Kelly Doran, PhD

Publications

• Kim BJ, Bee OB, McDonagh MA, Stebbins MJ, Palecek SP, Doran KS, Shusta EV. Modeling Group B Streptococcus and Blood-Brain Barrier Interaction by Using Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells. mSphere. 2017 Nov-Dec;2(6). PubMed PMID: 29104935
• Gendrin C, Shubin NJ, Boldenow E, Merillat S, Clauson M, Power D, Doran KS, Abrink M, Pejler G, Rajagopal L, Piliponsky AM. Mast cell chymase decreases the severity of group B Streptococcus infections. J Allergy Clin Immunol. 2017 Sep 12. [Epub ahead of print] PubMed PMID: 28916188
• Lazzarin M, Mu R, Fabbrini M, Ghezzo C, Rinaudo CD, Doran KS, Margarit I. Contribution of pilus type 2b to invasive disease caused by a Streptococcus agalactiae ST-17 strain. BMC Microbiol. 2017 Jul 3;17(1):148. PubMed PMID: 28673237
• Lin AE, Autran CA, Szyszka A, Escajadillo T, Huang M, Godula K, Prudden AR, Boons GJ, Lewis AL, Doran KS, Nizet V, Bode L. Human milk oligosaccharides inhibit growth of group B Streptococcus . J Biol Chem. 2017 Jul 7;292(27):11243-11249. PubMed PMID: 28416607
• Deng L, Mu R, Weston TA, Spencer BL, Liles R, Doran KS. Characterization of a two-component system transcriptional regulator LtdR that impacts Group B Streptococcal colonization and disease. Infect Immun. 2018 Apr 23. [Epub ahead of print] PubMed PMID: 29685987
• Vornhagen J, Armistead B, Santana-Ufret V, Gendrin C, Merillat S, Coleman M, Quach P, Boldenow E, Alishetti V, Leonhard-Melief C, Ngo LY, Whidbey C, Doran KS, Curtis C, Waldorf KMA, Nance E, Rajagopal L. Group B streptococcus exploits vaginal epithelial exfoliation for ascending infection. J Clin Invest. 2018 May 1;128(5):1985-1999. PubMed PMID: 29629904
• Gendrin C, Shubin NJ, Boldenow E, Merillat S, Clauson M, Power D, Doran KS, Abrink M, Pejler G, Rajagopal L, Piliponsky AM. Mast cell chymase decreases the severity of group B Streptococcus infections. J Allergy Clin Immunol. 2018 Jul;142(1):120-129.e6. PubMed PMID: 28916188
• Lozano-Pope I, Sharma A, Matthias M, Doran KS, Obonyo M. Effect of myeloid differentiation primary response gene 88 on expression profiles of genes during the development and progression of Helicobacter-induced gastric cancer. BMC Cancer. 2017 Feb 15;17(1):133. PubMed PMID: 28201999
• Hancock BM, Doran KS. Importance of strain lineages for Group B streptococcal survival. Virulence. 2017 Aug 18;8(6):646-648. PubMed PMID: 28033037
• Liwen Deng, Rong Mu, Thomas Weston, Brady Spencer, Roxanne Liles, and Kelly S. Doran. Characterization of a two-component system transcriptional regulator LtdR that impacts Group B Streptococcal colonization and disease. Infection and Immunity. submitted in 2017, in press.
• Deng L, Schilcher K, Burcham LR, Kwiecinski JM, Johnson PM, Head SR, Heinrichs DE, Horswill AR, Doran KS. Identification of Key Determinants of Staphylococcus aureus Vaginal Colonization. mBio. 2019 Dec 24;10(6). PubMed PMID: 31874913
• Burcham LR, Spencer BL, Keeler LR, Runft DL, Patras KA, Neely MN, Doran KS. Determinants of Group B streptococcal virulence potential amongst vaginal clinical isolates from pregnant women. PLoS One. 2019;14(12):e0226699. PubMed PMID: 31851721
• Spencer BL, Deng L, Patras KA, Burcham ZM, Sanches GF, Nagao PE, Doran KS. Cas9 Contributes to Group B Streptococcal Colonization and Disease. Front Microbiol. 2019;10:1930. PubMed PMID: 31497003
• Kim BJ, McDonagh MA, Deng L, Gastfriend BD, Schubert-Unkmeir A, Doran KS, Shusta EV. Streptococcus agalactiae disrupts P-glycoprotein function in brain endothelial cells. Fluids Barriers CNS. 2019 Aug 22;16(1):26. PubMed PMID: 31434575
• Kim BJ, Shusta EV, Doran KS. Past and Current Perspectives in Modeling Bacteria and Blood-Brain Barrier Interactions. Front Microbiol. 2019;10:1336. PubMed PMID: 31263460
• Manzer HS, Nobbs AH, Doran KS. The Multifaceted Nature of Streptococcal Antigen I/II Proteins in Colonization and Disease Pathogenesis. Front Microbiol. 2020;11:602305. PubMed PMID: 33329493
• Burcham LR, Le Breton Y, Radin JN, Spencer BL, Deng L, Hiron A, Ransom MR, Mendonça JDC, Belew AT, El-Sayed NM, McIver KS, Kehl-Fie TE, Doran KS. Identification of Zinc-Dependent Mechanisms Used by Group B Streptococcus To Overcome Calprotectin-Mediated Stress. mBio. 2020 Nov 10;11(6). PubMed PMID: 33173000
• Deng L, Spencer BL, Holmes JA, Mu R, Rego S, Weston TA, Hu Y, Sanches GF, Yoon S, Park N, Nagao PE, Jenkinson HF, Thornton JA, Seo KS, Nobbs AH, Doran KS. The Group B Streptococcal surface antigen I/II protein, BspC, interacts with host vimentin to promote adherence to brain endothelium and inflammation during the pathogenesis of meningitis. PLoS Pathog. 2019 Jun;15(6):e1007848. PubMed PMID: 31181121
• Alhajjar N, Chatterjee A, Spencer BL, Burcham LR, Willett JLE, Dunny GM, Duerkop BA, Doran KS. Genome-Wide Mutagenesis Identifies Factors Involved in Enterococcus faecalis Vaginal Adherence and Persistence. Infect Immun. 2020 Sep 18;88(10). PubMed PMID: 32778611
• Campeau A, Mills RH, Blanchette M, Bajc K, Malfavon M, Munji RN, Deng L, Hancock B, Patras KA, Olson J, Nizet V, Daneman R, Doran K, Gonzalez DJ. Multidimensional Proteome Profiling of Blood-Brain Barrier Perturbation by Group B Streptococcus . mSystems. 2020 Aug 25;5(4). PubMed PMID: 32843537
• Lannes-Costa PS, Baraúna RA, Ramos JN, Veras JFC, Conceição MVR, Vieira VV, de Mattos-Guaraldi AL, Ramos RTJ, Doran KS, Silva A, Nagao PE. Comparative genomic analysis and identification of pathogenicity islands of hypervirulent ST-17 Streptococcus agalactiae Brazilian strain. Infect Genet Evol. 2020 Jun;80:104195. PubMed PMID: 31954181
• Spencer BL, Chatterjee A, Duerkop BA, Baker CJ, Doran KS. Genome-Wide Mutagenesis Identifies Factors Involved in Enterococcus The complete genome of neonatal clinical group B streptococcal isolate, CJB111. Microbiology Resource Announcements (MRA) in press
• van Sorge NM, Bonsor, DA, Deng L, Lindahl E, Schmitt V, Lyndin M, Schmidt A, Nilsson OR, Brizuela J, Boero E, Sundberg EJ, van Strijp JAG, Doran KS, Singer BB, Lindahl G, McCarthy AJ. Bacterial protein domains with a novel Ig-like fold target human CEACAM receptors. The EMBO Journal. in press.
• Spencer BL, Tak U, Mendonça JC, Nagao PE, Niederweis M, Doran KS. A type VII secretion system in Group B Streptococcus mediates cytotoxicity and virulence. PLoS Pathog. 2021 Dec;17(12):e1010121. PubMed PMID: 34871327
• Keogh RA, Spencer BL, Sorensen HM, Zapf RL, Briaud P, Bonsall AE, Doran KS, Carroll RK. Global Annotation, Expression Analysis, and Stability of Candidate sRNAs in Group B Streptococcus. mBio. 2021 Dec 21;12(6):e0280321. PubMed PMID: 34724819
• Villarreal R, Manzer HS, Keestra-Gounder AM, Doran KS. Vimentin Regulates Chemokine Expression and NOD2 Activation in Brain Endothelium during Group B Streptococcal Infection. Infect Immun. 2021 Nov 16;89(12):e0034021. PubMed PMID: 34491787
• Lyon LM, Doran KS, Horswill AR. Staphylococcus aureus Fibronectin-Binding Proteins Contribute to Colonization of the Female Reproductive Tract. Infect Immun. 2022 Dec 13;:e0046022. [Epub ahead of print] PubMed PMID: 36511703
• Spencer BL, Doran KS, Burcham LR. The Virtual Streptococcal Seminar Series and Trainee Symposium: Adaptations of a Research Community during the COVID-19 Pandemic. J Microbiol Biol Educ. 2021;22(1). PubMed PMID: 33884095
• Keogh RA, Haeberle AL, Langouët-Astrié CJ, Kavanaugh JS, Schmidt EP, Moore GD, Horswill AR, Doran KS. Group B Streptococcus adaptation promotes survival in a hyperinflammatory diabetic wound environment. Sci Adv. 2022 Nov 11;8(45):eadd3221. PubMed PMID: 36367946
• van Sorge NM, Bonsor DA, Deng L, Lindahl E, Schmitt V, Lyndin M, Schmidt A, Nilsson OR, Brizuela J, Boero E, Sundberg EJ, van Strijp JAG, Doran KS, Singer BB, Lindahl G, McCarthy AJ. Bacterial protein domains with a novel Ig-like fold target human CEACAM receptors. EMBO J. 2021 Apr 1;40(7):e106103. PubMed PMID: 33522633
• Spencer BL, Chatterjee A, Duerkop BA, Baker CJ, Doran KS. Complete Genome Sequence of Neonatal Clinical Group B Streptococcal Isolate CJB111. Microbiol Resour Announc. 2021 Jan 14;10(2). PubMed PMID: 33446593
• de Figueiredo Sanches G, Lannes-Costa PS, Cristoforêto MC, Doran KS, Mattos-Guaraldi AL, Nagao PE. Streptococcus agalactiae strains isolated from cancer patients in Rio de Janeiro, Brazil. Braz J Microbiol. 2021 Mar;52(1):303-310. PubMed PMID: 33398672
• Manzer HS, Nguyen DT, Park JY, Park N, Seo KS, Thornton JA, Nobbs AH, Doran KS. The Group B Streptococcal Adhesin BspC Interacts with Host Cytokeratin 19 To Promote Colonization of the Female Reproductive Tract. mBio. 2022 Oct 26;13(5):e0178122. PubMed PMID: 36069447
• Burcham LR, Burcham ZM, Akbari MS, Metcalf JL, Doran KS. Interrelated Effects of Zinc Deficiency and the Microbiome on Group B Streptococcal Vaginal Colonization. mSphere. 2022 Aug 31;7(4):e0026422. PubMed PMID: 35943198
• Spencer BL, Doran KS. Evolving understanding of the type VII secretion system in Gram-positive bacteria. PLoS Pathog. 2022 Jul;18(7):e1010680. PubMed PMID: 35901012
• Akbari MS, Doran KS, Burcham LR. Metal Homeostasis in Pathogenic Streptococci. Microorganisms. 2022 Jul 25;10(8). PubMed PMID: 35893559
• Burcham LR, Akbari MS, Alhajjar N, Keogh RA, Radin JN, Kehl-Fie TE, Belew AT, El-Sayed NM, McIver KS, Doran KS. Genomic Analyses Identify Manganese Homeostasis as a Driver of Group B Streptococcal Vaginal Colonization. mBio. 2022 Jun 28;13(3):e0098522. PubMed PMID: 35658538
• Burcham LR, Bath JR, Werlang CA, Lyon LM, Liu N, Evans C, Ribbeck K, Doran KS. Role of MUC5B during Group B Streptococcal Vaginal Colonization. mBio. 2022 Apr 26;13(2):e0003922. PubMed PMID: 35323039
• Manzer HS, Villarreal RI, Doran KS. Targeting the BspC-vimentin interaction to develop anti-virulence therapies during Group B streptococcal meningitis. PLoS Pathog. 2022 Mar;18(3):e1010397. PubMed PMID: 35316308
• Joyce LR, Manzer HS, da C Mendonça J, Villarreal R, Nagao PE, Doran KS, Palmer KL, Guan Z. Identification of a novel cationic glycolipid in Streptococcus agalactiae that contributes to brain entry and meningitis. PLoS Biol. 2022 Feb;20(2):e3001555. PubMed PMID: 35180210
• Lyon LM, Doran KS. Human Milk Oligosaccharides versus Streptococcus: How a Human-Made Natural Product Protects Us from Pathogens. mSphere. 2022 Feb 23;7(1):e0004922. PubMed PMID: 35171690
• Manzer HS, Doran KS. Complete m6A and m4C methylomes for group B streptococcal clinical isolates CJB111, A909, COH1, and NEM316. Microbiol Resour Announc. 2023 Dec 15;:e0073323. [Epub ahead of print] PubMed PMID: 38099685
• Manzer HS, Brunetti T, Doran KS. Identification of a DNA-cytosine methyltransferase that impacts global transcription to promote group B streptococcal vaginal colonization. mBio. 2023 Oct 31;14(6):e0230623. [Epub ahead of print] PubMed PMID: 37905908
• Akbari MS, Keogh RA, Radin JN, Sanchez-Rosario Y, Johnson MDL, Horswill AR, Kehl-Fie TE, Burcham LR, Doran KS. The impact of nutritional immunity on Group B streptococcal pathogenesis during wound infection. mBio. 2023 Aug 31;14(4):e0030423. PubMed PMID: 37358277
• Spencer BL, Job AM, Robertson CM, Hameed ZA, Serchejian C, Wiafe-Kwakye CS, Mendonça JC, Apolonio MA, Nagao PE, Neely MN, Korotkova N, Korotkov KV, Patras KA, Doran KS. Heterogeneity of the group B streptococcal type VII secretion system and influence on colonization of the female genital tract. Mol Microbiol. 2023 Aug;120(2):258-275. PubMed PMID: 37357823
• da Conceição Mendonça J, Sobral Pena JM, Dos Santos Macêdo N, de Souza Rodrigues D, de Oliveira DA, Spencer BL, Lopes-Torres EJ, Burcham LR, Doran KS, Nagao PE. Enhanced Vulnerability of Diabetic Mice to Hypervirulent Streptococcus agalactiae ST-17 Infection. Pathogens. 2023 Apr 11;12(4). PubMed PMID: 37111466
• Derk J, Como CN, Jones HE, Joyce LR, Kim S, Spencer BL, Bonney S, O'Rourke R, Pawlikowski B, Doran KS, Siegenthaler JA. Formation and function of the meningeal arachnoid barrier around the developing mouse brain. Dev Cell. 2023 Apr 24;58(8):635-644.e4. PubMed PMID: 36996816
• Pinho-Ribeiro FA, Deng L, Neel DV, Erdogan O, Basu H, Yang D, Choi S, Walker AJ, Carneiro-Nascimento S, He K, Wu G, Stevens B, Doran KS, Levy D, Chiu IM. Bacteria hijack a meningeal neuroimmune axis to facilitate brain invasion. Nature. 2023 Mar;615(7952):472-481. PubMed PMID: 36859544
• Keogh RA, Doran KS. Group B Streptococcus and diabetes: Finding the sweet spot. PLoS Pathog. 2023 Feb;19(2):e1011133. PubMed PMID: 36795681
• Spencer BL, Job AM, Robertson CM, Hameed ZA, Serchejian C, Wiafe-Kwakye CS, Mendonça JC, Apolonio MA, Nagao PE, Neely MN, Korotkova N, Korotkov KV, Patras KA, Doran KS. Heterogeneity of the group B streptococcal type VII secretion system and influence on colonization of the female genital tract. bioRxiv. 2023 Jan 25. PubMed PMID: 36747681
• Joyce LR, Doran KS. Gram-positive bacterial membrane lipids at the host-pathogen interface. PLoS Pathog. 2023 Jan;19(1):e1011026. PubMed PMID: 36602959
• Lyon LM, Doran KS, Horswill AR. Staphylococcus aureus Fibronectin-Binding Proteins Contribute to Colonization of the Female Reproductive Tract. Infect Immun. 2023 Jan 24;91(1):e0046022. PubMed PMID: 36511703