Valeria Canto-Soler, PhD
Associate Professor, Ophthalmology

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Graduate School :
  • PhD, Universidad Austral (2002)
Fellowships:
  • Johns Hopkins University School of Medicine Program, Postdocoral Fellow, Retinal Degenerations Research Center, Department of Ophthalmology (2006)
Languages: English, Spanish
Department: Ophthalmology

Professional Titles

  • Doni Solich Family Chair in Ocular Stem Cell Research
  • Director, CellSight – Ocular Stem Cell and Regeneration Research Program

Recognition & Awards

  • William & Mary Greve Special Scholar Award, Research to Prevent Blindness (2013)
    2013 - 2018

Publications

  • Flores-Bellver M, Mighty J, Aparicio-Domingo S, Li KV, Shi C, Zhou J, Cobb H, McGrath P, Michelis G, Lenhart P, Bilousova G, Heissel S, Rudy MJ, Coughlan C, Goodspeed AE, Becerra SP, Redenti S, Canto-Soler MV. Extracellular vesicles released by human retinal pigment epithelium mediate increased polarised secretion of drusen proteins in response to AMD stressors. J Extracell Vesicles. 2021 Nov;10(13):e12165. PubMed PMID: 34750957
  • Zhou J, Flores-Bellver M, Pan J, Benito-Martin A, Shi C, Onwumere O, Mighty J, Qian J, Zhong X, Hogue T, Amponsah-Antwi B, Einbond L, Gharbaran R, Wu H, Chen BJ, Zheng Z, Tchaikovskaya T, Zhang X, Peinado H, Canto-Soler MV, Redenti S. Human retinal organoids release extracellular vesicles that regulate gene expression in target human retinal progenitor cells. Sci Rep. 2021 Oct 26;11(1):21128. PubMed PMID: 34702879
  • Cobb H, Aparicio-Domingo S, Canto-Soler MV. Transitioning into GMP-Compliance: Alternative Methods for Producing Retinal Organoids for Transplantation. Transl Vis Sci Technol. 2021 Aug 12;10(10):9. PubMed PMID: 34383873
  • Zhang J, Qin Y, Martinez M, Flores-Bellver M, Rodrigues M, Dinabandhu A, Cao X, Deshpande M, Qin Y, Aparicio-Domingo S, Rui Y, Tzeng SY, Salman S, Yuan J, Scott AW, Green JJ, Canto-Soler MV, Semenza GL, Montaner S, Sodhi A. HIF-1a and HIF-2a redundantly promote retinal neovascularization in patients with ischemic retinal disease. J Clin Invest. 2021 Jun 15;131(12). PubMed PMID: 34128478
  • Petrash CC, Palestine AG, Canto-Soler MV. Immunologic Rejection of Transplanted Retinal Pigmented Epithelium: Mechanisms and Strategies for Prevention. Front Immunol. 2021;12:621007. PubMed PMID: 34054796
  • Rubner R, Li KV, Canto-Soler MV. Progress of clinical therapies for dry age-related macular degeneration. Int J Ophthalmol 2022;15(1):157-166
  • Singh MS, Park SS, Albini TA, Canto-Soler MV, Klassen H, MacLaren RE, Takahashi M, Nagiel A, Schwartz SD, Bharti K. Retinal stem cell transplantation: Balancing safety and potential. Prog Retin Eye Res. 2020 Mar;75:100779. PubMed PMID: 31494256
  • Singh MS, Park SS, Albini TA, Canto-Soler MV, Klassen H, MacLaren RE, Takahashi M, Nagiel A, Schwartz SD, Bharti K. Retinal stem cell transplantation: Balancing safety and potential. Prog Retin Eye Res. 2019 Sep 5;:100779. [Epub ahead of print] PubMed PMID: 31494256
  • Bell WR, Meeker AK, Rizzo A, Rajpara S, Rosenthal IM, Flores Bellver M, Aparicio Domingo S, Zhong X, Barber JR, Joshu CE, Canto-Soler MV, Eberhart CG, Heaphy CM. A unique telomere DNA expansion phenotype in human retinal rod photoreceptors associated with aging and disease. Brain Pathol. 2019 Jan;29(1):45-52. PubMed PMID: 29668072
  • Bell WR, Meeker AK, Rizzo A, Rajpara S, Rosenthal IM, Flores Bellver M, Aparicio Domingo S, Zhong X, Barber JR, Joshu CE, Canto-Soler MV, Eberhart CG, Heaphy CM. A unique telomere DNA expansion phenotype in human retinal rod photoreceptors associated with aging and disease. Brain Pathol. 2019 Jan;29(1):45-52. PubMed PMID: 29668072
  • Zhou J, Benito-Martin A, Mighty J, Chang L, Ghoroghi S, Wu H, Wong M, Guariglia S, Baranov P, Young M, Gharbaran R, Emerson M, Mark MT, Molina H, Canto-Soler MV, Selgas HP, Redenti S. Retinal progenitor cells release extracellular vesicles containing developmental transcription factors, microRNA and membrane proteins. Sci Rep. 2018 Feb 12;8(1):2823. PubMed PMID: 29434302
  • Vergara MN, Flores-Bellver M, Aparicio-Domingo S, McNally M, Wahlin KJ, Saxena MT, Mumm JS, Canto-Soler MV. Three-dimensional automated reporter quantification (3D-ARQ) technology enables quantitative screening in retinal organoids. Development. 2017 Oct 15;144(20):3698-3705. PubMed PMID: 28870990
  • Canto-Soler MV, Rowland TJ, Park TS, Clegg DO, and Bharti K. Stem Cells and Cellular Therapy for Retinal Degenerative Diseases. Canto-Soler MV, Rowland TJ, Park TS, Clegg DO, and Bharti K. Ryan's Retina, Chapter 37. Editors: SriniVas Sadda, Andrew Schachat, Charles Wilkinson, David Hinton, Peter Wiedemann, K. Bailey Freund, David Sarraf. 7th Edition - May 25, 2022.
  • Yaowu Qin, Jing Zhang, Savalan Babapoor-Farrokhran, Brooks Applewhite, Monika Deshpande, Haley Megarity, Miguel Flores-Bellver, Silvia Aparicio-Domingo. Tao Ma, Yuan Rui, Stephany Y. Tzeng, Jordan J. Green, M. Valeria Canto-Soler, Silvia Montaner, and Akrit Sodhi. PAI-1 is a Vascular Cell-Specific HIF-2-Dependent Angiogenic Factor that Promotes Retinal Neovascularization in Diabetic Patients. Science Advances - In Press
  • Silvia Aparicio-Domingo, Miguel Flores-Bellver, Hannah Cobb, Kang Li, Bogi Conrad, Conan Chen, Joseph A. Brzezinski, and M. Valeria Canto-Soler. Generation of three-dimensional retinal tissue with physiologically competent, light sensitive photoreceptors from human induced pluripotent stem cells - NEUROMETHODS series, Springer Nature - Under Review by invitation
  • Michael Carlson, Sanghoon Kim, Silvia Aparicio-Domingo, Kang V. Li, Ben Puig, Subrata Batabyal, M. Valeria Canto-Soler, Samarendra Mohanty. OCT guided micro-focal ERG system with multiple stimulation wavelengths for characterization of ocular health. Scientific Reports - In Press
  • Kang V. Li, Miguel Flores-Bellver, Silvia Aparicio-Domingo, Carson Petrash, Hannah Cobb, Conan Chen, M. Valeria Canto-Soler, and Marc T. Mathias. A Surgical Kit for Stem Cell-derived Retinal Pigment Epithelium Transplants: Collection, Transportation, and Subretinal Delivery. Frontiers in Cell and Developmental Biology - Retinal Regenerative Medicine Strategies for Vision Preservation and Restoration - In Press
  • Yu Qin, Aumreetam Dinabandhu, Kathleen Jee, Murilo Rodrigues, Xuan Cao, Jaron Castillo Sanchez, Chuanyu Guo, Jing Zhang, Miguel Flores-Bellver, Jordan Vancel, Deepak Menon, Noore-Sabah Khan, Tao Ma, Stephany Y. Tzeng, Yassine Daoud, Valeria Canto-Soler, Jordan J. Green, Gregg L. Semenza, Silvia Montaner, and Akrit Sodhi. Angiopoietin-like 4 Influences the Response of Patients with Neovascular Age-Related Macular Degeneration to anti-VEGF Therapy. Journal of Clinical Investigation - Under Review
  • Solving Neurodegeneration: Common Mechanisms and Strategies for New Treatments. Lauren Wareham; Shane A. Liddelow; Sally Temple; Larry I. Benowitz; Adriana Di Polo; Cheryl Wellington; Jeffrey L. Goldberg; Zhigang He; Xin Duan; Guojun Bu; Albert A. Davis; Karthik Shekhar; Anna La Torre; David C. Chan; M. Valeria Canto-Soler; John G. Flanagan; Preeti Subramanian; Sharyn Rossi; Thomas Brunner; Diane E. Bovenkamp; David J. Calkins. Molecular Neurodegeneration - Under Review
View All (19 Total) View Less

Professional Memberships

  • American Society for Cell Biology, Member
  • Society for Neuroscience, Member
  • International Society for Eye Research, Member
  • The Association for Research in Vision and Ophthalmology, Member
  • International Society for Ocular Cell Biology, Member

General Information

Graduate Schools:
  • PhD, Universidad Austral (2002)
Fellowships:
  • Johns Hopkins University School of Medicine Program, Postdocoral Fellow, Retinal Degenerations Research Center, Department of Ophthalmology (2006)
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Languages: English, Spanish
Department: Ophthalmology
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