Educator of the Year, Colorado Bioscience Association
My scientific interests focus on developing engineered cell culture platforms that precisely and consistently mimic the dynamic and complex architecture, composition, and mechanical properties of lung tissue in vitro. These bioengineered lung models enable us to study lung disease and regeneration using patient-derived cells bridging the gap between basic research results obtained using traditional cell culture techniques and rodent animal models and the outcomes of clinical studies. Our results will provide a foundation for development of precision medical treatments.
Bailey KE, Pino C, Lennon ML, Lyons A, Jacot JG, Lammers SR, Königshoff M, Magin CM. Embedding of Precision-Cut Lung Slices in Engineered Hydrogel Biomaterials Supports Extended Ex Vivo Culture. Am J Respir Cell Mol Biol. 2020 Jan;62(1):14-22. PubMed PMID: 31513744
Petrou, Cassandra L., D’Ovidio, Tyler J., Tas, Sinem, Bölükbas, Deniz, Brown, R. Dale, Stenmark, Kurt R., Wager, Darcy E., Magin, Chelsea M. Clickable, decellularized extracellular matrix as a new tool for building dynamic, hybrid hydrogels to model chronic fibrotic diseases in vitro. Journal of Materials Chemistry B. DOI: 10.1039/D0TB00613K (2020).
T. J. D’Ovidio, A. R. W. Friederich, N. de Herrera, D. Davis-Hall, E. E. Mann, C. M. Magin, Biomedical Physics & Engineering Express 2019, 5, 065027.
D. Davis-Hall, V. Nguyen, T. J. D'Ovidio, E. Tsai, G. Bilousova, C. M. Magin, Peptide-functionalized hydrogels modulate integrin expression and stemness in adult human epidermal keratinocytes. Advanced Biosystems 2019, 3, 1900022.
Bailey KE, Floren ML, D'Ovidio TJ, Lammers SR, Stenmark KR, Magin CM. Tissue-informed engineering strategies for modeling human pulmonary diseases. Am J Physiol Lung Cell Mol Physiol. 2019 Feb 1;316(2):L303-L320. PubMed PMID: 30461289
Symmes BA, Stefanski AL, Magin CM, Evans CM. Role of mucins in lung homeostasis: regulated expression and biosynthesis in health and disease. Biochem Soc Trans. 2018 Jun 19;46(3):707-719. PubMed PMID: 29802217
Magin CM, Neale DB, Drinker MC, Willenberg BJ, Reddy ST, La Perle KM, Schultz GS, Brennan AB. Evaluation of a bilayered, micropatterned hydrogel dressing for full-thickness wound healing. Exp Biol Med (Maywood). 2016 May;241(9):986-95. PubMed PMID: 27037279
Mann EE, Magin CM, Mettetal MR, May RM, Henry MM, DeLoid H, Prater J, Sullivan L, Thomas JG, Twite MD, Parker AE, Brennan AB, Reddy ST. Micropatterned Endotracheal Tubes Reduce Secretion-Related Lumen Occlusion. Ann Biomed Eng. 2016 Dec;44(12):3645-3654. PubMed PMID: 27535564
May RM, Magin CM, Mann EE, Drinker MC, Fraser JC, Siedlecki CA, Brennan AB, Reddy ST. An engineered micropattern to reduce bacterial colonization, platelet adhesion and fibrin sheath formation for improved biocompatibility of central venous catheters. Clin Transl Med. 2015;4:9. PubMed PMID: 25852825
Magin CM, Finlay JA, Clay G, Callow ME, Callow JA, Brennan AB. Antifouling performance of cross-linked hydrogels: refinement of an attachment model. Biomacromolecules. 2011 Apr 11;12(4):915-22. PubMed PMID: 21401017
Magin CM, Long CJ, Cooper SP, Ista LK, López GP, Brennan AB. Engineered antifouling microtopographies: the role of Reynolds number in a model that predicts attachment of zoospores of Ulva and cells of Cobetia marina. Biofouling. 2010 Aug;26(6):719-27. PubMed PMID: 20706891
I enjoy a good project whether that's fixing up my 19th century house, throwing pottery or blazing a new trail on my bicycle.
Recently, I've been volunteering to design and sew cloth face coverings for healthcare and essential workers.
Public Speaking Yes
I've shared the results of our research with a variety of audiences in the community, including the Rocky Mountain Gator Club, an alumni group representing my alma mater, the University of Florida. Go Gators!