Michael Rosenberg, MD
Assistant Professor, Medicine-Cardiology

Professional Titles

• Cardiac Electrophysiologist

Research Interests

Teaching

Publications

• Simon ST, Trinkley KE, Malone DC, Rosenberg MA. Interpretable Machine Learning Prediction of Drug-Induced QT Prolongation: Electronic Health Record Analysis. J Med Internet Res. 2022 Dec 1;24(12):e42163. PubMed PMID: 36454608
• Simon S, Mandair D, Albakri A, Fohner A, Simon N, Lange L, Biggs M, Mukamal K, Psaty B, Rosenberg M. The Impact of Time Horizon on Classification Accuracy: Application of Machine Learning to Prediction of Incident Coronary Heart Disease. JMIR Cardio. 2022 Nov 2;6(2):e38040. PubMed PMID: 36322114
• Stacy J, Kim R, Barrett C, Sekar B, Simon S, Banaei-Kashani F, Rosenberg MA. Qualitative Evaluation of an Artificial Intelligence-Based Clinical Decision Support System to Guide Rhythm Management of Atrial Fibrillation: Survey Study. JMIR Form Res. 2022 Aug 11;6(8):e36443. PubMed PMID: 35969422
• Sabzwari SRA, Rosenberg MA, Mann J, Cerbin L, Barrett C, Garg L, Aleong RG, Sandhu A, West J, Tumolo AZ, Varosy PD, Sauer WH, Zipse MM, Tzou WS. Limitations of Unipolar Signals in Guiding Successful Outflow Tract Premature Ventricular Contraction Ablation. JACC Clin Electrophysiol. 2022 Jul;8(7):843-853. PubMed PMID: 35643806
• Mande A, Moore SL, Banaei-Kashani F, Echalier B, Bull S, Rosenberg MA. Assessment of a Mobile Health iPhone App for Semiautomated Self-management of Chronic Recurrent Medical Conditions Using an N-of-1 Trial Framework: Feasibility Pilot Study. JMIR Form Res. 2022 Apr 12;6(4):e34827. PubMed PMID: 35412460
• Huck DM, Rosenberg MA, Stauffer BL. Nebivolol and incident cardiovascular events in hypertensive patients compared with nonvasodilatory beta blockers. J Hypertens. 2022 May 1;40(5):1019-1029. PubMed PMID: 35202021
• Varela DL, Rosenberg MA, Borne RT, Sandhu A, Zipse MM, Tzou WS, Sauer WH, Scheinman MM, Nguyen DT. Increased incidence of cavotricuspid isthmus atrial flutter following slow pathway ablation. J Interv Card Electrophysiol. 2022 Apr;63(3):581-589. PubMed PMID: 34532821
• Albakri A, Orkaby A, Rosenberg MA. Feasibility of Frailty Assessment Integrated with Cardiac Implantable Electronic Device Clinic Follow-up: A Pilot Investigation. Gerontol Geriatr Med. 2021 Jan-Dec;7:2333721420987342. PubMed PMID: 33457464
• Kim RS, Simon S, Powers B, Sandhu A, Sanchez J, Borne RT, Tumolo A, Zipse M, West JJ, Aleong R, Tzou W, Rosenberg MA. Machine Learning Methodologies for Prediction of Rhythm-Control Strategy in Patients Diagnosed With Atrial Fibrillation: Observational, Retrospective, Case-Control Study. JMIR Med Inform. 2021 Dec 6;9(12):e29225. PubMed PMID: 34874889
• Varela DL, Rosenberg MA, Borne RT, Sandhu A, Zipse MM, Tzou WS, Sauer WH, Scheinman MM, Nguyen DT. Increased incidence of cavotricuspid isthmus atrial flutter following slow pathway ablation. J Interv Card Electrophysiol. 2021 Sep 17. [Epub ahead of print] PubMed PMID: 34532821
• Rosenberg MA. Trusting Magic: Interpretability of Predictions From Machine Learning Algorithms. Circulation. 2021 Mar 30;143(13):1299-1301. PubMed PMID: 33779269
• Trinkley KE, Pell JM, Martinez DD, Maude NR, Hale G, Rosenberg MA. Assessing Prescriber Behavior with a Clinical Decision Support Tool to Prevent Drug-Induced Long QT Syndrome. Appl Clin Inform. 2021 Jan;12(1):190-197. PubMed PMID: 33694143
• Simon ST, Mandair D, Tiwari P, Rosenberg MA. Prediction of Drug-Induced Long QT Syndrome Using Machine Learning Applied to Harmonized Electronic Health Record Data. J Cardiovasc Pharmacol Ther. 2021 Jul;26(4):335-340. PubMed PMID: 33682475
• Albakri A, Orkaby A, Rosenberg MA. Feasibility of Frailty Assessment Integrated with Cardiac Implantable Electronic Device Clinic Follow-up: A Pilot Investigation. Gerontol Geriatr Med. 2021 Jan-Dec;7:2333721420987342. PubMed PMID: 33457464
• Mantini N, Borne RT, Varosy PD, Rosenberg MA, Marzec LN, Sauer WH, Nguyen DT. Use of cell phone adapters is associated with reduction in disparities in remote monitoring of cardiac implantable electronic devices. J Interv Card Electrophysiol. 2021 Apr;60(3):469-475. PubMed PMID: 32399863
• Kim RS, Simon S, Powers B, Sandhu A, Sanchez J, Borne RT, Tumolo A, Zipse M, West JJ, Aleong R, Tzou W, Rosenberg MA. Machine Learning Methodologies for Prediction of Rhythm-Control Strategy in Patients Diagnosed With Atrial Fibrillation: Observational, Retrospective, Case-Control Study. JMIR Med Inform. 2021 Dec 6;9(12):e29225. PubMed PMID: 34874889
• Tiwari P, Colborn KL, Smith DE, Xing F, Ghosh D, Rosenberg MA. Assessment of a Machine Learning Model Applied to Harmonized Electronic Health Record Data for the Prediction of Incident Atrial Fibrillation. JAMA Netw Open. 2020 Jan 3;3(1):e1919396. PubMed PMID: 31951272
• Mandair D, Tiwari P, Simon S, Colborn KL, Rosenberg MA. Prediction of incident myocardial infarction using machine learning applied to harmonized electronic health record data. BMC Med Inform Decis Mak. 2020 Oct 2;20(1):252. PubMed PMID: 33008368
• Mantini N, Borne RT, Varosy PD, Rosenberg MA, Marzec LN, Sauer WH, Nguyen DT. Use of cell phone adapters is associated with reduction in disparities in remote monitoring of cardiac implantable electronic devices. J Interv Card Electrophysiol. 2020 May 12. [Epub ahead of print] PubMed PMID: 32399863
• Tiwari P, Colborn KL, Smith DE, Xing F, Ghosh D, Rosenberg MA. Assessment of a Machine Learning Model Applied to Harmonized Electronic Health Record Data for the Prediction of Incident Atrial Fibrillation. JAMA Netw Open. 2020 Jan 3;3(1):e1919396. PubMed PMID: 31951272
• Biswas M, Levy A, Weber R, Tarakji K, Chung M, Noseworthy PA, Newton-Cheh C, Rosenberg MA. Multicenter Analysis of Dosing Protocols for Sotalol Initiation. J Cardiovasc Pharmacol Ther. 2020 May;25(3):212-218. PubMed PMID: 31707834
• Biswas M, Levy A, Weber R, Tarakji K, Chung M, Noseworthy PA, Newton-Cheh C, Rosenberg MA. Multicenter Analysis of Dosing Protocols for Sotalol Initiation. J Cardiovasc Pharmacol Ther. 2019 Nov 10;:1074248419887710. [Epub ahead of print] PubMed PMID: 31707834
• Ream K, Sandhu A, Valle J, Weber R, Kaizer A, Wiktor DM, Borne RT, Tumolo AZ, Kunkel M, Zipse MM, Schuller J, Tompkins C, Rosenberg M, Nguyen DT, Cleveland JC Jr, Fullerton D, Carroll JD, Messenger J, Sauer WH, Aleong RG, Tzou WS. Ambulatory Rhythm Monitoring to Detect Late High-Grade Atrioventricular Block Following Transcatheter Aortic Valve Replacement. J Am Coll Cardiol. 2019 May 28;73(20):2538-2547. PubMed PMID: 31118148
• Levy AE, Biswas M, Weber R, Tarakji K, Chung M, Noseworthy PA, Newton-Cheh C, Rosenberg MA. Applications of machine learning in decision analysis for dose management for dofetilide. PLoS One. 2019;14(12):e0227324. PubMed PMID: 31891645
• Sandhu A, Zipse MM, Borne RT, Aleong RG, Tompkins C, Schuller J, Rosenberg M, Varosy PD, Tzou WS, Nguyen DT, Sauer WH. Esophageal position, measured luminal temperatures, and risk of atrioesophageal fistula with atrial fibrillation ablation. Pacing Clin Electrophysiol. 2019 Apr;42(4):458-463. PubMed PMID: 30779183
• Edward JA, Zipse MM, Tompkins C, Varosy PD, Sandhu A, Rosenberg M, Aleong R, Tzou WS, Borne RT, Sauer WH, Nguyen DT. Follow-Up After Catheter Ablation of Papillary Muscles and Valve Cusps. JACC Clin Electrophysiol. 2019 Oct;5(10):1185-1196. PubMed PMID: 31648744
• Chen MY, Orkaby AR, Rosenberg MA, Driver JA. Frailty, Implantable Cardioverter Defibrillators, and Mortality: a Systematic Review. J Gen Intern Med. 2019 Oct;34(10):2224-2231. PubMed PMID: 31264082
• Levy AE, Biswas M, Weber R, Tarakji K, Chung M, Noseworthy PA, Newton-Cheh C, Rosenberg MA. Applications of machine learning in decision analysis for dose management for dofetilide. PLoS One. 2019;14(12):e0227324. PubMed PMID: 31891645
• Ream K, Sandhu A, Valle J, Weber R, Kaizer A, Wiktor DM, Borne RT, Tumolo AZ, Kunkel M, Zipse MM, Schuller J, Tompkins C, Rosenberg M, Nguyen DT, Cleveland JC Jr, Fullerton D, Carroll JD, Messenger J, Sauer WH, Aleong RG, Tzou WS. Ambulatory Rhythm Monitoring to Detect Late High-Grade Atrioventricular Block Following Transcatheter Aortic Valve Replacement. J Am Coll Cardiol. 2019 May 28;73(20):2538-2547. PubMed PMID: 31118148
• Marzec L, Raghavan S, Banaei-Kashani F, Creasy S, Melanson EL, Lange L, Ghosh D, Rosenberg MA. Device-measured physical activity data for classification of patients with ventricular arrhythmia events: A pilot investigation. PLoS One. 2018;13(10):e0206153. PubMed PMID: 30372463
• Roselli C, Chaffin MD, Weng LC, Aeschbacher S, Ahlberg G, Albert CM, Almgren P, Alonso A, Anderson CD, Aragam KG, Arking DE, Barnard J, Bartz TM, Benjamin EJ, Bihlmeyer NA, Bis JC, Bloom HL, Boerwinkle E, Bottinger EB, Brody JA, Calkins H, Campbell A, Cappola TP, Carlquist J, Chasman DI, Chen LY, Chen YI, Choi EK, Choi SH, Christophersen IE, Chung MK, Cole JW, Conen D, Cook J, Crijns HJ, Cutler MJ, Damrauer SM, Daniels BR, Darbar D, Delgado G, Denny JC, Dichgans M, Dörr M, Dudink EA, Dudley SC, Esa N, Esko T, Eskola M, Fatkin D, Felix SB, Ford I, Franco OH, Geelhoed B, Grewal RP, Gudnason V, Guo X, Gupta N, Gustafsson S, Gutmann R, Hamsten A, Harris TB, Hayward C, Heckbert SR, Hernesniemi J, Hocking LJ, Hofman A, Horimoto ARVR, Huang J, Huang PL, Huffman J, Ingelsson E, Ipek EG, Ito K, Jimenez-Conde J, Johnson R, Jukema JW, Kääb S, Kähönen M, Kamatani Y, Kane JP, Kastrati A, Kathiresan S, Katschnig-Winter P, Kavousi M, Kessler T, Kietselaer BL, Kirchhof P, Kleber ME, Knight S, Krieger JE, Kubo M, Launer LJ, Laurikka J, Lehtimäki T, Leineweber K, Lemaitre RN, Li M, Lim HE, Lin HJ, Lin H, Lind L, Lindgren CM, Lokki ML, London B, Loos RJF, Low SK, Lu Y, Lyytikäinen LP, Macfarlane PW, Magnusson PK, Mahajan A, Malik R, Mansur AJ, Marcus GM, Margolin L, Margulies KB, März W, McManus DD, Melander O, Mohanty S, Montgomery JA, Morley MP, Morris AP, Müller-Nurasyid M, Natale A, Nazarian S, Neumann B, Newton-Cheh C, Niemeijer MN, Nikus K, Nilsson P, Noordam R, Oellers H, Olesen MS, Orho-Melander M, Padmanabhan S, Pak HN, Paré G, Pedersen NL, Pera J, Pereira A, Porteous D, Psaty BM, Pulit SL, Pullinger CR, Rader DJ, Refsgaard L, Ribasés M, Ridker PM, Rienstra M, Risch L, Roden DM, Rosand J, Rosenberg MA, Rost N, Rotter JI, Saba S, Sandhu RK, Schnabel RB, Schramm K, Schunkert H, Schurman C, Scott SA, Seppälä I, Shaffer C, Shah S, Shalaby AA, Shim J, Shoemaker MB, Siland JE, Sinisalo J, Sinner MF, Slowik A, Smith AV, Smith BH, Smith JG, Smith JD, Smith NL, Soliman EZ, Sotood... Multi-ethnic genome-wide association study for atrial fibrillation. Nat Genet. 2018 Sep;50(9):1225-1233. PubMed PMID: 29892015
• Rosenberg MA, Shores MM, Matsumoto AM, Bužková P, Lange LA, Kronmal RA, Heckbert SR, Mukamal KJ. Serum androgens and risk of atrial fibrillation in older men: The Cardiovascular Health Study. Clin Cardiol. 2018 Jun;41(6):830-836. PubMed PMID: 29671886
• Rosenberg MA, Lubitz SA, Lin H, Kosova G, Castro VM, Huang P, Ellinor PT, Perlis RH, Newton-Cheh C. Validation of Polygenic Scores for QT Interval in Clinical Populations. Circ Cardiovasc Genet. 2017 Oct;10(5). PubMed PMID: 28986454
• Strauss DG, Vicente J, Johannesen L, Blinova K, Mason JW, Weeke P, Behr ER, Roden DM, Woosley R, Kosova G, Rosenberg MA, Newton-Cheh C. Common Genetic Variant Risk Score Is Associated With Drug-Induced QT Prolongation and Torsade de Pointes Risk: A Pilot Study. Circulation. 2017 Apr 4;135(14):1300-1310. PubMed PMID: 28213480
• Tan AY, Nearing BD, Rosenberg M, Nezafat R, Josephson ME, Verrier RL. Interlead heterogeneity of R- and T-wave morphology in standard 12-lead ECGs predicts sustained ventricular tachycardia/fibrillation and arrhythmic death in patients with cardiomyopathy. J Cardiovasc Electrophysiol. 2017 Nov;28(11):1324-1333. PubMed PMID: 28675579
• Karas MG, Yee LM, Biggs ML, Djoussé L, Mukamal KJ, Ix JH, Zieman SJ, Siscovick DS, Gottdiener JS, Rosenberg MA, Kronmal RA, Heckbert SR, Kizer JR. Measures of Body Size and Composition and Risk of Incident Atrial Fibrillation in Older People: The Cardiovascular Health Study. Am J Epidemiol. 2016 Jun 1;183(11):998-1007. PubMed PMID: 27188936
• Levine YC, Matos J, Rosenberg MA, Manning WJ, Josephson ME, Buxton AE. Left ventricular sphericity independently predicts appropriate implantable cardioverter-defibrillator therapy. Heart Rhythm. 2016 Feb;13(2):490-7. PubMed PMID: 26409099
• Levine YC, Tuttle MK, Rosenberg MA, Goldberg R, Matos J, Samuel M, Kramer DB, Buxton AE. Prevalence and outcomes of patients receiving implantable cardioverter-defibrillators for primary prevention not based on guidelines. Am J Cardiol. 2015 Jun 1;115(11):1539-44. PubMed PMID: 25840578
• Rosenberg MA, Maziarz M, Tan AY, Glazer NL, Zieman SJ, Kizer JR, Ix JH, Djousse L, Siscovick DS, Heckbert SR, Mukamal KJ. Circulating fibrosis biomarkers and risk of atrial fibrillation: The Cardiovascular Health Study (CHS). Am Heart J. 2014 May;167(5):723-8.e2. PubMed PMID: 24766983
• Rosenberg MA, Lopez FL, Bužková P, Adabag S, Chen LY, Sotoodehnia N, Kronmal RA, Siscovick DS, Alonso A, Buxton A, Folsom AR, Mukamal KJ. Height and risk of sudden cardiac death: the Atherosclerosis Risk in Communities and Cardiovascular Health studies. Ann Epidemiol. 2014 Mar;24(3):174-179.e2. PubMed PMID: 24360853
• Rosenberg MA, Gandhavadi M, Tan AY. To the editor--Spontaneous conversion of a long RP to short RP tachycardia: what is the mechanism?. Heart Rhythm. 2014 Jun;11(6):E5. PubMed PMID: 24726976
• Rosenberg MA, Kaplan RC, Siscovick DS, Psaty BM, Heckbert SR, Newton-Cheh C, Mukamal KJ. Genetic variants related to height and risk of atrial fibrillation: the cardiovascular health study. Am J Epidemiol. 2014 Jul 15;180(2):215-22. PubMed PMID: 24944287
• North BJ, Rosenberg MA, Jeganathan KB, Hafner AV, Michan S, Dai J, Baker DJ, Cen Y, Wu LE, Sauve AA, van Deursen JM, Rosenzweig A, Sinclair DA. SIRT2 induces the checkpoint kinase BubR1 to increase lifespan. EMBO J. 2014 Jul 1;33(13):1438-53. PubMed PMID: 24825348
• Levine YC, Rosenberg MA, Mittleman M, Samuel M, Methachittiphan N, Link M, Josephson ME, Buxton AE. B-type natriuretic peptide is a major predictor of ventricular tachyarrhythmias. Heart Rhythm. 2014 Jul;11(7):1109-16. PubMed PMID: 24837348
• Rosenberg MA, Samuel M, Thosani A, Zimetbaum PJ. Use of a noninvasive continuous monitoring device in the management of atrial fibrillation: a pilot study. Pacing Clin Electrophysiol. 2013 Mar;36(3):328-33. PubMed PMID: 23240827
• Tan AY, Rosenberg MA. LOWERING THE RISK FOR THROMBUS AND STROKE IN ATRIAL FIBRILLATION PATIENTS: Will Dabigatran Replace Warfarin?. Clin Med Rev Vasc Health. 2013 Jun 20;5:1-8. PubMed PMID: 25253992
• Das S, Aiba T, Rosenberg M, Hessler K, Xiao C, Quintero PA, Ottaviano FG, Knight AC, Graham EL, Boström P, Morissette MR, del Monte F, Begley MJ, Cantley LC, Ellinor PT, Tomaselli GF, Rosenzweig A. Pathological role of serum- and glucocorticoid-regulated kinase 1 in adverse ventricular remodeling. Circulation. 2012 Oct 30;126(18):2208-19. PubMed PMID: 23019294
• Rosenberg MA, Manning WJ. Diastolic dysfunction and risk of atrial fibrillation: a mechanistic appraisal. Circulation. 2012 Nov 6;126(19):2353-62. PubMed PMID: 23129702
• Rosenberg MA, Patton KK, Sotoodehnia N, Karas MG, Kizer JR, Zimetbaum PJ, Chang JD, Siscovick D, Gottdiener JS, Kronmal RA, Heckbert SR, Mukamal KJ. The impact of height on the risk of atrial fibrillation: the Cardiovascular Health Study. Eur Heart J. 2012 Nov;33(21):2709-17. PubMed PMID: 22977225
• Rosenberg MA, Mukamal KJ. The Estimated Risk of Atrial Fibrillation Related to Alcohol Consumption. J Atr Fibrillation. 2012 Jun-Jul;5(1):424. PubMed PMID: 28496744
• Rosenberg MA, Das S, Quintero Pinzon P, Knight AC, Sosnovik DE, Ellinor PT, Rosenzweig A. A Novel Transgenic Mouse Model of Cardiac Hypertrophy and Atrial Fibrillation. J Atr Fibrillation. 2012 Feb-Mar;4(5):415. PubMed PMID: 28496713
• Rosenberg MA, Gottdiener JS, Heckbert SR, Mukamal KJ. Echocardiographic diastolic parameters and risk of atrial fibrillation: the Cardiovascular Health Study. Eur Heart J. 2012 Apr;33(7):904-12. PubMed PMID: 21990265
• Song X, Kusakari Y, Xiao CY, Kinsella SD, Rosenberg MA, Scherrer-Crosbie M, Hara K, Rosenzweig A, Matsui T. mTOR attenuates the inflammatory response in cardiomyocytes and prevents cardiac dysfunction in pathological hypertrophy. Am J Physiol Cell Physiol. 2010 Dec;299(6):C1256-66. PubMed PMID: 20861467
• Morissette MR, Stricker JC, Rosenberg MA, Buranasombati C, Levitan EB, Mittleman MA, Rosenzweig A. Effects of myostatin deletion in aging mice. Aging Cell. 2009 Sep;8(5):573-83. PubMed PMID: 19663901
• Morissette MR, Cook SA, Buranasombati C, Rosenberg MA, Rosenzweig A. Myostatin inhibits IGF-I-induced myotube hypertrophy through Akt. Am J Physiol Cell Physiol. 2009 Nov;297(5):C1124-32. PubMed PMID: 19759331
• Noseworthy PA, Rosenberg MA, Fifer MA, Palacios IF, Lowry PA, Ruskin JN, Sanborn DM, Picard MH, Vlahakes GJ, Mela T, Das S. Ventricular arrhythmia following alcohol septal ablation for obstructive hypertrophic cardiomyopathy. Am J Cardiol. 2009 Jul 1;104(1):128-32. PubMed PMID: 19576333