Chelsea Magin, PhD

Professional Titles

• Associate Professor
• Director, Quality Assurance & Regulatory Affairs Certificate Program

Recognitions

• Tullis Faculty Fellow, College of Engineering, Design and Computing (2026)
• NY and May Chang Research Excellence Award, College of Engineering, Design, and Computing, University of Colorado, Denver (2024)
• Excellence in Research and Creative Works Award, University of Colorado, Denver (2024)
• Cellular and Molecular Bioengineering Rising Star Junior Faculty Award, Biomedical Engineering Society (2023)
• Cellular and Molecular Bioengineering Young Innovator Award, Biomedical Engineering Society (2022)
• 40 Gators Under 40 Award, University of Florida (2021)
• Recognition of Early Academic Achievement Award, American Thoracic Society (2020)
• Educator of the Year, Colorado Bioscience Association (2019)

Research Interests

My scientific interests focus on developing engineered cell culture platforms that precisely and consistently mimic the dynamic and complex architecture, composition, and mechanical properties of lung tissue in vitro. These bioengineered lung models enable us to study lung disease and regeneration using patient-derived cells bridging the gap between basic research results obtained using traditional cell culture techniques and rodent animal models and the outcomes of clinical studies. Our results will provide a foundation for development of precision medical treatments.

Publications

• Reeser RS, VeDepo MC, Hewawasam RS, Waugh KA, Schade KA, Abdel-Hafiz M, Peña B, Mestroni L, Sbaizero O, Espinosa JM, Magin CM, Jacot JG. Aberrant tissue mechanics and mechanotransduction during heart development in down syndrome. J Biomech. 2026 Jan;195:113103. PubMed PMID: 41468742
• Kary AD, Noelle H, Magin CM. Tissue-Informed Biomaterial Innovations Advance Pulmonary Regenerative Engineering. ACS Macro Lett. 2025 Apr 15;14(4):434-447. PubMed PMID: 40102038
• Hauer C, Blomberg R, Sompel K, Magin CM, Tennis MA. Hydrogel-embedded precision-cut lung slices support ex vivo culture of in vivo-induced premalignant lung lesions. Physiol Rep. 2025 Jul;13(13):e70459. PubMed PMID: 40650429
• Tanneberger AE, Blomberg R, Bilousova G, Ryan AL, Magin CM. Engineered hydrogel biomaterials facilitate lung progenitor cell differentiation from induced pluripotent stem cells. Am J Physiol Lung Cell Mol Physiol. 2025 Mar 1;328(3):L379-L388. PubMed PMID: 39884665
• Mueller MC, Blomberg R, Tanneberger AE, Davis-Hall D, Neeves KB, Magin CM. Female Fibroblast Activation Is Estrogen-Mediated in Sex-Specific 3D-Bioprinted Pulmonary Artery Adventitia Models. ACS Biomater Sci Eng. 2025 May 12;11(5):2935-2945. PubMed PMID: 40285704
• Tanneberger AE, Blomberg R, Kary AD, Lu A, Riches DWH, Magin CM. Biomaterial-based 3D human lung models replicate pathological characteristics of early pulmonary fibrosis. Acta Biomater. 2025 Sep 15;204:277-292. PubMed PMID: 40782923
• Hynds RE, Magin CM, Ikonomou L, Aschner Y, Beers MF, Burgess JK, Heise RL, Hume PS, Krasnodembskaya AD, Mei SHJ, Misharin AV, Park JA, Reynolds SD, Tschumperlin DJ, Tanneberger AE, Vaidyanathan S, Waters CM, Zettler PJ, Weiss DJ, Ryan AL. Stem cells, cell therapies, and bioengineering in lung biology and diseases 2023. Am J Physiol Lung Cell Mol Physiol. 2024 Sep 1;327(3):L327-L340. PubMed PMID: 38772903
• Blomberg R, Sompel K, Hauer C, Smith AJ, Peña B, Driscoll J, Hume PS, Merrick DT, Tennis MA, Magin CM. Hydrogel-Embedded Precision-Cut Lung Slices Model Lung Cancer Premalignancy Ex Vivo. Adv Healthc Mater. 2024 Feb;13(4):e2302246. PubMed PMID: 37953708
• Montesi SB, Gomez CR, Beers M, Brown R, Chattopadhyay I, Flaherty KR, Garcia CK, Gomperts B, Hariri LP, Hogaboam CM, Jenkins RG, Kaminski N, Kim GHJ, Königshoff M, Kolb M, Kotton DN, Kropski JA, Lasky J, Magin CM, Maher TM, McCormick M, Moore BB, Nickerson-Nutter C, Oldham J, Podolanczuk AJ, Raghu G, Rosas I, Rowe SM, Schmidt WT, Schwartz D, Shore JE, Spino C, Craig JM, Martinez FJ. Pulmonary Fibrosis Stakeholder Summit: A Joint NHLBI, Three Lakes Foundation, and Pulmonary Fibrosis Foundation Workshop Report. Am J Respir Crit Care Med. 2024 Feb 15;209(4):362-373. PubMed PMID: 38113442
• Vukmirovic M, Benam KH, Rose JJ, Turner S, Magin CM, Lagares D, Cohen AH, Kaminski N, Hirota JA, Maher TM, Konigshoff M, Mallampalli RK, Sheppard D, Tarran R, Gomer RH, Kenyon NJ, Morris D, Hobbie S, Raju SV, Petrache I, Watkins T, Kumar R, Lam WA, Sherer T, Hecker L. Challenges and Opportunities for Commercializing Technologies in the Pulmonary Arena: An Official American Thoracic Society Report. Ann Am Thorac Soc. 2024 Jan;21(1):1-11. PubMed PMID: 37903340
• Tanneberger AE, Weiss DJ, Magin CM. An Introduction to Engineering and Modeling the Lung. Adv Exp Med Biol. 2023;1413:1-13. PubMed PMID: 37195523
• Blomberg R, Hewawasam RS, Šerbedžija P, Saleh K, Caracena T, Magin CM. Engineering Dynamic 3D Models of Lung. Adv Exp Med Biol. 2023;1413:155-189. PubMed PMID: 37195531
• Hewawasam RS, Blomberg R, Šerbedžija P, Magin CM. Chemical Modification of Human Decellularized Extracellular Matrix for Incorporation into Phototunable Hybrid-Hydrogel Models of Tissue Fibrosis. ACS Appl Mater Interfaces. 2023 Mar 29;15(12):15071-15083. PubMed PMID: 36917510
• Petrou CL, D'Ovidio TJ, Bölükbas DA, Tas S, Brown RD, Allawzi A, Lindstedt S, Nozik-Grayck E, Stenmark KR, Wagner DE, Magin CM. Clickable decellularized extracellular matrix as a new tool for building hybrid-hydrogels to model chronic fibrotic diseases in vitro. J Mater Chem B. 2020 Aug 21;8(31):6814-6826. PubMed PMID: 32343292
• George MP, Maier LA, Kasperbauer S, Eddy J, Mayer AS, Magin CM. How to Leverage Collaborations Between the BME Community and Local Hospitals to Address Critical Personal Protective Equipment Shortages During the COVID-19 Pandemic. Ann Biomed Eng. 2020 Sep;48(9):2281-2284. PubMed PMID: 32710248
• Bailey KE, Pino C, Lennon ML, Lyons A, Jacot JG, Lammers SR, Königshoff M, Magin CM. Embedding of Precision-Cut Lung Slices in Engineered Hydrogel Biomaterials Supports Extended Ex Vivo Culture. Am J Respir Cell Mol Biol. 2020 Jan;62(1):14-22. PubMed PMID: 31513744
• Petrou, Cassandra L., D’Ovidio, Tyler J., Tas, Sinem, Bölükbas, Deniz, Brown, R. Dale, Stenmark, Kurt R., Wager, Darcy E., Magin, Chelsea M. Clickable, decellularized extracellular matrix as a new tool for building dynamic, hybrid hydrogels to model chronic fibrotic diseases in vitro. Journal of Materials Chemistry B. DOI: 10.1039/D0TB00613K (2020).
• T. J. D’Ovidio, A. R. W. Friederich, N. de Herrera, D. Davis-Hall, E. E. Mann, C. M. Magin, Biomedical Physics & Engineering Express 2019, 5, 065027.
• D. Davis-Hall, V. Nguyen, T. J. D'Ovidio, E. Tsai, G. Bilousova, C. M. Magin, Peptide-functionalized hydrogels modulate integrin expression and stemness in adult human epidermal keratinocytes. Advanced Biosystems 2019, 3, 1900022.
• Bailey KE, Floren ML, D'Ovidio TJ, Lammers SR, Stenmark KR, Magin CM. Tissue-informed engineering strategies for modeling human pulmonary diseases. Am J Physiol Lung Cell Mol Physiol. 2019 Feb 1;316(2):L303-L320. PubMed PMID: 30461289
• Bailey, K.E., et al., Hybrid Three-Dimensional Lung Tissue Cultures to Improve Ex Vivo Models of Chronic Obstructive Pulmonary Disease. Annals of the American Thoracic Society, 2018. 15(Supplement_4): p. S288-S288.
• Symmes BA, Stefanski AL, Magin CM, Evans CM. Role of mucins in lung homeostasis: regulated expression and biosynthesis in health and disease. Biochem Soc Trans. 2018 Jun 19;46(3):707-719. PubMed PMID: 29802217
• Magin CM, Neale DB, Drinker MC, Willenberg BJ, Reddy ST, La Perle KM, Schultz GS, Brennan AB. Evaluation of a bilayered, micropatterned hydrogel dressing for full-thickness wound healing. Exp Biol Med (Maywood). 2016 May;241(9):986-95. PubMed PMID: 27037279
• Mann EE, Magin CM, Mettetal MR, May RM, Henry MM, DeLoid H, Prater J, Sullivan L, Thomas JG, Twite MD, Parker AE, Brennan AB, Reddy ST. Micropatterned Endotracheal Tubes Reduce Secretion-Related Lumen Occlusion. Ann Biomed Eng. 2016 Dec;44(12):3645-3654. PubMed PMID: 27535564
• May RM, Magin CM, Mann EE, Drinker MC, Fraser JC, Siedlecki CA, Brennan AB, Reddy ST. An engineered micropattern to reduce bacterial colonization, platelet adhesion and fibrin sheath formation for improved biocompatibility of central venous catheters. Clin Transl Med. 2015;4:9. PubMed PMID: 25852825
• Magin CM, Finlay JA, Clay G, Callow ME, Callow JA, Brennan AB. Antifouling performance of cross-linked hydrogels: refinement of an attachment model. Biomacromolecules. 2011 Apr 11;12(4):915-22. PubMed PMID: 21401017
• Magin CM, Long CJ, Cooper SP, Ista LK, López GP, Brennan AB. Engineered antifouling microtopographies: the role of Reynolds number in a model that predicts attachment of zoospores of Ulva and cells of Cobetia marina. Biofouling. 2010 Aug;26(6):719-27. PubMed PMID: 20706891

Professional Memberships

• Society for Biomaterials, Member
• American Thoracic Society, Member

Practice Locations

Center Affiliations

• Center for Women's Health Research
• Charles C. Gates Regenerative Medicine and Stem Cell Biology Center
• University of Colorado Cancer Center