Alexis Leal, MD

Professional Titles

• Assistant Professor of Medicine

Recognitions

• Bronze Mayo Quality Fellow Certification, Mayo Clinic School of Graduate Medical Education (2012)
• Silver Mayo Quality Fellow Certification, Mayo Clinic School of Graduate Medical Education (2016)
• Alpha Omega Alpha (AOA), Alpha Omega Alpha (AOA) Honor Medical Society (2010)
• Doctor of Medicine with Honors, Texas A&M Health Science Center College of Medicine (2011)

Publications

• Duma, N., O'Sullivan, C., Ruddy, K.J., Leal. A.D. "Special Issues in the Young Woman with Triple-Negative Breast Cancer." Triple-Negative Breast Cancer." In: Tan A. (eds) Triple-Negative Breast Cancer. Springer, Cham
• Leal, A.D., Van Houten, H., Sangaralingham, L., Freedman, R.A., Jemal, A., Haddad, T.C., Mutter, R.W., Mougalian, S.S., Loprinzi, C.L., Gross, C.P., Shah, N., Ruddy, K.J. Breast Cancer Survivorship Care Variations Between Adjuvant Chemotherapy Regimens. Clin Breast Cancer. 2017 Sep; S1526-8209(17)30422-6.
• Leal, A.D., Allmer, C., Maurer, M., Cerhan, J., Thompson, C.A. The Incidence of Inter-observer Variability of Performance Status Assessment between Patients with Hematologic Malignancies and their Physicians. Leuk Lymphoma. 2017 Jul 18:1-7.
• O'Sullivan, C.C., Van Houten, H.K., Sangaralingham, L., Leal, A.D., Shinde, S., Liu, H., Ettinger, D., Loprinzi, C.L., Ruddy, K.J. Ten Year Trends in Antiemetic Prescribing in Cancer Patients Receiving Highly Emetogenic Chemotherapy (HEC).
• Jones, J.C., Renfro, L.A., Alshamsi, H.O., Schrock, A.B., Rankin, A., Zhang, B.Y., Kasi, P.M., Voss, J.S., Leal, A.D., Sun, J., Ali, S.M., Hubbard, J.M., Kipp, B.R., McWilliams, R.R., Kopetz, S., Wolff, R.A., Grothey, A. (Non- V600) BRAF Mutations Define A Distinct Molecular Subtype of Metastatic Colorectal Cancer. J Clin Oncol. 2017 Aug 10;35(23):2624-2630.
• Leal AD, Krishnamurthy A, Head L, Messersmith WA. Antibody drug conjugates under investigation in phase I and phase II clinical trials for gastrointestinal cancer. Expert Opin Investig Drugs. 2018 Nov;27(11):901-916. PubMed PMID: 30359534
• O'Sullivan CC, Van Houten HK, Sangaralingham LR, Leal AD, Shinde S, Liu H, Ettinger D, Loprinzi CL, Ruddy KJ. Ten-Year Trends in Antiemetic Prescribing in Patients Receiving Highly Emetogenic Chemotherapy. J Natl Compr Canc Netw. 2018 Mar;16(3):294-299. PubMed PMID: 29523668
• Leal AD, Van Houten H, Sangaralingham L, Freedman RA, Jemal A, Neuman HB, Haddad TC, Mutter RW, Keegan THM, Mougalian SS, Loprinzi CL, Gross CP, Shah N, Ruddy KJ. Breast Cancer Survivorship Care Variations Between Adjuvant Chemotherapy Regimens. Clin Breast Cancer. 2018 Aug;18(4):e513-e520. PubMed PMID: 29054689
• Leal AD, Allmer C, Maurer MJ, Shanafelt TD, Cerhan JR, Link BK, Thompson CA. Variability of performance status assessment between patients with hematologic malignancies and their physicians. Leuk Lymphoma. 2018 Mar;59(3):695-701. PubMed PMID: 28718335
• Thomas J, Leal A, Overman MJ. Clinical Development of Immunotherapy for Deficient Mismatch Repair Colorectal Cancer. Clin Colorectal Cancer. 2020 Jun;19(2):73-81. PubMed PMID: 32173280
• Oba A, Wu YHA, Lieu CH, Meguid C, Colborn KL, Beaty L, Al-Musawi MH, Davis SL, Leal AD, Purcell T, King G, Wooten ES, Fujiwara Y, Goodman KA, Schefter T, Karam SD, Gleisner AL, Ahrendt S, Leong S, Messersmith WA, Schulick RD, Del Chiaro M. Outcome of neoadjuvant treatment for pancreatic cancer in elderly patients: comparative, observational cohort study. Br J Surg. 2021 Aug 19;108(8):976-982. PubMed PMID: 34155509
• Leal AD, Messersmith WA, Lieu CH. Neoadjuvant treatment of localized pancreatic adenocarcinoma. J Gastrointest Oncol. 2021 Oct;12(5):2461-2474. PubMed PMID: 34790407
• Kastelowitz N, Marsh MD, McCarter M, Meguid RA, Bhardwaj NW, Mitchell JD, Weyant MJ, Scott C, Schefter T, Stumpf P, Leong S, Messersmith W, Lieu C, Leal AD, Davis SL, Purcell WT, Kane M, Wani S, Shah R, Hammad H, Edmundowicz S, Goodman KA. Impact of Radiation Dose on Postoperative Complications in Esophageal and Gastroesophageal Junction Cancers. Front Oncol. 2021;11:614640. PubMed PMID: 33777751
• Hartman SJ, Bagby SM, Yacob BW, Simmons DM, MacBeth M, Lieu CH, Davis SL, Leal AD, Tentler JJ, Diamond JR, Eckhardt SG, Messersmith WA, Pitts TM. WEE1 Inhibition in Combination With Targeted Agents and Standard Chemotherapy in Preclinical Models of Pancreatic Ductal Adenocarcinoma. Front Oncol. 2021;11:642328. PubMed PMID: 33869031
• Pant S, Wainberg ZA, Weekes CD, Furqan M, Kasi PM, Devoe CE, Leal AD, Chung V, Basturk O, VanWyk H, Tavares AM, Seenappa LM, Perry JR, Kheoh T, McNeil LK, Welkowsky E, DeMuth PC, Haqq CM, O'Reilly EM. Lymph-node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: the phase 1 AMPLIFY-201 trial. Nat Med. 2024 Feb;30(2):531-542. PubMed PMID: 38195752
• Kim R, Leal AD, Parikh A, Ryan DP, Wang S, Bahamon B, Gupta N, Moss A, Pye J, Miao H, Inguilizian H, Cleary JM. A phase I, first-in-human study of TAK-164, an antibody-drug conjugate, in patients with advanced gastrointestinal cancers expressing guanylyl cyclase C. Cancer Chemother Pharmacol. 2023 Apr;91(4):291-300. PubMed PMID: 36738333
• Kim R, Leal AD, Parikh A, Ryan DP, Wang S, Bahamon B, Gupta N, Moss A, Pye J, Miao H, Inguilizian H, Cleary JM. Correction to: A phase I, first-in-human study of TAK-164, an antibody-drug conjugate, in patients with advanced gastrointestinal cancers expressing guanylyl cyclase C. Cancer Chemother Pharmacol. 2023 Apr;91(4):301. PubMed PMID: 36967405
• Amo-Aparicio J, Dominguez A, Atif SM, Dinarello A, Azam T, Alula KM, Piper M, Lieu CH, Lentz RW, Leal AD, Bagby SM, Messersmith WA, Karam SD, Dinarello CA, Pitts TM, Marchetti C. Pancreatic Ductal Adenocarcinoma Cells Regulate NLRP3 Activation to Generate a Tolerogenic Microenvironment. Cancer Res Commun. 2023 Sep 20;3(9):1899-1911. PubMed PMID: 37772994

Professional Memberships

• American Society of Clinical Oncology, Member
• American Association for Cancer Research, Member

Practice Locations

University of Colorado Cancer Center - Anschutz Medical Campus
1665 Aurora Ct
Aurora, CO 80045
720-848-0300

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

UCHealth Anschutz Outpatient Pavilion - Anschutz Medical Campus
1635 Aurora Ct
Aurora, CO 80045
720-848-0000

Pancreas & Biliary Multidisciplinary Clinic - Anschutz
1665 Aurora Ct
3rd Floor
Aurora, CO 80045
1-855-824-7262

Hospital Affiliation

• University of Colorado Hospital

Center Affiliations

• University of Colorado Cancer Center

Specialty Information

Specialties

• Medical Oncology, Board Certification (2017)
• Internal Medicine, Board Certification (2014)

Conditions & Treatments

• Cancers - Anal Cancer
• Cancers
• Cancers - Biliary Cancer
• Cancers - Colorectal Cancer
• Cancers - Gastroenterologic Cancer (Colon, Stomach, Esophageal, Liver)
• Cancers - Pancreatic Cancer
• Cancers - Chemotherapy