Andrii Rozhok, PhD

Publications

• Zhang G, Scarborough H, Kim J, Rozhok AI, Chen YA, Zhang X, Song L, Bai Y, Fang B, Liu RZ, Koomen J, Tan AC, Degregori J, Haura EB. Coupling an EML4-ALK-centric interactome with RNA interference identifies sensitizers to ALK inhibitors. Sci Signal. 2016 Oct 18;9(450):rs12. PubMed PMID: 27811184
• Marusyk A, Tabassum DP, Janiszewska M, Place AE, Trinh A, Rozhok AI, Pyne S, Guerriero JL, Shu S, Ekram M, Ishkin A, Cahill DP, Nikolsky Y, Chan TA, Rimawi MF, Hilsenbeck S, Schiff R, Osborne KC, Letai A, Polyak K. Spatial Proximity to Fibroblasts Impacts Molecular Features and Therapeutic Sensitivity of Breast Cancer Cells Influencing Clinical Outcomes. Cancer Res. 2016 Nov 15;76(22):6495-6506. PubMed PMID: 27671678
• Gregory MA, D'Alessandro A, Alvarez-Calderon F, Kim J, Nemkov T, Adane B, Rozhok AI, Kumar A, Kumar V, Pollyea DA, Wempe MF, Jordan CT, Serkova NJ, Tan AC, Hansen KC, DeGregori J. ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia. Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):E6669-E6678. PubMed PMID: 27791036
• Rozhok AI, Salstrom JL, DeGregori J. Stochastic modeling reveals an evolutionary mechanism underlying elevated rates of childhood leukemia. Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):1050-5. PubMed PMID: 26755588
• Rozhok AI, DeGregori J (2016) The evolution of lifespan and age-dependent cancer risk. Trends in Cancer 2(10):552-560
• Rozhok AI, DeGregori J (2016) Aging, somatic evolution and cancer. In: On human nature: evolution, diversity, psychology, ethics, politics and religion (eds Tibayrenc M, Ayala FJ). Elsevier: Academic Press
• Rozhok AI, Degregori J. Somatic maintenance impacts the evolution of mutation rate. doi: https://doi.org/10.1101/181065 (in publishing process)
• Rozhok AI, DeGregori J. A generalized theory of somatic evolution. doi: https://doi.org/10.1101/298422 (in publication process)
• Rozhok A, Silberman RE, Amon A, DeGregori J. A somatic evolutionary model of the dynamics of aneuploid cells during hematopoietic reconstitution. doi: https://doi.org/10.1101/355826 (in publication process)
• Rozhok A, DeGregori J. Somatic maintenance impacts the evolution of mutation rate. BMC Evol Biol. 2019 Aug 23;19(1):172. PubMed PMID: 31443631
• Rozhok A, DeGregori J. A generalized theory of age-dependent carcinogenesis. Elife. 2019 Apr 29;8. PubMed PMID: 31034356
• Pham-Danis C, Gehrke S, Danis E, Rozhok AI, Daniels MW, Gao D, Collins C, Paola JTD, D'Alessandro A, DeGregori J. Urea Cycle Sustains Cellular Energetics upon EGFR Inhibition in EGFR-Mutant NSCLC. Mol Cancer Res. 2019 Jun;17(6):1351-1364. PubMed PMID: 30808730
• Tu MM, Lee FYF, Jones RT, Kimball AK, Saravia E, Graziano RF, Coleman B, Menard K, Yan J, Michaud E, Chang H, Abdel-Hafiz HA, Rozhok AI, Duex JE, Agarwal N, Chauca-Diaz A, Johnson LK, Ng TL, Cambier JC, Clambey ET, Costello JC, Korman AJ, Theodorescu D. Targeting DDR2 enhances tumor response to anti-PD-1 immunotherapy. Sci Adv. 2019 Feb;5(2):eaav2437. PubMed PMID: 30801016
• Rozhok AI, Silberman RE, Higa KC, Liggett LA, Amon A, DeGregori J. A somatic evolutionary model of the dynamics of aneuploid cells during hematopoietic reconstitution. Sci Rep. 2020 Jul 22;10(1):12198. PubMed PMID: 32699207
• Rozhok A, Chann H, Jesberg P, Kogut I, Bilousova G. Paralogs and genes with repetitive and re-used exonic structure impose significant limitations on the applicability of short-read next-generation sequencing in genetic disease research: a Tenascin XB case study and implications. (in preparation)
• Rozhok AI, DeGregori J. The three dimensions of somatic evolution: Integrating the role of genetic damage, life-history traits, and aging in carcinogenesis. Evol Appl. 2020 Aug;13(7):1569-1580. PubMed PMID: 32821273
• Kizub I, Rozhok A, Bilousova G. Induced Pluripotent Stem Cells: Advances and Applications in Regenerative Medicine. In: Kitala D, Blumenberg M, editors. Possibilities and Limitations in Current Translational Stem Cell Research [Internet] London, United Kingdom: IntechOpen; 2023. Chapter 13; p.295-320