Krista Eschbach, MD

Professional Titles

• Associate Professor
• Pediatric Epilepsy Fellowship Associate Program Director

Recognitions

• Patient Family Experience Top Performer Award, Children's Hospital Colorado (2019)

Research Interests

My research interests are focused on the field of epilepsy and include refractory status epilepticus, neonatal epilepsy, and epilepsy surgery. I am specifically interested in long-term outcomes related to each of these conditions. Currently, my primary research focus is new-onset refractory status epilepticus and febrile infection-related epilepsy syndrome (FIRES). These are rare conditions and I hope that through multi-center collaboration we can improve the recognition, treatment, and outcomes for patients with this type of epilepsy.

Publications

• Ziobro J, Eschbach K, Sullivan JE, Knupp KG. Current Treatment Strategies and Future Treatment Options for Dravet Syndrome. Curr Treat Options Neurol. 2018 Oct 13;20(12):52. PubMed PMID: 30315507
• Benke T, Geiger E, Yu HC, Eschbach K, Mirsky D, Shaikh T, Demarest S. Whole exome sequencing (WES) in 21 patients with infantile spasms. AES annual meeting. December 2018.
• Eschbach K, Moss A, Joshi C, Angione K, Smith G, Dempsey A, Juarez-Colunga E, Demarest ST. Diagnosis switching and outcomes in a cohort of patients with potential epilepsy with myoclonic-atonic seizures. Epilepsy Res. 2018 Nov;147:95-101. PubMed PMID: 30286391
• Eschbach K, Scarbro S, Juarez-Colunga E, Allen V, Hsu S, Knupp K. Growth and endocrine function in children with Dravet syndrome. Seizure. 2017 Nov;52:117-122. PubMed PMID: 29031192
• Eschbach K, Knupp KG. Stiripentol for the treatment of seizures in Dravet syndrome. Expert Rev Clin Pharmacol. 2019 May;12(5):379-388. PubMed PMID: 31017478
• Angione K, Eschbach K, Smith G, Joshi C, Demarest S. Genetic testing in a cohort of patients with potential epilepsy with myoclonic-atonic seizures. Epilepsy Res. 2019 Feb;150:70-77. PubMed PMID: 30660939
• Marks J & Eschbach K. Seizures. In B. Bolick, K. Reuter-Rice, M. Madden, & B. Severin (Eds.), Pediatric acute Care: A guide for Interprofessional practice. St. Louis, Mo: Elsevier
• Olson RJ, Morava E, Baldridge D, Constantino JN, Chandy N, Lim-Melia E, Gibbons M, Eschbach K, Hurst A, Berger S, Iglesias A, Orera M, Fernández-Jaén A, Kozicz T, Klee EW. Genetic Testing Reveals a Novel Association between an X-linked Gene and ASD/ADHD. ACMG Conference March 2020. 
• Kazazian K, Gaspard N, Hirsch L, Kellogg M, Hocker S, Wong N, Nora Wong, Farias-Moeller R, Eschbach K, & Gofton T. New-Onset Refractory Status Epilepticus (NORSE / FIRES) Family Registry. American Epilepsy Society (Abst. 713) 2020.
• Calhoun JD, Gunti J, Angione K, Geiger E, Eschbach K, Smith G, Joshi C, Shaikh T, Demarest S, Carvil G. Not just GLUT1: genome sequencing reveals genetic heterogeneity in Doose syndrome. Journal of Clinical Translational Science. July 2020.
• Talai A, Stence N, Chapman K, O'Neill B, Alexander A, Bird W, Joshi C, Eschbach K. Comparison of subdural grid and stereoelectroencephalography monitoring in pediatric patients. CNS / ICNA 2020. Poster 109.
• Nickels K, Kossoff E, Eschbach K, Joshi C. Epilepsy with Myoclonic Atonic Seizures (Doose Syndrome): A Severe Epileptic Encephalopathy with a Positive Outlook? CNS/ICNA 2020. Platform 17.
• Lai YC, Muscal E, Wells E, Shukla N, Eschbach K, Hyeong Lee K, Kaliakatsos M, Desai N, Wickström R, Viri M, Freri E, Granata T, Nangia S, Dilena R, Brunklaus A, Wainwright MS, Gorman MP, Stredny CM, Asiri A, Hundallah K, Doja A, Payne E, Wirrell E, Koh S, Carpenter JL, Riviello J. Anakinra usage in febrile infection related epilepsy syndrome: an international cohort. Ann Clin Transl Neurol. 2020 Dec;7(12):2467-2474. PubMed PMID: 33506622
• Guglielmi G, Eschbach KL, Alexander AL. Smaller Knife, Fewer Seizures? Recent Advances in Minimally Invasive Techniques in Pediatric Epilepsy Surgery. Semin Pediatr Neurol. 2021 Oct;39:100913. PubMed PMID: 34620456
• Talai A, Eschbach K, Stence NV, Palmer C, Bird W, Alexander A, O'Neill BR, Chapman KE, Joshi C. Comparison of subdural grid and stereoelectroencephalography in a cohort of pediatric patients. Epilepsy Res. 2021 Nov;177:106758. PubMed PMID: 34530304
• Ziobro JM, Eschbach K, Shellhaas RA. Novel Therapeutics for Neonatal Seizures. Neurotherapeutics. 2021 Aug 12. [Epub ahead of print] PubMed PMID: 34386906
• Joshi C, Jacobson M, Silveira L, Shea S, Yang M, Eschbach K. Risk of Admission to the Emergency Room/Inpatient Service After a Neurology Telemedicine Visit During COVID-19 Pandemic. Pediatr Neurol. 2021 Sep;122:15-19. PubMed PMID: 34243046
• Perry MS, Shandley S, Perelman M, Singh RK, Wong-Kisiel L, Sullivan J, Gonzalez-Giraldo E, Romanowski EF, McNamara NA, Marashly A, Ostendorf AP, Alexander A, Eschbach K, Bolton J, Wolf S, McGoldrick P, Depositario-Cabacar DF, Ciliberto MA, Gedela S, Sannagowdara K, Karia S, Shrey DW, Tatachar P, Nangia S, Grinspan Z, Reddy SB, Shital P, Coryell J. Surgical evaluation in children <3 years of age with drug-resistant epilepsy: Patient characteristics, diagnostic utilization, and potential for treatment delays. Epilepsia. 2021 Nov 15. [Epub ahead of print] PubMed PMID: 34778945
• Eschbach K, Karia S, Depositario-Cabacar D, et al. Epilepsy Surgery in Tuberous Sclerosis Complex: Results from the Pediatric Epilepsy Research Consortium Epilepsy Surgery Database. Poster session presented at: American Epilepsy Society Annual Meeting. December 3rd-7th 2021. Chicago IL.
• Perry MS, Arrowood R, Wong-Kisiel L, et al, Racial and Ethnic Disparities in Pediatric Epilepsy Surgery. Poster session presented at: American Epilepsy Society Annual Meeting. December 3rd-7th 2021. Chicago IL
• Singh RK, Alexander A, Eschbach K, et al. Responsive Neurostimulation in Refractory Pediatric Epilepsy: Findings from the PERC (Pediatric Epilepsy Research Consortium) Epilepsy Surgery Subgroup. Poster session presented at: American Epilepsy Society Annual Meeting. December 3rd-7th 2021. Chicago IL
• Jeno M, Sachinkumar S, Arrowood R, et al. Comparing characteristics and outcome of palliative and definitive pediatric epilepsy surgery patients using the Pediatric Epilepsy Research Consortium (PERC) Surgery Database. Poster session presented at: American Epilepsy Society Annual Meeting. December 3rd-7th 2021. Chicago IL.
• Kazazian K, Gaspard N, Hirsch L, et al, Communication and prognostic discussion in NORSE/FIRES: Insights from the NORSE/FIRES Family Registry. Poster session presented at: American Epilepsy Society Annual Meeting. December 3rd-7th 2021. Chicago IL
• Joshi CN, Yang ML, Eschbach K, Tong S, Jacobson MP, Stillman C, Kropp AE, Shea SA, Frunzi GM, Thomas JF, Olson CA. Quality and Safety Analysis of 2,999 Telemedicine Encounters During the COVID-19 Pandemic. Neurol Clin Pract. 2021 Apr;11(2):e73-e82. PubMed PMID: 33842074
• Kazazian K, Kellogg M, Wong N, Eschbach K, Moeller RF, Gaspard N, Hirsch LJ, Hocker S, Gofton T. How to Help Your Patients Enroll in the New-Onset Refractory Status Epilepticus (NORSE) and Febrile Infection-Related Epilepsy Syndrome (FIRES) Family Registry, and Other Rare Epilepsy Registries. Epilepsy Curr. 2021 Mar 26;:15357597211002869. [Epub ahead of print] PubMed PMID: 33769129
• Koh S, Wirrell E, Vezzani A, Nabbout R, Muscal E, Kaliakatsos M, Wickström R, Riviello JJ, Brunklaus A, Payne E, Valentin A, Wells E, Carpenter JL, Lee K, Lai YC, Eschbach K, Press CA, Gorman M, Stredny CM, Roche W, Mangum T. Proposal to optimize evaluation and treatment of Febrile infection-related epilepsy syndrome (FIRES): A Report from FIRES workshop. Epilepsia Open. 2021 Mar;6(1):62-72. PubMed PMID: 33681649
• Demarest S, Calhoun J, Eschbach K, Yu HC, Mirsky D, Angione K, Shaikh TH, Carvill GL, Benke TA. Whole-exome sequencing and adrenocorticotropic hormone therapy in individuals with infantile spasms. Dev Med Child Neurol. 2022 May;64(5):633-640. PubMed PMID: 35830182
• Nickels K, Kossoff EH, Eschbach K, Joshi C. Epilepsy with myoclonic-atonic seizures (Doose syndrome): Clarification of diagnosis and treatment options through a large retrospective multicenter cohort. Epilepsia. 2021 Jan;62(1):120-127. PubMed PMID: 33190223
• Perry MS, Shandley S, Perelman M, Singh RK, Wong-Kisiel L, Sullivan J, Gonzalez-Giraldo E, Romanowski EF, McNamara NA, Marashly A, Ostendorf AP, Alexander A, Eschbach K, Bolton J, Wolf S, McGoldrick P, Depositario-Cabacar DF, Ciliberto MA, Gedela S, Sannagowdara K, Karia S, Shrey DW, Tatachar P, Nangia S, Grinspan Z, Reddy SB, Shital P, Coryell J. Surgical evaluation in children <3 years of age with drug-resistant epilepsy: Patient characteristics, diagnostic utilization, and potential for treatment delays. Epilepsia. 2022 Jan;63(1):96-107. PubMed PMID: 34778945
• Dubow E & Eschbach K. (2022). Developmental-Behavioral Pediatrics E-Book - Google Books. In H. M. Feldman, N. J. Blum, E. R. Elias, M. Jimenez, & T. Stancin (Eds.) Developmental-Behavioral Pediatrics E-book (pp. 304–314). Elsevier Health Sciences.
• Nelson J, Reed L, Silviera L, Eschbach K. Neonatal seizures: implementation of an EEG grading scale and its correlation with seizures in neonatal with and without HIE. Pediatric Academic Society Annual Conference, April 2022, Denver CO.
• Coryell J, Alexander A, Armstrong D, Bolton J, Ciliberto M, Eschbach K, et al. Epilepsy surgery amongst pediatric patients with genetic etiology. American Epilepsy Society Annual Meeting, December 5th 2022, Nashville TN.
• Gofton T, Kazazian K, Gaspard N, Hirsch L, Kellogg M, Hocker S, Wong N, Farias-Moeller R, Eschbach K. The NORSE / FIRES Family Registry: A comparison of pediatric and adult presentations and outcomes. American Epilepsy Society Annual Meeting, December 4th 2022, Nashville TN.
• Esteban D, Shandley S, Brock E, Conrad S, Alexander A, Eschbach K, et al. The impact of presurgical diagnostic testing on surgical decision making in pediatric MRI-negative drug-resistant epilepsy. American Epilepsy Society Annual Meeting, December 3rd 2022, Nashville TN.
• Hansen D, Shandley S, Keator C, Perry S, Alexander A, Eschbach K, et al. A multi-institutional comparison of contemporary surgical approaches and outcomes of corpus callosotomy, American Epilepsy Society Annual Meeting, December 4th 2022, Nashville TN.
• Marashly A, Elizebath R, Lew S, Alexander A, Armstrong D, Bolton J, Brock E, Ciliberto M, Coryell J, Depositario-Cabacar D, Eschbach K, et al, Outcomes and prognostic factors of pediatric frontal lobe epilepsy surgery: A multi-center study, American Epilepsy Society Annual Meeting, December 3rd 2022, Nashville TN.
• McNamara N, Alexander A, Ciliberto M, Eschbach K, et al, Stereoencephalography planning for phase 2 monitoring and risk for hemorrhage, American Epilepsy Society Annual Meeting, December 5th 2022, Nashville TN.
• Nelson J, Reed L, Silviera L, Eschbach K, Neonatal seizures: Implementation of an EEG background grading scale and correlation with seizures in neonates with and without HIE, American Epilepsy Society Annual Meeting, December 5th 2022, Nashville TN.
• Kazazian K, Gaspard N, Hirsch L, Kellogg M, Hocker S, Wong N, Farias-Moeller R, Eschbach K, Gofton T. The new-onset refractory status epilepticus (NORSE / FIRES) Family Registry, American Academy of Neurology Annual Meeting. April 5th 2022.
• Singh RK, Eschbach K, Samanta D, Perry MS, Liu G, Alexander AL, Wong-Kisiel L, Ostendorf A, Tatachar P, Reddy SB, McCormack MJ, Manuel CM, Gonzalez-Giraldo E, Numis AL, Wolf S, Karia S, Karakas C, Olaya J, Shrey D, Auguste KI, Depositario-Cabacar D. Responsive Neurostimulation in Drug-Resistant Pediatric Epilepsy: Findings From the Epilepsy Surgery Subgroup of the Pediatric Epilepsy Research Consortium. Pediatr Neurol. 2023 Jun;143:106-112. PubMed PMID: 37084698
• Shrestha A, Wood EL, Berrios-Siervo G, Stredny CM, Boyer K, Vega C, Nangia S, Muscal E, Eschbach K. Long-term neuropsychological outcomes in children with febrile infection-related epilepsy syndrome (FIRES) treated with anakinra. Front Neurol. 2023;14:1100551. PubMed PMID: 36970506
• McKnight D, Morales A, Hatchell KE, Bristow SL, Bonkowsky JL, Perry MS, Berg AT, Borlot F, Esplin ED, Moretz C, Angione K, Ríos-Pohl L, Nussbaum RL, Aradhya S, Haldeman-Englert CR, Levy RJ, Parachuri VG, Lay-Son G, de Montellano DJD, Ramirez-Garcia MA, Benítez Alonso EO, Ziobro J, Chirita-Emandi A, Felix TM, Kulasa-Luke D, Megarbane A, Karkare S, Chagnon SL, Humberson JB, Assaf MJ, Silva S, Zarroli K, Boyarchuk O, Nelson GR, Palmquist R, Hammond KC, Hwang ST, Boutlier SB, Nolan M, Batley KY, Chavda D, Reyes-Silva CA, Miroshnikov O, Zuccarelli B, Amlie-Wolf L, Wheless JW, Seinfeld S, Kanhangad M, Freeman JL, Monroy-Santoyo S, Rodriguez-Vazquez N, Ryan MM, Machie M, Guerra P, Hassan MJ, Candee MS, Bupp CP, Park KL, Muller E 2nd, Lupo P, Pedersen RC, Arain AM, Murphy A, Schatz K, Mu W, Kalika PM, Plaza L, Kellogg MA, Lora EG, Carson RP, Svystilnyk V, Venegas V, Luke RR, Jiang H, Stetsenko T, Dueñas-Roque MM, Trasmonte J, Burke RJ, Hurst ACE, Smith DM, Massingham LJ, Pisani L, Costin CE, Ostrander B, Filloux FM, Ananth AL, Mohamed IS, Nechai A, Dao JM, Fahey MC, Aliu E, Falchek S, Press CA, Treat L, Eschbach K, Starks A, Kammeyer R, Bear JJ, Jacobson M, Chernuha V, Meibos B, Wong K, Sweney MT, Espinoza AC, Van Orman CB, Weinstock A, Kumar A, Soler-Alfonso C, Nolan DA, Raza M, Rojas Carrion MD, Chari G, Marsh ED, Shiloh-Malawsky Y, Parikh S, Gonzalez-Giraldo E, Fulton S, Sogawa Y, Burns K, Malets M, Montiel Blanco JD, Habela CW, Wilson CA, Guzmán GG, Pavliuk M. Genetic Testing to Inform Epilepsy Treatment Management From an International Study of Clinical Practice. JAMA Neurol. 2022 Dec 1;79(12):1267-1276. PubMed PMID: 36315135
• Ostendorf AP, Axeen ET, Eschbach K, Fedak Romanowski E, Morgan LA, Gross P, Narayanan UG, Glader L, Noritz G. Epilepsy and proxy-reported health-related quality of life in children and young people with non-ambulatory cerebral palsy. Dev Med Child Neurol. 2023 Feb;65(2):200-206. PubMed PMID: 35820144
• Berl MM, Koop JI, Ailion A, Bearden DJ, Boyer K, Cooper CM, Decrow AM, Duong PH, Espe-Pfeifer P, Gabriel M, Hodges E, Marshall DF, McNally KA, Molnar AE, Olsen EK, Ono KE, Patrick KE, Paul BM, Romain J, Sepeta LN, Stilp RLH, Wilkening GN, Zaccariello M, Zelko F, Perry MS. Leveraging expertise and optimizing clinical research: Initial success of a pediatric epilepsy surgery collaborative. Epilepsia. 2023 Jun;64(6):1554-1567. PubMed PMID: 36897767
• Hansen D, Shandley S, Olaya J, Hauptman J, Auguste K, Ostendorf AP, Depositario-Cabacar DF, Wong-Kisiel LC, Reddy SB, McCormack MJ, Gonzalez-Giraldo E, Sullivan J, Pradeep J, Singh RK, Romanowski EF, McNamara NA, Ciliberto MA, Tatachar P, Shrey DW, Karakas C, Karia S, Kheder A, Gedela S, Alexander A, Eschbach K, Bolton J, Marashly A, Wolf S, McGoldrick P, Nangia S, Grinspan Z, Coryell J, Samanta D, Armstrong D, Perry MS. A multi-center comparison of surgical techniques for corpus Callosotomy in pediatric drug-resistant epilepsy. Epilepsia. 2023 Dec 7. [Epub ahead of print] PubMed PMID: 38062633
• Jimenez AD, Gopaul M, Asbell H, Aydemir S, Basha MM, Batra A, Damien C, Day GS, Eka O, Eschbach K, Fatima S, Fields MC, Foreman B, Gerard EE, Gofton TE, Haider HA, Hantus ST, Hocker S, Jongeling A, Kalkach Aparicio M, Kandula P, Kang P, Kazazian K, Kellogg MA, Kim M, Lee JW, Marcuse LV, McGraw CM, Mohamed W, Orozco J, Pimentel C, Punia V, Ramirez AM, Steriade C, Struck AF, Taraschenko O, Treister AK, Yoo JY, Zafar S, Zhou DJ, Zutshi D, Gaspard N, Hirsch LJ, Hanin A. Comparative analysis of patients with new onset refractory status epilepticus preceded by fever (febrile infection-related epilepsy syndrome) versus without prior fever: An interim analysis. Epilepsia. 2024 Jun;65(6):e87-e96. PubMed PMID: 38625055
• Jeno M, Zimmerman MB, Shandley S, Wong-Kisiel L, Singh RK, McNamara N, Fedak Romanowski E, Grinspan ZM, Eschbach K, Alexander A, McGoldrick P, Wolf S, Nangia S, Bolton J, Olaya J, Shrey DW, Karia S, Karakas C, Tatachar P, Ostendorf AP, Gedela S, Javarayee P, Reddy S, Manuel CM, Gonzalez-Giraldo E, Sullivan J, Coryell J, Depositario-Cabacar DFT, Hauptman JS, Samanta D, Armstrong D, Perry MS, Marashly A, Ciliberto M. Pediatric Palliative Epilepsy Surgery: A Report From the Pediatric Epilepsy Research Consortium (PERC) Surgery Database. Pediatr Neurol. 2024 Aug;157:70-78. PubMed PMID: 38897096
• Joshi CN, Karakas C, Eschbach K, Samanta D, Auguste K, Desai V, Singh R, McGoldrick P, Wolf S, Abel TJ, Novotny E, Oluigbo C, Reddy SB, Alexander A, Price A, Reeders P, Mcnamara N, Romanowski EF, Mutchnick I, Ostendorf AP, Shaikhouni A, Knox A, Aungaroon G, Olaya J, Muh CR. Pediatric neuromodulation for drug-resistant epilepsy: Survey of current practices, techniques, and outcomes across US epilepsy centers. Epilepsia Open. 2024 Apr;9(2):785-792. PubMed PMID: 38421143
• Hanin A, Eschbach K, Gofton TE, Gopaul M, Howe CL, Lai YC, Koh S, Shen H, Hirsch LJ. New onset refractory status epilepticus: Summary of the NORSE Institute roundtable during the 2023 American Epilepsy Society meeting, Orlando, Florida. Epilepsia. 2024 Apr;65(4):1145-1146. PubMed PMID: 38421053
• Coryell J, Singh R, Ostendorf AP, Eisner M, Alexander A, Eschbach K, Shrey DW, Olaya J, Ciliberto MA, Karakas C, Karia S, McNamara N, Romanowski EF, Kheder A, Pradeep J, Reddy SB, McCormack MJ, Bolton J, Wolf S, McGoldrick P, Hauptman JS, Samanta D, Tatachar P, Sullivan J, Auguste K, Gonzalez-Giraldo E, Marashly A, Depositario-Cabacar DF, Wong-Kisiel LC, Perry S. Epilepsy surgery in children with genetic etiologies: A prospective evaluation of current practices and outcomes. Seizure. 2023 Dec;113:6-12. PubMed PMID: 38189708

Professional Memberships

• American Epilepsy Society, Active Member
• American Academy of Neurology, Active Member
• American Clinical Neurophysiology Society, Active Member
• Child Neurology Society, Active Member

Practice Locations

Children's Hospital Colorado Anschutz Medical Campus
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hospital Affiliation

• Children's Hospital Colorado

Center Affiliations

• Center for Neuroscience

Specialty Information

Specialties

• Child Neurology, Board Certification (2016)
• Epilepsy, Board Certification (2018)

Conditions & Treatments

• Brain and Nervous System
• Brain and Nervous System - Epilepsy