I study basic mechanisms of how epilepsy develops using human and mouse models.
Teaching
Attending Physician
(2017)
School of Medicine,
Neurosurgery
Pediatric Neurosurgery: epilepsy, craniosynostosis, traumatic brain injury
Publications
Responsive Neurostimulation in Drug-Resistant Pediatric Epilepsy: Findings From the Epilepsy Surgery Subgroup of the Pediatric Epilepsy Research Consortium.
Singh RK, Eschbach K, Samanta D, Perry MS, Liu G, Alexander AL, Wong-Kisiel L, Ostendorf A, Tatachar P, Reddy SB, McCormack MJ, Manuel CM, Gonzalez-Giraldo E, Numis AL, Wolf S, Karia S, Karakas C, Olaya J, Shrey D, Auguste KI, Depositario-Cabacar D; PERC Surgery Registry Workgroup.
2. Hoffman P, Svalina MN, Flores C, Brzezinski C, Kushner JK, Staple B, Franco S, and Alexander AL. Developmental Characterization of Neuronal Migration Anomalies and Axon Proliferation in mTOR pathway-associated Malformations of Cortical Development bioRxiv [preprint]. Posted 3/12/23. Available at: https://doi.org/10.1101/2023.03.11.532231
37. Welton TA, George NM, Ozbay BN, Gentile Polese A, Osborne G, Futia G, Kushner JK, Klenschmidt-Demasters B, Alexander AL, Abosch A, Ojemann S, Restrepo D, Gibson EA. Two-Photon Microendoscope for Label-Free Imaging in Stereotactic Neurosurgery. Biomedical Optics Express, 2023 Jun 27;14(7):3705-3725. doi: 10.1364/BOE.492552. eCollection 2023 Jul 1.
Highlights From the Annual Meeting of the American Epilepsy Society 2022
Ignacio Valencia, MD https://orcid.org/0000-0003-2385-4933 ignacio.valencia@towerhealth.org, Allyson L. Alexander, MD, PhD, […], and Barbara Jobst, MD, PhD https://orcid.org/0000-0001-9243-2238+109View all authors and affiliations
OnlineFirst
https://doi.org/10.1177/15357597231187227
Nagahama Y, Alexander AL, O'Neill BR. Intracranial pressure monitoring during stereoelectroencephalography implantation: a technical note. J Neurosurg Pediatr. 2022 Jan 21;:1-4. [Epub ahead of print] PubMed PMID: 35061987
Perry MS, Shandley S, Perelman M, Singh RK, Wong-Kisiel L, Sullivan J, Gonzalez-Giraldo E, Romanowski EF, McNamara NA, Marashly A, Ostendorf AP, Alexander A, Eschbach K, Bolton J, Wolf S, McGoldrick P, Depositario-Cabacar DF, Ciliberto MA, Gedela S, Sannagowdara K, Karia S, Shrey DW, Tatachar P, Nangia S, Grinspan Z, Reddy SB, Shital P, Coryell J. Surgical evaluation in children <3 years of age with drug-resistant epilepsy: Patient characteristics, diagnostic utilization, and potential for treatment delays. Epilepsia. 2022 Jan;63(1):96-107. PubMed PMID: 34778945
Somatic variants in diverse genes leads to a spectrum of focal cortical malformations
Brain. 2022 Aug 27;145(8):2704-2720. doi: 10.1093/brain/awac117.
Dulcie Lai 1, Meethila Gade 1, Edward Yang 2, Hyun Yong Koh 3 4, Jinfeng Lu 1, Nicole M Walley 5, Anne F Buckley 6, Tristan T Sands 7 8, Cigdem I Akman 8, Mohamad A Mikati 9 10, Guy M McKhann 11, James E Goldman 12, Peter Canoll 12, Allyson L Alexander 13, Kristen L Park 14, Gretchen K Von Allmen 15 16, Olga Rodziyevska 16, Meenakshi B Bhattacharjee 17, Hart G W Lidov 18, Hannes Vogel 19, Gerald A Grant 20, Brenda E Porter 21, Annapurna H Poduri 3 4, Peter B Crino 22, Erin L Heinzen 1 23
Postoperative general medical ward admission following Chiari malformation decompression.
Finneran MM, Graber S, Poppleton K, Alexander AL, Wilkinson CC, O'Neill BR, Hankinson TC, Handler MH.
J Neurosurg Pediatr. 2022 Sep 16;30(6):602-608. doi: 10.3171/2022.7.PEDS22226. Print 2022 Dec 1.
PMID: 36115060
Intracranial pressure monitoring during stereoelectroencephalography implantation: a technical note.
Nagahama Y, Alexander AL, O'Neill BR.
J Neurosurg Pediatr. 2022 Jan 21;29(4):454-457. doi: 10.3171/2021.12.PEDS21490. Print 2022 Apr 1.
PMID: 35061987
Surgical evaluation in children <3 years of age with drug-resistant epilepsy: Patient characteristics, diagnostic utilization, and potential for treatment delays.
Perry MS, Shandley S, Perelman M, Singh RK, Wong-Kisiel L, Sullivan J, Gonzalez-Giraldo E, Romanowski EF, McNamara NA, Marashly A, Ostendorf AP, Alexander A, Eschbach K, Bolton J, Wolf S, McGoldrick P, Depositario-Cabacar DF, Ciliberto MA, Gedela S, Sannagowdara K, Karia S, Shrey DW, Tatachar P, Nangia S, Grinspan Z, Reddy SB, Shital P, Coryell J.
Epilepsia. 2022 Jan;63(1):96-107. doi: 10.1111/epi.17124. Epub 2021 Nov 15.
Leveraging expertise and optimizing clinical research: Initial success of a pediatric epilepsy surgery collaborative.
Berl MM, Koop JI, Ailion A, Bearden DJ, Boyer K, Cooper CM, Decrow AM, Duong PH, Espe-Pfeifer P, Gabriel M, Hodges E, Marshall DF, McNally KA, Molnar AE, Olsen EK, Ono KE, Patrick KE, Paul BM, Romain J, Sepeta LN, Stilp RLH, Wilkening GN, Zaccariello M, Zelko F, Perry MS; PERC Surgery Workgroup.
Epilepsia. 2023 Jun;64(6):1554-1567. doi: 10.1111/epi.17579. Epub 2023 Mar 24.
Guglielmi G, Eschbach KL, Alexander AL. Smaller Knife, Fewer Seizures? Recent Advances in Minimally Invasive Techniques in Pediatric Epilepsy Surgery. Semin Pediatr Neurol. 2021 Oct;39:100913. PubMed PMID: 34620456
Nagahama Y, Zervos TM, Murata KK, Holman L, Karsonovich T, Parker JJ, Chen JS, Phillips HW, Fajardo M, Nariai H, Hussain SA, Porter BE, Grant GA, Ragheb J, Wang S, O'Neill BR, Alexander AL, Bollo RJ, Fallah A. Real-World Preliminary Experience With Responsive Neurostimulation in Pediatric Epilepsy: A Multicenter Retrospective Observational Study. Neurosurgery. 2021 Nov 18;89(6):997-1004. PubMed PMID: 34528103
Flores CA, French BM, Alexander AL, Graber S, Wittenberg B, Poppleton K, Wilkinson CC. Vascularized Pericranial Flap as a Method to Prevent Persistent Skull Defects After Craniectomy for Sagittal Synostosis. J Craniofac Surg. 2021 Nov-Dec 01;32(8):2744-2748. PubMed PMID: 34238877
Talai A, Eschbach K, Stence NV, Palmer C, Bird W, Alexander A, O'Neill BR, Chapman KE, Joshi C. Comparison of subdural grid and stereoelectroencephalography in a cohort of pediatric patients. Epilepsy Res. 2021 Nov;177:106758. PubMed PMID: 34530304
Andrews M, Allen G, Alexander A, French B, Wilkinson C, Mason A. Evolution of a Virtual Multidisciplinary Cleft and Craniofacial Team Clinic During the COVID-19 Pandemic: Children's Hospital Colorado Experience. Cleft Palate Craniofac J. 2021 May;58(5):653-657. PubMed PMID: 33356504
Cea-Del Rio CA, Nunez-Parra A, Freedman SM, Kushner JK, Alexander AL, Restrepo D, Huntsman MM. Disrupted inhibitory plasticity and homeostasis in Fragile X syndrome. Neurobiol Dis. 2020 Aug;142:104959. PubMed PMID: 32512151
Karsonovich T, Alexander A, Graber S, O'Neill BR. Placement of leads for stereotactic electroencephalography without the use of anchor bolts: technical note.
J Neurosurg Pediatr. 2020 Dec 18:1-6. doi: 10.3171/2020.7.PEDS20403. Online ahead of print. PMID: 33338995
Maureen Andrews, Greg Allen, Allyson Alexander, Brooke French, Corbett Wilkinson, Aaron Mason. Evolution of a Virtual Multidisciplinary Cleft and Craniofacial Team Clinic During the COVID-19 Pandemic: Children's Hospital Colorado Experience. Cleft Palate Craniofac J
. 2020 Dec 28;1055665620961904. doi: 10.1177/1055665620961904. Online ahead of print. PMID: 33356504
Characterizing the diversity of L2/3 human neocortical neurons in epilepsy
J. Keenan Kushner, Paige B. Hoffman, Christine Brzezinski, Molly M. Huntsman, Allyson L. Alexander
bioRxiv 2022.06.13.495678; doi: https://doi.org/10.1101/2022.06.13.495678
Clinical Interests
surgical treatment of epilepsy; craniosynostosis; hydrocephalus and shunts; Chiari malformations; tethered cords; general pediatric neurosurgery
Care Philosophy
Providing compassionate surgical care to children with neurosurgical conditions before, during, and after surgery.
Personal Interests
I spend my free time with my husband and two daughters exploring the city, finding the best playgrounds, cooking and baking, and traveling.