Slobodan Todorovic, MD, PhD

Professor, Anesthesiology


FacultyPhoto
Graduate Schools
  • PhD, University of Illinois At Chicago (1990)
  • MD, University of Belgrade (1982)
Internship
  • McGaw Medical Center of Northwestern University Program (1992)
Residencies
  • Washington University in St. Louis, Anesthesiology (1996)
  • Washington University/Barnes-Jewish Hospital/St. Louis Children's Hospital, Neurology (1993)
Fellowships
  • Washington University in St. Louis, Anesthesiology (1998)
Languages
English, Serbian
Department
Anesthesiology

Professional Titles

  • Professor of Anesthesiology

Research Interests

I am interested in mechanism of action and safety of general anesthetics

Publications

  • Todorovic SM. Painful Diabetic Neuropathy: Prevention or Suppression?. Int Rev Neurobiol. 2016;127:211-25. PubMed PMID: 27133151
  • Dalla Massara L, Osuru HP, Oklopcic A, Milanovic D, Joksimovic SM, Caputo V, DiGruccio MR, Ori C, Wang G, Todorovic SM, Jevtovic-Todorovic V. General Anesthesia Causes Epigenetic Histone Modulation of c-Fos and Brain-derived Neurotrophic Factor, Target Genes Important for Neuronal Development in the Immature Rat Hippocampus. Anesthesiology. 2016 Jun;124(6):1311-27. PubMed PMID: 27028464
  • Todorovic SM. Is Diabetic Nerve Pain Caused by Dysregulated Ion Channels in Sensory Neurons?. Diabetes. 2015 Dec;64(12):3987-9. PubMed PMID: 26604173
  • Joksimovic SJ, Eggan P, Izumi Y, Joksimovic SLj, Tesic V, Dietz RM, Orfila JE, DiGruccio MR, Herson PS, Jevtovic-Todorovic V, Zorumski CF, Todorovic SM. The role of T-type calcium channels in the subiculum: to burst or not to burst? J Physiol, 2017, 000.00:1-22.
  • TT Stamenic and SM Todorovic. Electrophysiological characterization of T-type calcium channels in central medical nucleus of the rat thalamus. Biophysical Journal, vol. 112 (3), Supplement 1, p107a, February 2017.
  • Joksimovic SL, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Neurosteroids in Pain Management: A New Perspective on an Old Player. Front Pharmacol. 2018;9:1127. PubMed PMID: 30333753
  • Joksimovic SL, Joksimovic SM, Tesic V, García-Caballero A, Feseha S, Zamponi GW, Jevtovic-Todorovic V, Todorovic SM. Selective inhibition of Ca(V)3.2 channels reverses hyperexcitability of peripheral nociceptors and alleviates postsurgical pain. Sci Signal. 2018 Aug 28;11(545). PubMed PMID: 30154101
  • Tracy ME, Tesic V, Stamenic TT, Joksimovic SM, Busquet N, Jevtovic-Todorovic V, Todorovic SM. Ca(V)3.1 isoform of T-type calcium channels supports excitability of rat and mouse ventral tegmental area neurons. Neuropharmacology. 2018 Jun;135:343-354. PubMed PMID: 29578032
  • Atluri N, Joksimovic SM, Oklopcic A, Milanovic D, Klawitter J, Eggan P, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. A neurosteroid analogue with T-type calcium channel blocking properties is an effective hypnotic, but is not harmful to neonatal rat brain. Br J Anaesth. 2018 Apr;120(4):768-778. PubMed PMID: 29576117
  • Stamenic TT, Todorovic SM. Cytosolic ATP Relieves Voltage-Dependent Inactivation of T-Type Calcium Channels and Facilitates Excitability of Neurons in the Rat Central Medial Thalamus. eNeuro. 2018 Jan-Feb;5(1). PubMed PMID: 29468189
  • Joksimovic SM, Osuru HP, Oklopcic A, Beenhakker MP, Jevtovic-Todorovic V, Todorovic SM. Histone Deacetylase Inhibitor Entinostat (MS-275) Restores Anesthesia-induced Alteration of Inhibitory Synaptic Transmission in the Developing Rat Hippocampus. Mol Neurobiol. 2018 Jan;55(1):222-228. PubMed PMID: 28840475
  • Woodward TJ, Tesic V, Stamenic TT, Jevtovic-Todorovic V, Todorovic SM. Pharmacological Antagonism of T-Type Calcium Channels Constrains Rebound Burst Firing in Two Distinct Subpopulations of GABA Neurons in the Rat Ventral Tegmental Area: Implications for a-Lipoic Acid. Front Pharmacol. 2019;10:1402. PubMed PMID: 31849661
  • Joksimovic SL, Joksimovic SM, Manzella FM, Asnake B, Orestes P, Raol YH, Krishnan K, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Novel neuroactive steroid with hypnotic and T-channel blocking properties exerts effective analgesia in a rodent model of post-surgical pain. Br J Pharmacol. 2019 Nov 15. [Epub ahead of print] PubMed PMID: 31732978
  • Chemin J, Stamenic TT, Cazade M, Llinares J, Blesneac I, Todorovic SM, Lory P. A novel phospho-modulatory mechanism contributes to the calcium-dependent regulation of T-type Ca(2 ) channels. Sci Rep. 2019 Oct 30;9(1):15642. PubMed PMID: 31666636
  • Joksimovic SM, DiGruccio MR, Boscolo A, Jevtovic-Todorovic V, Todorovic SM. The Role of Free Oxygen Radicals in Lasting Hyperexcitability of Rat Subicular Neurons After Exposure to General Anesthesia During Brain Development. Mol Neurobiol. 2019 Sep 6. [Epub ahead of print] PubMed PMID: 31493241
  • Joksimovic SM, Izumi Y, Joksimovic SL, Tesic V, Krishnan K, Asnake B, Jevtovic-Todorovic V, Covey DF, Zorumski CF, Todorovic SM. Novel neurosteroid hypnotic blocks T-type calcium channel-dependent rebound burst firing and suppresses long-term potentiation in the rat subiculum. Br J Anaesth. 2019 May;122(5):643-651. PubMed PMID: 30916017
  • Woodward TJ, Timic Stamenic T, Todorovic SM. Neonatal general anesthesia causes lasting alterations in excitatory and inhibitory synaptic transmission in the ventrobasal thalamus of adolescent female rats. Neurobiol Dis. 2019 Jul;127:472-481. PubMed PMID: 30825640
  • Timic Stamenic T, Feseha S, Valdez R, Zhao W, Klawitter J, Todorovic SM. Alterations in Oscillatory Behavior of Central Medial Thalamic Neurons Demonstrate a Key Role of CaV3.1 Isoform of T-Channels During Isoflurane-Induced Anesthesia. Cereb Cortex. 2019 Dec 17;29(11):4679-4696. PubMed PMID: 30715245
  • Joksimovic SL, Donald RR, Park JY, Todorovic SM. Inhibition of multiple voltage-gated calcium channels may contribute to spinally mediated analgesia by epipregnanolone in a rat model of surgical paw incision. Channels (Austin). 2019 Dec;13(1):48-61. PubMed PMID: 30672394
  • Tat QL, Joksimovic SM, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Preemptive Analgesic Effect of Intrathecal Applications of Neuroactive Steroids in a Rodent Model of Post-Surgical Pain: Evidence for the Role of T-Type Calcium Channels. Cells. 2020 Dec 12;9(12). PubMed PMID: 33322727
  • Feseha S, Timic Stamenic T, Wallace D, Tamag C, Yang L, Pan JQ, Todorovic SM. Global genetic deletion of Ca(V)3.3 channels facilitates anaesthetic induction and enhances isoflurane-sparing effects of T-type calcium channel blockers. Sci Rep. 2020 Dec 9;10(1):21510. PubMed PMID: 33299036
  • Raol YH, Joksimovic SM, Sampath D, Matter BA, Lam PM, Kompella UB, Todorovic SM, González MI. The role of KCC2 in hyperexcitability of the neonatal brain. Neurosci Lett. 2020 Nov 1;738:135324. PubMed PMID: 32860887
  • Manzella FM, Joksimovic SM, Orfila JE, Fine BR, Dietz RM, Sampath D, Fiedler HK, Tesic V, Atluri N, Raol YH, Jevtovic-Todorovic V, Herson PS, Todorovic SM. Neonatal Ketamine Alters High-Frequency Oscillations and Synaptic Plasticity in the Subiculum But Does not Affect Sleep Macrostructure in Adolescent Rats. Front Syst Neurosci. 2020;14:26. PubMed PMID: 32528257
  • Timic Stamenic T, Feseha S, Manzella FM, Wallace D, Wilkey D, Corrigan T, Fiedler H, Doerr P, Krishnan K, Raol YH, Covey DF, Jevtovic-Todorovic V, Todorovic SM. The T-type calcium channel isoform Ca(v)3.1 is a target for the hypnotic effect of the anaesthetic neurosteroid (3ß,5ß,17ß)-3-hydroxyandrostane-17-carbonitrile. Br J Anaesth. 2020 Aug 25. [Epub ahead of print] PubMed PMID: 32859366
  • Tesic V, Joksimovic SM, Quillinan N, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Neuroactive steroids alphaxalone and CDNC24 are effective hypnotics and potentiators of GABA(A) currents, but are not neurotoxic to the developing rat brain. Br J Anaesth. 2020 May;124(5):603-613. PubMed PMID: 32151384
  • Joksimovic SL, Joksimovic SM, Manzella FM, Asnake B, Orestes P, Raol YH, Krishnan K, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Novel neuroactive steroid with hypnotic and T-type calcium channel blocking properties exerts effective analgesia in a rodent model of post-surgical pain. Br J Pharmacol. 2020 Apr;177(8):1735-1753. PubMed PMID: 31732978
  • Joksimovic SL, Evans JG, McIntire WE, Orestes P, Barrett PQ, Jevtovic-Todorovic V, Todorovic SM. Glycosylation of Ca(V)3.2 Channels Contributes to the Hyperalgesia in Peripheral Neuropathy of Type 1 Diabetes. Front Cell Neurosci. 2020;14:605312. PubMed PMID: 33384586
  • Joksimovic SM, DiGruccio MR, Boscolo A, Jevtovic-Todorovic V, Todorovic SM. The Role of Free Oxygen Radicals in Lasting Hyperexcitability of Rat Subicular Neurons After Exposure to General Anesthesia During Brain Development. Mol Neurobiol. 2020 Jan;57(1):208-216. PubMed PMID: 31493241
  • Hoffmann T, Kistner K, Joksimovic SLJ, Todorovic SM, Reeh PW, Sauer SK. Painful diabetic neuropathy leads to functional Ca(V)3.2 expression and spontaneous activity in skin nociceptors of mice. Exp Neurol. 2021 Dec;346:113838. PubMed PMID: 34450183
  • Coulter I, Timic Stamenic T, Eggan P, Fine BR, Corrigan T, Covey DF, Yang L, Pan JQ, Todorovic SM. Different roles of T-type calcium channel isoforms in hypnosis induced by an endogenous neurosteroid epipregnanolone. Neuropharmacology. 2021 Oct 1;197:108739. PubMed PMID: 34339750
  • Joksimovic SM, Sampath D, Krishnan K, Covey DF, Jevtovic-Todorovic V, Raol YH, Todorovic SM. Differential effects of the novel neurosteroid hypnotic (3ß,5ß,17ß)-3-hydroxyandrostane-17-carbonitrile on electroencephalogram activity in male and female rats. Br J Anaesth. 2021 Sep;127(3):435-446. PubMed PMID: 33972091
  • Joksimovic SL, Lamborn N, Jevtovic-Todorovic V, Todorovic SM. Alpha lipoic acid attenuates evoked and spontaneous pain following surgical skin incision in rats. Channels (Austin). 2021 Dec;15(1):398-407. PubMed PMID: 33843451
  • Timic Stamenic T, Feseha S, Manzella FM, Wallace D, Wilkey D, Corrigan T, Fiedler H, Doerr P, Krishnan K, Raol YH, Covey DF, Jevtovic-Todorovic V, Todorovic SM. The T-type calcium channel isoform Ca(v)3.1 is a target for the hypnotic effect of the anaesthetic neurosteroid (3ß,5ß,17ß)-3-hydroxyandrostane-17-carbonitrile. Br J Anaesth. 2021 Jan;126(1):245-255. PubMed PMID: 32859366
  • Joksimovic SL, Jevtovic-Todorovic V, Todorovic SM. The role of voltage-gated calcium channels in the mechanisms of anesthesia and perioperative analgesia. Curr Opin Anaesthesiol. 2022 Aug 1;35(4):436-441. PubMed PMID: 35787588
  • Timic Stamenic T, Manzella FM, Maksimovic S, Krishnan K, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Further Evidence that Inhibition of Neuronal Voltage-Gated Calcium Channels Contributes to the Hypnotic Effect of Neurosteroid Analogue, 3ß-OH. Front Pharmacol. 2022;13:850658. PubMed PMID: 35677453
  • Joksimovic SL, Jevtovic-Todorovic V, Todorovic SM. The Mechanisms of Plasticity of Nociceptive Ion Channels in Painful Diabetic Neuropathy. Front Pain Res (Lausanne). 2022;3:869735. PubMed PMID: 35419564
  • Ghodsi SM, Walz M, Schneider T, Todorovic SM. L-cysteine modulates visceral nociception mediated by the Ca(V)2.3 R-type calcium channels. Pflugers Arch. 2022 Apr;474(4):435-445. PubMed PMID: 35267086
  • Timic Stamenic T, Todorovic SM. Thalamic T-Type Calcium Channels as Targets for Hypnotics and General Anesthetics. Int J Mol Sci. 2022 Feb 21;23(4). PubMed PMID: 35216466
  • Fine-Raquet B, Manzella FM, Joksimovic SM, Dietz RM, Orfila JE, Sampath D, Tesic V, Atluri N, Covey DF, Raol YH, Jevtovic-Todorovic V, Herson PS, Todorovic SM. Neonatal exposure to a neuroactive steroid alters low-frequency oscillations in the subiculum. Exp Biol Med (Maywood). 2023 Apr;248(7):578-587. PubMed PMID: 37309730
  • Moreno M, Minjarez C, Todorovic SM, Quillinan N. Distinct excitability of thalamocortical neurons correlates with the presence of cerebellar afferents. bioRxiv. 2023 May 26. PubMed PMID: 37292810
  • Joksimovic SM, Ghodsi SM, Heinsbroek JA, Orfila JE, Busquet N, Tesic V, Valdez R, Fine-Raquet B, Jevtovic-Todorovic V, Raol YH, Herson PS, Todorovic SM. Ca(V)3.1 T-type calcium channels are important for spatial memory processing in the dorsal subiculum. Neuropharmacology. 2023 Mar 15;226:109400. PubMed PMID: 36586474
  • Todorovic SM. Opioid-induced hyperalgesia: Are thalamic T-type calcium channels treatment targets?. J Clin Invest. 2022 Dec 15;132(24). PubMed PMID: 36519545
  • Manzella FM, Cabrera OH, Wilkey D, Fine-Raquet B, Klawitter J, Krishnan K, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Sex-specific hypnotic effects of the neuroactive steroid (3ß,5ß,17ß)-3-hydroxyandrostane-17-carbonitrile are mediated by peripheral metabolism into an active hypnotic steroid. Br J Anaesth. 2023 Feb;130(2):154-164. PubMed PMID: 36428160
  • Cabrera OH, Useinovic N, Maksimovic S, Near M, Quillinan N, Todorovic SM, Jevtovic-Todorovic V. Neonatal ketamine exposure impairs infrapyramidal bundle pruning and causes lasting increase in excitatory synaptic transmission in hippocampal CA3 neurons. Neurobiol Dis. 2022 Dec;175:105923. PubMed PMID: 36371060
  • Maksimovic S, Useinovic N, Quillinan N, Covey DF, Todorovic SM, Jevtovic-Todorovic V. General Anesthesia and the Young Brain: The Importance of Novel Strategies with Alternate Mechanisms of Action. Int J Mol Sci. 2022 Feb 8;23(3). PubMed PMID: 35163810
  • Joksimovic SL, Jevtovic-Todorovic V, Todorovic SM. The role of voltage-gated calcium channels in the mechanisms of anesthesia and perioperative analgesia. Curr Opin Anaesthesiol. 2022 Aug 1;35(4):436-441. PubMed PMID: 35787588
  • Timic Stamenic T, Manzella FM, Maksimovic S, Krishnan K, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Further Evidence that Inhibition of Neuronal Voltage-Gated Calcium Channels Contributes to the Hypnotic Effect of Neurosteroid Analogue, 3ß-OH. Front Pharmacol. 2022;13:850658. PubMed PMID: 35677453
  • Joksimovic SL, Jevtovic-Todorovic V, Todorovic SM. The Mechanisms of Plasticity of Nociceptive Ion Channels in Painful Diabetic Neuropathy. Front Pain Res (Lausanne). 2022;3:869735. PubMed PMID: 35419564
  • Manzella FM, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Synthetic neuroactive steroids as new sedatives and anaesthetics: Back to the future. J Neuroendocrinol. 2022 Feb;34(2):e13086. PubMed PMID: 35014105
  • Ghodsi SM, Walz M, Schneider T, Todorovic SM. L-cysteine modulates visceral nociception mediated by the Ca(V)2.3 R-type calcium channels. Pflugers Arch. 2022 Apr;474(4):435-445. PubMed PMID: 35267086
  • Timic Stamenic T, Todorovic SM. Thalamic T-Type Calcium Channels as Targets for Hypnotics and General Anesthetics. Int J Mol Sci. 2022 Feb 21;23(4). PubMed PMID: 35216466
  • Maksimovic S, Useinovic N, Quillinan N, Covey DF, Todorovic SM, Jevtovic-Todorovic V. General Anesthesia and the Young Brain: The Importance of Novel Strategies with Alternate Mechanisms of Action. Int J Mol Sci. 2022 Feb 8;23(3). PubMed PMID: 35163810
  • Manzella FM, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Synthetic neuroactive steroids as new sedatives and anaesthetics: Back to the future. J Neuroendocrinol. 2022 Feb;34(2):e13086. PubMed PMID: 35014105

Professional Memberships

  • Society For Neuroscience, member
  • American Society of Anesthesiologists, member
  • Colorado Society of Anesthesiologists, member
  • Association of University Anesthesiologists, member

Practice Locations

Hospital Affiliation
  • Veterans Affairs Medical Center

Specialty Information

Specialties
  • Anesthesiology, Board Certification
Personal Interests
In my spare time I enjoy outdoor cycling and working out in gym