David Thomas, PhD

Professional Titles

• Associate Professor

Research Interests

My research interests lie at the interface of Engineering and Life Sciences and the implementation of signal processing, statistics, mathematics and physics, to provide the next generation of diagnostic and novel therapeutic techniques. We are interested in the use of optical, acoustic and X-Ray technologies to illuminate a broad spectrum of mechanisms, which span from molecular imaging of the cell to quantitative anatomical imaging and in-vivo dosimetry

Publications

• Thomas DH, Ruan D, Williams P, Lamb J, White BM, Dou T, O'Connell D, Lee P, Low DA. Is there an ideal set of prospective scan acquisition phases for fast-helical based 4D-CT?. Phys Med Biol. 2016 Dec 7;61(23):N632-N641. PubMed PMID: 27811397
• Chow PE, Thomas DH, Agazaryan N, Cao M, Low DA, Yang Y, Steinberg ML, Lee P, Lamb JM. Technical Note: Dosimetric effects of couch position variability on treatment plan quality with an MRI-guided Co-60 radiation therapy machine. Med Phys. 2016 Aug;43(8):4514. PubMed PMID: 27487868
• Shaverdian N, Yang Y, Hu P, Hart S, Sheng K, Lamb J, Cao M, Agazaryan N, Thomas D, Steinberg M, Low DA, Lee P. Feasibility evaluation of diffusion-weighted imaging using an integrated MRI-radiotherapy system for response assessment to neoadjuvant therapy in rectal cancer. Br J Radiol. 2017 Jan 12;:20160739. [Epub ahead of print] PubMed PMID: 28079398
• Low, D.A., Lisa Yang, L., Chen, J., O’Connell, D., Lewis, J, Thomas, D.H., Lee, P., Technical Note: Analysis of Motion Blurring Artifact in Fast Helical Free Breathing Thoracic CT Scans, In: Medical Physics (in-press)
• Thomas DH, Tan J, Neylon J, Dou T, O'Connell D, McNitt-Gray M, Lee P, Lamb J, Low DA. Investigating the minimum scan parameters required to generate free-breathing motion artefact-free fast-helical CT. Br J Radiol. 2018 Feb;91(1082):20170597. PubMed PMID: 29099616
• Thomas DH, Santhanam A, Kishan AU, Cao M, Lamb J, Min Y, O'Connell D, Yang Y, Agazaryan N, Lee P, Low D. Initial clinical observations of intra- and interfractional motion variation in MR-guided lung SBRT. Br J Radiol. 2018 Feb;91(1083):20170522. PubMed PMID: 29166129
• Thomas DH, Tan J, Neylon J, Dou T, O'Connell D, McNitt-Gray M, Lee P, Lamb J, Low DA. Investigating the minimum scan parameters required to generate free-breathing motion artefact-free fast-helical CT. Br J Radiol. 2018 Feb;91(1082):20170597. PubMed PMID: 29099616
• Thomas DH, Santhanam A, Kishan AU, Cao M, Lamb J, Min Y, O'Connell D, Yang Y, Agazaryan N, Lee P, Low D. Initial clinical observations of intra- and interfractional motion variation in MR-guided lung SBRT. Br J Radiol. 2018 Jan 22;:20170522. [Epub ahead of print] PubMed PMID: 29166129
• O'Connell D, Ruan D, Thomas DH, Dou TH, Lewis JH, Santhanam A, Lee P, Low DA. A prospective gating method to acquire a diverse set of free-breathing CT images for model-based 4DCT. Phys Med Biol. 2018 Feb 15;63(4):04NT03. PubMed PMID: 29350191
• O'Connell D, Thomas DH, Lamb JM, Lewis JH, Dou T, Sieren JP, Saylor M, Hofmann C, Hoffman EA, Lee PP, Low DA. Dependence of subject-specific parameters for a fast helical CT respiratory motion model on breathing rate: an animal study. Phys Med Biol. 2018 Feb 20;63(4):04NT04. PubMed PMID: 29360098
• Lamb JM, Ginn JS, O'Connell DP, Agazaryan N, Cao M, Thomas DH, Yang Y, Lazea M, Lee P, Low DA. Dosimetric validation of a magnetic resonance image gated radiotherapy system using a motion phantom and radiochromic film. J Appl Clin Med Phys. 2017 May;18(3):163-169. PubMed PMID: 28436094
• Low DA, Yang L, Chen J, O'Connel D, Lewis JH, Thomas DH, Lee P. Technical Note: Analysis of motion blurring artifact in fast helical free-breathing thoracic CT scans. Med Phys. 2017 Apr;44(4):1456-1461. PubMed PMID: 28185281
• O'Connell D, Thomas DH, Lamb JM, Lewis JH, Dou TH, Sieren JP, Saylor M, Hofmann C, Hoffman EA, Lee PP, Low DA. Dependence of subject-specific parameters for a fast helical CT respiratory motion model on breathing rate: an animal study. Phys Med Biol. 2018 Jan 23. [Epub ahead of print] PubMed PMID: 29360098
• O'Connell D, Ruan D, Thomas DH, Dou TH, Lewis JH, Santhanam AP, Lee PP, Low DA. A prospective gating method to acquire a diverse set of free-breathing CT images for model-based 4DCT. Phys Med Biol. 2018 Jan 19. [Epub ahead of print] PubMed PMID: 29350191
• O'Connell D, Ruan D, Thomas DH, Dou TH, Lewis JH, Santhanam AP, Lee PP, Low DA. A prospective gating method to acquire a diverse set of free-breathing CT images for model-based 4DCT. Phys Med Biol. 2018 Jan 19. [Epub ahead of print] PubMed PMID: 29350191
• O'Connell D, Shaverdian N, Kishan AU, Thomas DH, Dou TH, Lewis JH, Lamb JM, Cao M, Tenn S, Percy LP, Low DA. Comparison of lung tumor motion measured using a model-based 4DCT technique and a commercial protocol. Pract Radiat Oncol. 2017 Nov 11. [Epub ahead of print] PubMed PMID: 29429921
• O'Connell D, Shaverdian N, Kishan AU, Thomas DH, Dou TH, Lewis JH, Lamb JM, Cao M, Tenn S, Percy LP, Low DA. Comparison of lung tumor motion measured using a model-based 4DCT technique and a commercial protocol. Pract Radiat Oncol. 2018 May - Jun;8(3):e175-e183. PubMed PMID: 29429921
• Ginn JS, O'Connell D, Thomas DH, Low DA, Lamb JM. Model-Interpolated Gating for Magnetic Resonance Image-Guided Radiation Therapy. Int J Radiat Oncol Biol Phys. 2018 Nov 15;102(4):885-894. PubMed PMID: 29970314
• O'Connell D, Thomas DH, Lewis JH, Hasse K, Santhanam A, Lamb JM, Cao M, Tenn S, Agazaryan N, Lee PP, Low DA. Safety-oriented design of in-house software for new techniques: a case study using a model-based 4DCT protocol. Med Phys. 2019 Jan 17. [Epub ahead of print] PubMed PMID: 30656699
• Lamb J, Cao M, Kishan A, Agazaryan N, Thomas DH, Shaverdian N, Yang Y, Ray S, Low DA, Raldow A, Steinberg ML, Lee P. Online Adaptive Radiation Therapy: Implementation of a New Process of Care. Cureus. 2017 Aug 27;9(8):e1618. PubMed PMID: 29104835
• O'Connell D, Thomas DH, Lewis JH, Hasse K, Santhanam A, Lamb JM, Cao M, Tenn S, Agazaryan N, Lee PP, Low DA. Safety-oriented design of in-house software for new techniques: A case study using a model-based 4DCT protocol. Med Phys. 2019 Apr;46(4):1523-1532. PubMed PMID: 30656699
• Schubert LK, Hendrickson K, Miften M, McNulty M, Vinogradskiy YY, Thomas DH, Westerly D, Stuhr K, Corral J, Royer D. The Current State of Physics Plan Review Training in Medical Physics Residency Programs in North America. Pract Radiat Oncol. 2019 Sep 14. [Epub ahead of print] PubMed PMID: 31526898
• Forghani F, Mahl A, Patton TJ, Jones BL, Borden MA, Westerly DC, Altunbas C, Miften M, Thomas DH. Simulation of X-ray induced acoustic imaging for absolute dosimetry: accuracy of image reconstruction methods. Med Phys. 2019 Dec 11. [Epub ahead of print] PubMed PMID: 31828781
• Thomas DH, Schubert LK, Vinogradskiy Y, Nath S, Kavanagh B, Miften M, Jones B. Technical Note: Deep Learning approach for automatic detection and identification of patient positioning devices for radiation therapy. Med Phys. 2020 Jun 20. [Epub ahead of print] PubMed PMID: 32562501
• Thomas DH, Miller B, Rabinovitch R, Milgrom S, Kavanagh B, Diot Q, Miften M, Schubert LK. Integration of automation into an existing clinical workflow to improve efficiency and reduce errors in the manual treatment planning process for total body irradiation (TBI). J Appl Clin Med Phys. 2020 Jul;21(7):100-106. PubMed PMID: 32426947
• Thomas DH, Schubert LK, Vinogradskiy Y, Nath S, Kavanagh B, Miften M, Jones B. Technical Note: Deep Learning approach for automatic detection and identification of patient positioning devices for radiation therapy. Med Phys. 2020 Oct;47(10):5061-5069. PubMed PMID: 32562501
• Thomas DH, Miller B, Rabinovitch R, Milgrom S, Kavanagh B, Diot Q, Miften M, Schubert LK. Integration of automation into an existing clinical workflow to improve efficiency and reduce errors in the manual treatment planning process for total body irradiation (TBI). J Appl Clin Med Phys. 2020 Jul;21(7):100-106. PubMed PMID: 32426947
• Forghani F, Mahl A, Patton TJ, Jones BL, Borden MA, Westerly DC, Altunbas C, Miften M, Thomas DH. Simulation of x-ray-induced acoustic imaging for absolute dosimetry: Accuracy of image reconstruction methods. Med Phys. 2020 Mar;47(3):1280-1290. PubMed PMID: 31828781
• Schubert LK, Hendrickson K, Miften M, McNulty M, Vinogradskiy YY, Thomas DH, Westerly D, Stuhr K, Corral J, Royer D. The Current State of Physics Plan Review Training in Medical Physics Residency Programs in North America. Pract Radiat Oncol. 2020 May - Jun;10(3):e166-e172. PubMed PMID: 31526898
• Forghani F, Patton T, Kwak J, Thomas D, Diot Q, Rusthoven C, Castillo R, Castillo E, Grills I, Guerrero T, Miften M, Vinogradskiy Y. Characterizing spatial differences between SPECT-ventilation and SPECT-perfusion in patients with lung cancer undergoing radiotherapy. Radiother Oncol. 2021 Jul;160:120-124. PubMed PMID: 33964328
• 65th American Association of Physicists in Medicine (AAPM) Annual Meeting and Exhibition - BEST IN PHYSICS - "Computer Vision Assisted Alignment for SBRT" Atharva Peshkar, D Gurari, DH Thomas., 2023 July.
• American Radium Society, Lahaina, Hi. “Computer Vision assisted Collision Avoidance for Radiation Therapy”, DH Thomas, Moyed Miften, Brian Kavanagh, Bernard Trip Jones, 2023 May
• 65th American Association of Physicists in Medicine (AAPM) Annual Meeting and Exhibition - Will Franz, M Borden, DH Thomas "Vaporizable Endoskeletal Droplets for In Vivo Dosimetry."
• 97th ACS Colloid and Surface Science Symposium - "Vaporizable endoskeletal droplets for contrast enhanced x-ray acoustic imaging." Will Franz, DH Thomas, M Borden
• Summer Biomechanics, Bioengineering, and Biotransport Conference (SB3C) - "Model for heat conduction in vaporizable endoskeletal droplet in response to x-ray photon absorption." Will Franz, DH Thomas, M Borden
• Physics-driven and robust CBCT-based dose calculations during radiation therapy delivery, AAPM, 07/2023
• Bayat F, Miller B, Park Y, Yu Z, Alexeev T, Thomas D, Stuhr K, Kavanagh B, Miften M, Altunbas C. A 2D antiscatter grid and scatter sampling based CBCT method for online dose calculations during CBCT guided radiation therapy of pelvis. ArXiv. 2023 Oct 10. PubMed PMID: 37873015

Practice Locations

University of Colorado Cancer Center - Anschutz Medical Campus
1665 Aurora Ct
Aurora, CO 80045
720-848-0300

Specialty Information

Specialties

• Radiation Oncology