Katharine Smith, PhD

Publications

• Welle TM, Smith KR. Release your inhibitions: The cell biology of GABAergic postsynaptic plasticity. Curr Opin Neurobiol. 2024 Dec 24;90:102952. [Epub ahead of print] PubMed PMID: 39721557
• Welle TM, Rajgor D, Kareemo DJ, Garcia JD, Zych SM, Wolfe SE, Gookin SE, Martinez TP, Dell'Acqua ML, Ford CP, Kennedy MJ, Smith KR. miRNA-mediated control of gephyrin synthesis drives sustained inhibitory synaptic plasticity. EMBO Rep. 2024 Nov;25(11):5141-5168. PubMed PMID: 39294503
• Burch AM, Garcia JD, O'Leary H, Haas A, Orfila JE, Tiemeier E, Chalmers N, Smith KR, Quillinan N, Herson PS. TRPM2 and CaMKII Signaling Drives Excessive GABAergic Synaptic Inhibition Following Ischemia. J Neurosci. 2024 May 8;44(19). PubMed PMID: 38565288
• Garcia JD, Wolfe SE, Stewart AR, Tiemeier E, Gookin SE, Guerrero MB, Quillinan N, Smith KR. Distinct mechanisms drive sequential internalization and degradation of GABA(A)Rs during global ischemia and reperfusion injury. iScience. 2023 Oct 20;26(10):108061. PubMed PMID: 37860758
• Ramsay HJ, Gookin SE, Ramsey AM, Kareemo DJ, Crosby KC, Stich DG, Olah SS, Actor-Engel HS, Smith KR, Kennedy MJ. AMPA and GABAA receptor nanodomains assemble in the absence of synaptic neurotransmitter release. Front Mol Neurosci. 2023;16:1232795. PubMed PMID: 37602191
• Olah SS, Kareemo DJ, Buchta WC, Sinnen BL, Miller CN, Actor-Engel HS, Gookin SE, Winborn CS, Kleinjan MS, Crosby KC, Aoto J, Smith KR, Kennedy MJ. Acute reorganization of postsynaptic GABA(A) receptors reveals the functional impact of molecular nanoarchitecture at inhibitory synapses. Cell Rep. 2023 Nov 28;42(11):113331. PubMed PMID: 37910506
• Piguel NH, Sanders SS, De Simone FI, Martin-de-Saavedra MD, McCoig E, Dionisio LE, Smith KR, Thomas GM, Penzes P. Palmitoylation controls the stability of 190 kDa ankyrin-G in dendritic spines and is regulated by ZDHHC8 and lithium. Front Mol Neurosci. 2023;16:1144066. PubMed PMID: 36969554
• Gookin SE, Taylor MR, Schwartz SL, Kennedy MJ, Dell'Acqua ML, Crosby KC, Smith KR. Complementary Use of Super-Resolution Imaging Modalities to Study the Nanoscale Architecture of Inhibitory Synapses. Front Synaptic Neurosci. 2022;14:852227. PubMed PMID: 35463850
• Piguel NH, Yoon S, Gao R, Horan KE, Garza JC, Petryshen TL, Smith KR, Penzes P. Lithium rescues dendritic abnormalities in Ank3 deficiency models through the synergic effects of GSK3ß and cyclic AMP signaling pathways. Neuropsychopharmacology. 2022 Nov 14. [Epub ahead of print] PubMed PMID: 36376465
• Rajgor D, Welle TM, Smith KR. The Coordination of Local Translation, Membranous Organelle Trafficking, and Synaptic Plasticity in Neurons. Front Cell Dev Biol. 2021;9:711446. PubMed PMID: 34336865
• Towers CG, Wodetzki DK, Thorburn J, Smith KR, Caino MC, Thorburn A. Mitochondrial-derived vesicles compensate for loss of LC3-mediated mitophagy. Dev Cell. 2021 Jul 26;56(14):2029-2042.e5. PubMed PMID: 34171288
• Actor-Engel HS, Schwartz SL, Crosby KC, Sinnen BL, Prikhodko O, Ramsay HJ, Bourne JN, Winborn CS, Lucas A, Smith KR, Dell'Acqua ML, Kennedy MJ. Precision Mapping of Amyloid-ß Binding Reveals Perisynaptic Localization and Spatially Restricted Plasticity Deficits. eNeuro. 2021 Nov 17. [Epub ahead of print] PubMed PMID: 34789478
• Joshua D. Garcia, Sara E. Gookin, Kevin C. Crosby, Samantha L. Schwartz, Erika Tiemeier, Matthew J. Kennedy, Mark L. Dell’Acqua, Paco S. Herson, Nidia Quillinan and Katharine R. Smith (2021) Step-wise disassembly of GABAergic synapses during pathogenic excitotoxicity, Cell Reports
• Guthman EM, Garcia JD, Ma M, Chu P, Baca SM, Smith KR, Restrepo D, Huntsman MM. Cell-type-specific control of basolateral amygdala neuronal circuits via entorhinal cortex-driven feedforward inhibition. Elife. 2020 Jan 9;9. PubMed PMID: 31916940
• Schürmann B, Bermingham DP, Kopeikina KJ, Myczek K, Yoon S, Horan KE, Kelly CJ, Martin-de-Saavedra MD, Forrest MP, Fawcett-Patel JM, Smith KR, Gao R, Bach A, Burette AC, Rappoport JZ, Weinberg RJ, Martina M, Penzes P. A novel role for the late-onset Alzheimer's disease (LOAD)-associated protein Bin1 in regulating postsynaptic trafficking and glutamatergic signaling. Mol Psychiatry. 2020 Sep;25(9):2000-2016. PubMed PMID: 30967682
• Rajgor D, Purkey AM, Sanderson JL, Welle TM, Garcia JD, Dell'Acqua ML, Smith KR. Local miRNA-Dependent Translational Control of GABA(A)R Synthesis during Inhibitory Long-Term Potentiation. Cell Rep. 2020 Jun 23;31(12):107785. PubMed PMID: 32579917
• Crosby KC, Gookin SE, Garcia JD, Hahm KM, Dell'Acqua ML, Smith KR. Nanoscale Subsynaptic Domains Underlie the Organization of the Inhibitory Synapse. Cell Rep. 2019 Mar 19;26(12):3284-3297.e3. PubMed PMID: 30893601
• Schürmann B, Bermingham DP, Kopeikina KJ, Myczek K, Yoon S, Horan KE, Kelly CJ, Martin-de-Saavedra MD, Forrest MP, Fawcett-Patel JM, Smith KR, Gao R, Bach A, Burette AC, Rappoport JZ, Weinberg RJ, Martina M, Penzes P. A novel role for the late-onset Alzheimer's disease (LOAD)-associated protein Bin1 in regulating postsynaptic trafficking and glutamatergic signaling. Mol Psychiatry. 2019 Apr 9. [Epub ahead of print] PubMed PMID: 30967682
• Oh WC, Smith KR. Activity-dependent development of GABAergic synapses. Brain Res. 2019 Mar 15;1707:18-26. PubMed PMID: 30439352
• Smith KR, Penzes P. Ankyrins: Roles in synaptic biology and pathology. Mol Cell Neurosci. 2018 Sep;91:131-139. PubMed PMID: 29730177
• Oh WC, Smith KR. Activity-dependent development of GABAergic synapses. Brain Res. 2018 Nov 12. [Epub ahead of print] PubMed PMID: 30439352
• Russell TA, Grubisha MJ, Remmers CL, Kang SK, Forrest MP, Smith KR, Kopeikina KJ, Gao R, Sweet RA, Penzes P. A Schizophrenia-Linked KALRN Coding Variant Alters Neuron Morphology, Protein Function, and Transcript Stability. Biol Psychiatry. 2018 Mar 15;83(6):499-508. PubMed PMID: 29241584
• Smith KR, Jones KA, Kopeikina KJ, Burette AC, Copits BA, Yoon S, Forrest MP, Fawcett-Patel JM, Hanley JG, Weinberg RJ, Swanson GT, Penzes P. Cadherin-10 Maintains Excitatory/Inhibitory Ratio through Interactions with Synaptic Proteins. J Neurosci. 2017 Nov 15;37(46):11127-11139. PubMed PMID: 29030434
• Russell TA, Grubisha MJ, Remmers CL, Kang SK, Forrest MP, Smith KR, Kopeikina KJ, Gao R, Sweet RA, Penzes P. A Schizophrenia-Linked KALRN Coding Variant Alters Neuron Morphology, Protein Function, and Transcript Stability. Biol Psychiatry. 2017 Nov 7. [Epub ahead of print] PubMed PMID: 29241584
• Smith KR, Rajgor D, Hanley JG. Differential regulation of the Rac1 GTPase-activating protein (GAP) BCR during oxygen/glucose deprivation in hippocampal and cortical neurons. J Biol Chem. 2017 Dec 8;292(49):20173-20183. PubMed PMID: 29046349
• Hiester BG, Bourke AM, Sinnen BL, Cook SG, Gibson ES, Smith KR, Kennedy MJ. L-Type Voltage-Gated Ca(2 ) Channels Regulate Synaptic-Activity-Triggered Recycling Endosome Fusion in Neuronal Dendrites. Cell Rep. 2017 Nov 21;21(8):2134-2146. PubMed PMID: 29166605