Matthew Leroue, MD

Assistant Professor, Pediatrics-Critical Care Medicine

Provider Credentials
Doctor of Medicine
Faculty Photo

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Medical School
  • MD, University of Colorado Denver School of Medicine (2013)
Undergraduate School
  • BA, University of Colorado - Boulder (CO) (2008)
Internship
  • University of Colorado (Children's Hospital Colorado) Program (2013)
Residency
  • University of Colorado (Children's Hospital Colorado) Program, Pediatrics (2014)
Languages
English, Spanish
Department
Pediatrics-Critical Care Medicine

Professional Titles

  • Assistant Professor

Publications

  • Spyhalsky AM, Welter KJ, DeVine MN, Gordon S, Leroue MK, Loi M. Intermittent Subcutaneous Unfractionated Heparin for Venous Thromboembolism Prophylaxis in Pediatric Intensive Care Unit Patients. Pediatr Blood Cancer. 2026 Sep;73(9):e70524. PubMed PMID: 42489566
  • Nader MA, Leroue MK, Kilgallon KB, Kim JS, Good RJ. Enhancing Pediatric Extracorporeal Membrane Oxygenation Education Through Process-Oriented Guided Inquiry Learning Sessions for Fellows and Advanced Practice Providers. MedEdPORTAL. 2026;22:11600. PubMed PMID: 42130686
  • Lydon EC, Deosthale P, Glascock A, Phan HV, Osborne CM, Leroue MK, Allen J, Mick E, Wagner BD, DeRisi JL, Ambroggio L, Mourani PM, Langelier CR. Host-microbiome archetypes differentiate infection from pathogen carriage in the human lower airway. Nat Commun. 2026 Apr 13;17(1). PubMed PMID: 41974724
  • Chu VT, Spottiswoode N, Ward R, Yokoe DS, Ramirez-Avila L, Phelps MS, Glascock A, Crawford ED, Kamm J, Hao S, Li L, Dynerman D, Waltari E, Nafees S, Kalantar KL, Caldera S, Madera S, Guerrero ES, Ivashin D, Serpa PH, Love C, Mwakibete LL, Doernberg SB, Kistler A, Alvino R, Engel J, Chiu CY, Pak C, Cunningham G, Reyes H, Buie B, Messacar K, Leroue M, Prince BC, Detweiler AM, Stanley K, Caughell C, McNeil N, Neff N, Nichols A, Miller S, DeRisi JL, Tato CM, Langelier CR. Implementation and outcomes of a rapid response genomic hospital epidemiology programme at an academic medical centre over 7 years. Lancet Microbe. 2026 Feb;7(2):101277. PubMed PMID: 41512899
  • Leroue MK, Maddux AB, Lehmann T, Niemiec S, Mancuso CA, Khailova L, Mourani PM, Klawitter J, Davidson JA. Alteration in Indole Metabolites After Cardiopulmonary Bypass Surgery in Neonates and Infants. Crit Care Explor. 2025 May 1;7(5):e1267. PubMed PMID: 40327389
  • Osborne CM, Ambroggio L, Langelier C, Silviera L, Wagner BD, Yehya N, Levy R, Carpenter TC, Simões EAF, Maddux AB, Leroue MK, Tsitsiklas A, Mick E, Williamson K, Mourani PM, Dominguez SR. Multiplex Polymerase Chain Reaction Versus Standard Bacterial Culture in Critically Ill Children With Suspected Pneumonia. Pediatr Infect Dis J. 2025 Mar 1;44(3):263-269. PubMed PMID: 39853255
  • Lydon E, Osborne CM, Wagner BD, Ambroggio L, Harris JK, Reeder R, Carpenter TC, Maddux AB, Leroue MK, Yehya N, DeRisi JL, Hall MW, Zuppa AF, Carcillo J, Meert K, Sapru A, Pollack MM, McQuillen P, Notterman DA, Langelier CR, Mourani PM. Proteomic profiling of the local and systemic immune response to pediatric respiratory viral infections. mSystems. 2025 Jan 21;10(1):e0133524. PubMed PMID: 39611811
  • Faustino EVS, Kandil SB, Leroue MK, Sochet AA, Kong M, Cholette JM, Nellis ME, Pinto MG, Chegondi M, Ramirez M, Schreiber H, Kerris EWJ, Glau CL, Kolmar A, Muisyo TM, Sharathkumar A, Polikoff L, Silva CT, Ehrlich L, Navarro OM, Spinella PC, Raffini L, Taylor SN, McPartland T, Shabanova V. Protocol for the Catheter-Related Early Thromboprophylaxis With Enoxaparin (CRETE) Studies. Pediatr Crit Care Med. 2025 Jan 1;26(1):e95-e105. PubMed PMID: 39560771
  • Kilgallon KB, Leroue M, Shankman S, Shea T, Buckvold S, Mitchell M, Morgan G, Zablah J, Maddux AB. Extubated, Rehabilitation-Focused Extracorporeal Membrane Oxygenation for Pediatric Coronavirus Disease 2019: A Case Series. ASAIO J. 2025 Apr 1;71(4):e66-e71. PubMed PMID: 39052889
  • NA
  • Faustino EVS, Kandil SB, Leroue MK, Sochet AA, Kong M, Cholette JM, Nellis ME, Pinto MG, Chegondi M, Ramirez M, Schreiber H, Kerris EWJ, Glau CL, Kolmar A, Muisyo TM, Sharathkumar A, Polikoff L, Silva CT, Ehrlich L, Navarro OM, Spinella PC, Raffini L, Taylor SN, McPartland T, Shabanova V. Protocol for the Catheter-Related Early Thromboprophylaxis With Enoxaparin (CRETE) Studies. Pediatr Crit Care Med. 2024 Nov 19. [Epub ahead of print] PubMed PMID: 39560771
  • Lydon E, Osborne CM, Wagner BD, Ambroggio L, Kirk Harris J, Reeder R, Carpenter TC, Maddux AB, Leroue MK, Yehya N, DeRisi JL, Hall MW, Zuppa AF, Carcillo J, Meert K, Sapru A, Pollack MM, McQuillen P, Notterman DA, Langelier CR, Mourani PM. Proteomic profiling of the local and systemic immune response to pediatric respiratory viral infections. bioRxiv. 2024 Oct 10. PubMed PMID: 39416167
  • Kilgallon KB, Leroue M, Shankman S, Shea T, Buckvold S, Mitchell M, Morgan G, Zablah J, Maddux AB. Extubated, Rehabilitation-Focused Extracorporeal Membrane Oxygenation for Pediatric Coronavirus Disease 2019: A Case Series. ASAIO J. 2024 Jul 25. [Epub ahead of print] PubMed PMID: 39052889
  • Osborne CM, Langelier C, Kamm J, Williamson K, Ambroggio L, Reeder RW, Locandro C, Kirk Harris J, Wagner BD, Maddux AB, Caldera S, Lyden A, Soesanto V, Simões EAF, Leroue MK, Carpenter TC, Hall MW, Zuppa AF, Carcillo JA, Meert KL, Pollack MM, McQuillen PS, Notterman DA, DeRisi J, Mourani PM. Viral Detection by Reverse Transcriptase Polymerase Chain Reaction in Upper Respiratory Tract and Metagenomic RNA Sequencing in Lower Respiratory Tract in Critically Ill Children With Suspected Lower Respiratory Tract Infection. Pediatr Crit Care Med. 2024 Jan 1;25(1):e1-e11. PubMed PMID: 37732845
  • Mick E, Tsitsiklis A, Kamm J, Kalantar KL, Caldera S, Lyden A, Tan M, Detweiler AM, Neff N, Osborne CM, Williamson KM, Soesanto V, Leroue M, Maddux AB, Simões EA, Carpenter TC, Wagner BD, DeRisi JL, Ambroggio L, Mourani PM, Langelier CR. Integrated host/microbe metagenomics enables accurate lower respiratory tract infection diagnosis in critically ill children. J Clin Invest. 2023 Apr 3;133(7). PubMed PMID: 37009900
  • Zambrano LD, Wu MJ, Martin L, Malloch L, Chen S, Newhams MM, Kucukak S, Son MB, Sanders C, Patterson K, Halasa N, Fitzgerald JC, Leroue MK, Hall M, Irby K, Rowan CM, Wellnitz K, Sahni LC, Loftis L, Bradford TT, Staat M, Babbitt C, Carroll CL, Pannaraj PS, Kong M, Schuster JE, Chou J, Patel MM, Randolph AG, Campbell AP, Hobbs CV. Risk Factors for Multisystem Inflammatory Syndrome in Children: A Case-control Investigation. Pediatr Infect Dis J. 2023 Jun 1;42(6):e190-e196. PubMed PMID: 37000922
  • Leroue MK, Williamson KM, Curtin PC, Sontag MK, Wagner BD, Ambroggio L, Bixby M, Busgang SA, Murphy SE, Peterson LA, Vevang KR, Sipe CJ, Kirk Harris J, Reeder RW, Locandro C, Carpenter TC, Maddux AB, Simões EAF, Osborne CM, Robertson CE, Langelier C, Carcillo JA, Meert KL, Pollack MM, McQuillen PS, Mourani PM. Tobacco smoke exposure, the lower airways microbiome and outcomes of ventilated children. Pediatr Res. 2023 Aug;94(2):660-667. PubMed PMID: 36750739
  • Good RJ, Mashburn D, Jekich E, Miller K, Leroue MK, Woods J, Czaja AS. Simulation-Based Training for Ultrasound-Guided Central Venous Catheter Placement in Pediatric Patients. MedEdPORTAL. 2022;18:11276. PubMed PMID: 36249594
  • Tsitsiklis A, Osborne CM, Kamm J, Williamson K, Kalantar K, Dudas G, Caldera S, Lyden A, Tan M, Neff N, Soesanto V, Harris JK, Ambroggio L, Maddux AB, Carpenter TC, Reeder RW, Locandro C, Simões EAF, Leroue MK, Hall MW, Zuppa AF, Carcillo J, Meert KL, Sapru A, Pollack MM, McQuillen PS, Notterman DA, Dean JM, Zinter MS, Wagner BD, DeRisi JL, Mourani PM, Langelier CR. Lower respiratory tract infections in children requiring mechanical ventilation: a multicentre prospective surveillance study incorporating airway metagenomics. Lancet Microbe. 2022 Apr;3(4):e284-e293. PubMed PMID: 35544065
  • Leroue MK, Maddux AB, Mourani PM. Prone positioning in children with respiratory failure because of coronavirus disease 2019. Curr Opin Pediatr. 2021 Jun 1;33(3):319-324. PubMed PMID: 33782242
  • Mourani PM, Sontag MK, Williamson KM, Harris JK, Reeder R, Locandro C, Carpenter TC, Maddux AB, Ziegler K, Simões EAF, Osborne CM, Ambroggio L, Leroue MK, Robertson CE, Langelier C, DeRisi JL, Kamm J, Hall MW, Zuppa AF, Carcillo J, Meert K, Sapru A, Pollack MM, McQuillen P, Notterman DA, Dean JM, Wagner BD. Temporal airway microbiome changes related to ventilator-associated pneumonia in children. Eur Respir J. 2021 Mar;57(3). PubMed PMID: 33008935
  • Leroue MK, Maddux AB, Mourani PM. Prone positioning in children with respiratory failure because of coronavirus disease 2019. Curr Opin Pediatr. 2021 Jun 1;33(3):319-324. PubMed PMID: 33782242
  • Mourani PM, Sontag MK, Williamson KM, Harris JK, Reeder R, Locandro C, Carpenter TC, Maddux AB, Ziegler K, Simões EAF, Osborne CM, Ambroggio L, Leroue MK, Robertson CE, Langelier C, DeRisi JL, Kamm J, Hall MW, Zuppa AF, Carcillo J, Meert K, Sapru A, Pollack MM, McQuillen P, Notterman DA, Dean JM, Wagner BD. Temporal airway microbiome changes related to ventilator-associated pneumonia in children. Eur Respir J. 2021 Mar;57(3). PubMed PMID: 33008935
  • Good RJ, Leroue MK, Czaja AS. Accuracy of Administrative Codes for Distinguishing Positive Pressure Ventilation From High-Flow Nasal Cannula. Hosp Pediatr. 2018 Jul;8(7):426-429. PubMed PMID: 29880578
  • Leroue MK, Harris JK, Burgess KM, Stevens MJ, Miller JI, Sontag MK, Sierra YL, Wagner BD, Mourani PM. Molecular analysis of endotracheal tube biofilms and tracheal aspirates in the pediatric intensive care unit. Adv Pediatr Res. 2017 Dec;4(3). PubMed PMID: 29963643
  • Leroue MK, Good RJ, Skillman HE, Czaja AS. Enteral Nutrition Practices in Critically Ill Children Requiring Noninvasive Positive Pressure Ventilation. Pediatr Crit Care Med. 2017 Dec;18(12):1093-1098. PubMed PMID: 28816919
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Professional Memberships

  • Alpha Omega Alpha, Member
  • American Academy of Pediatrics, Member
  • Gold Humanism Honor Society, Member
  • Pediatric Acute Lung Injury and Sepsis Investigators, Member

Practice Locations

Children's Hospital Colorado Anschutz Medical Campus
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hospital Affiliation
  • Children's Hospital Colorado

Specialty Information

Specialties
  • Pediatrics, Board Certification (2017, 2022)
  • Pediatric Critical Care Medicine, Board Certification (2021)
Public Speaking
Yes


School of Medicine

CU Anschutz

Fitzsimons Building

13001 East 17th Place

Campus Box C290

Aurora, CO 80045

303.724.5375

School
General
Students