Ramon Lorca, PhD
Assistant Professor, OB-GYN-Basic Repro Science
Graduate School
- PhD, Pontificia Universidad Católica de Chile (2008)
Languages
English, SpanishDepartment
OB-GYN-Basic Repro SciencePublications
- Li Y, Lorca RA, Su EJ. Molecular and cellular underpinnings of normal and abnormal human placental blood flows. J Mol Endocrinol. 2018 Jan;60(1):R9-R22. PubMed PMID: 29097590
- Lorca RA, Ma X, England SK. The unique N-terminal sequence of the BKCa channel a-subunit determines its modulation by ß-subunits. PLoS One. 2017;12(7):e0182068. PubMed PMID: 28750098
- Lorca RA, Wakle-Prabagaran M, Freeman WE, Pillai MK, England SK. The large-conductance voltage- and Ca(2 ) -activated K( ) channel and its ?1 subunit modulate mouse uterine artery function during pregnancy. J Physiol. 2018 Jan 10. [Epub ahead of print] PubMed PMID: 29319186
- Lorca RA, Wakle-Prabagaran M, Freeman WE, Pillai MK, England SK. The large-conductance voltage- and Ca(2 ) -activated K( ) channel and its ?1-subunit modulate mouse uterine artery function during pregnancy. J Physiol. 2018 Mar 15;596(6):1019-1033. PubMed PMID: 29319186
- Li Y, Lorca RA, Su EJ. Molecular and cellular underpinnings of normal and abnormal human placental blood flows. J Mol Endocrinol. 2018 Jan;60(1):R9-R22. PubMed PMID: 29097590
- Lane SL, Doyle AS, Bales ES, Lorca RA, Julian CG, Moore LG. Increased uterine artery blood flow in hypoxic murine pregnancy is not sufficient to prevent fetal growth restriction. Biol Reprod. 2019 Nov 11. [Epub ahead of print] PubMed PMID: 31711123
- Guerra DD, Bok R, Vyas V, Orlicky DJ, Lorca RA, Hurt KJ. Akt phosphorylation of neuronal nitric oxide synthase regulates gastrointestinal motility in mouse ileum. Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17541-17546. PubMed PMID: 31405982
- Lane SL, Dodson RB, Doyle AS, Park H, Rathi H, Matarrazo CJ, Moore LG, Lorca RA, Wolfson GH, Julian CG. Pharmacological activation of peroxisome proliferator-activated receptor ? (PPAR-?) protects against hypoxia-associated fetal growth restriction. FASEB J. 2019 Aug;33(8):8999-9007. PubMed PMID: 31039323
- Lorca RA, Lane SL, Bales ES, Nsier H, Yi H, Donnelly MA, Euser AG, Julian CG, Moore LG. High Altitude Reduces NO-Dependent Myometrial Artery Vasodilator Response During Pregnancy. Hypertension. 2019 Jun;73(6):1319-1326. PubMed PMID: 31006328
- Lane SL, Houck JA, Doyle AS, Bales ES, Lorca RA, Julian CG, Moore LG. AMP-activated protein kinase activator AICAR attenuates hypoxia-induced murine fetal growth restriction in part by improving uterine artery blood flow. J Physiol. 2020 Sep;598(18):4093-4105. PubMed PMID: 32592403
- Lorca RA, Matarazzo CJ, Bales ES, Houck JA, Orlicky DJ, Euser AG, Julian CG, Moore LG. AMPK activation in pregnant human myometrial arteries from high-altitude and intrauterine growth-restricted pregnancies. Am J Physiol Heart Circ Physiol. 2020 Jul 1;319(1):H203-H212. PubMed PMID: 32502374
- Guerra DD, Bok R, Lorca RA, Hurt KJ. Protein kinase A facilitates relaxation of mouse ileum via phosphorylation of neuronal nitric oxide synthase. Br J Pharmacol. 2020 Jun;177(12):2765-2778. PubMed PMID: 31975425
- Lane SL, Doyle AS, Bales ES, Houck JA, Lorca RA, Moore LG, Julian CG. Peroxisome proliferator-activated receptor gamma blunts endothelin-1-mediated contraction of the uterine artery in a murine model of high-altitude pregnancy. FASEB J. 2020 Mar;34(3):4283-4292. PubMed PMID: 31970838
- Vaughan OR, Thompson F, Lorca RA, Julian CG, Powell TL, Moore LG, Jansson T. Effect of high altitude on human placental amino acid transport. J Appl Physiol (1985). 2020 Jan 1;128(1):127-133. PubMed PMID: 31804891
- Lane SL, Doyle AS, Bales ES, Lorca RA, Julian CG, Moore LG. Increased uterine artery blood flow in hypoxic murine pregnancy is not sufficient to prevent fetal growth restriction†. Biol Reprod. 2020 Mar 13;102(3):660-670. PubMed PMID: 31711123
- Jones AK, Rozance PJ, Brown LD, Lorca RA, Julian CG, Moore LG, Limesand SW, Wesolowski SR. Uteroplacental nutrient flux and evidence for metabolic reprogramming during sustained hypoxemia. Physiol Rep. 2021 Sep;9(18):e15033. PubMed PMID: 34558219
- Bok R, Guerra DD, Lorca RA, Wennersten SA, Harris PS, Rauniyar AK, Stabler SP, MacLean KN, Roede JR, Brown LD, Hurt KJ. Cystathionine ?-lyase promotes estrogen-stimulated uterine artery blood flow via glutathione homeostasis. Redox Biol. 2021 Apr;40:101827. PubMed PMID: 33485059
- Lorca RA, Houck JA, Laurent LC, Matarazzo CJ, Baker K, Horii M, Nelson KK, Bales ES, Euser AG, Parast MM, Moore LG, Julian CG. High altitude regulates the expression of AMPK pathways in human placenta. Placenta. 2021 Jan 15;104:267-276. PubMed PMID: 33472134
- Fallahi S, Houck JA, Euser AG, Julian CG, Moore LG, Lorca RA. High altitude differentially modulates potassium channel-evoked vasodilatation in pregnant human myometrial arteries. J Physiol. 2022 Oct 26. [Epub ahead of print] PubMed PMID: 36286320
- Moore LG, Wesolowski SR, Lorca RA, Murray AJ, Julian CG. Why is human uterine artery blood flow during pregnancy so high?. Am J Physiol Regul Integr Comp Physiol. 2022 Nov 1;323(5):R694-R699. PubMed PMID: 36094446
- Bresnitz W, Lorca RA. Potassium Channels in the Uterine Vasculature: Role in Healthy and Complicated Pregnancies. Int J Mol Sci. 2022 Aug 21;23(16). PubMed PMID: 36012712
- Julian CG, Houck JA, Fallahi S, Lazo-Vega L, Matarazzo CJ, Diamond B, Miranda-Garrido V, Krause BJ, Moore LG, Shortt JA, Toledo-Jaldin L, Lorca RA. Altered placental ion channel gene expression in preeclamptic high-altitude pregnancies. Physiol Genomics. 2023 Sep 1;55(9):357-367. PubMed PMID: 37458464
- Kyllo HM, Wang D, Lorca RA, Julian CG, Moore LG, Wilkening RB, Rozance PJ, Brown LD, Wesolowski SR. Adaptive responses in uteroplacental metabolism and fetoplacental nutrient shuttling and sensing during placental insufficiency. Am J Physiol Endocrinol Metab. 2023 Jun 1;324(6):E556-E568. PubMed PMID: 37126847
Professional Memberships
- Society for Reproductive Investigation, Regular Member
- Perinatal Research Society, Associate Member