Doni Solich Family Chair in Ocular Stem Cell Research
Director, CellSight – Ocular Stem Cell and Regeneration Research Program
Recognition & Awards
William & Mary Greve Special Scholar Award, Research to Prevent Blindness
(2013)
2013 - 2018
Publications
Flores-Bellver M, Mighty J, Aparicio-Domingo S, Li KV, Shi C, Zhou J, Cobb H, McGrath P, Michelis G, Lenhart P, Bilousova G, Heissel S, Rudy MJ, Coughlan C, Goodspeed AE, Becerra SP, Redenti S, Canto-Soler MV. Extracellular vesicles released by human retinal pigment epithelium mediate increased polarised secretion of drusen proteins in response to AMD stressors. J Extracell Vesicles. 2021 Nov;10(13):e12165. PubMed PMID: 34750957
Zhou J, Flores-Bellver M, Pan J, Benito-Martin A, Shi C, Onwumere O, Mighty J, Qian J, Zhong X, Hogue T, Amponsah-Antwi B, Einbond L, Gharbaran R, Wu H, Chen BJ, Zheng Z, Tchaikovskaya T, Zhang X, Peinado H, Canto-Soler MV, Redenti S. Human retinal organoids release extracellular vesicles that regulate gene expression in target human retinal progenitor cells. Sci Rep. 2021 Oct 26;11(1):21128. PubMed PMID: 34702879
Cobb H, Aparicio-Domingo S, Canto-Soler MV. Transitioning into GMP-Compliance: Alternative Methods for Producing Retinal Organoids for Transplantation. Transl Vis Sci Technol. 2021 Aug 12;10(10):9. PubMed PMID: 34383873
Zhang J, Qin Y, Martinez M, Flores-Bellver M, Rodrigues M, Dinabandhu A, Cao X, Deshpande M, Qin Y, Aparicio-Domingo S, Rui Y, Tzeng SY, Salman S, Yuan J, Scott AW, Green JJ, Canto-Soler MV, Semenza GL, Montaner S, Sodhi A. HIF-1a and HIF-2a redundantly promote retinal neovascularization in patients with ischemic retinal disease. J Clin Invest. 2021 Jun 15;131(12). PubMed PMID: 34128478
Petrash CC, Palestine AG, Canto-Soler MV. Immunologic Rejection of Transplanted Retinal Pigmented Epithelium: Mechanisms and Strategies for Prevention. Front Immunol. 2021;12:621007. PubMed PMID: 34054796
Rubner R, Li KV, Canto-Soler MV. Progress of clinical therapies for dry age-related macular degeneration. Int J Ophthalmol
2022;15(1):157-166
Singh MS, Park SS, Albini TA, Canto-Soler MV, Klassen H, MacLaren RE, Takahashi M, Nagiel A, Schwartz SD, Bharti K. Retinal stem cell transplantation: Balancing safety and potential. Prog Retin Eye Res. 2020 Mar;75:100779. PubMed PMID: 31494256
Singh MS, Park SS, Albini TA, Canto-Soler MV, Klassen H, MacLaren RE, Takahashi M, Nagiel A, Schwartz SD, Bharti K. Retinal stem cell transplantation: Balancing safety and potential. Prog Retin Eye Res. 2019 Sep 5;:100779. [Epub ahead of print] PubMed PMID: 31494256
Bell WR, Meeker AK, Rizzo A, Rajpara S, Rosenthal IM, Flores Bellver M, Aparicio Domingo S, Zhong X, Barber JR, Joshu CE, Canto-Soler MV, Eberhart CG, Heaphy CM. A unique telomere DNA expansion phenotype in human retinal rod photoreceptors associated with aging and disease. Brain Pathol. 2019 Jan;29(1):45-52. PubMed PMID: 29668072
Bell WR, Meeker AK, Rizzo A, Rajpara S, Rosenthal IM, Flores Bellver M, Aparicio Domingo S, Zhong X, Barber JR, Joshu CE, Canto-Soler MV, Eberhart CG, Heaphy CM. A unique telomere DNA expansion phenotype in human retinal rod photoreceptors associated with aging and disease. Brain Pathol. 2019 Jan;29(1):45-52. PubMed PMID: 29668072
Zhou J, Benito-Martin A, Mighty J, Chang L, Ghoroghi S, Wu H, Wong M, Guariglia S, Baranov P, Young M, Gharbaran R, Emerson M, Mark MT, Molina H, Canto-Soler MV, Selgas HP, Redenti S. Retinal progenitor cells release extracellular vesicles containing developmental transcription factors, microRNA and membrane proteins. Sci Rep. 2018 Feb 12;8(1):2823. PubMed PMID: 29434302
Vergara MN, Flores-Bellver M, Aparicio-Domingo S, McNally M, Wahlin KJ, Saxena MT, Mumm JS, Canto-Soler MV. Three-dimensional automated reporter quantification (3D-ARQ) technology enables quantitative screening in retinal organoids. Development. 2017 Oct 15;144(20):3698-3705. PubMed PMID: 28870990
Canto-Soler MV, Rowland TJ, Park TS, Clegg DO, and Bharti K. Stem Cells and Cellular Therapy for Retinal Degenerative Diseases. Canto-Soler MV, Rowland TJ, Park TS, Clegg DO, and Bharti K. Ryan's Retina, Chapter 37. Editors: SriniVas Sadda, Andrew Schachat, Charles Wilkinson, David Hinton, Peter Wiedemann, K. Bailey Freund, David Sarraf. 7th Edition - May 25, 2022.
Yaowu Qin, Jing Zhang, Savalan Babapoor-Farrokhran, Brooks Applewhite, Monika Deshpande, Haley Megarity, Miguel Flores-Bellver, Silvia Aparicio-Domingo. Tao Ma, Yuan Rui, Stephany Y. Tzeng, Jordan J. Green, M. Valeria Canto-Soler, Silvia Montaner, and Akrit Sodhi. PAI-1 is a Vascular Cell-Specific HIF-2-Dependent Angiogenic Factor that Promotes Retinal Neovascularization in Diabetic Patients. Science Advances - In Press
Silvia Aparicio-Domingo, Miguel Flores-Bellver, Hannah Cobb, Kang Li, Bogi Conrad, Conan Chen, Joseph A. Brzezinski, and M. Valeria Canto-Soler. Generation of three-dimensional retinal tissue with physiologically competent, light sensitive photoreceptors from human induced pluripotent stem cells - NEUROMETHODS series, Springer Nature - Under Review by invitation
Michael Carlson, Sanghoon Kim, Silvia Aparicio-Domingo, Kang V. Li, Ben Puig, Subrata Batabyal, M. Valeria Canto-Soler, Samarendra Mohanty. OCT guided micro-focal ERG system with multiple stimulation wavelengths for characterization of ocular health. Scientific Reports - In Press
Kang V. Li, Miguel Flores-Bellver, Silvia Aparicio-Domingo, Carson Petrash, Hannah Cobb, Conan Chen, M. Valeria Canto-Soler, and Marc T. Mathias. A Surgical Kit for Stem Cell-derived Retinal Pigment Epithelium Transplants: Collection, Transportation, and Subretinal Delivery. Frontiers in Cell and Developmental Biology - Retinal Regenerative Medicine Strategies for Vision Preservation and Restoration - In Press
Yu Qin, Aumreetam Dinabandhu, Kathleen Jee, Murilo Rodrigues, Xuan Cao, Jaron Castillo Sanchez, Chuanyu Guo, Jing Zhang, Miguel Flores-Bellver, Jordan Vancel, Deepak Menon, Noore-Sabah Khan, Tao Ma, Stephany Y. Tzeng, Yassine Daoud, Valeria Canto-Soler, Jordan J. Green, Gregg L. Semenza, Silvia Montaner, and Akrit Sodhi. Angiopoietin-like 4 Influences the Response of Patients with Neovascular Age-Related Macular Degeneration to anti-VEGF Therapy. Journal of Clinical Investigation - Under Review
Solving Neurodegeneration: Common Mechanisms and Strategies for New Treatments. Lauren Wareham; Shane A. Liddelow; Sally Temple; Larry I. Benowitz; Adriana Di Polo; Cheryl Wellington; Jeffrey L. Goldberg; Zhigang He; Xin Duan; Guojun Bu; Albert A. Davis; Karthik Shekhar; Anna La Torre; David C. Chan; M. Valeria Canto-Soler; John G. Flanagan; Preeti Subramanian; Sharyn Rossi; Thomas Brunner; Diane E. Bovenkamp; David J. Calkins. Molecular Neurodegeneration - Under Review