Amanda Piquet, MD
Associate Professor, Neurology

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Medical School:
  • MD, Pennsylvania State University College of Medicine
Internship:
  • Massachusetts General Hospital Program
Residency:
  • Massachusetts General Hospital/Brigham and Women's Hospital/Harvard Medical School Program, Neurology
Fellowships:
  • University of Utah Medical Center Program, Autoimmune Neurology/Neuroimmunology Fellowship Program
Department: Neurology

Research Interests

My research interests include optimizing diagnosis and treatment for patients with autoimmune neurological diseases; this includes the development of standardized guidelines and protocols for the diagnostic work up and treatment for autoimmune encephalitis.

Publications

  • Matthews E, Beckham JD, Piquet AL, Tyler KL, Chauhan L, Pastula DM. Herpesvirus-Associated Encephalitis: an Update. Curr Trop Med Rep. 2022;9(3):92-100. PubMed PMID: 36186545
  • Krett JD, Beckham JD, Tyler KL, Piquet AL, Chauhan L, Wallace CJ, Pastula DM, Kapadia RK. Neurology of Acute Viral Infections. Neurohospitalist. 2022 Oct;12(4):632-646. PubMed PMID: 36147750
  • Pastula DM, Copeland MJ, Hannan MC, Rapaka S, Kitani T, Kleiner E, Showler A, Yuen C, Ferriman EM, House J, O'Brien S, Burakoff A, Gupta B, Money KM, Matthews E, Beckham JD, Chauhan L, Piquet AL, Kumar RN, Tornatore CS, Padgett K, O'Laughlin K, Mangla AT, Kumar PN, Tyler KL, O'Connor SM. Two Cases of Monkeypox-Associated Encephalomyelitis - Colorado and the District of Columbia, July-August 2022. MMWR Morb Mortal Wkly Rep. 2022 Sep 23;71(38):1212-1215. PubMed PMID: 36136957
  • Chauhan L, Matthews E, Piquet AL, Henao-Martinez A, Franco-Paredes C, Tyler KL, Beckham D, Pastula DM. Nervous System Manifestations of Arboviral Infections. Curr Trop Med Rep. 2022 Sep 15;:1-12. [Epub ahead of print] PubMed PMID: 36124288
  • Passeri M, Matthews E, Kammeyer R, Piquet AL. Update in autoimmune and paraneoplastic myelopathies: Newly described antigen targets and antibody testing. Front Neurol. 2022;13:972143. PubMed PMID: 35968301
  • Matthews E, Schmitt B, Passeri M, Mizenko C, Orjuela K, Piquet A. AMPA Receptor Encephalitis in a Patient With Metastatic Breast Cancer Receiving Palbociclib: A Case Report. Neurol Neuroimmunol Neuroinflamm. 2022 Sep;9(5). PubMed PMID: 35794024
  • Matthews E, Chauhan L, Piquet AL, Tyler KL, Pastula DM. An Overview of La Crosse Virus Disease. Neurohospitalist. 2022 Jul;12(3):587-588. PubMed PMID: 35755222
  • Kammeyer R, Mizenko C, Sillau S, Richie A, Owens G, Nair KV, Alvarez E, Vollmer TL, Bennett JL, Piquet AL. Evaluation of Plasma Neurofilament Light Chain Levels as a Biomarker of Neuronal Injury in the Active and Chronic Phases of Autoimmune Neurologic Disorders. Front Neurol. 2022;13:689975. PubMed PMID: 35309573
  • Sloane KL, Miller JJ, Piquet A, Edlow BL, Rosenthal ES, Singhal AB. Prognostication in Acute Neurological Emergencies. J Stroke Cerebrovasc Dis. 2022 Mar;31(3):106277. PubMed PMID: 35007934
  • Valencia-Sanchez C, Knight AM, Hammami MB, Guo Y, Mills JR, Kryzer TJ, Piquet AL, Amin A, Heinzelmann M, Lucchinetti CF, Lennon VA, McKeon A, Pittock SJ, Dubey D. Characterisation of TRIM46 autoantibody-associated paraneoplastic neurological syndrome. J Neurol Neurosurg Psychiatry. 2022 Feb;93(2):196-200. PubMed PMID: 34921120
  • Venkataraman, I, Heckler, I, Piquet, AL. The Testing Landscape of Autoimmune Neurological Conditions: Newly Discovered Cell Surface and Intracellular Antigens. 2022. J Clinical Chem Lab Med. 5:211.
  • Garza M, Piquet AL. Update in Autoimmune Movement Disorders: Newly Described Antigen Targets in Autoimmune and Paraneoplastic Cerebellar Ataxia. Front Neurol. 2021;12:683048. PubMed PMID: 34489848
  • Mizenko C, Bennett JL, Owens G, Vollmer TL, Piquet AL. A Longitudinal, Observational Analysis of Neuronal Injury Biomarkers in a Case Report of a Patient With Paraneoplastic Anti-CRMP5 Antibody-Associated Transverse Myelitis. Front Neurol. 2021;12:691509. PubMed PMID: 34349723
  • Kapadia RK, Gill CM, Baca C, McMenamin C, Kannappan A, Niehaus WN, Tyler KL, Pastula DM, Piquet AL. Enterovirus A71 causing meningoencephalitis and acute flaccid myelitis in a patient receiving rituximab. J Neuroimmunol. 2021 Sep 15;358:577639. PubMed PMID: 34214953
  • Coleman KJ, Chauhan L, Piquet AL, Tyler KL, Pastula DM. An Overview of Jamestown Canyon Virus Disease. Neurohospitalist. 2021 Jul;11(3):277-278. PubMed PMID: 34163560
  • Piquet AL, Corboy JR, Vollmer TL. Correspondence to: Humoral immune response to COVID-19 mRNA vaccine in patients with multiple sclerosis treated with high-efficacy disease-modifying therapies. Ther Adv Neurol Disord. 2021;14:17562864211019567. PubMed PMID: 34104219
  • High B, Hixon AM, Tyler KL, Piquet AL, Pelak VS. Neurology and the COVID-19 Pandemic: Gathering Data for an Informed Response. Neurol Clin Pract. 2021 Apr;11(2):e48-e63. PubMed PMID: 33842072
  • Garza M, Piquet AL. Update in Autoimmune Movement Disorders: Newly Described Antigen Targets in Autoimmune and Paraneoplastic Cerebellar Ataxia. Front Neurol. 2021;12:683048. PubMed PMID: 34489848
  • Mizenko C, Bennett JL, Owens G, Vollmer TL, Piquet AL. A Longitudinal, Observational Analysis of Neuronal Injury Biomarkers in a Case Report of a Patient With Paraneoplastic Anti-CRMP5 Antibody-Associated Transverse Myelitis. Front Neurol. 2021;12:691509. PubMed PMID: 34349723
  • Kapadia RK, Gill CM, Baca C, McMenamin C, Kannappan A, Niehaus WN, Tyler KL, Pastula DM, Piquet AL. Enterovirus A71 causing meningoencephalitis and acute flaccid myelitis in a patient receiving rituximab. J Neuroimmunol. 2021 Sep 15;358:577639. PubMed PMID: 34214953
  • Coleman KJ, Chauhan L, Piquet AL, Tyler KL, Pastula DM. An Overview of Jamestown Canyon Virus Disease. Neurohospitalist. 2021 Jul;11(3):277-278. PubMed PMID: 34163560
  • Piquet AL, Corboy JR, Vollmer TL. Correspondence to: Humoral immune response to COVID-19 mRNA vaccine in patients with multiple sclerosis treated with high-efficacy disease-modifying therapies. Ther Adv Neurol Disord. 2021;14:17562864211019567. PubMed PMID: 34104219
  • High B, Hixon AM, Tyler KL, Piquet AL, Pelak VS. Neurology and the COVID-19 Pandemic: Gathering Data for an Informed Response. Neurol Clin Pract. 2021 Apr;11(2):e48-e63. PubMed PMID: 33842072
  • Kapadia RK, Chauhan L, Piquet AL, Tyler KL, Pastula DM. An Overview of Eastern Equine Encephalitis (EEE). Neurohospitalist. 2020 Jul;10(3):161-162. PubMed PMID: 32549937
  • Kapadia RK, Ney DE, Hannan M, Farley M, Pastula DM, Piquet AL. Glial fibrillary acidic protein (GFAP) associated autoimmune meningoencephalitis in a patient receiving nivolumab. J Neuroimmunol. 2020 Jul 15;344:577259. PubMed PMID: 32416558
  • Macchi ZA, Kleinschmidt-DeMasters BK, Orjuela KD, Pastula DM, Piquet AL, Baca CB. Glioblastoma as an autoimmune limbic encephalitis mimic: A case and review of the literature. J Neuroimmunol. 2020 Mar 7;342:577214. [Epub ahead of print] PubMed PMID: 32182452
  • Gill CM, Kapadia RK, Beckham JD, Piquet AL, Tyler KL, Pastula DM. Usutu virus disease: a potential problem for North America?. J Neurovirol. 2020 Apr;26(2):149-154. PubMed PMID: 31858483
  • Deuel, L, Yu, C. Vaughan, C, Piquet, AL. Oro-bucco-lingual dyskinesia, weight loss, and cognitive decline in anti-DPPX antibody-mediated encephalitis. Movement Disorders Clinical Practice. 2020 Sept. doi:10.1002/mdc3.13058
  • High, B, Hixon, AM, Tyler, KL, Piquet, AL, Pelak, VS. Neurology and the COVID-19 Pandemic: Gathering Data for an Informed Response. Neurol Clin Pract Jul 2020. DOI: 10.1212/CPJ.0000000000000908
  • Piquet, AL, Alvarez, E, Bennett, JL, Knapp, C, Sillau, S, Mizenko, C, Nair, K, Vollmer, T. A Retrospective, Cross-sectional Study Evaluating Plasma Neurofilament Light Levels in Autoimmune Neurological Disorders. American Neurological Association, Virtual meeting, October 2020.
  • Deuel LM, Yu CH, Vaughan CL, Piquet AL. Oro-Bucco-Lingual Dyskinesia, Weight Loss, and Cognitive Decline in Anti-DPPX Antibody-Mediated Encephalitis. Mov Disord Clin Pract. 2020 Sep;7(Suppl 3):S80-S82. PubMed PMID: 33015231
  • Kapadia RK, Chauhan L, Piquet AL, Tyler KL, Pastula DM. An Overview of Eastern Equine Encephalitis (EEE). Neurohospitalist. 2020 Jul;10(3):161-162. PubMed PMID: 32549937
  • Kapadia RK, Ney DE, Hannan M, Farley M, Pastula DM, Piquet AL. Glial fibrillary acidic protein (GFAP) associated autoimmune meningoencephalitis in a patient receiving nivolumab. J Neuroimmunol. 2020 Jul 15;344:577259. PubMed PMID: 32416558
  • Macchi ZA, Kleinschmidt-DeMasters BK, Orjuela KD, Pastula DM, Piquet AL, Baca CB. Glioblastoma as an autoimmune limbic encephalitis mimic: A case and review of the literature. J Neuroimmunol. 2020 Mar 7;342:577214. [Epub ahead of print] PubMed PMID: 32182452
  • Gill CM, Kapadia RK, Beckham JD, Piquet AL, Tyler KL, Pastula DM. Usutu virus disease: a potential problem for North America?. J Neurovirol. 2020 Apr;26(2):149-154. PubMed PMID: 31858483
  • Kammeyer R, Piquet AL. Multiple co-existing antibodies in autoimmune encephalitis: A case and review of the literature. J Neuroimmunol. 2019 Dec 15;337:577084. PubMed PMID: 31655424
  • Khan M, Beckham JD, Piquet AL, Tyler KL, Pastula DM. An Overview of Powassan Virus Disease. Neurohospitalist. 2019 Oct;9(4):181-182. PubMed PMID: 31534605
  • Gill CM, Beckham JD, Piquet AL, Tyler KL, Pastula DM. Five Emerging Neuroinvasive Arboviral Diseases: Cache Valley, Eastern Equine Encephalitis, Jamestown Canyon, Powassan, and Usutu. Semin Neurol. 2019 Aug;39(4):419-427. PubMed PMID: 31533182
  • Piquet AL, Khan M, Warner JEA, Wicklund MP, Bennett JL, Leehey MA, Seeberger L, Schreiner TL, Paz Soldan MM, Clardy SL. Novel clinical features of glycine receptor antibody syndrome: A series of 17 cases. Neurol Neuroimmunol Neuroinflamm. 2019 Sep;6(5):e592. PubMed PMID: 31355325
  • Khan M, Ney DE, Kleinschmidt-DeMasters BK, Horton L, Alvarez E, Piquet AL. CNS atypical T-cell lymphoproliferative disease following treatment with alemtuzumab. Neurol Clin Pract. 2019 Jun;9(3):273-276. PubMed PMID: 31341717
  • Kammeyer R, Piquet AL. Multiple co-existing antibodies in autoimmune encephalitis: A case and review of the literature. J Neuroimmunol. 2019 Dec 15;337:577084. PubMed PMID: 31655424
  • Khan M, Beckham JD, Piquet AL, Tyler KL, Pastula DM. An Overview of Powassan Virus Disease. Neurohospitalist. 2019 Oct;9(4):181-182. PubMed PMID: 31534605
  • Gill CM, Beckham JD, Piquet AL, Tyler KL, Pastula DM. Five Emerging Neuroinvasive Arboviral Diseases: Cache Valley, Eastern Equine Encephalitis, Jamestown Canyon, Powassan, and Usutu. Semin Neurol. 2019 Aug;39(4):419-427. PubMed PMID: 31533182
  • Piquet AL, Khan M, Warner JEA, Wicklund MP, Bennett JL, Leehey MA, Seeberger L, Schreiner TL, Paz Soldan MM, Clardy SL. Novel clinical features of glycine receptor antibody syndrome: A series of 17 cases. Neurol Neuroimmunol Neuroinflamm. 2019 Sep;6(5):e592. PubMed PMID: 31355325
  • Khan M, Ney DE, Kleinschmidt-DeMasters BK, Horton L, Alvarez E, Piquet AL. CNS atypical T-cell lymphoproliferative disease following treatment with alemtuzumab. Neurol Clin Pract. 2019 Jun;9(3):273-276. PubMed PMID: 31341717
  • López-Chiriboga AS, Klein C, Zekeridou A, McKeon A, Dubey D, Flanagan EP, Lennon VA, Tillema JM, Wirrell EC, Patterson MC, Gadoth A, Aaen JG, Brenton JN, Bui JD, Moen A, Otten C, Piquet A, Pittock SJ. LGI1 and CASPR2 neurological autoimmunity in children. Ann Neurol. 2018 Sep;84(3):473-480. PubMed PMID: 30076629
  • López-Chiriboga AS, Klein C, Zekeridou A, McKeon A, Dubey D, Flanagan EP, Lennon VA, Tillema JM, Wirrell EC, Patterson MC, Gadoth A, Aaen JG, Brenton JN, Bui JD, Moen A, Otten C, Piquet A, Pittock SJ. LGI1 and CASPR2 neurological autoimmunity in children. Ann Neurol. 2018 Sep;84(3):473-480. PubMed PMID: 30076629
  • Piquet AL, Clardy SL. Infection, Immunodeficiency, and Inflammatory Diseases in Autoimmune Neurology. Semin Neurol. 2018 Jun;38(3):379-391. PubMed PMID: 30011417
  • Galli J, Clardy SL, Piquet AL. NMDAR Encephalitis Following Herpes Simplex Virus Encephalitis. Curr Infect Dis Rep. 2017 Jan;19(1):1. PubMed PMID: 28102519
  • Piquet AL, Lyons JL. Infectious Meningitis and Encephalitis. Semin Neurol. 2016 Aug;36(4):367-72. PubMed PMID: 27643906
  • Piquet AL, Cho TA. The Clinical Approach to Encephalitis. Curr Neurol Neurosci Rep. 2016 May;16(5):45. PubMed PMID: 27021774
  • Venkiteswaran K, Alexander DN, Puhl MD, Rao A, Piquet AL, Nyland JE, Subramanian MP, Iyer P, Boisvert MM, Handly E, Subramanian T, Grigson PS. Transplantation of human retinal pigment epithelial cells in the nucleus accumbens of cocaine self-administering rats provides protection from seeking. Brain Res Bull. 2016 May;123:53-60. PubMed PMID: 26562520
  • Piquet AL, Venkiteswaran K, Marupudi NI, Berk M, Subramanian T. The immunological challenges of cell transplantation for the treatment of Parkinson's disease. Brain Res Bull. 2012 Jul 1;88(4):320-31. PubMed PMID: 22521427
  • Pagán OR, Rowlands AL, Azam M, Urban KR, Bidja AH, Roy DM, Feeney RB, Afshari LK. Reversal of cocaine-induced planarian behavior by parthenolide and related sesquiterpene lactones. Pharmacol Biochem Behav. 2008 Apr;89(2):160-70. PubMed PMID: 18222535
  • Rowlands AL, Pagán OR. Parthenolide prevents the expression of cocaine-induced withdrawal behavior in planarians. Eur J Pharmacol. 2008 Mar 31;583(1):170-2. PubMed PMID: 18275955
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Practice Locations

UCHealth Neurosciences Center - Anschutz Medical Campus
1635 Aurora Ct
4th Floor
Aurora, CO 80045
720-848-2080

UCHealth Anschutz Outpatient Pavilion - Anschutz Medical Campus
1635 Aurora Ct
Aurora, CO 80045
720-848-0000

Hospital Affiliation
  • University of Colorado Hospital
  • Children's Hospital Colorado

Specialty Information

Specialties
  • Neurology, Board Certification
  • Neuroimmunology
Conditions & Treatments
  • Immune System - Autoimmune Disorders
  • Immune System
  • Brain and Nervous System - Multiple Sclerosis
  • Brain and Nervous System
Clinical Interests
Dr. Piquet sub-specializes in autoimmune neurological diseases, multiple sclerosis and other inflammatory diseases of the central nervous system. Her main clinical interest includes antibody-mediated disorders of the nervous system such as autoimmune encephalitis and stiff person syndrome (SPS) as well as demyelinating disease including multiple sclerosis and neuromyelitis optica spectrum disorder (NMOSD). She has expertise in other inflammatory diseases including neurosarcoidosis, vasculitis, and central nervous system complications of rheumatological diseases such as lupus and Sjögren syndrome, among others.

General Information

Medical Schools:
  • MD, Pennsylvania State University College of Medicine (0001)
Internships:
  • Massachusetts General Hospital Program (0001)
Residency Programs:
  • Massachusetts General Hospital/Brigham and Women's Hospital/Harvard Medical School Program, Neurology (0001)
Fellowships:
  • University of Utah Medical Center Program, Autoimmune Neurology/Neuroimmunology Fellowship Program (0001)
Download CV
Department: Neurology
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Contact Us
CU Anschutz
Fitzsimons Building
13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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