Heather Hoch De Keyser, MD

Medical School

MD, University of Colorado Denver Health Sciences Center (2010)

Graduate School

MD, University of Colorado Health Sciences Center (2010)

Undergraduate School

BA, Washington University in Saint Louis (MO) (2006)

Residency

University of Colorado (Children's Hospital Colorado) Program, Pediatrics (2010)

Fellowships

University of Colorado (Children's Hospital Colorado) Program, Pediatric Pulmonology (2013)

Department

Pediatrics-Pulmonary Medicine

Professional Titles

Assistant Professor

Research Interests

My research interests primarily focus on medication adherence and health behavior change in children and adolescents with asthma. Additionally, I have studied how to use clinical data to predict and prevent asthma exacerbations.

Publications

Chan AHY, De Keyser HH, Horne R, Szefler SJ. Defining adherence phenotype and endotypes to personalise asthma management. Eur Respir J. 2024 Nov 27. [Epub ahead of print] PubMed PMID: 39603674
Lovinsky-Desir S, Riley IL, Bryant-Stephens T, De Keyser H, Forno E, Kozik AJ, Louisias M, Matsui EC, Sheares BJ, Thakur N, Apter AJ, Beck AF, Bentley-Edwards KL, Berkowitz C, Braxton C, Dean J, Jones CP, Koinis-Mitchell D, Okelo SO, Taylor-Cousar JL, Teach SJ, Wechsler ME, Gaffin JM, Federico MJ. Research Priorities in Pediatric Asthma Morbidity: Addressing the Impacts of Systemic Racism on Children with Asthma in the United States. An Official American Thoracic Society Workshop Report. Ann Am Thorac Soc. 2024 Oct;21(10):1349-1364. PubMed PMID: 39352175
Huebschmann AG, Wagner NM, Gleason M, Brinton JT, Brtnikova M, Brewer SE, Begum A, Armstrong R, DeCamp LR, McFarlane A, DeKeyser H, Coleman H, Federico MJ, Szefler SJ, Cicutto LC. Reducing asthma attacks in disadvantaged school children with asthma: study protocol for a type 2 hybrid implementation-effectiveness trial (Better Asthma Control for Kids, BACK). Implement Sci. 2024 Aug 15;19(1):60. PubMed PMID: 39148094
Brewer SE, DeCamp LR, Reedy J, Armstrong R, DeKeyser HH, Federico MJ, McFarlane A 2nd, Figlio G, Huebschmann AG, Szefler SJ, Cicutto L. Developing a Social Determinants of Health Needs Assessment for Colorado Kids (SNACK) Tool for a School-Based Asthma Program: Findings from a Pilot Study. Ethn Dis. 2023 Dec;DECIPHeR(Spec Issue):126-131. PubMed PMID: 38846737
De Keyser H, Vuong V, Kaye L, Anderson WC 3rd, Szefler S, Stempel DA. Reply to "Breath-taking compliance: Does lower adherence translate to inferiority?". J Allergy Clin Immunol Pract. 2023 Dec;11(12):3813-3814. PubMed PMID: 38065642
Keyser HH, Brinton JT, Bothwell S, Camacho M, Kempe A, Szefler SJ. Encouraging adherence in adolescents with asthma using financial incentives: An RCT. Pediatr Pulmonol. 2023 Oct;58(10):2823-2831. PubMed PMID: 37449768
De Keyser H, Vuong V, Kaye L, Anderson WC 3rd, Szefler S, Stempel DA. Is Once Versus Twice Daily Dosing Better for Adherence in Asthma and Chronic Obstructive Pulmonary Disease?. J Allergy Clin Immunol Pract. 2023 Jul;11(7):2087-2093.e3. PubMed PMID: 37088377
De Keyser H, Vuong V, Kaye L, Anderson WC 3rd, Szefler S, Stempel DA. Is Once Versus Twice Daily Dosing Better for Adherence in Asthma and Chronic Obstructive Pulmonary Disease?. J Allergy Clin Immunol Pract. 2023 Jul;11(7):2087-2093.e3. PubMed PMID: 37088377
Keyser HH, Brinton JT, Bothwell S, Camacho M, Kempe A, Szefler SJ. Encouraging adherence in adolescents with asthma using financial incentives: An RCT. Pediatr Pulmonol. 2023 Oct;58(10):2823-2831. PubMed PMID: 37449768
Sweenie R, Keyser HH, Gutiérrez-Colina AM, Brammer C, Ramsey RR. Adherence and Self-management Interventions among Systemically Marginalized and Underserved Youth with Asthma. Clin Pract Pediatr Psychol. 2022 Dec;10(4):394-408. PubMed PMID: 37275278
De Keyser HH, Chipps B, Dinakar C. Biologics for Asthma and Allergic Skin Diseases in Children. Pediatrics. 2021 Nov;148(5). PubMed PMID: 34663682
Udoko M, De Keyser H, Szefler SJ. Should children with asthma simply be treated as little adults?. Ann Allergy Asthma Immunol. 2021 Nov;127(5):520-521. PubMed PMID: 34260900
Anderson WC 3rd, Gondalia R, De Keyser HE, Kaye L, Szefler SJ, Stempel DA. Digital assessment of medication utilization by age and diagnosis of asthma or COPD. J Allergy Clin Immunol Pract. 2021 Apr;9(4):1723-1725. PubMed PMID: 33212238
Navanandan N, Moran E, Smith H, Hoch H, Mistry RD. Primary care provider preferences for glucocorticoid management of acute asthma exacerbations in children. J Asthma. 2021 Apr;58(4):547-553. PubMed PMID: 31877252
Anderson WC 3rd, Gondalia R, Hoch HE, Kaye L, Barrett M, Szefler SJ, Stempel DA. Assessing asthma control: comparison of electronic-recorded short-acting beta-agonist rescue use and self-reported use utilizing the asthma control test. J Asthma. 2021 Feb;58(2):271-275. PubMed PMID: 31668103
Anderson WC 3rd, Gondalia R, Hoch HE, Kaye L, Barrett M, Szefler SJ, Stempel DA. Assessing asthma control: comparison of electronic-recorded short-acting beta-agonist rescue use and self-reported use utilizing the asthma control test. J Asthma. 2021 Feb;58(2):271-275. PubMed PMID: 31668103
Cotter JM, Tyler A, Reese J, Ziniel S, Federico MJ, Anderson Iii WC, Kupfer O, Szefler SJ, Kerby G, Hoch HE. Steroid variability in pediatric inpatient asthmatics: survey on provider preferences of dexamethasone versus prednisone. J Asthma. 2020 Sep;57(9):942-948. PubMed PMID: 31113252
De Keyser HH, Szefler S. Asthma attacks in children are always preceded by poor asthma control: myth or maxim?. Breathe (Sheff). 2020 Sep;16(3):200169. PubMed PMID: 33447278
Anderson WC 3rd, Gondalia R, De Keyser HE, Kaye L, Szefler SJ, Stempel DA. Digital assessment of medication utilization by age and diagnosis of asthma or COPD. J Allergy Clin Immunol Pract. 2020 Nov 16. [Epub ahead of print] PubMed PMID: 33212238
De Keyser HEH, Kaye L, Anderson WC, Gondalia R, Theye B, Szefler SJ, Stempel DA. Electronic medication monitors help determine adherence subgroups in asthma. Respir Med. 2020 Apr;164:105914. PubMed PMID: 32094102
De Keyser HH, Ramsey R, Federico MJ. They just don't take their medicines: Reframing medication adherence in asthma from frustration to opportunity. Pediatr Pulmonol. 2020 Mar;55(3):818-825. PubMed PMID: 31944593
Navanandan N, Moran E, Smith H, Hoch H, Mistry RD. Primary care provider preferences for glucocorticoid management of acute asthma exacerbations in children. J Asthma. 2020 Jan 14;:1-7. [Epub ahead of print] PubMed PMID: 31877252
Hoch H, Kattan M, Szefler SJ. Challenges in managing difficult-to-treat asthma in children: Stop, look, and listen. Pediatr Pulmonol. 2020 Mar;55(3):791-794. PubMed PMID: 31710161
Cotter JM, Tyler A, Reese J, Ziniel S, Federico MJ, Anderson Iii WC, Kupfer O, Szefler SJ, Kerby G, Hoch HE. Steroid variability in pediatric inpatient asthmatics: survey on provider preferences of dexamethasone versus prednisone. J Asthma. 2020 Sep;57(9):942-948. PubMed PMID: 31113252
Hoch H, Kattan M, Szefler SJ. Challenges in managing difficult-to-treat asthma in children: Stop, look, and listen. Pediatr Pulmonol. 2020 Mar;55(3):791-794. PubMed PMID: 31710161
De Keyser HEH, Kaye L, Anderson WC, Gondalia R, Theye B, Szefler SJ, Stempel DA. Electronic medication monitors help determine adherence subgroups in asthma. Respir Med. 2020 Apr;164:105914. PubMed PMID: 32094102
De Keyser HH, Ramsey R, Federico MJ. They just don't take their medicines: Reframing medication adherence in asthma from frustration to opportunity. Pediatr Pulmonol. 2020 Mar;55(3):818-825. PubMed PMID: 31944593
De Keyser HH, Szefler S. Asthma attacks in children are always preceded by poor asthma control: myth or maxim?. Breathe (Sheff). 2020 Sep;16(3):200169. PubMed PMID: 33447278
Cotter JM, Tyler A, Reese J, Ziniel S, Federico MJ, Anderson Iii WC, Kupfer O, Szefler SJ, Kerby G, Hoch HE. Steroid variability in pediatric inpatient asthmatics: survey on provider preferences of dexamethasone versus prednisone. J Asthma. 2019 Jun 12;:1-7. [Epub ahead of print] PubMed PMID: 31113252
Hoch HE, Houin PR, Stillwell PC. Asthma in Children: A Brief Review for Primary Care Providers. Pediatr Ann. 2019 Mar 1;48(3):e103-e109. PubMed PMID: 30874817
Anderson WC 3rd, Gondalia R, Hoch HE, Kaye L, Szefler SJ, Stempel DA. Screening for inhalation technique errors with electronic medication monitors. J Allergy Clin Immunol Pract. 2019 Jul - Aug;7(6):2065-2067. PubMed PMID: 30776523
Szefler SJ, Hoch HE, Tuffli M, Gondalia R, Barrett MA, Van Sickle D, Stempel DA. Quantifying beta-agonist utilization: Occasions or puffs?. J Allergy Clin Immunol Pract. 2019 Mar;7(3):1088-1090. PubMed PMID: 30218718
Press VG, Hoch H. The Search for Culturally Tailored Inhaled Corticosteroid Adherence Interventions Continues: A Dearth of Effective Strategies for African Americans with Asthma. J Allergy Clin Immunol Pract. 2019 Apr;7(4):1194-1196. PubMed PMID: 30961840
Tyler A, Cotter JM, Moss A, Topoz I, Dempsey A, Reese J, Szefler S, Hoch H. Outcomes for Pediatric Asthmatic Inpatients After Implementation of an Emergency Department Dexamethasone Treatment Protocol. Hosp Pediatr. 2019 Feb;9(2):92-99. PubMed PMID: 30670462
Hoch H, Kempe A, Brinton J, Szefler S. Feasibility of medication monitoring sensors in high risk asthmatic children. J Asthma. 2019 Mar;56(3):270-272. PubMed PMID: 29641374
Hoch H, Kempe A, Brinton J, Szefler S. Feasibility of medication monitoring sensors in high risk asthmatic children. J Asthma. 2018 Apr 11;:1-3. [Epub ahead of print] PubMed PMID: 29641374
Hoch H, Sontag MK, Scarbro S, Juarez-Colunga E, McLean C, Kempe A, Sagel SD. Clinical outcomes in U.S. infants with cystic fibrosis from 2001 to 2012. Pediatr Pulmonol. 2018 Sep 26. [Epub ahead of print] PubMed PMID: 30259702
Szefler SJ, Hoch H, Tuffli M, Gondalia R, Barrett MA, Van Sickle D, Stempel DA. Quantifying beta agonist utilization: occasions or puffs?. J Allergy Clin Immunol Pract. 2018 Sep 12. [Epub ahead of print] PubMed PMID: 30218718
Hoch H, Mallory GB Jr, Taussig L. Retrospectoscope: Are the peripheral airways in infants and young children disproportionately small, putting them at risk for severe respiratory illnesses?. Pediatr Pulmonol. 2017 Nov;52(11):1405-1407. PubMed PMID: 28869363
Hoch HE, Collaco JM. Recurrent Wheezing in Childhood and Palivizumab. Am J Respir Crit Care Med. 2017 Jul 1;196(1):1-2. PubMed PMID: 28665205
Hoch HE, Collaco JM. Recurrent Wheezing in Childhood and Palivizumab. Am J Respir Crit Care Med. 2017 Jul 1;196(1):1-2. PubMed PMID: 28665205
Hoch HE, Calatroni A, West JB, Liu AH, Gergen PJ, Gruchalla RS, Khurana Hershey GK, Kercsmar CM, Kim H, Lamm CI, Makhija MM, Mitchell HE, Teach SJ, Wildfire JJ, Busse WW, Szefler SJ. Can we predict fall asthma exacerbations? Validation of the seasonal asthma exacerbation index. J Allergy Clin Immunol. 2017 Oct;140(4):1130-1137.e5. PubMed PMID: 28238748
Hoch H, Mallory GB Jr, Taussig L. Retrospectoscope: Are the peripheral airways in infants and young children disproportionately small, putting them at risk for severe respiratory illnesses?. Pediatr Pulmonol. 2017 Nov;52(11):1405-1407. PubMed PMID: 28869363
Szefler S et al. Personalizing Asthma Management for the Clinician: 1st Edition. 2017
Hoch HE, Szefler SJ. Intermittent steroid inhalation for the treatment of childhood asthma. Expert Rev Clin Immunol. 2016;12(2):183-94. PubMed PMID: 26561351
Federico MJ, Hoch HE, Anderson WC 3rd, Spahn JD, Szefler SJ. Asthma Management for Children: Risk Identification and Prevention. Adv Pediatr. 2016 Aug;63(1):103-26. PubMed PMID: 27426897
Hoch HE, Szefler SJ. Intermittent steroid inhalation for the treatment of childhood asthma. Expert Rev Clin Immunol. 2016;12(2):183-94. PubMed PMID: 26561351

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Professional Memberships

American Academy of Pediatrics, Fellow
American Thoracic Society, Fellow
American College of Chest Physicians, Fellow

Practice Locations

Children's Hospital Colorado Anschutz Medical Campus
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Children's Hospital Colorado South Campus - Highlands Ranch
1811 Plaza Drive
Highlands Ranch, CO 80129
720-478-1234

Hospital Affiliation

Children's Hospital Colorado

Specialty Information

Specialties

Pediatric Pulmonology, Board Certification (2016)
Pediatrics, Board Certification (2010)

Conditions & Treatments

Lungs and Breathing
Lungs and Breathing - Asthma

Clinical Interests
My primary clinical interest is in the area of asthma, including severe asthma, difficult to treat asthma, and early asthma. Additionally, I study health behavior change and medication adherence in children and adolescents. My goal is to not only provide children and families with the most up to date and evidence-based therapies to treat their disease, but to also provide them with the tools that they need to implement these therapies in their daily lives. Medicines only work if we can find a way to help you to take them!

Care Philosophy
I work to provide the best possible care for my patients. I believe strongly that parents are the best advocates for their children, and I strive to actively listen to concerns and develop care plans in conjunction with families to meet their needs. I believe that the best outcomes for children happen when everyone works together, including providers and families! I am especially interested in the care of children with asthma, but I see children with many different lung diseases!

Associate Professor, Pediatrics-Pulmonary Medicine