Beat Vögeli, PhD

Associate Professor, Biochemistry & Molecular Genetics

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Graduate School
  • PhD, Swiss Federal Institute of Technology (ETH) (2005)
Department
Biochemistry & Molecular Genetics

Professional Titles

  • Assistant Professor

Publications

  • Lambert KA, Clements CM, Mukherjee N, Pacheco TR, Shellman SX, Henen MA, Vögeli B, Goldstein NB, Birlea S, Hintzsche J, Caryotakis G, Tan AC, Zhao R, Norris DA, Robinson WA, Wang Y, VanTreeck JG, Shellman YG. SASH1 S519N Variant Links Skin Hyperpigmentation and Premature Hair Graying to Dysfunction of Melanocyte Lineage. J Invest Dermatol. 2025 Jan;145(1):144-154.e3. PubMed PMID: 38848986
  • Nichols PJ, Welty R, Krall JB, Henen MA, Vicens Q, Vögeli B. Za Domain of ADAR1 Binds to an A-Form-like Nucleic Acid Duplex with Low Micromolar Affinity. Biochemistry. 2024 Mar 19;63(6):777-787. PubMed PMID: 38437710
  • Nichols PJ, Krall JB, Henen MA, Welty R, Macfadden A, Vicens Q, Vögeli B. Z-Form Adoption of Nucleic Acid is a Multi-Step Process Which Proceeds through a Melted Intermediate. J Am Chem Soc. 2024 Jan 10;146(1):677-694. PubMed PMID: 38131335
  • Yao L, Vögeli B (Editors). Residual dipolar couplings: Principles and applications. Royal Society of Chemistry, 2024, 31, 402 pages, https://doi.org/10.1039/9781839167898.
  • Yao L, Vögeli B, Bax A. Introduction to Residual Dipolar Coupling. ‘Residual Dipolar Couplings: Principles and Applications’, 2024, R. Soc. Chem., 31, 1-4
  • Keeney JG, Astling D, Andries V, Vandepoele K, Anderson N, Davis JM, Lopert P, Vandenbussche J, Gevaert K, Staes A, Paukovich N, Vögeli B, Jones KL, van Roy F, Patel M, Sikela JM. Olduvai domain expression downregulates mitochondrial pathways: implications for human brain evolution and neoteny. bioRxiv. 2024 Oct 22. PubMed PMID: 39484454
  • Beck LG, Krall JB, Nichols PJ, Vicens Q, Henen MA, Vögeli B. Solution NMR backbone assignment of the N-terminal tandem Za1-Za2 domains of Z-DNA binding protein 1. Biomol NMR Assign. 2024 Dec;18(2):245-252. PubMed PMID: 39215796
  • Romero MF, Krall JB, Nichols PJ, Vantreeck J, Henen MA, Dejardin E, Schulz F, Vicens Q, Vögeli B, Diallo MA. Novel Z-DNA binding domains in giant viruses. J Biol Chem. 2024 Aug;300(8):107504. PubMed PMID: 38944123
  • Nichols PJ, Krall JB, Henen MA, Welty R, Macfadden A, Vicens Q, Vögeli B. Z-Form Adoption of Nucleic Acid is a Multi-Step Process Which Proceeds through a Melted Intermediate. J Am Chem Soc. 2023 Dec 22. [Epub ahead of print] PubMed PMID: 38131335
  • Lambert KA, Clements CM, Mukherjee N, Pacheco TR, Shellman SX, Henen MA, Vögeli B, Goldstein NB, Birlea S, Hintzsche J, Tan AC, Zhao R, Norris DA, Robinson WA, Wang Y, VanTreeck JG, Shellman YG. SASH1 interacts with TNKS2 and promotes human melanocyte stem cell maintenance. bioRxiv. 2023 Sep 27. PubMed PMID: 37808724
  • Maurina SF, O'Sullivan JP, Sharma G, Pineda Rodriguez DC, MacFadden A, Cendali F, Henen MA, Vögeli B, Kieft JS, Glasgow A, Steckelberg AL. An Evolutionarily Conserved Strategy for Ribosome Binding and Host Translation Inhibition by ß-coronavirus Non-structural Protein 1. J Mol Biol. 2023 Oct 15;435(20):168259. PubMed PMID: 37660941
  • Henen MA, Paukovich N, Prekeris R, Vögeli B. Solution NMR Backbone Assignment of the C-Terminal Region of Human Dynein Light Intermediate Chain 2 (LIC2-C) Unveils Structural Resemblance with Its Homologue LIC1-C. Magnetochemistry. 2023 Jul;9(7). PubMed PMID: 37476506
  • Maurina SF, O'Sullivan JP, Sharma G, Pineda Rodriguez DC, MacFadden A, Cendali F, Henen MA, Kieft JS, Glasgow A, Steckelberg AL. An evolutionarily conserved strategy for ribosome binding and inhibition by ß-coronavirus non-structural protein 1. bioRxiv. 2023 Jun 8. PubMed PMID: 37333070
  • Clements CM, Henen MA, Vögeli B, Shellman YG. The Structural Dynamics, Complexity of Interactions, and Functions in Cancer of Multi-SAM Containing Proteins. Cancers (Basel). 2023 Jun 1;15(11). PubMed PMID: 37296980
  • Clements CM, Vögeli B, Shellman YG, Henen MA. Solution NMR backbone assignment of the SASH1 SLy proteins associated disordered region (SPIDER). Biomol NMR Assign. 2023 Jun;17(1):151-157. PubMed PMID: 37155029
  • Nichols PJ, Bevers S, Henen MA, Kieft JS, Vicens Q, Vögeli B. Adoption of A-Z Junctions in RNAs by Binding of Za Domains. Methods Mol Biol. 2023;2651:251-275. PubMed PMID: 36892773
  • Langeberg CJ, Nichols PJ, Henen MA, Vicens Q, Vögeli B. Differential Structural Features of Two Mutant ADAR1p150 Za Domains Associated with Aicardi-Goutières Syndrome. J Mol Biol. 2023 Apr 15;435(8):168040. PubMed PMID: 36889460
  • De Silva SM, Dhiman A, Sood S, Mercedes KF, Simmons WJ, Henen MA, Vögeli B, Dykhuizen EC, Musselman CA. PBRM1 bromodomains associate with RNA to facilitate chromatin association. Nucleic Acids Res. 2023 May 8;51(8):3631-3649. PubMed PMID: 36808431
  • Vugmeyster L, Nichols PJ, Ostrovsky D, McKnight CJ, Vögeli B. Slow methyl axes motions in perdeuterated villin headpiece subdomain probed by cross-correlated NMR relaxation measurements. Magnetochemistry. 2023 Jan;9(1). PubMed PMID: 36776538
  • Krall JB, Nichols PJ, Henen MA, Vicens Q, Vögeli B. Structure and Formation of Z-DNA and Z-RNA. Molecules. 2023 Jan 14;28(2). PubMed PMID: 36677900
  • Nichols PJ, Krall JB, Henen MA, Vögeli B, Vicens Q. Z-RNA biology: a central role in the innate immune response?. RNA. 2023 Mar;29(3):273-281. PubMed PMID: 36596670
  • Pacheco A, Issaian A, Davis J, Anderson N, Nemkov T, Paukovich N, Henen MA, Vögeli B, Sikela JM, Hansen K. Proteolytic activation of human-specific Olduvai domains by the furin protease. Int J Biol Macromol. 2023 Apr 15;234:123041. PubMed PMID: 36581038
  • Pacheco A, Issaian A, Davis J, Anderson N, Nemkov T, Paukovich N, Henen MA, Vögeli B, Sikela JM, Hansen K. Proteolytic activation of human-specific Olduvai domains by the furin protease. Int J Biol Macromol. 2022 Dec 26. [Epub ahead of print] PubMed PMID: 36581038
  • Clements CM, Vögeli B, Shellman YG, Henen MA. SAM1 domain of SASH1 harbors distinctive structural heterogeneity. J Struct Biol. 2022 Dec;214(4):107914. PubMed PMID: 36341956
  • Hussain A, Paukovich N, Henen MA, Vögeli B. Advances in the exact nuclear Overhauser effect 2018-2022. Methods. 2022 Oct;206:87-98. PubMed PMID: 35985641
  • Ashkinadze D, Kadavath H, Pokharna A, Chi CN, Friedmann M, Strotz D, Kumari P, Minges M, Cadalbert R, Königl S, Güntert P, Vögeli B, Riek R. Atomic resolution protein allostery from the multi-state structure of a PDZ domain. Nat Commun. 2022 Oct 20;13(1):6232. PubMed PMID: 36266302
  • Kim JS, Born A, Till JKA, Liu L, Kant S, Henen MA, Vögeli B, Vázquez-Torres A. Promiscuity of response regulators for thioredoxin steers bacterial virulence. Nat Commun. 2022 Oct 20;13(1):6210. PubMed PMID: 36266276
  • Born A, Soetbeer J, Henen MA, Breitgoff F, Polyhach Y, Jeschke G, Vögeli B. Ligand-specific conformational change drives interdomain allostery in Pin1. Nat Commun. 2022 Aug 4;13(1):4546. PubMed PMID: 35927276
  • Paukovich N, Henen MA, Hussain A, Issaian A, Sikela JM, Hansen KC, Vögeli B. Solution NMR backbone assignments of disordered Olduvai protein domain CON1 employing Ha-detected experiments. Biomol NMR Assign. 2022 Apr;16(1):113-119. PubMed PMID: 35098449
  • Born A, Henen MA, Nichols PJ, Vögeli B. On the use of residual dipolar couplings in multi-state structure calculation of two-domain proteins. Magn Reson Lett. 2022 May;2(2):61-68. PubMed PMID: 35734611
  • Hu K, Lee W, Montelione GT, Sgourakis NG, Vögeli B. Editorial: Computational approaches for interpreting experimental data and understanding protein structure, dynamics and function relationships. Front Mol Biosci. 2022;9:1018149. PubMed PMID: 36262477
  • Born A, Soetbeer J, Breitgoff F, Henen MA, Sgourakis N, Polyhach Y, Nichols PJ, Strotz D, Jeschke G, Vögeli B. Reconstruction of Coupled Intra- and Interdomain Protein Motion from Nuclear and Electron Magnetic Resonance. J Am Chem Soc. 2021 Oct 6;143(39):16055-16067. PubMed PMID: 34579531
  • Herbert A, Karapetyan S, Poptsova M, Vasquez KM, Vicens Q, Vögeli B. Special Issue: A, B and Z: The Structure, Function and Genetics of Z-DNA and Z-RNA. Int J Mol Sci. 2021 Jul 19;22(14). PubMed PMID: 34299306
  • Wang RX, Henen MA, Lee JS, Vögeli B, Colgan SP. Microbiota-derived butyrate is an endogenous HIF prolyl hydroxylase inhibitor. Gut Microbes. 2021 Jan-Dec;13(1):1938380. PubMed PMID: 34190032
  • Redzic JS, Lee E, Born A, Issaian A, Henen MA, Nichols PJ, Blue A, Hansen KC, D'Alessandro A, Vögeli B, Eisenmesser EZ. The Inherent Dynamics and Interaction Sites of the SARS-CoV-2 Nucleocapsid N-Terminal Region. J Mol Biol. 2021 Jul 23;433(15):167108. PubMed PMID: 34161778
  • Alexeev EE, Dowdell AS, Henen MA, Lanis JM, Lee JS, Cartwright IM, Schaefer REM, Ornelas A, Onyiah JC, Vögeli B, Colgan SP. Microbial-derived indoles inhibit neutrophil myeloperoxidase to diminish bystander tissue damage. FASEB J. 2021 May;35(5):e21552. PubMed PMID: 33826788
  • Nichols PJ, Henen MA, Vicens Q, Vögeli B. Solution NMR backbone assignments of the N-terminal Za-linker-Zß segment from Homo sapiens ADAR1p150. Biomol NMR Assign. 2021 Oct;15(2):273-279. PubMed PMID: 33742389
  • Tengesdal IW, Menon DR, Osborne DG, Neff CP, Powers NE, Gamboni F, Mauro AG, D'Alessandro A, Stefanoni D, Henen MA, Mills TS, De Graaf DM, Azam T, Vogeli B, Palmer BE, Pietras EM, DeGregori J, Tan AC, Joosten LAB, Fujita M, Dinarello CA, Marchetti C. Targeting tumor-derived NLRP3 reduces melanoma progression by limiting MDSCs expansion. Proc Natl Acad Sci U S A. 2021 Mar 9;118(10). PubMed PMID: 33649199
  • Nichols PJ, Bevers S, Henen M, Kieft JS, Vicens Q, Vögeli B. Recognition of non-CpG repeats in Alu and ribosomal RNAs by the Z-RNA binding domain of ADAR1 induces A-Z junctions. Nat Commun. 2021 Feb 4;12(1):793. PubMed PMID: 33542240
  • Henen MA, Myers W, Schmitt LR, Wade KJ, Born A, Nichols PJ, Vögeli B. The Disordered Spindly C-terminus Interacts with RZZ Subunits ROD-1 and ZWL-1 in the Kinetochore through the Same Sites in C. Elegans. J Mol Biol. 2021 Feb 19;433(4):166812. PubMed PMID: 33450249
  • Born A, Henen MA, Nichols PJ, Vogeli B, On the use of residual dipolar couplings in multi-state structure calculation of two-domain proteins. Magn. Reson. Lett. 2021;https://doi.org/10.1016/j.mrl.2021.10.003.
  • Henen MA, Myers W, Schmitt LR, Wade KJ, Born A, Nichols PJ, Vögeli B. The disordered Spindly C-terminus interacts with RZZ subunits ROD-1 and ZWL-1 in the kinetochore through the same sites in C. elegans. J Mol Biol. 2021 Jan 12;:166812. [Epub ahead of print] PubMed PMID: 33450249
  • Nichols PJ, Born A, Henen MA, Strotz D, Jones DN, Delaglio F, Vögeli B. Reducing the measurement time of exact NOEs by non-uniform sampling. J Biomol NMR. 2020 Dec;74(12):717-739. PubMed PMID: 32880802
  • Strotz D, Orts J, Kadavath H, Friedmann M, Ghosh D, Olsson S, Chi CN, Pokharna A, Güntert P, Vögeli B, Riek R. Protein Allostery at Atomic Resolution. Angew Chem Int Ed Engl. 2020 Dec 1;59(49):22132-22139. PubMed PMID: 32797659
  • Grohe K, Patel S, Hebrank C, Medina S, Klein A, Rovó P, Vasa SK, Singh H, Vögeli B, Schäfer LV, Linser R. Protein Motional Details Revealed by Complementary Structural Biology Techniques. Structure. 2020 Sep 1;28(9):1024-1034.e3. PubMed PMID: 32579946
  • Bottaro S, Nichols PJ, Vögeli B, Parrinello M, Lindorff-Larsen K. Integrating NMR and simulations reveals motions in the UUCG tetraloop. Nucleic Acids Res. 2020 Jun 19;48(11):5839-5848. PubMed PMID: 32427326
  • Nichols PJ, Falconer I, Griffin A, Mant C, Hodges R, McKnight CJ, Vögeli B, Vugmeyster L. Deuteration of nonexchangeable protons on proteins affects their thermal stability, side-chain dynamics, and hydrophobicity. Protein Sci. 2020 Jul;29(7):1641-1654. PubMed PMID: 32356390
  • Nashaat S, Henen MA, El-Messery SM, Eisa H. Synthesis, state-of-the-art NMR-binding and molecular modeling study of new benzimidazole core derivatives as Pin1 inhibitors: Targeting breast cancer. Bioorg Med Chem. 2020 Jun 1;28(11):115495. PubMed PMID: 32307260
  • El-Khouly OA, Henen MA, El-Sayed MA, Shabaan MI, El-Messery SM. Synthesis, anticancer and antimicrobial evaluation of new benzofuran based derivatives: PI3K inhibition, quorum sensing and molecular modeling study. Bioorg Med Chem. 2020 Dec 27;31:115976. [Epub ahead of print] PubMed PMID: 33388654
  • Nichols PJ, Falconer I, Griffin A, Mant C, Hodges R, McKnight CJ, Vögeli B, Vugmeyster L, Deuteration of non-exchangeable protons on proteins affects their thermal stability, side-chain dynamics and hydrophobicity, Protein Sci. 2020;29,1641-1654 PubMed PMID 32356390
  • Born A, Henen MA, Vögeli B. Activity and Affinity of Pin1 Variants. Molecules. 2019 Dec 20;25(1). PubMed PMID: 31861908
  • Issaian A, Schmitt L, Born A, Nichols PJ, Sikela J, Hansen K, Vögeli B, Henen MA. Solution NMR backbone assignment reveals interaction-free tumbling of human lineage-specific Olduvai protein domains. Biomol NMR Assign. 2019 Oct;13(2):339-343. PubMed PMID: 31264103
  • Grohe K, Nimerovsky E, Singh H, Vasa SK, Söldner B, Vögeli B, Rienstra CM, Linser R. Exact distance measurements for structure and dynamics in solid proteins by fast-magic-angle-spinning NMR. Chem Commun (Camb). 2019 Jul 14;55(55):7899-7902. PubMed PMID: 31199417
  • Celestino R, Henen MA, Gama JB, Carvalho C, McCabe M, Barbosa DJ, Born A, Nichols PJ, Carvalho AX, Gassmann R, Vögeli B. A transient helix in the disordered region of dynein light intermediate chain links the motor to structurally diverse adaptors for cargo transport. PLoS Biol. 2019 Jan;17(1):e3000100. PubMed PMID: 30615611
  • Born A, Nichols PJ, Henen MA, Chi CN, Strotz D, Bayer P, Tate SI, Peng JW, Vögeli B. Backbone and side-chain chemical shift assignments of full-length, apo, human Pin1, a phosphoprotein regulator with interdomain allostery. Biomol NMR Assign. 2019 Apr;13(1):85-89. PubMed PMID: 30353504
  • Vögeli B, Vugmeyster L. Distance-independent Cross-correlated Relaxation and Isotropic Chemical Shift Modulation in Protein Dynamics Studies. Chemphyschem. 2019 Jan 21;20(2):178-196. PubMed PMID: 30110510
  • Jemth P, Karlsson E, Vögeli B, Guzovsky B, Andersson E, Hultqvist G, Dogan J, Güntert P, Riek R, Chi CN. Structure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins. Sci Adv. 2018 Oct;4(10):eaau4130. PubMed PMID: 30397651
  • Born A, Nichols PJ, Henen MA, Chi CN, Strotz D, Bayer P, Tate SI, Peng JW, Vögeli B. Backbone and side-chain chemical shift assignments of full-length, apo, human Pin1, a phosphoprotein regulator with interdomain allostery. Biomol NMR Assign. 2018 Oct 23. [Epub ahead of print] PubMed PMID: 30353504
  • Nichols PJ, Henen MA, Born A, Strotz D, Güntert P, Vögeli B. High-resolution small RNA structures from exact nuclear Overhauser enhancement measurements without additional restraints. Commun Biol. 2018;1:61. PubMed PMID: 30271943
  • Vugmeyster L, Griffin A, Ostrovsky D, Bhattacharya S, Nichols PJ, McKnight CJ, Vögeli B. Correlated motions of C'-N and C(a)-C(ß) pairs in protonated and per-deuterated GB3. J Biomol NMR. 2018 Oct;72(1-2):39-54. PubMed PMID: 30121872
  • Vögeli B, Vugmeyster L. Distance-independent Cross-correlated Relaxation and Isotropic Chemical Shift Modulation in Protein Dynamics Studies. Chemphyschem. 2018 Aug 15. [Epub ahead of print] PubMed PMID: 30110510
  • Nichols PJ, Born A, Henen MA, Strotz D, Celestine CN, Güntert P, Vögeli B. Extending the Applicability of Exact Nuclear Overhauser Enhancements to Large Proteins and RNA. Chembiochem. 2018 Jun 8. [Epub ahead of print] PubMed PMID: 29883016
  • Chi CN, Strotz D, Riek R, Vögeli B. NOE-Derived Methyl Distances from a 360 kDa Proteasome Complex. Chemistry. 2018 Feb 9;24(9):2270-2276. PubMed PMID: 29265588
  • Born A, Henen MA, Nichols P, Wang J, Jones DN, Vögeli B, Efficient stereospecific Hß2/3 NMR assignment strategy for mid-size proteins. Magnetochemistry, 2018;4;25
  • Chi C, Strotz D, Riek R, Vögeli B, NOE-derived methyl distances from a 360 kDa proteasome complex. Chem Eur J, DOI: 10.1002/chem.201705551
  • Sundell GN, Vögeli B, Ivarsson Y, Chi CN. The Sign of Nuclear Magnetic Resonance Chemical Shift Difference as a Determinant of the Origin of Binding Selectivity: Elucidation of the Position Dependence of Phosphorylation in Ligands Binding to Scribble PDZ1. Biochemistry. 2017 Nov 27. [Epub ahead of print] PubMed PMID: 29144123
  • Fenwick RB, Vögeli B. Detection of Correlated Protein Backbone and Side-Chain Angle Fluctuations. Chembiochem. 2017 Oct 18;18(20):2016-2021. PubMed PMID: 28771902
  • Strotz D, Orts J, Chi CN, Riek R, Vögeli B. eNORA2 Exact NOE Analysis Program. J Chem Theory Comput. 2017 Sep 12;13(9):4336-4346. PubMed PMID: 28727914
  • Nichols PJ, Born A, Henen MA, Strotz D, Orts J, Olsson S, Güntert P, Chi CN, Vögeli B. The Exact Nuclear Overhauser Enhancement: Recent Advances. Molecules. 2017 Jul 14;22(7). PubMed PMID: 28708092
  • Vögeli B. Cross-correlated relaxation rates between protein backbone H-X dipolar interactions. J Biomol NMR. 2017 Mar;67(3):211-232. PubMed PMID: 28286915
  • Celestino R, Henen MA, Gama JB, Carvalho C, McCabe M, Barbosa DJ, Born A, Nichols PJ, Carvalho AX, Gassmann R, Vögeli B, A transient helix in the disordered region of dynein light intermediate chain links the motor to structurally diverse adaptors for cargo transport, PLoS Biol


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