistry RD, Florin TA, Yoder AC, Moore CM, Szefler SJ, Liu AH, Seibold MA. Viral Determinants of Childhood Asthma Exacerbation Severity and Treatment Response. J Allergy Clin Immunol Pract. 2024 Oct 3. [Epub ahead of print] PubMed PMID: 39368548
• Hamlington KL, Liu AH. Airway inflammation, asthma, and soot. Pediatr Res. 2024 Aug 24. [Epub ahead of print] PubMed PMID: 39181983
• Younoszai N, Hollander C, Kinney GL, Hamlington KL, Klawitter J, Sempio C, Christians U, Dabelea D, Moore BF. Childhood exposure to cannabidiol and lung function: A pilot study. Pediatr Pulmonol. 2024 Dec;59(12):3766-3769. PubMed PMID: 39056509
• DeBoer EM, Smith BM, Williamson AA, Tapia IE, Gaffin JM, Hamlington KL, Zeeman JM, McLaughlin J, Hatch J, Davis SD, Flower KB, Tschudy MM. Initiatives to improve lung and sleep health in children: Delphi consensus from the pediatrics, pulmonary, and sleep conference. Pediatr Pulmonol. 2024 Nov;59(11):2800-2808. PubMed PMID: 38869166
• Hamlington KL, Navanandan N. A step toward predicting recurrence in preschool-age severe wheeze. J Allergy Clin Immunol Pract. 2024 Apr;12(4):1071-1072. PubMed PMID: 38583924
• Skeen EH, Moore CM, Federico MJ, Seibold MA, Liu AH, Hamlington KL. The Child Opportunity Index 2.0 and exacerbation-prone asthma in a cohort of urban children. Pediatr Pulmonol. 2024 Jul;59(7):1894-1904. PubMed PMID: 38558492
• Hamlington KL, Cooper EH, Bresselsmith RJ, Keck A, Vielkind ML, Wolter-Warmerdam K, Brinton JT, Hickey F, DeBoer EM. Oscillometry Phenotypes in Children With Down Syndrome. C63 PEDIATRIC IMMUNOLOGY, ONCOLOGY, PHYSIOLOGY, AND CELL BIOLOGY. American Thoracic Society International Conference Abstracts: 2024:A6127. Available from: https://doi.org/10.1164/ajrccm-conference.2024.209.1_MeetingAbstracts.A6127
• Secor E, Hamlington KL, Everman JL, Diener K, Jackson ND, Stewart Z, Pruesse E, Hardee I, Moore CM, Navanandan N, Liu AH, Seibold MA. Rhinovirus (HRV) Infection Drives Severe Wheezing Episodes in Toddlers: Viral Metagenomic Analysis in the WINDOWS Study. D28 PEDIATRIC PULMONOLOGY BENCH-TO-BEDSIDE: GENETICS, WHOLE-EXOME SEQUENCING, AND OMICS. American Thoracic Society International Conference Abstracts: 2024:A7152. Available from: https://doi.org/10.1164/ajrccm-conference.2024.209.1_MeetingAbstracts.A7152
• Moore CM, Thornburg J, Secor EA, Hamlington KL, Schiltz AM, Freeman KL, Everman JL, Fingerlin TE, Liu AH, Seibold MA. Breathing zone pollutant levels are associated with asthma exacerbations in high-risk children. medRxiv. 2023 Sep 23. PubMed PMID: 37790375
• Navanandan N, Mistry RD, Muller C, Edid A, Brinton JT, Yoder, AC, Szefler SJ, Liu AH, Hamlington KL. Respiratory Impedance Corresponds to Clinical Outcomes in Children with Acute Asthma Exacerbations in the Pediatric Emergency Department. B99 ALL THAT WHEEZES: TRANSLATIONAL STUDIES IN ASTHMA: American Thoracic Society International Conference; 2023. A4255p. Available from: https://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2023.207.1_MeetingAbstracts .A4255.
• Skeen E, Moore CM, Liu AH, Seibold MA, Hamlington KL. Neighborhood-level Child Opportunity Predicts Exacerbation-prone Status In A Cohort Of Urban Children With Asthma. B96 BEST IN PEDIATRICS: American Thoracic Society International Conference; 2023. A4227p. Available from: https://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2023.207.1_MeetingAbstracts.A4227.
• Bates JHT, Hamlington KL, Garrison G, Kinsey CM. Prediction of lung cancer risk based on age and smoking history. Comput Methods Programs Biomed. 2022 Apr;216:106660. PubMed PMID: 35114461
• Vielkind ML, Hamlington KL, Wolter-Warmerdam K, Meier MR, Liu AH, Hickey FJ, Brown MA, DeBoer EM. Airwave oscillometry to measure lung function in children with Down syndrome. Pediatr Res. 2022 Jun;91(7):1775-1780. PubMed PMID: 34326475
• Hamlington KL, Keck AN, Smith BJ, DeBoer EM. Respiratory Oscillometry to Assess Airway Inflammation, Dysphagia, and Treatment Responses in the Aerodigestive Clinic. A18. Improvements in PFTs and New Applications: American Thoracic Society International Conference. May 2022. A1047.
• Sanborn T, Hamlington KL, Schiltz AM, Freeman KL, Liu AH. Lower Household Income is Associated with Higher Airway Inflammation and Furry Animal Allergen Sensitization in Urban Children with Exacerbation-Prone Asthma. Journal of Allergy and Clinical Immunology. 2022;149(2): AB86.
• Goldfarbmuren KC, Moore CM, Zinnen GL, Fairbanks-Mahnke A, Pruesse E, Jackson ND, Sajuthi S, Everman JL, Anderson KC, Hamlington KL, Schiltz AM, Freeman K, Fingerlin TE, Liu AH, Seibold MA. Heterogeneity in Clinically and Molecularly Defined Airway Type 2 Inflammation Among Children with Exacerbation-Prone Asthma. B101. Varied Omics Techniques Applied to Allergic and Respiratory Traits: American Thoracic Society International Conference. May 2022. A3478.
• Vielkind ML, Hamlington KL, Wolter-Warmerdam K, Meier MR, Liu AH, Hickey FJ, Brown MA, DeBoer EM. Airwave oscillometry to measure lung function in children with Down syndrome. Pediatr Res. 2021 Jul 29. [Epub ahead of print] PubMed PMID: 34326475
• Navanandan N, Hamlington KL, Mistry RD, Szefler SJ, Liu AH. Oscillometry for acute asthma in the pediatric emergency department: A feasibility study. Ann Allergy Asthma Immunol. 2020 Nov;125(5):607-609. PubMed PMID: 32652127
• Smith BJ, Roy GS, Cleveland A, Mattson C, Okamura K, Charlebois CM, Hamlington KL, Novotny MV, Knudsen L, Ochs M, Hite RD, Bates JHT. Three Alveolar Phenotypes Govern Lung Function in Murine Ventilator-Induced Lung Injury. Front Physiol. 2020;11:660. PubMed PMID: 32695013
• Navanandan N, Mistry RD, Szefler SJ, Liu AH, Hamlington KL. Oscillometry for the Evaluation and Management of Children with Acute Asthma Exacerbations in the Emergency Department: A Pilot Study. C28 PEDIATRIC RESPIRATORY PHYSIOLOGY: American Thoracic Society; 2020. p. A4671-A.
• Vielkind M, Meier MRK, DeBoer EM, Hamlington KL, Hickey F, Liu AH, Wolter-Warmerdam K, Brown MA. Lung Function in Children with Down Syndrome. C28 PEDIATRIC RESPIRATORY PHYSIOLOGY: American Thoracic Society; 2020. p. A4672-A.
• Schiltz AM, Mazzella MJ, Colicino E, Hamlington KL, Freeman KL, Barr DB, Panuwet P, Lee G, Hecht SS, Murphy SE, Peterson LA, Vevang KR, Chen M, Luo K, Sipe C, Children's Health Exposure Analysis R, Liu AH. Phthalate Mixture Effects on Children with Exacerbation-Prone Asthma in a Study of Multiple Pollutants and Asthma Severity. A48 ENVIRONMENTAL ASTHMA: American Thoracic Society; 2020. p. A1836-A.
• Romero J, Hamlington KL, Schiltz AM, Freeman KL, Liu AH. Dog Allergen Component Sensitization and the Health Impact of Epitope Spreading in Dog-Exposed Children with Asthma. A32 ASTHMA CLINICAL STUDIES: American Thoracic Society; 2020. p. A1327-A.

Practice Locations

Children's Hospital Colorado Anschutz Medical Campus
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Specialty Information

Specialties

• Public Health, Certificate (2016)
• Personalized and Genomic Medicine, Certificate (2025)
• Biomedical Engineering (PhD), Other (2013)
• Lung Physiology (Post-doctoral Training), Other (2017)

Conditions & Treatments

• Lungs and Breathing