Vesna Jevtovic-Todorovic, MD, PhD

Professional Titles

• Professor

Research Interests

Developmental Neurotoxicity Pharmacology and mechanisms of chronic pain

Publications

• Sanner K, Kawell S, Evans JG, Elekovic V, Walz M, Joksimovic SL, Joksimovic SM, Donald RR, Tomic M, Orestes P, Feseha S, Dedek A, Ghodsi SM, Fallon IP, Lee J, Hwang SM, Hong SJ, Mayer JP, Covey DF, Romano C, Timic Stamenic T, Chemin J, Bourinet E, Poulen G, Longon N, Vachiery-Lahaye F, Bauchet L, Zorumski CF, Stowell MHB, Hildebrand ME, Eisenmesser EZ, Jevtovic-Todorovic V, Todorovic SM. Facilitation of Ca (V) 3.2 channel gating in pain pathways reveals a novel mechanism of serum-induced hyperalgesia. bioRxiv. 2025 Jan 16. PubMed PMID: 39868306
• Saric N, Atak Z, Sade CF, Reddy N, Bell G, Tolete C, Rajtboriraks MT, Hashimoto-Torii K, Jevtovic-Todorovic V, Haydar TF, Ishibashi N. Ciliopathy interacts with neonatal anesthesia to cause non-apoptotic caspase-mediated motor deficits. bioRxiv. 2024 Nov 27. PubMed PMID: 39651246
• Nguyen TB, Weitzel N, Hogan C, Kacmar RM, Williamson KM, Pattee J, Jevtovic-Todorovic V, Simmons CG, Faruki AA. Comparing Anesthesia and Surgery Controlled Time for Primary Total Knee and Hip Arthroplasty Between an Academic Medical Center and a Community Hospital: Retrospective Cohort Study. JMIR Perioper Med. 2024 Feb 26;7:e45126. PubMed PMID: 38407957
• Manzella FM, Cabrera OH, Wilkey D, Fine-Raquet B, Klawitter J, Krishnan K, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Sex-specific hypnotic effects of the neuroactive steroid (3ß,5ß,17ß)-3-hydroxyandrostane-17-carbonitrile are mediated by peripheral metabolism into an active hypnotic steroid. Br J Anaesth. 2023 Feb;130(2):154-164. PubMed PMID: 36428160
• Jevtovic-Todorovic V, Todorovic SM. The Role of Neuroactive Steroids in Analgesia and Anesthesia: An Interesting Comeback?. Biomolecules. 2023 Nov 15;13(11). PubMed PMID: 38002336
• Useinovic N, Near M, Cabrera OH, Boscolo A, Milosevic A, Harvey R, Newson A, Chastain-Potts S, Quillinan N, Jevtovic-Todorovic V. Neonatal sevoflurane exposure induces long-term changes in dendritic morphology in juvenile rats and mice. Exp Biol Med (Maywood). 2023 Apr;248(7):641-655. PubMed PMID: 37309741
• Fine-Raquet B, Manzella FM, Joksimovic SM, Dietz RM, Orfila JE, Sampath D, Tesic V, Atluri N, Covey DF, Raol YH, Jevtovic-Todorovic V, Herson PS, Todorovic SM. Neonatal exposure to a neuroactive steroid alters low-frequency oscillations in the subiculum. Exp Biol Med (Maywood). 2023 Apr;248(7):578-587. PubMed PMID: 37309730
• Useinovic N, Jevtovic-Todorovic V. Controversies in anesthesia-induced developmental neurotoxicity. Best Pract Res Clin Anaesthesiol. 2023 Mar;37(1):28-39. PubMed PMID: 37295851
• Jevtovic-Todorovic V, Useinovic N. Early exposure to general anaesthesia and increasing trends in developmental behavioural impairments: is there a link?. Br J Anaesth. 2023 Aug;131(2):208-211. PubMed PMID: 37173202
• Joksimovic SM, Ghodsi SM, Heinsbroek JA, Orfila JE, Busquet N, Tesic V, Valdez R, Fine-Raquet B, Jevtovic-Todorovic V, Raol YH, Herson PS, Todorovic SM. Ca(V)3.1 T-type calcium channels are important for spatial memory processing in the dorsal subiculum. Neuropharmacology. 2023 Mar 15;226:109400. PubMed PMID: 36586474
• Manzella FM, Cabrera OH, Wilkey D, Fine-Raquet B, Klawitter J, Krishnan K, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Sex-specific hypnotic effects of the neuroactive steroid (3ß,5ß,17ß)-3-hydroxyandrostane-17-carbonitrile are mediated by peripheral metabolism into an active hypnotic steroid. Br J Anaesth. 2023 Feb;130(2):154-164. PubMed PMID: 36428160
• Cabrera OH, Useinovic N, Maksimovic S, Near M, Quillinan N, Todorovic SM, Jevtovic-Todorovic V. Neonatal ketamine exposure impairs infrapyramidal bundle pruning and causes lasting increase in excitatory synaptic transmission in hippocampal CA3 neurons. Neurobiol Dis. 2022 Dec;175:105923. PubMed PMID: 36371060
• Simmons CG, Alvey NJ, Kaizer AM, Williamson K, Faruki AA, Kacmar RM, Jevtovic-Todorovic V, Weitzel NS. Correction to: Benchmarking of Anesthesia and Surgical Control Times by Current Procedural Terminology (CPT®) Codes. J Med Syst. 2022 Aug 11;46(9):60. PubMed PMID: 35951122
• Joksimovic SL, Jevtovic-Todorovic V, Todorovic SM. The role of voltage-gated calcium channels in the mechanisms of anesthesia and perioperative analgesia. Curr Opin Anaesthesiol. 2022 Aug 1;35(4):436-441. PubMed PMID: 35787588
• Useinovic N, Jevtovic-Todorovic V. Novel anesthetics in pediatric practice: is it time?. Curr Opin Anaesthesiol. 2022 Aug 1;35(4):425-435. PubMed PMID: 35787582
• Useinovic N, Maksimovic S, Liechty C, Cabrera OH, Quillinan N, Jevtovic-Todorovic V. Systemic inflammation exacerbates developmental neurotoxicity induced by sevoflurane in neonatal rats. Br J Anaesth. 2022 Oct;129(4):555-566. PubMed PMID: 35701270
• Timic Stamenic T, Manzella FM, Maksimovic S, Krishnan K, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Further Evidence that Inhibition of Neuronal Voltage-Gated Calcium Channels Contributes to the Hypnotic Effect of Neurosteroid Analogue, 3ß-OH. Front Pharmacol. 2022;13:850658. PubMed PMID: 35677453
• Saric N, Hashimoto-Torii K, Jevtovic-Todorovic V, Ishibashi N. Nonapoptotic caspases in neural development and in anesthesia-induced neurotoxicity. Trends Neurosci. 2022 Jun;45(6):446-458. PubMed PMID: 35491256
• Joksimovic SL, Jevtovic-Todorovic V, Todorovic SM. The Mechanisms of Plasticity of Nociceptive Ion Channels in Painful Diabetic Neuropathy. Front Pain Res (Lausanne). 2022;3:869735. PubMed PMID: 35419564
• Simmons CG, Alvey NJ, Kaizer AM, Williamson K, Faruki AA, Kacmar RM, Jevtovic-Todorovic V, Weitzel NS. Benchmarking of Anesthesia and Surgical Control Times by Current Procedural Terminology (CPT®) Codes. J Med Syst. 2022 Mar 4;46(4):19. PubMed PMID: 35244783
• Maksimovic S, Useinovic N, Quillinan N, Covey DF, Todorovic SM, Jevtovic-Todorovic V. General Anesthesia and the Young Brain: The Importance of Novel Strategies with Alternate Mechanisms of Action. Int J Mol Sci. 2022 Feb 8;23(3). PubMed PMID: 35163810
• Useinovic N, Maksimovic S, Near M, Quillinan N, Jevtovic-Todorovic V. Do We Have Viable Protective Strategies against Anesthesia-Induced Developmental Neurotoxicity?. Int J Mol Sci. 2022 Jan 20;23(3). PubMed PMID: 35163060
• Jevtovic-Todorovic V. Testosterone: much more for the brain than a sex hormone. Br J Anaesth. 2022 Mar;128(3):411-413. PubMed PMID: 35115156
• Manzella FM, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Synthetic neuroactive steroids as new sedatives and anaesthetics: Back to the future. J Neuroendocrinol. 2022 Feb;34(2):e13086. PubMed PMID: 35014105
• Jevtovic-Todorovic V. Sex hormones and the young brain: are we ready to embrace neuroprotective strategies?. Br J Anaesth. 2022 Feb;128(2):229-231. PubMed PMID: 34857358
• Joksimovic SM, Ghodsi SM, Heinsbroek JA, Orfila JE, Busquet N, Tesic V, Valdez R, Fine-Raquet B, Jevtovic-Todorovic V, Raol YH, Herson PS, Todorovic SM. Ca(V)3.1 T-type calcium channels are important for spatial memory processing in the dorsal subiculum. Neuropharmacology. 2022 Dec 29;226:109400. [Epub ahead of print] PubMed PMID: 36586474
• Jevtovic-Todorovic V. Sex hormones and the young brain: are we ready to embrace neuroprotective strategies? Br J Anaesth. 2021, in press.
• Manzella FM, Gulvezan BF, *Maksimovic S, *Useinovic N, Raol YH, Joksimovic SM, Jevtovic-Todorovic V, Todorovic SM Neonatal Isoflurane Does Not Affect Sleep Architecture and Minimally Alters Neuronal Beta Oscillations in Adolescent Rats. Front Behav Neurosci. 2021, 15:703859.
• Penning DH, Cazacu S, Brodie A, Jevtovic-Todorovic V, Kalkanis SN, Lewis M, Brodie C. Neuron-Glia Crosstalk Plays a Major Role in the Neurotoxic Effects of Ketamine via Extracellular Vesicles. Front Cell Dev Biol. 2021, 9: 691648.
• *Cabrera OH, *Useinovic N, Jevtovic-Todorovic V. Neonatal Anesthesia and dysregulation of the Epigenome. Biol Reprod. 2021, 105(3):720-734.
• Joksimovic SL, Lamborn N, Jevtovic-Todorovic V, Todorovic SM. Alpha lipoic acid attenuates evoked and spontaneous pain following surgical skin incision in rats. Channels 2021 15: 398-407.
• Joksimovic SM, Sampath D, Krishnan K, Covey DF, Jevtovic-Todorovic V, Raol YH, Todorovic SM. Differential effects of the novel neurosteroid hypnotic (3ß,5ß,17ß)-3-hydroxyandrostane-17-carbonitrile on electroencephalogram activity in male and female rats. Br J Anaesth. 2021, in press.
• Jevtovic-Todorovic V. Detrimental effects of general anaesthesia on young primates: are we closer to understanding the link? Br J Anaesth. 2021 126: 575-577.
• Anesthesia and Cancer, Friend or Foe? A Narrative Review. Montejano J, Jevtovic-Todorovic V. Front Oncol. 2021 Dec 23;11:803266. doi: 10.3389/fonc.2021.803266. eCollection 2021. PMID: 35004329
• Synthetic neuroactive steroids as new sedatives and anaesthetics: Back to the future. Manzella FM, Covey DF, Jevtovic-Todorovic V, Todorovic SM. J Neuroendocrinol. 2021 Dec 30:e13086. doi: 10.1111/jne.13086. Online ahead of print. PMID: 35014105
• The T-type calcium channel isoform Cav3.1 is a target for the hypnotic effect of the anaesthetic neurosteroid (3ß,5ß,17ß)-3-hydroxyandrostane-17-carbonitrile. Timic Stamenic T, Feseha S, Manzella FM, Wallace D, Wilkey D, Corrigan T, Fiedler H, Doerr P, Krishnan K, Raol YH, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Br J Anaesth. 2021 Jan;126(1):245-255. doi: 10.1016/j.bja.2020.07.022. Epub 2020 Aug 25. PMID: 32859366
• Jevtovic-Todorovic V, Vutskits L. Beyond Anesthesia Apoptosis: Wiring and Communication Matter!. Anesthesiology. 2020 Sep;133(3):495-496. PubMed PMID: 32788555
• Tesic V, Joksimovic SM, Quillinan N, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Neuroactive steroids alphaxalone and CDNC24 are effective hypnotics and potentiators of GABA(A) currents, but are not neurotoxic to the developing rat brain. Br J Anaesth. 2020 May;124(5):603-613. PubMed PMID: 32151384
• Chinn GA, Pearn ML, Vutskits L, Mintz CD, Loepke AW, Lee JJ, Chen J, Bosnjak ZJ, Brambrink AM, Jevtovic-Todorovic V, Sun LS, Sall JW. Standards for preclinical research and publications in developmental anaesthetic neurotoxicity: expert opinion statement from the SmartTots preclinical working group. Br J Anaesth. 2020 May;124(5):585-593. PubMed PMID: 32145876
• Cabrera OH, Gulvezan T, Symmes B, Quillinan N, Jevtovic-Todorovic V. Sex differences in neurodevelopmental abnormalities caused by early-life anaesthesia exposure: a narrative review. Br J Anaesth. 2020 Mar;124(3):e81-e91. PubMed PMID: 31980157
• Chastain-Potts SE, Tesic V, Tat QL, Cabrera OH, Quillinan N, Jevtovic-Todorovic V. Sevoflurane Exposure Results in Sex-Specific Transgenerational Upregulation of Target IEGs in the Subiculum. Mol Neurobiol. 2020 Jan;57(1):11-22. PubMed PMID: 31512116
• Diana P, Joksimovic SM, Faisant A, Jevtovic-Todorovic V. Early exposure to general anesthesia impairs social and emotional development in rats. Mol Neurobiol. 2020 Jan;57(1):41-50. PubMed PMID: 31494825
• Cabrera OH, Tesic V, Tat QL, Chastain S, Quillinan N, Jevtovic-Todorovic V. Sevoflurane-Induced Dysregulation of Cation-Chloride Cotransporters NKCC1 and KCC2 in Neonatal Mouse Brain. Mol Neurobiol. 2020 Jan;57(1):1-10. PubMed PMID: 31493242
• Joksimovic SM, DiGruccio MR, Boscolo A, Jevtovic-Todorovic V, Todorovic SM. The Role of Free Oxygen Radicals in Lasting Hyperexcitability of Rat Subicular Neurons After Exposure to General Anesthesia During Brain Development. Mol Neurobiol. 2020 Jan;57(1):208-216. PubMed PMID: 31493241
• Joksimovic SL, Joksimovic SM, Manzella FM, Asnake B, Orestes P, Raol YH, Krishnan K, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Novel neuroactive steroid with hypnotic and T-type calcium channel blocking properties exerts effective analgesia in a rodent model of post-surgical pain. Br J Pharmacol. 2020 Apr;177(8):1735-1753. PubMed PMID: 31732978
• Manzella FM, Joksimovic SM, Orfila JE, Fine BR, Dietz RM, Sampath D, Fiedler HK, Tesic V, Atluri N, Raol YH, Jevtovic-Todorovic V, Herson PS, Todorovic SM. Neonatal Ketamine Alters High-Frequency Oscillations and Synaptic Plasticity in the Subiculum But Does not Affect Sleep Macrostructure in Adolescent Rats. Front Syst Neurosci. 2020;14:26. PubMed PMID: 32528257
• Tat QL, Joksimovic SM, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Preemptive Analgesic Effect of Intrathecal Applications of Neuroactive Steroids in a Rodent Model of Post-Surgical Pain: Evidence for the Role of T-Type Calcium Channels. Cells. 2020 Dec 12;9(12). PubMed PMID: 33322727
• Timic Stamenic T, Feseha S, Manzella FM, Wallace D, Wilkey D, Corrigan T, Fiedler H, Doerr P, Krishnan K, Raol YH, Covey DF, Jevtovic-Todorovic V, Todorovic SM. The T-type calcium channel isoform Ca(v)3.1 is a target for the hypnotic effect of the anaesthetic neurosteroid (3ß,5ß,17ß)-3-hydroxyandrostane-17-carbonitrile. Br J Anaesth. 2020 Aug 25. [Epub ahead of print] PubMed PMID: 32859366
• Joksimovic SL, Evans JG, McIntire WE, Orestes P, Barrett PQ, Jevtovic-Todorovic V, Todorovic SM. Glycosylation of Ca(V)3.2 Channels Contributes to the Hyperalgesia in Peripheral Neuropathy of Type 1 Diabetes. Front Cell Neurosci. 2020;14:605312. PubMed PMID: 33384586
• 1. Tat QL, Joksimovic SM, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Preemptive Analgesic Effect of Intrathecal Applications of Neuroactive Steroids in a Rodent Model of Post-Surgical Pain: Evidence for the Role of T-Type Calcium Channels. Cells 2020, 9: 2674-2686.
• 2. Joksimovic SL, Evans JG, McIntire WE, Orestes P, Barrett PQ, Jevtovic-Todorovic V, Todorovic SM. Glycosylation of CaV3.2 Channels Contributes to the Hyperalgesia in Peripheral Neuropathy of Type 1 Diabetes. Front Cell Neurosci. 2020 15;14:605312.
• 3. Timic Stamenic T, Feseha S, Manzella FM, Wallace D, Wilkey D, Corrigan T, Fiedler H, Doerr P, Krishnan K, Raol YH, Covey DF, Jevtovic-Todorovic V, Todorovic SM. The T-type calcium channel isoform Cav3.1 is a target for the hypnotic effect of the anaesthetic neurosteroid (3ß,5ß,17ß)-3-hydroxyandrostane-17-carbonitrile. Br J Anaesth. 2020, S0007-0912 (20)30611-5.
• 5. Manzella FM, Joksimovic SM, Orfila JE, Fine BR, Dietz RM, Sampath D, Fiedler HK, *Tesic V, *Atluri N, Raol YH, Jevtovic-Todorovic V, Herson PS, Todorovic SM. Neonatal Ketamine Alters High-Frequency Oscillations and Synaptic Plasticity in the Subiculum But Does not Affect Sleep Macrostructure in Adolescent Rats. Front Syst Neurosci. 2020, 14:26.
• 6. *Tesic V, Joksimovic SM, Quillinan N, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Neuroactive steroids alphaxalone and CDNC24 are effective hypnotics and potentiators of GABAA currents, but are not neurotoxic to the developing rat brain. Br J Anaesth. 2020, 124(5): 603-613.
• 7. Chinn GA, Pearn ML, Vutskits L, Mintz CD, Loepke AW, Lee JJ, Chen J, Bosnjak ZJ, Brambrink AM, Jevtovic-Todorovic V, Sun LS, Sall JW. Standards for preclinical research and publications in developmental anaesthetic neurotoxicity: expert opinion statement from the SmartTots preclinical working group. Br J Anaesth. 2020, 124(5): 585-593.
• 8. *Cabrera OH, *Gulvezan T, *Symmes B, Quillinan N, Jevtovic-Todorovic V. Sex differences in neurodevelopmental abnormalities caused by early-life anaesthesia exposure: a narrative review. Br J Anaesth. 2020;124(3): e81-e91.
• Joksimovic SM, Izumi Y, Joksimovic SL, Tesic V, Krishnan K, Asnake B, Jevtovic-Todorovic V, Covey DF, Zorumski CF, Todorovic SM. Novel neurosteroid hypnotic blocks T-type calcium channel-dependent rebound burst firing and suppresses long-term potentiation in the rat subiculum. Br J Anaesth. 2019 May;122(5):643-651. PubMed PMID: 30916017
• Woodward TJ, Tesic V, Stamenic TT, Jevtovic-Todorovic V, Todorovic SM. Pharmacological Antagonism of T-Type Calcium Channels Constrains Rebound Burst Firing in Two Distinct Subpopulations of GABA Neurons in the Rat Ventral Tegmental Area: Implications for a-Lipoic Acid. Front Pharmacol. 2019;10:1402. PubMed PMID: 31849661
• Joksimovic SL, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Neurosteroids in Pain Management: A New Perspective on an Old Player. Front Pharmacol. 2018;9:1127. PubMed PMID: 30333753
• Joksimovic SL, Joksimovic SM, Tesic V, García-Caballero A, Feseha S, Zamponi GW, Jevtovic-Todorovic V, Todorovic SM. Selective inhibition of Ca(V)3.2 channels reverses hyperexcitability of peripheral nociceptors and alleviates postsurgical pain. Sci Signal. 2018 Aug 28;11(545). PubMed PMID: 30154101
• Vutskits L, Sall JW, Jevtovic-Todorovic V. A poisoned chalice: the heritage of parental anaesthesia exposure. Br J Anaesth. 2018 Aug;121(2):337-339. PubMed PMID: 30032869
• Tracy ME, Tesic V, Stamenic TT, Joksimovic SM, Busquet N, Jevtovic-Todorovic V, Todorovic SM. Ca(V)3.1 isoform of T-type calcium channels supports excitability of rat and mouse ventral tegmental area neurons. Neuropharmacology. 2018 Jun;135:343-354. PubMed PMID: 29578032
• Atluri N, Joksimovic SM, Oklopcic A, Milanovic D, Klawitter J, Eggan P, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. A neurosteroid analogue with T-type calcium channel blocking properties is an effective hypnotic, but is not harmful to neonatal rat brain. Br J Anaesth. 2018 Apr;120(4):768-778. PubMed PMID: 29576117
• Jevtovic-Todorovic V. Monkey business: the importance of mounting behavioural evidence for anaesthesia-induced developmental neurotoxicity. Br J Anaesth. 2018 Apr;120(4):617-619. PubMed PMID: 29576100
• Maloney SE, Creeley CE, Hartman RE, Yuede CM, Zorumski CF, Jevtovic-Todorovic V, Dikranian K, Noguchi KK, Farber NB, Wozniak DF. Using animal models to evaluate the functional consequences of anesthesia during early neurodevelopment. Neurobiol Learn Mem. 2018 Mar 14. [Epub ahead of print] PubMed PMID: 29550366
• Jevtovic-Todorovic V. Exposure of Developing Brain to General Anesthesia: What Is the Animal Evidence?. Anesthesiology. 2018 Apr;128(4):832-839. PubMed PMID: 29271804
• Joksimovic SM, Osuru HP, Oklopcic A, Beenhakker MP, Jevtovic-Todorovic V, Todorovic SM. Histone Deacetylase Inhibitor Entinostat (MS-275) Restores Anesthesia-induced Alteration of Inhibitory Synaptic Transmission in the Developing Rat Hippocampus. Mol Neurobiol. 2018 Jan;55(1):222-228. PubMed PMID: 28840475
• Obradovic AL, Atluri N, Dalla Massara L, Oklopcic A, Todorovic NS, Katta G, Osuru HP, Jevtovic-Todorovic V. Early Exposure to Ketamine Impairs Axonal Pruning in Developing Mouse Hippocampus. Mol Neurobiol. 2018 Jan;55(1):164-172. PubMed PMID: 28840469
• Jevtovic-Todorovic V, Brambrick A. General Anesthesia and Young Brain: What is New?. J Neurosurg Anesthesiol. 2018 Jul;30(3):217-222. PubMed PMID: 28622158
• Jevtovic-Todorovic V. Anesthetics and Cognitive Impairments in Developing Children: What is Our Responsibility? JAMA Pediatr. 171: 1135-1136, 2017.
• Soriano SG, Vutskits L, Jevtovic-Todorovic V, Hemmings HC. Thinking, fast and slow: highlights from the 2016 BJA seminar on anaesthetic neurotoxicity and neutoplasticity. Br J Anaesth. 119(3):443-447, 2017.
• Jevotovic-Todorovic V. Anaesthesia-induced developmental neurotoxicity: reality or fiction? Br J Anaesth. 119(3):455-457, 2017.
• Jin L, Ding M, Oklopcic A, Aghdasi B, Xiao L, Li Z, Jevtovic-Todorovic V. Nanoparticle fullerol alleviates radiculopathy via NLRP3 inflammasome and neuropeptides. Nanomedicine: Nanotechnology, Biology, and Medicine. 13(6):2049-2059, 2017.
• *Milanovic D, Pesic V, Loncarevic-Vasiljkovic N, Avramovic V, Tesic V, Jevtovic-Todorovic V, Kanazir S, Ruzdijic S. Neonatal Propofol Anesthesia Changes Expression of Synaptic Plasticity Proteins and Increases Stereotypic and Anxyolitic Behavior in Adult Rats. Neurotoxicity Research, 32(2):247-263, 2017.
• Joksimovic SM, Eggan P, Izumi Y, Joksimovic SLj, Tesic V, *Osuru HP, DiGruccio MR, Jevtovic-Todorovic V, Zorumski CF, TodorovicSM. The role of T-channels in the subiculum: to burst or not to burst? J Physiology, 595(19):6327-6348, 2017.
• Jevtovic-Todorovic V, Paule MG. Introduction to the Special Issue "Developmental Neurotoxicity Associated with Pediatric General Anesthesia: Preclinical Findings". Neurotoxicol Teratol, 2017.
• *Weaver J, Arandjelovic S, Brown G, Mendu S, Schappe M, Buckley M, Chiu Y-H, Shu S, Kim J, Chung J, Krupa J, Jevtovic-Todorovic V, Desai B, Ravichandran K, Bayliss DA. Hematopoietic pannexin 1 function is critical for neuropathic pain. Sci Rep. 7: 42550, 2017.
• *Zanghi CN, Jevtovic-Todorovic V. A holistic approach to anesthesia-induced neurotoxicity and its implications for future mechanistic studies. Neurotoxicol Teratol. 60:24-32, 2017.
• Jevtovic-Todorovic V. General Anesthetics and Neurotoxicity: How Much Do We Know? Anesthesiol Clin. 2016, 34(3):439-51.
• Milanovic D, Pesic V, Loncarevic-Vasiljkovic N, Pavkovic Z, Popic J, Kanazir S, Jevtovic-Todorovic V, Ruzdijic S. The Fas Ligand/Fas Death Receptor Pathways Contribute to Propofol-Induced Apoptosis and Neuroinflammation in the Brain of Neonatal Rats. Neurotox Res. 2016, 30(3):434-52.
• Dalla Massara L, Osuru HP, Oklopcic A, Milanovic D, Joksimovic SM, Caputo V, DiGruccio MR, Ori C, Wang G, Todorovic SM, Jevtovic-Todorovic V. General Anesthesia Causes Epigenetic Histone Modulation of c-Fos and Brain-derived Neurotrophic Factor, Target Genes Important for Neuronal Development in the Immature Rat Hippocampus. Anesthesiology 2016; 124(6):1311-27.
• 4. Jevtovic-Todorovic V, Vutskits L. Beyond Anesthesia Apoptosis: Wiring and Communication Matter! Anesthesiology 2020, 133(3):495-496.
• Jevtovic-Todorovic, V. General Anesthetics and the Young Brain. Editor(s): Michael J. Aminoff, Robert B. Daroff, Encyclopedia of the Neurological Sciences (Third Edition), Academic Press, in press, 2025.

Practice Locations

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

Hospital Affiliation

• University of Colorado Hospital

Center Affiliations

• Center for Neuroscience

Specialty Information

Specialties

• Anesthesiology, Board Certification