Lindsay Brubaker, MD

Recognitions

• The Stanford OB-GYN Julianne O’Callahan Award for Compassion in Patient Care, Stanford Department of OB-GYN (2015)
• Humanism and Excellence in Teaching Award, The Arnold P. Gold Foundation (2014)

Research Interests

I am dedicated to research to advance the field of gynecologic oncology, collaborating closely with the Bitler-Behbakht Lab in translational efforts to overcome chemotherapy resistance in ovarian cancer. I am also involved in clinical research with a particular interest in palliative care and medical education.

Publications

• Greenwood A, Woodruff ER, Nguyen C, Piper C, Clauset A, Brubaker LW, Behbakht K, Bitler BG. Early Ovarian Cancer Detection in the Age of Fallopian Tube Precursors: A Systematic Review. Obstet Gynecol. 2024 Jan 4. [Epub ahead of print] PubMed PMID: 38176019
• Bapat J, Yamamoto TM, Woodruff ER, Qamar L, Mikeska RG, Aird KM, Watson ZL, Brubaker LW, Bitler BG. CASC4/GOLM2 drives high grade serous carcinoma anoikis resistance through the recycling of EGFR. Cancer Gene Ther. 2024 Feb;31(2):300-310. PubMed PMID: 38030811
• Floyd J, DeSanto K, Bitler BG, Brubaker LW. Polycomb Repressor Complex 1 (PRC1) in ovarian cancer: A scoping literature review. Crit Rev Oncol Hematol. 2024 Oct;202:104456. PubMed PMID: 39033867
• Iwanaga R, Yamamoto TM, Gomez K, Nguyen LL, Woodruff ER, Post MD, Mikeska RG, Danis E, Danhorn T, Boorgula MP, Mitra SS, Marjon NA, Bitler BG, Brubaker LW. Tumor-Intrinsic Activity of Chromobox 2 Remodels the Tumor Microenvironment in High-grade Serous Carcinoma. Cancer Res Commun. 2024 Aug 1;4(8):1919-1932. PubMed PMID: 38984891
• Van Kleunen L, Ahmadian M, Post MD, Wolsky RJ, Rickert C, Jordan K, Hu J, Richer JK, Marjon NA, Behbakht K, Sikora MJ, Bitler BG, Clauset A. The spatial structure of the tumor immune microenvironment can explain and predict patient response in high-grade serous carcinoma. bioRxiv. 2024 Jan 29. PubMed PMID: 38352574
• Dexter JM, Brubaker LW, Bitler BG, Goff BA, Menon U, Moore KN, Sundaram KM, Walsh CS, Guntupalli SR, Behbakht K. Ovarian cancer think tank: An overview of the current status of ovarian cancer screening and recommendations for future directions. Gynecol Oncol Rep. 2024 Jun;53:101376. PubMed PMID: 38590930
• Greenwood A, Woodruff ER, Nguyen C, Piper C, Clauset A, Brubaker LW, Behbakht K, Bitler BG. Early Ovarian Cancer Detection in the Age of Fallopian Tube Precursors: A Systematic Review. Obstet Gynecol. 2024 Mar 1;143(3):e63-e77. PubMed PMID: 38176019
• Van Kleunen LB, Ahmadian M, Post MD, Wolsky RJ, Rickert C, Jordan KR, Hu J, Richer JK, Brubaker LW, Marjon N, Behbakht K, Sikora MJ, Bitler BG, Clauset A. The Spatial Structure of the Tumor Immune Microenvironment Can Explain and Predict Patient Response in High-Grade Serous Carcinoma. Cancer Immunol Res. 2024 Nov 4;12(11):1492-1507. PubMed PMID: 39115368
• Smith LP, Brubaker LW, Wolsky RJ. It Does Exist! Diagnosis and Management of Thyroid Carcinomas Originating in Struma Ovarii. Surg Pathol Clin. 2023 Mar;16(1):75-86. PubMed PMID: 36739168
• Bapat J, Yamamoto TM, Woodruff ER, Qamar L, Mikeska RG, Aird KM, Watson ZL, Brubaker LW, Bitler BG. CASC4/GOLM2 drives high grade serous carcinoma anoikis resistance through the recycling of EGFR. Cancer Gene Ther. 2023 Nov 29. [Epub ahead of print] PubMed PMID: 38030811
• Porragas-Paseiro HS, Johnson S, Brubaker L, Sanders BE. Pneumocystis jirovecii pneumonia complicating methotrexate treatment in a patient with low-risk post-molar gestational trophoblastic neoplasia: A case report and review of the literature. Gynecol Oncol Rep. 2023 Dec;50:101286. PubMed PMID: 37860081
• Persenaire C, Spinosa DL, Brubaker LW, Lefkowits CJ. Incorporation of Palliative Care in Gynecologic Oncology. Curr Oncol Rep. 2023 Nov;25(11):1295-1305. PubMed PMID: 37792249
• Brubaker LW, Backos DS, Nguyen VT, Reigan P, Yamamoto TM, Woodruff ER, Iwanaga R, Wempe MF, Kumar V, Persenaire C, Watson ZL, Bitler BG. Novel chromobox 2 inhibitory peptide decreases tumor progression. Expert Opin Ther Targets. 2023 Apr-May;27(4-5):361-371. PubMed PMID: 37243607
• Sanders BE, Wolsky R, Doughty ES, Wells KL, Ghosh D, Ku L, Pressey JG, Bitler BB, Brubaker LW. Small cell carcinoma of the ovary hypercalcemic type (SCCOHT): A review and novel case with dual germline SMARCA4 and BRCA2 mutations. Gynecol Oncol Rep. 2022 Dec;44:101077. PubMed PMID: 36249907
• Haag JG, Adler AD, Sheeder J, Brubaker LW, Lefkowits C. Patterns of palliative care referral in platinum resistant ovarian cancer demonstrate reactive rather than proactive approach. Gynecol Oncol Rep. 2022 Oct;43:101053. PubMed PMID: 35958954
• Smith LP, Brubaker LW, Wolsky RJ. It does exist! Diagnosis and Management of Thyroid Carcinomas arising in Struma Ovarii. Surgical Pathology Clinics. Available online 13 December 2022. https://doi.org/10.1016/j.path.2022.09.008
• Steinhart B, Jordan KR, Bapat J, Post MD, Brubaker LW, Bitler BG, Wrobel J. The Spatial Context of Tumor-Infiltrating Immune Cells Associates with Improved Ovarian Cancer Survival. Mol Cancer Res. 2021 Dec;19(12):1973-1979. PubMed PMID: 34615692
• Johnson S, Renz M, Wheeler L, Diver E, Dorigo O, Litkouhi B, Behbakht K, Howitt B, Karam A. Vulvar sarcoma outcomes by histologic subtype: a Surveillance, Epidemiology, and End Results (SEER) database review. Int J Gynecol Cancer. 2020 Aug;30(8):1118-1123. PubMed PMID: 32641392
• Guntupalli SR, Brennecke A, Behbakht K, Tayebnejad A, Breed CA, Babayan LM, Cheng G, Ramzan AA, Wheeler LJ, Corr BR, Lefkowits C, Sheeder J, Matsuo K, Flink D. Safety and Efficacy of Apixaban vs Enoxaparin for Preventing Postoperative Venous Thromboembolism in Women Undergoing Surgery for Gynecologic Malignant Neoplasm: A Randomized Clinical Trial. JAMA Netw Open. 2020 Jun 1;3(6):e207410. PubMed PMID: 32589230
• Wheeler LJ, Guntupalli SR. Female Sexual Dysfunction: Pharmacologic and Therapeutic Interventions. Obstet Gynecol. 2020 Jul;136(1):174-186. PubMed PMID: 32541291

Professional Memberships

• Society of Gynecologic Oncology (SGO), Member
• The American Congress of Obstetricians and Gynecologists (ACOG), Member

Practice Locations

UCHealth Women's Care Clinic - Anschutz Medical Campus
1635 Aurora Ct
Anschutz Outpatient Pavilion, 3rd Fl
Aurora, CO 80045
720-848-1060

CU Medicine Medical Oncology - Cherry Creek Medical Center
100 Cook Street
Suite 202
Denver, CO 80206
720-516-9413

UCHealth Ambulatory Surgery Center - Cherry Creek Medical Center
100 Cook Street
Suite 500
Denver, CO 80206
720-516-9373

Hospital Affiliation

• University of Colorado Hospital

Center Affiliations

• University of Colorado Cancer Center

Specialty Information

Specialties

• Gynecologic Oncology

Conditions & Treatments

• Women's Health
• Cancers - Cancer Surgery
• Cancers
• Cancers - Cervical Cancer
• Cancers - Uterine Cancer
• Cancers - Ovarian Cancer
• Cancers - Gynecologic Cancer