Alexis Leal, MD

Professional Titles

• Assistant Professor of Medicine

Recognitions

• Silver Mayo Quality Fellow Certification, Mayo Clinic School of Graduate Medical Education (2016)
• Bronze Mayo Quality Fellow Certification, Mayo Clinic School of Graduate Medical Education (2012)
• Doctor of Medicine with Honors, Texas A&M Health Science Center College of Medicine (2011)
• Alpha Omega Alpha (AOA), Alpha Omega Alpha (AOA) Honor Medical Society (2010)

Publications

• Pant S, Wainberg ZA, Weekes CD, Furqan M, Kasi PM, Devoe CE, Leal AD, Chung V, Basturk O, VanWyk H, Tavares AM, Seenappa LM, Perry JR, Kheoh T, McNeil LK, Welkowsky E, DeMuth PC, Haqq CM, O'Reilly EM. Lymph-node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: the phase 1 AMPLIFY-201 trial. Nat Med. 2024 Feb;30(2):531-542. PubMed PMID: 38195752
• Rodriguez Franco S, Ghaffar SA, Jin Y, Weiss R, Hamermesh M, Khomiak A, Sugawara T, Franklin O, Leal AD, Lieu CH, Schulick RD, Del Chiaro M, Ahrendt S, McCarter MD, Gleisner AL. Pathological Features Associated with Lymph Node Disease in Patients with Appendiceal Neuroendocrine Tumors. Cancers (Basel). 2024 Aug 22;16(16). PubMed PMID: 39199692
• Borazanci EH, Bahary N, Chung V, Huyck TK, Kio EA, Chiorean EG, Skeel RT, Alese OB, Cardin DB, Fountzilas C, Hanna WT, Leal AD, Lee V, Noonan AM, Philip PA, Wainberg ZA, Pashova H, Mann G, Oberstein PE. Relacorilant plus nab-paclitaxel for the treatment of metastatic pancreatic ductal adenocarcinoma: results from the open-label RELIANT study. Oncologist. 2024 Nov 4;29(11):957-965. PubMed PMID: 39191530
• Leary JB, Hu J, Leal A, Davis SL, Kim S, Lentz R, Friedrich T, Herter W, Messersmith WA, Lieu CH. Risk Without Reward: Differing Patterns of Chemotherapy Use Do Not Improve Outcomes in Stage II Early-Onset Colon Cancer. JCO Oncol Pract. 2024 Jul 24;:OP2400159. [Epub ahead of print] PubMed PMID: 39047212
• Lentz RW, Friedrich TJ, Blatchford PJ, Jordan KR, Pitts TM, Robinson HR, Davis SL, Kim SS, Leal AD, Lee MR, Waring MRN, Martin AC, Dominguez ATA, Bagby SM, Hartman SJ, Eckhardt SG, Messersmith WA, Lieu CH. A Phase II Study of Potentiation of Pembrolizumab with Binimetinib and Bevacizumab in Refractory Microsatellite-Stable Colorectal Cancer. Clin Cancer Res. 2024 Sep 3;30(17):3768-3778. PubMed PMID: 38869830
• Davis SL, Messersmith WA, Purcell WT, Lam ET, Corr BR, Leal AD, Lieu CH, O'Bryant CL, Smoots SG, Dus ED, Jordan KR, Serkova NJ, Pitts TM, Diamond JR. A Phase Ib Expansion Cohort Evaluating Aurora A Kinase Inhibitor Alisertib and Dual TORC1/2 Inhibitor Sapanisertib in Patients with Advanced Solid Tumors. Cancers (Basel). 2024 Apr 10;16(8). PubMed PMID: 38672538
• Hawkins HJ, Yacob BW, Brown ME, Goldstein BR, Arcaroli JJ, Bagby SM, Hartman SJ, Macbeth M, Goodspeed A, Danhorn T, Lentz RW, Lieu CH, Leal AD, Messersmith WA, Dempsey PJ, Pitts TM. Examination of Wnt signaling as a therapeutic target for pancreatic ductal adenocarcinoma (PDAC) using a pancreatic tumor organoid library (PTOL). PLoS One. 2024;19(4):e0298808. PubMed PMID: 38598488
• Pant S, Wainberg ZA, Weekes CD, Furqan M, Kasi PM, Devoe CE, Leal AD, Chung V, Basturk O, VanWyk H, Tavares AM, Seenappa LM, Perry JR, Kheoh T, McNeil LK, Welkowsky E, DeMuth PC, Haqq CM, O'Reilly EM. Lymph-node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: the phase 1 AMPLIFY-201 trial. Nat Med. 2024 Feb;30(2):531-542. PubMed PMID: 38195752
• Kim R, Leal AD, Parikh A, Ryan DP, Wang S, Bahamon B, Gupta N, Moss A, Pye J, Miao H, Inguilizian H, Cleary JM. A phase I, first-in-human study of TAK-164, an antibody-drug conjugate, in patients with advanced gastrointestinal cancers expressing guanylyl cyclase C. Cancer Chemother Pharmacol. 2023 Apr;91(4):291-300. PubMed PMID: 36738333
• Kim R, Leal AD, Parikh A, Ryan DP, Wang S, Bahamon B, Gupta N, Moss A, Pye J, Miao H, Inguilizian H, Cleary JM. Correction to: A phase I, first-in-human study of TAK-164, an antibody-drug conjugate, in patients with advanced gastrointestinal cancers expressing guanylyl cyclase C. Cancer Chemother Pharmacol. 2023 Apr;91(4):301. PubMed PMID: 36967405
• Amo-Aparicio J, Dominguez A, Atif SM, Dinarello A, Azam T, Alula KM, Piper M, Lieu CH, Lentz RW, Leal AD, Bagby SM, Messersmith WA, Karam SD, Dinarello CA, Pitts TM, Marchetti C. Pancreatic Ductal Adenocarcinoma Cells Regulate NLRP3 Activation to Generate a Tolerogenic Microenvironment. Cancer Res Commun. 2023 Sep 20;3(9):1899-1911. PubMed PMID: 37772994
• Oba A, Wu YHA, Lieu CH, Meguid C, Colborn KL, Beaty L, Al-Musawi MH, Davis SL, Leal AD, Purcell T, King G, Wooten ES, Fujiwara Y, Goodman KA, Schefter T, Karam SD, Gleisner AL, Ahrendt S, Leong S, Messersmith WA, Schulick RD, Del Chiaro M. Outcome of neoadjuvant treatment for pancreatic cancer in elderly patients: comparative, observational cohort study. Br J Surg. 2021 Aug 19;108(8):976-982. PubMed PMID: 34155509
• Leal AD, Messersmith WA, Lieu CH. Neoadjuvant treatment of localized pancreatic adenocarcinoma. J Gastrointest Oncol. 2021 Oct;12(5):2461-2474. PubMed PMID: 34790407
• Kastelowitz N, Marsh MD, McCarter M, Meguid RA, Bhardwaj NW, Mitchell JD, Weyant MJ, Scott C, Schefter T, Stumpf P, Leong S, Messersmith W, Lieu C, Leal AD, Davis SL, Purcell WT, Kane M, Wani S, Shah R, Hammad H, Edmundowicz S, Goodman KA. Impact of Radiation Dose on Postoperative Complications in Esophageal and Gastroesophageal Junction Cancers. Front Oncol. 2021;11:614640. PubMed PMID: 33777751
• Hartman SJ, Bagby SM, Yacob BW, Simmons DM, MacBeth M, Lieu CH, Davis SL, Leal AD, Tentler JJ, Diamond JR, Eckhardt SG, Messersmith WA, Pitts TM. WEE1 Inhibition in Combination With Targeted Agents and Standard Chemotherapy in Preclinical Models of Pancreatic Ductal Adenocarcinoma. Front Oncol. 2021;11:642328. PubMed PMID: 33869031
• Thomas J, Leal A, Overman MJ. Clinical Development of Immunotherapy for Deficient Mismatch Repair Colorectal Cancer. Clin Colorectal Cancer. 2020 Jun;19(2):73-81. PubMed PMID: 32173280
• Leal AD, Krishnamurthy A, Head L, Messersmith WA. Antibody drug conjugates under investigation in phase I and phase II clinical trials for gastrointestinal cancer. Expert Opin Investig Drugs. 2018 Nov;27(11):901-916. PubMed PMID: 30359534
• O'Sullivan CC, Van Houten HK, Sangaralingham LR, Leal AD, Shinde S, Liu H, Ettinger D, Loprinzi CL, Ruddy KJ. Ten-Year Trends in Antiemetic Prescribing in Patients Receiving Highly Emetogenic Chemotherapy. J Natl Compr Canc Netw. 2018 Mar;16(3):294-299. PubMed PMID: 29523668
• Leal AD, Van Houten H, Sangaralingham L, Freedman RA, Jemal A, Neuman HB, Haddad TC, Mutter RW, Keegan THM, Mougalian SS, Loprinzi CL, Gross CP, Shah N, Ruddy KJ. Breast Cancer Survivorship Care Variations Between Adjuvant Chemotherapy Regimens. Clin Breast Cancer. 2018 Aug;18(4):e513-e520. PubMed PMID: 29054689
• Leal AD, Allmer C, Maurer MJ, Shanafelt TD, Cerhan JR, Link BK, Thompson CA. Variability of performance status assessment between patients with hematologic malignancies and their physicians. Leuk Lymphoma. 2018 Mar;59(3):695-701. PubMed PMID: 28718335
• Jones, J.C., Renfro, L.A., Alshamsi, H.O., Schrock, A.B., Rankin, A., Zhang, B.Y., Kasi, P.M., Voss, J.S., Leal, A.D., Sun, J., Ali, S.M., Hubbard, J.M., Kipp, B.R., McWilliams, R.R., Kopetz, S., Wolff, R.A., Grothey, A. (Non- V600) BRAF Mutations Define A Distinct Molecular Subtype of Metastatic Colorectal Cancer. J Clin Oncol. 2017 Aug 10;35(23):2624-2630.
• Duma, N., O'Sullivan, C., Ruddy, K.J., Leal. A.D. "Special Issues in the Young Woman with Triple-Negative Breast Cancer." Triple-Negative Breast Cancer." In: Tan A. (eds) Triple-Negative Breast Cancer. Springer, Cham
• Leal, A.D., Van Houten, H., Sangaralingham, L., Freedman, R.A., Jemal, A., Haddad, T.C., Mutter, R.W., Mougalian, S.S., Loprinzi, C.L., Gross, C.P., Shah, N., Ruddy, K.J. Breast Cancer Survivorship Care Variations Between Adjuvant Chemotherapy Regimens. Clin Breast Cancer. 2017 Sep; S1526-8209(17)30422-6.
• Leal, A.D., Allmer, C., Maurer, M., Cerhan, J., Thompson, C.A. The Incidence of Inter-observer Variability of Performance Status Assessment between Patients with Hematologic Malignancies and their Physicians. Leuk Lymphoma. 2017 Jul 18:1-7.
• O'Sullivan, C.C., Van Houten, H.K., Sangaralingham, L., Leal, A.D., Shinde, S., Liu, H., Ettinger, D., Loprinzi, C.L., Ruddy, K.J. Ten Year Trends in Antiemetic Prescribing in Cancer Patients Receiving Highly Emetogenic Chemotherapy (HEC).

Professional Memberships

• American Society of Clinical Oncology, Member
• American Association for Cancer Research, Member

Practice Locations

University of Colorado Cancer Center - Anschutz Medical Campus
1665 Aurora Ct
Aurora, CO 80045
720-848-0300

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

UCHealth Anschutz Outpatient Pavilion - Anschutz Medical Campus
1635 Aurora Ct
Aurora, CO 80045
720-848-0000

UCHealth Pancreas and Biliary Multidisciplinary Clinic - Anschutz Medical Campus
1665 Aurora Ct
3rd Floor
Aurora, CO 80045
1-855-824-7262

Hospital Affiliation

• University of Colorado Hospital

Center Affiliations

• University of Colorado Cancer Center

Specialty Information

Specialties

• Medical Oncology, Board Certification (2017)
• Internal Medicine, Board Certification (2014)

Conditions & Treatments

• Cancers - Anal Cancer
• Cancers
• Cancers - Biliary Cancer
• Cancers - Colorectal Cancer
• Cancers - Gastroenterologic Cancer (Colon, Stomach, Esophageal, Liver)
• Cancers - Pancreatic Cancer
• Cancers - Chemotherapy